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LifeLines 20 Apr 2016

This is the expansion of a project supporting volunteers aged 50 plus to run activities for vulnerable older people to improve health and well-being. These have previously included art classes, creative writing, yoga and computer club. The group will expand across the city, recruiting more volunteers, supporting more than 800 new people and establishing a Men’s Network to encourage older men to socialise regularly. It will also extend its HealthLink scheme to help older people get to medical appointments.

Kilkeel RBL - Saving Our Community Venue 22 Oct 2015

The group is a community and voluntary based organisation providing a range of services and activities to the local community. They received a grant of £10,000 to make improvements to their venue so that it can be used for more classes and activities.

Grant to Royal British Legion Tipton Branch 19 May 2016

Remembering Tipton's World War One Heroes

Grant awarded to The Royal British Legion (Forest Hall) Branch And Club (Tyne & Wear) 20 Nov 1998

Towards improving access and facilities for disabled people at the Forest Hall Ex-Servicemen's Institute.

Grant awarded to Community Service Volunteers (Training and Enterprise NE) (Tyne & Wear) 13 Jul 2004

To provide daycare services to older people living in high rise flats in Newcastle.

An Imaging pipeline for screening mouse embryos. 25 Feb 2009

We have established two innovative approaches for mouse embryo phenotyping. At Oxford, magnetic resonance imaging (MRI) provides a high-throughput/low-resolution approach that can quickly identify abnormal tissue or organ morphology using fixed embryos; at NIMR, high resolution episcopic imaging (HREM), a low-throughput/high-resolution approach based on block face imaging of fixed embryos, provides extremely detailed morphology of whole embryos, with resolution approaching that obtained by hist ological analysis. We propose to establish an imaging pipeline that combines MRI and HREM analysis of whole mouse embryos. We will complement the existing Oxford MRI facility with a dedicated HREM facility at NIMR. This pipeline will be used to analyse embryos from ongoing mutagenesis screens in the mouse. The data collected will, for the first time, provide systematic and comprehensive imaging in a form that permits analysis at high resolution by both 2D and 3D methods. Such data will be pro vided to the research community as a resource to investigate any aspect of mouse embryo morphology and for identification of mutant lines in which the organ or tissue of interest is affected. Such a resource will facilitate others to exploit the use of mutagenesis programmes for studies of many aspects of embryo development.

Amount: £384,906
Funder: The Wellcome Trust
Recipient: Medical Research Council

Workshop on new antiretroviral therapy (ART) trials in Africa to be held in Entebbe, Uganda on 29-30 March 2007. 30 Jan 2007

Workshop on new anti-retroviral therapy (ART) trials in Africa Prioritising the main questions about ART treatment strategies now facing Africa needs to be undertaken by professionals at sites treating adults, children and families with HIV infection on the ground in Africa, in particular centres who have already been involved in addressing research questions around current first-line ART. Partnerships between such groups and those from the North in order to build on expertise learnt from managing patients, as well as expertise in the design and execution of large multicentre clinical trials is needed to identify knowledge gaps and opportunities and to drive the agenda forward. A number of questions need answers from large randomised controlled trials. These can be broadly divided into: The timing of ART decisions When to start When to switch from first-line to second-line ART Strategies to maximise long-term efficacy and minimise toxicity. Approaches for both first and second-line ART include cycling drugs and drugs regimens, induction-maintenance approaches, simplification of treatment to improve adherence, and intermittent therapy. Monitoring patients prior to and on ART - with which tests and how frequently Management of patients failing second-line therapy Use of adjunctive therapies with ART - such as immunomodulants, nutritional supplements and drugs for prevention of opportunistic infections.

Amount: £15,000
Funder: The Wellcome Trust
Recipient: Medical Research Council

Structural basis for the role of K-homology Splicing Regulator Protein in mRNA turnover. 27 Feb 2007

mRNA stability is an important parameter in determining the level of gene expression and can be selectively regulated. Adenine uracil-rich elements (AREs)-mediated mRNA decay (AMD) modulates the stability of many mRNAs that encode transcription factors and other regulatory proteins. In AMD, ARE-binding proteins (ABPs) recruit the exosome to long AREs embedded in the 3 untranslated region (3 UTR) of selected mRNAs. However the specificity of ABP-ARE interactions (and therefore of exosome recruit ment) is poorly understood at the molecular level. It seems likely that the recognition of the long ARE sequences by ABPs is based on multiple protein-RNA interactions and that RNA structural elements play a role. This hypothesis is supported by functional studies on several ABPs, but also by our preliminary biophysical results with the functionally well-characterised K-homology Splicing Regulator Protein (KSRP). These results also indicate that interactions between the domains of the protein pl ay a role in recognition. We want to solve the structure of the RNA binding region of KSRP alone and in complex with both single stranded and partially structured RNA targets. The fundamental question we wish to answer is how ARE recognition is linked to the RNA structure and to the interactions existing between protein domains.

