- Total grants
- Total funders
- Total recipients
- Earliest award date
- 20 Nov 1998
- Latest award date
- 18 Jan 2019
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
LifeLines 20 Apr 2016
This is the expansion of a project supporting volunteers aged 50 plus to run activities for vulnerable older people to improve health and well-being. These have previously included art classes, creative writing, yoga and computer club. The group will expand across the city, recruiting more volunteers, supporting more than 800 new people and establishing a Menâ€™s Network to encourage older men to socialise regularly. It will also extend its HealthLink scheme to help older people get to medical appointments.
Kilkeel RBL - Saving Our Community Venue 22 Oct 2015
The group is a community and voluntary based organisation providing a range of services and activities to the local community. They received a grant of Â£10,000 to make improvements to their venue so that it can be used for more classes and activities.
Towards improving access and facilities for disabled people at the Forest Hall Ex-Servicemen's Institute.
Grant awarded to Community Service Volunteers (Training and Enterprise NE) (Tyne & Wear) 13 Jul 2004
To provide daycare services to older people living in high rise flats in Newcastle.
The mechanisms controlling adrenal development, cell growth and differentiation are at present unknown. Two potential candidates for regulators of this process are Bone Morphogenetic Protein 3B (BMP3B) and Sonic Hedgehog (Shh). They are expressed in the subcapsular region of the adrenal gland where progenitor stem cells are thought to reside. This project will further investigate the expression of BMP3B and other BMPs during adrenal development in foetal and adult rat. We will compare their s ites of expression with respect to adrenal cell proliferation and zonation, using in situ hybridisation, immunohistochemistry and immunofluorescence on adrenal sections. The adrenal is a dynamic organ and adrenal remodelling experiments will be performed in the presence of exogenous BMPs. We will experiment on normal and remodelled rats and BMP3B null mice to observe the effect on zonation, cell proliferation, and steroid output. Together these experiments will give a comprehensive picture of BMP signalling in the adrenal cortex and its contribution to cell proliferation, differentiation and steroidogenesis. Human adrenal adenomas will be collected and the expression of both BMP and Shh pathway components will be analysed and compared to normal tissue. This will test the hypothesis that these signalling pathways influence the development of adrenal cancer.
The key goals of SACORE are to develop and sustain a critical mass of local research scientists to be independent investigators and leaders capable of attracting competitive research grants. To achieve this we plan to improve research management and support capacity, introduce undergraduates to research, and stimulate research outputs at all levels of the research career pathway. This will be achieved through a number of interventions within the southern Africa region: 1. Developing south-south and strengthening existing north-south networks, through annual scientific meetings, mentorship, and joint PhD supervision. 2. Developing research leadership through mentorship of mid-level and senior scientists and by conducting relevant leadership and training courses. 3. Building a critical mass of research scientists, and research career pathways for them, through: a. competitive WT-SACORE PhD scholarships. b. competitive WT-SACORE post-doctoral fellowships. c. competitive WT-SACORE MSc scholarships d. providing competitive small research grants e. providing focus workshops to enhance research skills. 4. Consolidating career progression using professional development planning for all staff. 5. Establishing and strengthening Research Support Centres in the three low-income institutions including the provision of appropriate staff, equipment and skills and developing appropriate research governance and support frameworks. Importantly, the RSCs will pro-actively encourage and support scientists in their grant applications.
The research I plan will be a close examination of syphilis in the pivotal period of the eighteenth century. The focus of the study is on the female experience of the disease. First, to determine the understanding of syphilis and other sexual diseases, the research will explore what information women had access to and how they participated in the discourse on venereal disease. In the process of revealing the discourse on syphilis, I intend to document the medical history of the disease in the period, including the practice of medicine that was considered "clandestine" by leading physicians. Then, the project will trace women's reactions to syphilis and investigate female agency in the context of the redefinition of the private and public spheres. Specifically, the research will study how social concern about syphilis included women in the efforts to check the spread of the disease and demonstrate how women influenced the developing sexual morals. The main goals of this comprehensive study on syphilis and women is to document the gendered experience of venereal disease, to augment the medical history of eighteenth-century France and illuminate the developing sexual morals. Through this research, I hope to contribute to the field and spur further studies by incorporating overlooked sources and analyzing materials with innovative approaches to historical research.
Coeliac disease is a common condition of children and adults, where dietary wheat rye and barley causes intestinal damage. Why only some of the population develop coeliac disease when nearly all eat wheat remains unclear, despite advances in understanding which wheat fragments presented by HLA-DQ2/8 generate T-cell mediated immune responses. HLADQ2/8 is common (30%) in the population, being necessary but not sufficient for disease. Coeliac disease has a strong inherited genetic tendency of which only a minor part is currently understood. We performed a genome wide association study in 778 coeliac cases and 1422 healthy controls using 310,605 Illumina SNP markers. A clear association was identified (which we have now replicated in five independent collections) in the IL2/IL21 gene cluster (van Heel et al. Nature Genetics 2007). Interestingly this region also contains risk variants for type 1 diabetes and rheumatoid arthritis. Current studies, using ~2000 cases and 3000 controls (WTCCC Nature 2007), have shown substantial gains in statistical power and identification of multiple disease risk variants. We therefore propose to both enlarge both sample size (to 6x the original coeliac study) and genomic coverage to include copy number variants, in order to identify further disease risk variants.
