- Total grants
- Total funders
- Total recipients
- Earliest award date
- 20 Nov 1998
- Latest award date
- 05 May 2020
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
Proteomics at the Wellcome Trust Centre for Cell Biology (WTCCB) and School of Biological Sciences (SBS), Edinburgh. 11 Jun 2015
This application requests funds to expand the existing proteomics resources for WTCCB and SBS at UoEdinburgh through the purchase of a next-generation Orbitrap Fusion mass spectrometer, to replace a dated instrument installed in 2006. All organisms depend on exquisite control of the proteome and the precisely orchestrated interplay of proteins, RNA and/or DNA. Our overall research goal is to mechanistically dissect key cell biological processes by identification of all salient proteins and their myriad interactions. We have developed novel approaches, including protein cross-linking and chromatin purifications, to reveal the structure and dynamics of protein interactions at unprecedented resolution. However, many regulatory proteins are scarce and hence at the margins of detection with our current instrumentation. Most of our projects involve complex protein mixtures that require substantial measurement times, such that instrument availability is a serious bottleneck to research produc tivity. Our novel protocols for the analysis of protein structure by mass spectrometry require a specific instrument configuration that is only sub-optimally available with our current instrument. The Fusion instrument requested will provide substantial improvements in sensitivity, speed and configuration that will alleviate current limitations and ensure the on-going competitiveness of WTCCB/SBS across a large body of Wellcome Trust-funded research activities.
Development of a biomarker to predict the need for biologic therapy at the time of Rheumatoid Arthritis Diagnosis. 25 Aug 2015
Development of a biomarker to predict the need for biologic therapy at the time of Rheumatoid Arthritis DiagnosisOf the 400,000 patients with Rheumatoid Arthritis in the UK, only 10% become eligible for a disease-modifying biologic therapy after delays of a year or more. About a third of these patients remain refractory for such therapy following their diagnosis. Delaying effective therapy reduces the chances of a patient ever achieving clinical remission and increases their risk of long-term joint damage. Dr Mohini Gray and colleagues at the University of Edinburgh have discovered a predictive biomarker that can identify these patients at diagnosis, allowing for the rapid transition to effective biologic therapy.Utilising Next Generation Sequencing (NGS), of peripheral blood B cells, Gray and her team will develop this predictive biomarker, to rapidly identify refractory patients. With Pathfinder funding the team will validate the assay using larger independent cohorts of patients. In addition, the assay will be simplified to test applicability to a real-life clinical setting.
The Time Travelling Operating Theatre. 14 Jan 2015
In the past three years Imperial's Department of Surgery has run a series of highly successful, Wellcome-funded events using surgical simulation. The objective of these events has been to simulate current day operating theatres as a way of opening the closed world of surgery to the public. Alongside this the department has run another Wellcome-funded project recapturing the history of twentieth-century surgery through simulation-based re-enactment. Through this project, pioneering work has been undertaken investigating the roots of 'minimally invasive' surgery, a practice now considered standard. Our project takes these ideas a creative step forward by constructing a transportable simulation, which will show three different eras of surgery - 1884, 1984 and 2014 - during one viewing (a sequential simulation). Each two-hour event will comprise a comparable re-enactment of surgery from each of these three dates, performed by medical professionals from our wide range of contacts. In -between each performance there will be an opportunity for discussion between the audience, the performers and a small panel of experts, including historians, ethicists and medical professionals. Thus, the events will be fully participatory, with audience members invited not just to listen and witness but also to engage and contribute. By stimulating discussion about what surgery has been and what it might become, this project will contribute to public understanding of the history of surgery. It will also invite new perspectives on expectations upon future surgery, which will feed into wider ethical discussions and policy-making.
The Heart & Lung Repair Shops Extension 31 Mar 2015
The Heart and Lung Convenience Store will be the National Heart and Lung Institute's second popup science shop, embedding creative science engagement within the community setting of a bustling West London shopping centre. Academics, clinicians and researchers will collaborate with artists, designers, craftspeople and performers to transform an empty retail unit in Hammersmith's Kings Mall into a visually captivating space. The visitor experience will incorporate interactive multi-sensory activities engaging audiences with topics including personalised medicine, rapid diagnosis, targeted treatments, healthcare technologies and generally more convenient heart and lung healthcare for the future. The shop will open for two weeks from 19 October-1 November 2015. Audiences will engage through visual exhibits and displays, participatory installations, demonstrations, workshops, talks and performances. In addition to standard opening hours we will hold special events both within the shop and at local community venues including evening debates, schools workshops, a heart and lung comedy night, a heart and lung pub quiz and a heart and lung hackathon. The project will have an online presence through the NHLI website, The Heart and Lung Convenience Store Shopping Channel on YouTube where filmed content will be collected, partner organisation websites (including Fun Kids radio) and social media channels.