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Results

LifeLines 20 Apr 2016

This is the expansion of a project supporting volunteers aged 50 plus to run activities for vulnerable older people to improve health and well-being. These have previously included art classes, creative writing, yoga and computer club. The group will expand across the city, recruiting more volunteers, supporting more than 800 new people and establishing a Men’s Network to encourage older men to socialise regularly. It will also extend its HealthLink scheme to help older people get to medical appointments.

Kilkeel RBL - Saving Our Community Venue 22 Oct 2015

The group is a community and voluntary based organisation providing a range of services and activities to the local community. They received a grant of £10,000 to make improvements to their venue so that it can be used for more classes and activities.

Grant to Royal British Legion Tipton Branch 19 May 2016

Remembering Tipton's World War One Heroes

Grant awarded to The Royal British Legion (Forest Hall) Branch And Club (Tyne & Wear) 20 Nov 1998

Towards improving access and facilities for disabled people at the Forest Hall Ex-Servicemen's Institute.

Grant awarded to Community Service Volunteers (Training and Enterprise NE) (Tyne & Wear) 13 Jul 2004

To provide daycare services to older people living in high rise flats in Newcastle.

Expansion of Confocal Laser Scanning Microscopy. 15 Mar 2011

Confocal laser scanning microscopy (CLSM) has revolutionised our ability to visualise the dynamic spatio-temporal behaviour of cellular processes. This proposal describes the centrality of CLSM in the applicants ongoing research programmes and its contribution to numerous high-impact publications. The recognition of our excellence in this area has been key in the award of significant grant income (> 12M). However, the provision of new equipment that caters for our present and anticipated requir ements has become critical to our ability to continue to conduct internationally-leading research. Without investment in new equipment, basic and translational research that is already funded through numerous agencies, including Medical Research Council, Wellcome Trust, British Heart Foundation, Biotechnology and Biological Sciences Research Council and European Union will not be undertaken. The applicants request a new confocal system, to support the continued development of their research in l ine with user demand and technological requirements.

Amount: £196,565
Funder: The Wellcome Trust
Recipient: Cardiff University

Making and breaking habits: the role of chromatin remodelling in the acquisition and expression of habitual behaviour. 11 Apr 2011

The project will examine the role of epigenetic mechanisms in brain processes underlying habit formation - the transition of behaviour from being initially goal-directed and sensitive to the outcome of the behaviour ('actions') to being more rigid , inflexible and relatively insensitive to the outcome of behaviour ('habits').

Amount: £50,534
Funder: The Wellcome Trust
Recipient: Cardiff University

Validation and characterisation of a new method for in vivo assesment of human donor cells. 11 Apr 2011

To characterise a novel preclin ical screening tool (the desensitisation animal model) in order to inform its use for use for the screening of human donor cells for neural transplantation therapies.

Amount: £23,898
Funder: The Wellcome Trust
Recipient: Cardiff University

The role of the extracellular calcium sensing receptor (CaSR) in development and plasticity. 11 Apr 2011

1. Investigate a possible role for CaSR in regulating dendritic spine density & morphology in the hippocampus 2. Further characterize the published role of CaSR in regulating gross dendritic morphology in developing neurons [1] 3. Extend preliminary observations suggesting CaSR may have a role in early development of sympathetic neuroblasts and neurons (see Appendix) 4. Participate in studies to elucidate the intracellular signaling pathways by which CaSR promotes axon growth in fetal sympathetic neurons

Amount: £31,111
Funder: The Wellcome Trust
Recipient: Cardiff University

The use of embryonic dopaminergic tissues for Parkinson's Disease transplantation therapy. 11 Apr 2011

Overall aim: Improve dopamine cell yield and function in Parkinson's disease transplantation therapy (in rats) . Objective 1: Investigate the time course of dopamine neuron development in-vitro and in dopamine grafts. Objective 2: Characterise cell populations in rat and human embryonic dopamine grafts in a rat model of PD. Objective 3: Improve the survival of rat and human embryonic dopamine grafts and cultures. Objective 4: Determine the embryonic donor age in human embryos from which >50% survival can be obtained (equivalent to E12 in rats).