Amount: £275,812
Funder: The Wellcome Trust
Recipient: Medical Research Council

Core costs 18 Jan 2019

To support the work of the charity r.

Amount: £1,000
Funder: County Durham Community Foundation
Recipient: Royal British Legion

Life course and trans-generational influences on cardiovascular disease and cancer 05 Dec 2006

CVD and cancer are major causes of death and morbidity in developed countries; they are assuming increasing importance in non-industrialised societies. Risk factors measured in middle- and older-age do not fully explain socioeconomic or geographical differentials in these chronic diseases, so implicating processes occurring earlier in life, and even between generations, in the aetiology of CVD and cancer. A small number of recent studies have identified some potential pre-adult risk indices for later CVD and cancer. I plan to expand this evidence base by examining the role of new and emerging physiological, behavioural, socioeconomic and psychological risk factors (and their cross-generation transmission) in later disease risk. To do so I will utilise data from a series of studies from low and high income countries. During the tenure of the fellowship, in collaboration with colleagues, I will produce manuscripts for publications in high-impact, peer-reviewed journals; present my work at international meetings; supervise/teach post-graduate students; and seek funding for further data collection in selected studies. This body of work may be used in interventions in childhood and young adults aimed at reducing the burden of CVD and cancer in later life.

Amount: £574,957
Funder: The Wellcome Trust
Recipient: Medical Research Council

RBL Portstewart Branching Out 26 Apr 2018

The group, based in Portstewart, are using a grant of £6,500 to replace their hall’s heating system and improve its insulation, making it more usable for community events.

Grant to Royal British Legion, Greenhithe & Swanscombe 23 May 2014

The impact of WW1 on Dartford and its residents

Grant to Royal British Legion, Downs Branch 15 Jul 2014

First Day Commemoration of World War I

Grant to Royal British Legion 19 Sep 2013

Events to commemorate the Centenary of the First World War in 2014

Grant to Royal British Legion Leiston Branch 13 Feb 2014

Commemorating Leiston in the Great War

Improving patient assessment after stroke: The Cambridge and Oxford Automated Screening Test (COAST) 28 Nov 2013

Every year 150,000 UK residents suffer a stroke. Cognitive problems (e.g. difficulties with language) and low mood are common and undermine recovery. Consequently NHS guidelines recommend that all patients have brief test ‘screens’ to detect these problems and better target care. Unfortunately, due to a lack of materials, skilled staff and staff-time, audits show these targets are often unmet.The Cambridge and Oxford Automated Screening Test (COAST) is designed to solve this problem. It is a set of brief computerised cognitive and mood measures, easily administered by staff using touchscreen tablets. COAST guides health workers through the tests, collects responses from patients, and automatically generates clinical reports. The tests are specially designed to detect problems prevalent after stroke and to include all patients. It is highly portable and requires no specialist equipment beyond devices already widely in use. It frees staff from administrative chores allowing increased patient contact. A project team led by Dr Tom Manly (MRC Cambridge) and Professor Glyn Humphreys (University of Oxford) have developed COAST from a rigorous evidence-base. The award will support the crucial final stages of the project (collecting assessment results from patient and healthy populations and NHS field trials), enabling COAST to make a real difference to clinical care within 3 years.

Amount: £117,308
Funder: The Wellcome Trust
Recipient: Medical Research Council

Cargo transport by dynein/dynactin 10 Apr 2018

Eukaryotic cells rely on motor proteins for their internal organization and movement. I want to ask how one cytoplasmic dynein, together with its cofactor dynactin, can be responsible for almost all of the minus-end directed microtubule transport in our cells. My group will focus on endosome transport as a model system to understand which adaptor proteins are needed to link dynein to cargos. We will use in vitro reconstitution and cryo-EM to ask how different candidate adaptors interact with dynein/dynactin. We will also use structural approaches to understand how the different adaptors are themselves linked to membrane surfaces. To complement this approach we will purify endosomes and use cross-linking and mass spectrometry to search for any missing components required for dynein binding. We will take advantage of recent advances in cryo-electron tomography (cryoET) to ask how dynein/dynactin complexes and their associated connections are arranged on endosomes, both in vitro and in axons of cultured neurons. These studies will uncover the principles governing dynein/dynactin interactions with cargos and will allow us to ask how the process can be hijacked by pathogens such as herpes or rabies viruses.

Amount: £1,450,105
Funder: The Wellcome Trust
Recipient: Medical Research Council