- Total grants
- Total funders
- Total recipients
- Earliest award date
- 20 Nov 1998
- Latest award date
- 05 May 2020
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
New perspectives for anti-viral therapy: The regulatory roles of genomic RNA in virus assembly, infection and evolution. 02 Dec 2015
Creating responsive health systems: improving the use of feedback from service users in quality assurance and human resource management in Bangladesh 15 Mar 2016
The AIM of this project is to assist the policymakers in designing a comprehensive health systems intervention to make the Bangladesh's health system more responsive. Specific project OBJECTIVES are to work closely with national and local decision-makers to: 1. Develop an in-depth understanding of the nature and contents of, and key reasons for, feedback received from health service users at Upazila level; 2. Analyse the processes of collecting and responding to service users' feedback at Upazila level, as well as the key contextual facilitators and constraints influencing these processes; 3. Assess the approach to, and processes of, service quality assurance and human resource management, focusing specifically on the use of feedback from service users at Upazila level; 4. Using results of objectives 1-3, develop a comprehensive health systems intervention to improve the use of feedback from service users in quality assurance and human resource management processes at Upazila level.This project focuses on Bangladesh, a low income Asian country where the Ministry of Health and Family Welfare (MOHFW) is implementing a program allowing service users to send feedback via SMS texts. This 18-months project will analyse the national user feedback data and focus in-depth on two Upazila Health Complexes (UHC) in one district. Throughout the project, we will work closely with decision-makers, to facilitate the shared understanding, adoption of results into policy and practice and achieving its highest impact. The project results will be communicated widely through development of policy briefs, presentations at management meetings, development of newsletters and press-releases, to ensure their uptake in policy and practice in Bangladesh and wider.
High-throughput cell separation in physiologically-relevant media using remote, surface-acoustic-wave-induced dielectrophoresis for autologous cell therapies' 13 Jan 2016
The separation of specific cell types from mixed populations is fundamental to a growing number of emerging medical procedures, including autologous cell therapies. The increasing importance of such therapies is overshadowed by technological shortfalls in the efficient, minimally manipulative enrichment of specific, viable cell populations within intra-operative timescales. Current separation techniques (e.g. adherence, density or antibody-binding) cannot satisfy these criteria, hence a growing urgency exists to discover technological solutions to these challenges. Here, we use shear-horizontal surface acoustic waves (SH-SAWs) to induce dielectrophoretic (DEP)-based enrichment of viable, human mesenchymal stromal cells from bone marrow aspirate, with which we will demonstrate enhanced wound repair in critical calvarial defects. SAWs propagate at the surface of piezoelectric materials, away from electrodes positioned externally to a cell-containing fluidic channel. SH-SAWs do not induce density-based cell separation through generation of fluidic pressure-waves, but instead, non-uniform electric fields coupled to the SAW form virtual electrodes within the fluid. These induce highly-specific DEP-based cell separation – critically, without inducing electrochemical reactions that would affect cell viability or phenotype, thereby allowing operation in physiologically-relevant medium. SAW-DEP therefore differs from all previous SAW- or DEP-based separation, overcoming the limitations of either technology in isolation, and satisfying the required clinical criteria.
Development of a microfluidic device to study single cells in controllable microenvironments 01 Apr 2016
The project is coming together of two exciting areas of sciences, which we think will make a significant contribution to our understanding for the nature of basic unit of life, the cells. The first aspect is the use of microfluidic technology as a quantitative and reproducible method for monitoring individual cells. The second aspect is the research of Embryonic Stem (ES) cells representing an excellent system to study the interaction between intrinsic and extrinsic factors in cell fate decisions. The primary goal of this research is the development of a microfluidic methodology that enables study of the gene expression occurring in a single cell, and controlling the microenvironments enclosing cells. The microfluidic technology will open the possibility of exploring problems in eukaryotic cells as much of our ability to harness the potential of ES cells will depend on our ability to control interactions between the cell and the signals that determine its behaviour.