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Results

LifeLines 20 Apr 2016

This is the expansion of a project supporting volunteers aged 50 plus to run activities for vulnerable older people to improve health and well-being. These have previously included art classes, creative writing, yoga and computer club. The group will expand across the city, recruiting more volunteers, supporting more than 800 new people and establishing a Men’s Network to encourage older men to socialise regularly. It will also extend its HealthLink scheme to help older people get to medical appointments.

Kilkeel RBL - Saving Our Community Venue 22 Oct 2015

The group is a community and voluntary based organisation providing a range of services and activities to the local community. They received a grant of £10,000 to make improvements to their venue so that it can be used for more classes and activities.

Grant to Royal British Legion Tipton Branch 19 May 2016

Remembering Tipton's World War One Heroes

Grant awarded to The Royal British Legion (Forest Hall) Branch And Club (Tyne & Wear) 20 Nov 1998

Towards improving access and facilities for disabled people at the Forest Hall Ex-Servicemen's Institute.

Grant awarded to Community Service Volunteers (Training and Enterprise NE) (Tyne & Wear) 13 Jul 2004

To provide daycare services to older people living in high rise flats in Newcastle.

Development of monoclonal antibody products for post-exposure prophylaxis of rabies. 05 Oct 2010

This research project will involve the identification and characterization of monoclonal antibodies (mAbs) that neutralize classic rabies virus strains and emerging lyssaviruses. Antibodies targeting different virus strains and different epitopes of the rabies glycoprotein will be combined into cocktails that will be tested to determine their ability to prevent virus escapes under selection pressure. The best candidates will be cloned and used to develop two products a cocktail of full-size mA bs suitable for the replacement of RIG in standard post-exposure prophylaxis, and a range of candidate antibody fragments with the ability to traverse the blood-brain barrier, targeting elimination of rabies virus in the CNS and prevention of rabies encephalitis. mAb cocktail products will be expressed in plants to overcome economic barriers preventing the development of such prophylactics containing multiple mAbs and to ensure that the products can be produced on a large enough scale to cope wi th demand. The plant-derived antibodies and fragments will be characterized in vitro in terms of their structure and binding properties, and will be tested in vitro and in vivo for their ability to neutralize rabies virus infections in an animal model.

Amount: £292,519
Funder: The Wellcome Trust
Recipient: St George's University of London

The interaction of paramyxoviruses with the interferon system. 02 Feb 2009

Whilst much has been learnt over recent years about how viruses interact with the interferon (IFN) system, there are still significant gaps in our knowledge. By building upon our extensive experience on the interaction of paramyxoviruses with the IFN system we propose to address some of these questions. More specifically, we will continue to characterise the nature of (paramyxo)virus inducers of IFN and how the IFN-induction cascade is activated and controlled, with particular reference to obser ved heterocellular nature of IFN induction. We will also identify the IFN-induced genes that affect the replication of paramyxoviruses (in particular PIV5), and detail how these viruses deal with cells in a pre-exisitng IFN-induced anti-viral state. In this regards, the importance of virus cytoplasmic bodies to the life-sytle of these viruses and their ability to establish prolonged/persistent infections will be examined. In addition, we will develop generalised methods for the rapid selection o f viruses that are either good inducers of IFN or cannot block IFN signalling, both for our fundamental studies and because such viruses may be developed as potential attenuated vaccine candidates. Such procedures may be particularly valuable for newly emerging viruses that pose an immediate threat to human and animal welfare.

Amount: £721,092
Funder: The Wellcome Trust
Recipient: St George's University of London

Student Elective Prize for Mr Rickey Raja 29 Aug 2008

The burden of Metabolic Syndrome in patients with stages 3-5 CKD between an urban and a rural population in Chandigarh, India

Amount: £1,600
Funder: The Wellcome Trust
Recipient: St George's University of London

Student Elective Prize for Ms Emily Burridge 29 Aug 2008

'Is podoconiosis associated with decreased lung function (restrictive or obstructive pattern)?''