Amount: £25,151
Funder: The Wellcome Trust
Recipient: Cardiff University

4th International Workshop on Genetics, Medicine and History "Early history of human molecular genetics" to be held in Gothenburg between 11-12 June 2010 30 Jan 2009

To bring together those working on and interested in the history of human and medical genetics, whether clinicians, laboratory or social scientists, or historians. This international workshop is one of a series of workshops organized by the Genetics and Medicine Historical Network as satellite meetings of the annual conference of the European Society of Human Genetics. The first three workshops (Birmingham 2003, Brno 2005, Barcelona 2008) were very successful judging from attendance and the discussions and collaborations they stimulated. The theme "Early History of Human Molecular Genetics" emphasizes the importance and urgency of recording the personal experiences of the protagonists of this essentially recent scientific era that has transformed modern medicine. It is hoped that this theme will bring together geneticists, historians and philosophers of science from other continents as well as Europe in a true international spirit.

Amount: £3,000
Funder: The Wellcome Trust
Recipient: Cardiff University

Open Access Awards. 16 Sep 2008

Not available

Amount: £30,000
Funder: The Wellcome Trust
Recipient: Cardiff University

Neural network function in a mouse model of Alzheimer's disease. 15 Jul 2008

A recent revision to the amyloid cascade hypothesis has highlighted the important role played by intermediate AB oligomers in early-stage synaptic and cognitive dysfunction in Alzheimer's Disease 1. This revised hypothesis predicts that the very earliest stages of amyloid-induced cognitive dysfunction are a result of a breakdown in synaptic plasticity processes and the subsequent disruption to neural network activity that encodes and retrieves information 2. However, there has been little or no research carried out to examine how amyloid production influences network activity in murine models of amyloid pathology. The main aim of this proposal is to build upon our preliminary work that shows amyloid production disrupts network activity within the hippocampus and between the hippocampus and key regions contributing to memory. Furthermore we will examine how exercise-induced plasticity in the hippocampus (most notably in the dentate gyrus) influences network properties in APP over expressing mice.

Amount: £139,636
Funder: The Wellcome Trust
Recipient: Cardiff University

The use of embryonic dopaminergic tissues for Parkinson's Disease transplantation therapy. 21 Jul 2009

Overall aim: Improve dopamine cell yield and function in Parkinson's disease transplantation therapy (in rats) . Objective 1: Investigate the time course of dopamine neuron development in-vitro and in dopamine grafts. Objective 2: Characterise cell populations in rat and human embryonic dopamine grafts in a rat model of PD. Objective 3: Improve the survival of rat and human embryonic dopamine grafts and cultures. Objective 4: Determine the embryonic donor age in human embryos from which >50% survival can be obtained (equivalent to E12 in rats).

Amount: £141,950
Funder: The Wellcome Trust
Recipient: Cardiff University

Functional analysis of nuclear proteins in the Drosophila male germ-line. 25 Feb 2009

Understanding cell type specific regulation of gene expression is critical for understanding differentiation in multi-cellular organisms. The male germ-line is a unipotent cell type, committed only to making sperm. During spermatogenesis dramatic changes in gene expression occur, to facilitate the differentiation of highly specialised cells. We have previously identified a group of testis specific transcriptional regulators important for this spermatogenesis specific gene expression in Drosop hila. We will test the TEV protease system for cleavage of target proteins in the Drosophila male germ-line with known factors, and develop a P-element replacement exon tagging approach to allow specific ablation of potentially many target proteins in a controlled manner. We will test this approach by initiating the analysis of testis-specific functions of conserved potential transcriptional regulators that act in both the male germ-line and in other cell types, concentrating on a small set of proteins for which we already have localisation data and functional predictions.

Amount: £90,898
Funder: The Wellcome Trust
Recipient: Cardiff University

Role of ascending cholinergic and monoaminergic systems in absence epilepsy 14 Jun 2010

The expression of absence seizures in humans and experimental models strongly depends on the behavioural state. However, the precise contribution of different neurotransmitters that control vigilance states to the generation of these non-convulsive seizures is still controversial, mainly because of the inability to selectively manipulate these neurotransmitter systems using conventional tools. Using an optogenetics approach that will allows us to excite or inhibit neuronal populations with high temporal resolution and strong cellular selectivity, the aim of this project is to investigate the effect(s) of the cholinergic (Ach), noradrenergic (NA) and serotoninergic (5HT) systems in the generation and maintenance of absence seizures in well established mouse models of this neurological disease. The results of this study will further our understanding of the role(s) of these neurotransmitters in absence seizures, and may lead to the identification of novel therapeutic targets for the treatment of absence epilepsy.

