- Total grants
- Total funders
- Total recipients
- Earliest award date
- 03 Jan 2017
- Latest award date
- 21 Dec 2017
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
New Year 9 Cup competition 23 May 2017
Funding under Sport England's Small Grants funding programme for a Revenue project titled 'New Year 9 Cup competition'. This project is a Association Football project, with a focus on younger beneficiaries.
Funding under Sport England's Core GIA funding programme for a Revenue project titled 'NBS Efficiency Report at Harvey Hadden Sports Park'. This project lists its main activity as Swimming & Diving. This funding has contributed towards a Swimming Pool - Swimming Pool (Leisure)
Swimming Pool Building Refurbishment 11 Aug 2017
Funding under Sport England's Community Asset Fund funding programme for a Capital project titled 'Swimming Pool Building Refurbishment'. This project lists its main activity as Multi Sports. This funding has contributed towards a Swimming Pool - Swimming Pool (No Sub-Facility)
The role of malignant B cells in Hodgkin lymphoma is unknow. Recent studies in Birmingham have provided preliminary evidence that non-malignant B cells frequently infiltrate the tissue of Hodgkin’s lymphoma. Furthermore, previous studies reported the clinical benefit of Rituximab, with CD20 negative tumour cells, which was unanticipated as it is a therapy targeted to CD20 positive cells. This suggested that non-tumour B cells promote tumour cell survival. Moreover, my supervisor's lab has recently optimised highly sensitive in situ hybridisation to detect in tissue sections the immunosuppressive cytokine IL-10, widely established as a marker of a subset of regulatory B cells. Taking these findings into consideration I am to: Characterise the non-tumour B cell population of Hodgkin’s lymphoma Determine the extent to which the phenotype of non-malignant B cells in Hodgkin’s lymphoma varies with tumour subtype and EBV status To determine the extent at which Hodgkin’s lymphoma xenografts recapitulate B cell infiltration in a humanised mouse model
Gamma knife®(GK) is a stereotactic radiosurgery that can be used to treat trigeminal neuralgia(TN), without the need for pharmacological medication, and has been shown to result in patients being pain free without medication from as early as 6 months after surgery (Loescher et al, 2012). TN is a serious health issue that causes short, reoccurring sessions of intense, sharp facial pain, which has been compared to the feeling of an electric shock (Headache Classification Subcommittee of the International Headache Society, 2013). The cost effectiveness of GK has yet to be fully elucidated. Qualitative work has evaluated the effects of the drug of choice, Carbamazepine, used to treat TN, and found that patients report motor and cognitive difficulties (Zakrzewska et al, 2017). However, a more objective, quantitative investigation into the effects of Carbamazepine and GK treatment on patients with TN would allow for standardised assessment of risks and benefits and therefore make cost-effectiveness discussions more informed. This study will investigate the effects of different treatment regimens on manual dexterity tasks, where participants use a handheld stylus to interact with visual stimuli and postural stability tasks, where participants are exposed to a cognitive load and their gross motor control is measured.
The Ketone Diet and Embryological Development; Examining the cellular variations in brain and spinal cord precursor cells in a ketogenic supplemented cell culture model 27 Apr 2017
The ketone diet (KD) replaces glucose for ketone bodies as the primary brain fuel by reducing carbohydrate and increasing fat and protein intake. The diet is growing in popularity and many women of childbearing age are choosing the ketone diet for greater long-term weight loss results. Some data suggests that KD during pregnancy results in foetal anatomical abnormalities, predicting organ dysfunction post-natally. This study will evaluate the potential cellular effects of beta-hydroxybutyrate (ketogenic) supplementation on neural precursors and their subsequent lineage potentials during central nervous system (CNS) formation in a C57B6 mouse cell culture model. Vimentin and nestin are present on all neural precursors. Upon differentiation to astrocytes, these proteins are down-regulated in exchange for increased expression of brain lipid binding protein (BLBP) which is strictly expressed on mature astrocytes. The study will examine expression of these and other biomarkers in an effort to observe abnormalities and understand the mechanisms behind ketosis induced alterations in CNS cell growth. The final goal is to determine if KD during embryological development exerts an effect on cell lineage and phenotype. Results will provide information to educate women and health professionals considering KD.
Internal daily timekeeping systems known as circadian clocks are used by all types of organisms to regulate their metabolism. For example, the clock-controlled scheduling of food intake and use affects health and longevity in both mammals and insects. Time-restricted or nutrient-restricted feeding improves the health of both mice and fruit flies (Panda, Science 2016). The period gene, which plays a key role in the circadian clocks of animals, provides a link between daily timekeeping and metabolic health. Flies lacking the period gene store less glycogen and triglycerides in spite of ingesting more food and are, therefore, more sensitive to starvation. I propose to test where and how the period gene provides this metabolic function. In particular, I will ask whether its role in starvation resistance is due to its control of sleep/wake rhythms or its function in periperhal clocks of metabolic tissues such as the fat body. Moreover, Dr Wijnen's laboratory recently showed that the period gene is induced at colder temperatures (Goda et al., Proc Biosci 2014) and I will test whether period-mediated starvation resistance is found preferentially at colder temperatures.
Testicular germ cell tumour (TGCT) has a strong inherited basis with brothers of cases having a 6—10 fold increased risk of disease and heritability of >45%. Whilst GWAS studies have identified >25 loci associated with disease, the underlying causative variants and mechanisms for conferring susceptibility to the disease are poorly understood. Furthermore, whilst recent whole exome analysis had implicated rare variants in genes related to microtubule and ciliary function in familial TGCT, these rare variants only account for a modest proportion of disease heritability. To date there has been no exposition of the role of copy number variation in susceptibility to TGCT and it is plausible that copy number variants may contribute to the "missing heritability" of TGCT. Furthermore, identification of copy number variants implicated in TGCT susceptibility may be informative with regard to highlighting novel TGCT susceptibility genes located within the regions of copy number variation. In this project I shall deploy copy number-calling algorithms on (i) SNP array data on 7319 TGCT cases and 23082 controls and (ii) whole exome sequencing data on an overlapping set of 962 TGCT cases and 1644 controls.
Mathematical skills predict career outcomes, health literacy, and finance skills. Troublingly, almost half of the adult population in the UK have a mathematical skill level equivalent to primary education. In order to remediate this and design effective, early interventions, it is important that we first understand how mathematical skills develop. In particular, little is currently known about the cognitive skills underlying mathematical skills. We will focus on understanding word problems because this is the type of mathematical information people more commonly encounter in daily life. We are interested in how high-level cognitive skills (known as executive functions) and language skills help solve mathematical word problems in children ages 5 and 6 – the age at which children first start formal schooling. Furthermore, since little attention has been placed on different types of word problems, we propose to investigate specifically which cognitive skills 5 to 6 years-old children use while solving ‘consistent problems’ (word problems involving relational terms that are consistent with the required mathematical operator) and ‘inconsistent problems’ (relational terms conflicting with the required mathematical operator). Findings will contribute to our understanding of how children acquire complex problem-solving skills and offer guidance on where to focus educational and interventional effort.