Amount: £1,531
Funder: The Wellcome Trust
Recipient: St George's University of London

Congenic cell bank for pigmentary mutations. 16 Jul 2012

The Wellcome Trust Functional Genomics Cell Bank holds a large collection of mammalian cell lines, especially mouse melanocyte and melanoblast lines carrying specific pigmentary mutations, and provides these to researchers as a service, together with advice on melanocyte culture. We request funds to continue this service for a second quinquennium. We will establish additional lines of mutant mouse and human melanocytes known to be of current research interest. We will also use cells from the collection ourselves, in research on two main areas. One is the mechanism of cell determination from pluripotent precursors, using the melanocyte lineage as a model. We will use our pluripotent neural crest-like cell lines, and existing and new melanocyte and melanoblast lines deficient in key transcription factors, especially the putative master controller Mitf. We will examine the dynamics of changes after induction of (exogenous) Mitf expression, and effects of different levels of the factor. Global mRNA and protein analyses by microarrays and DIGE will be followed by focussing on changes in candidate regulators, then building and testing of model(s) integrating available knowledge. The other area is that of the regulators and effectors involved in the synthesis of pheomelanin (red/yellow pigment), still very poorly understood.

Amount: £14,157
Funder: The Wellcome Trust
Recipient: St George's University of London

Institutional Strategic Support Fund 2011/12. 17 Oct 2011

Facilitating collaboration: A key element of the strategy of all research institutes is to prioritise collaboration, particularly at inter-institutional and inter-university level In 2014-15 ISSF intended use is:(a) Bridging funds(b) Core technical support(c) Strategic investment in equipment(d) PhD studentships in collaboration with external partners(e) Public engagement Bridging funds (£120K)The objective is to facilitate retention of key staff. Up to 6 months salary can be committed to research staff (excluding PhD students) who are approaching the end of their research contracts. Core technical support (£180K)We will continue with our previous strategy of supporting key core services that are of value toISSF 05/148multiple research groups and provide opportunities to establish new research collaborations Strategic investment in equipment (£125K)As in previous years, we will use ISSF to provide funding for significant pieces of equipment that have multi-user applications and support the Research Institutes strategies, particularly where added value can be generated for Wellcome Trust funded research PhD studentships in collaboration with external partners (£50K)A key pillar of the research strategy at St. George’s is to support early career researchers (ECR) to build research teams and establish themselves with independent research programmes. Public engagement (£25K)Public engagement (PE) at St. George’s has taken a massive step forward as a result of ISSF support and the budget for PE activities has increased each year. Wandsworth Prison Science ClubWorking with Claire Fairclough on the Education team at HMP Wandsworth, we have begun consultation to create a science club. Application for additional strategic infrastructural support (£250K)A proposal for a GCLP suite of laboratories for development of diagnostic tests in collaboration with industry partners.The newly created Centre for Diagnostics and Antimicrobial Resistance (CDAR) is part of the Institute for Infection and Immunity at SGUL. this proposal is for funding to develop new strategic infrastructure for CDAR that will specifically allow early stage commercial development of diagnostic devices at St. George’s with industrial partners. Appointment of an Associate Dean to focus on Career Development of Research Staff.b) Introduction of a part-time, portfolio-based Postgraduate Certificate in Research Skills bringing together various core and optional development opportunities and supported by an individual mentor. This course has been commended by its external examiners and by Vitae as an example of excellent practice in researcher career development.c) Implementation of a requirement that all staff with management responsibility for research engage positively with researcher’s skills and career development, including regular probation, review and performance management meetings.

Amount: £500,000
Funder: The Wellcome Trust
Recipient: St George's University of London

A reappraisal of mycobacterial chaperonin 60 structure and function and its role in tuberculosis. 08 Feb 2007