Amount: £143,094
Funder: The Wellcome Trust
Recipient: Cardiff University

Signal transduction of Ca2+ oscillations in eggs at fertilization 13 Oct 2009

Egg activation and early development in animals is controlled by intracellular factors, such as Ca2+ increases, cell cycle proteins, and protein kinases. The downstream effects of Ca2+ are mediated by protein kinases and most studies on eggs have focussed on protein kinase C (PKC) and calmodulin-dependent protein kinase II (CaMKII). The technology to monitor Ca2+ in single eggs with fluorescent and luminescence probes has existed for some time. Fluorescent fusion proteins have also allowed us t o follow the concentration changes of proteins such as cyclin B in living eggs. However, to analyse the activity of, or phosphorylation due to, protein kinases, we still rely on cell-destructive biochemical assays. In this project, we will use FRET-based indicators for measuring the activity of PKC and CaMKII in oocytes, eggs and early embryos. We shall first establish how a range of different Ca2+ stimuli are transduced by these protein kinases in mouse eggs. Physiological changes in PKC and C aMKII will also be determined in real time during oogenesis and during early development in sea urchins and ascidians. We shall also generate a new range of luciferase-based probes and test their potential to monitor the dynamics of protein phosphorylation in intact eggs.

Amount: £199,335
Funder: The Wellcome Trust
Recipient: Cardiff University

Quantifying vascular influences on neurovascular coupling with fMRI. 07 Dec 2009

The fMRI BOLD signal is not a direct measure of neuronal activity. When comparing groups, the implicit assumption that neurovascular coupling properties are equivalent is made. Any alterations in cerebrovascular dynamics lead to BOLD differences that are unrelated to neuronal activity. Using an elderly group as a model for altered coupling, this proposal will investigate such BOLD differences, thus developing suitable correction strategies. The project has three main objectives that are inco rporated into an fMRI-cerebrovascular modelling framework: 1) Quantify the influence of dynamic cerebral autoregulation on the BOLD signal to account for blood pressure-related perfusion fluctuations; 2) Account for vascular reactivity-related changes in BOLD signals, thus providing a novel marker of cerebrovascular health; 3) Translate these cerebrovascular models into young/elderly group comparisons by testing their ability to characterise group differences that are present in MEG-derived neur onal activity measures. Since normal ageing and many clinical conditions are accompanied by alterations in microvasculature, fMRI will be unreliable unless appropriate corrections for neurovascular coupling differences are made. Modelling strategies that address these concerns not only increase the robustness of normal ageing fMRI studies but translate to many clinical conditions that are more frequent in the ageing population such as hypertension, dementia and diabetes.

Amount: £775,035
Funder: The Wellcome Trust
Recipient: Cardiff University

The Origins Of Human And Medical Genetics: Cataloguing and Digitising The Human Genetics Historical Library 30 Jun 2010

The Human Genetics Historical Library, www.genmedhist.info/HumanHistLib/, forming part of Cardiff University Library's Special Collections and Archives, has grown since its founding in 2003 to just over 3000 volumes covering all aspects of human and medical genetics. The Library is unique world-wide as a collection specifically focused on human and medical genetics and contains the complete working libraries of a number of key early workers in this field. 1500 volumes have already been fully catalogued, thanks to earlier support from Wellcome Trust and Cardiff University; we now request funds for cataloguing of the 1500 remaining volumes, received since the initial award. This will allow the current collection to be completely catalogued; since details are accessible remotely to scholars on the Web based Cardiff University Voyager catalogue http://library.cf.ac.uk/, it will be possible for scholars world wide to analyse the development of human and medical genetics through its books, including those of specific key workers. While most of the library represents the 'working books' of human geneticists over the second part of the twentieth century, the collection also contains older important and scarce volumes; we propose to digitise a small number of those (totalling c. 2,500 pages) that are of particular historical as well as scientific interest.

Amount: £14,200
Funder: The Wellcome Trust
Recipient: Cardiff University

Microbiology, genomics, and beyond: regulating dual use technologies into the 21st Century. 13 Jul 2010

Explore and develop definitions of dual use paying due regard to differing interpretations. Consider the challenges raised by current and future developments in biotechnology & their increasing availability (garage genomics). Develop the regulatory dialogue in the UK around dual use biological technologies leading to a set of recommendations.

Amount: £5,000
Funder: The Wellcome Trust
Recipient: Cardiff University