The pathology of the emotions 10 Jun 2010
My research will show how melancholy in nineteenth-century Britain was conceptualised as a disease of the emotions situated in the brain through the influence of German psychiatry and neurology. There are five main goals to this project: - To address a lack in existing historical scholarship as no comprehensive study of nineteenth-century melancholy exists. - To demonstrate how the understanding of melancholy as a disease of the emotions was facilitated by two key developments: Firstly, the creation of 'emotions' as a psychological category within the emergent evolutionary paradigm, and secondly the growing influence of physiology and neurology on psychiatric thought and practice which involved understanding its functions through the concept of 'mental reflex'. - To show how emotions were produced as symptoms of melancholy and made into a useful psychiatric category. - To explore, through a close reading of case reports and patient letters, - To consider what the implications were of this biomedical cerebral melancholy for how 'normal' and 'pathological' emotions came to be understood and defined in the late nineteenth century.
Is ATP the missing link between peripheral nerve injury and the enhanced regenerative capacity of sensory neurons? 17 Apr 2008
The basic aim is to understand the events in injured peripheral nerves which lead to retrograde activation of events in neurons which are beneficial to axonal regeneration. We will test the specific hypothesis, supported by preliminary data, that ATP released instantly upon nerve injury triggers the subsequent release of the cytokines. Specific aims are 1) to determine whether P2 receptor antagonists can attenuate the enhanced axon regeneration by peripheral nerve injury or intraneurally injecte d ATP, 2) to determine whether intraneural injection of ATP can stimulate cell body responses favourable to regeneration in vivo, 3) to see whether or not axonal regeneration is impaired in mice with knockout of the P2X7 receptor, 4) to identify the early signal pathways activated in DRG neurons by intraneurally injected ATP, 5) to assess the effects of media conditioned by non-neuronal cells in peripheral nerves on neurite outgrowth from neurons in vitro and 6) to seek evidence that ATP stimula tes the release of candidate cytokines from non-neuronal cells in nerves.
The aim of this project is to dissect the mechanisms behind the inhibitory role of endogenous Annexin 1 (AnxA1) in inflammatory arthritis. We propose to evaluate the impact of the AnxA1 system both from a functional and a morphological point of view, and by assessing its translational potential. The working hypothesis is that a down-regulation or malfunctioning of the AnxA1 system within the arthritic joint contributes to disease progression. This hypothesis will be challenged by integrated analyses in the KxB/N model of arthritis, thereby: i) Comparing the inflammatory response in AnxA1 null mice versus wild type animals; ii) Monitoring the appearance and disposition of the AnxA1 gene by RT-PCR (in wild type animals) and immunohistochemistry (in the AnxA1 null mice) in the joint. Monitoring expression of the AnxA1 receptor(s) by RT-PCR. iii) Testing the effect of glucocorticoids in the two genotypes, as well as the effect of local delivery of a bioactive fragment of the protei n. iv) Assessing the translational impact of this line of research, using the chimaeric SCID mouse model with fragments of human synovial tissue from rheumatoid arthritis patients.
Step-down affordable treatment for chronic hepatitis B infection in Africa and India Acronym - STEP-HEP 06 Jun 2012
Chronic infection with the hepatitis B virus is common throughout the developing world. Effective treatments are too costlyand complex for widespread use leading to signficant preventable morbidity and mortality. We will complete a randomisedcontrolled clinical trial examining a new approach to therapy in which virological response is induced by therapy withexpensive tenofovir and patients are then randomised to either continue tenofovir monotherapy or receive cheaperlamivudine.The primary objective of the study is to determine whether treatment of chronic hepatitis B infection with an inductionmaintenanceregime of tenofovir stepping down to lamivudine is safe and feasible in developing countries. Specifically wewill test the hypothesis that in patients with chronic HBV infection and active liver inflammation, 48 weeks induction therapywith tenofovir can be followed by successful transfer to lamivudine therapy in patients with a 'normal' ALT and any relapsecan be controlled by reintroduction of tenofovir. The primary objective of the study is safety and we will determine whetheran induction-maintenance regime followed by re-introduction of tenofovir in those who fail to respond to lamivudine isinferior to continuous tenofovir.Secondary objectives are:-To determine what proportion of patients can successfully be converted to lamivudine and a critical secondary objective isthe cost effectiveness of this approach.To determine whether treatment modifications can be guided by the use of liver function tests rather than sophisticatedvirological monitoring.
Medical and Cultural Constructions of Female Mental Illness in Britain and the United States, 1948-1965 02 May 2012
This dissertation will explore changing conceptions of female depression and anxiety disorders in Britain and the United States to uncover the formative role of different health care systems in the development of psychiatric categories and their popular representation. In doing it will analyse the relationship between internal, national cultures and international cultures within the specific context of postwar gender and medical developments.