The study of the highly conserved and essential E. coli chaperonin 60 (GroEL) has been instrumental in the establishment of a new paradigm for the cellular control of protein folding. In the last decade this protein and some of its homologues have also been found to induce activation of myeloid cells, suggesting it can act as a 'danger signal' in immunity. Recent structural and functional studies of the two chaperonin 60 (Cpn60) proteins of the major human pathogen Mycobacterium tuberculosis have revealed major differences to E. coli GroEL in oligomeric structure, protein folding function and intercellular signalling activity. Neither of the two M. tuberculosis Cpn60 proteins form the typical "double ring" form of E. coli GroEL under standard conditions, but we have found that both are able to complement at least partially for loss of the essential E. coli groEL gene. We have also recently found that that the cpn60.1 gene of M. tuberculosis can be deleted without a significant effect on bacterial growth, but that organisms lacking this gene fail to induce chronic granulomatous lung inflammation in both mice and guinea pigs. This proposal is to investigate the highly atypical structure and function of the Mycobacterial chaperonins in more detail, and, in particular, to test the hypothesis that there is a link between their atypical structures and their roles in infection, cell signalling, and bacterial growth.

Amount: £151,307
Funder: The Wellcome Trust
Recipient: St George's University of London

Core costs 18 Jan 2019

To support the work of the charity r.

Amount: £1,000
Funder: County Durham Community Foundation
Recipient: Royal British Legion

Congenic cell bank for pigmentary mutations 17 Oct 2005

The Wellcome Trust Functional Genomics Cell Bank holds a large collection of mammalian cell lines, especially mouse melanocyte and melanoblast lines carrying specific pigmentary mutations, and provides these to researchers as a service, together with advice on melanocyte culture. We request funds to continue this service for a second quinquennium. We will establish additional lines of mutant mouse and human melanocytes known to be of current research interest. We will also use cells from the collection ourselves, in research on two main areas. One is the mechanism of cell determination from pluripotent precursors, using the melanocyte lineage as a model. We will use our pluripotent neural crest-like cell lines, and existing and new melanocyte and melanoblast lines deficient in key transcription factors, especially the putative master controller Mitf. We will examine the dynamics of changes after induction of (exogenous) Mitf expression, and effects of different levels of the factor. Global mRNA and protein analyses by microarrays and DIGE will be followed by focussing on changes in candidate regulators, then building and testing of model(s) integrating available knowledge. The other area is that of the regulators and effectors involved in the synthesis of pheomelanin (red/yellow pigment), still very poorly understood.

Amount: £491,972
Funder: The Wellcome Trust
Recipient: St George's University of London

Student elective for Mark Lawrence 19 Jul 2006

Characterisation of sensory neurons produced by pluripotent mouse neural crest-like stem cells The regulation of cell determination is a central issue in developmental biology. There has been much recent interest in postnatal stem cells and their unexpectedly broad differentiation capacity because of the potential therapeutic implications. We established from neonatal mouse skin three immortal, pluripotent stem cell lines that resemble neural crest stem cells and are capable of producing at least three cell lineages (melanoblasts/melanocytes, neurons and Schwann precursor cells).They promise to be valuable tools for study of cell determination. Neuronal differentiation of these cell lines is the least well characterised. We plan to expose pluripotent neural crest-like stem cells to growth/differentiation factors known to control determination of sensory neurons in short-term cultures: brain derived neurotrophic factor (BDNF), neurotrophic factor (NT3), fibroblast growth factor 2 (FGF2) and nerve growth factor (NGF). We have preliminary data showing that in the presence of these factors very long bipolar neuron-like cells and large, dendritic cells resembling sensory neurons appear in the cultures. The student will repeat and confirm these observations, analysing and recording changes of cell morphology using photo microscopy. He will also study effect of these factors on cell proliferation by counting cell numbers before and some time after growing the cells in the presence of these growth actors by haemocytometer. To test whether morphologically different cells are indeed sensory neurons he will perform immunocytochemical analysis of these cells by using a marker of sensory neurons (substance P) and neuronal markers (neuronal tubulin beta 3 and a neurofilament subunit).

Amount: £1,600
Funder: The Wellcome Trust
Recipient: St George's University of London

RBL Portstewart Branching Out 26 Apr 2018

The group, based in Portstewart, are using a grant of £6,500 to replace their hall’s heating system and improve its insulation, making it more usable for community events.

Grant to Royal British Legion, Greenhithe & Swanscombe 23 May 2014

The impact of WW1 on Dartford and its residents

Grant to Royal British Legion, Downs Branch 15 Jul 2014

First Day Commemoration of World War I