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LifeLines 20 Apr 2016

This is the expansion of a project supporting volunteers aged 50 plus to run activities for vulnerable older people to improve health and well-being. These have previously included art classes, creative writing, yoga and computer club. The group will expand across the city, recruiting more volunteers, supporting more than 800 new people and establishing a Men’s Network to encourage older men to socialise regularly. It will also extend its HealthLink scheme to help older people get to medical appointments.

Kilkeel RBL - Saving Our Community Venue 22 Oct 2015

The group is a community and voluntary based organisation providing a range of services and activities to the local community. They received a grant of £10,000 to make improvements to their venue so that it can be used for more classes and activities.

Grant to Royal British Legion Tipton Branch 19 May 2016

Remembering Tipton's World War One Heroes

Grant awarded to The Royal British Legion (Forest Hall) Branch And Club (Tyne & Wear) 20 Nov 1998

Towards improving access and facilities for disabled people at the Forest Hall Ex-Servicemen's Institute.

Grant awarded to Community Service Volunteers (Training and Enterprise NE) (Tyne & Wear) 13 Jul 2004

To provide daycare services to older people living in high rise flats in Newcastle.

High content analysis of inflammasome activation 31 Aug 2011

Epithelial and innate immune cells have evolved complex systems for sensing and responding to a multitude of virulence factors and danger signals. Recognition of a diverse range of microbial, stress and damage signals by cytosolic multiprotein complexes called inflammasomes results in activation ofcaspase-1, which subsequently induces secretion of potent pro-inflammatory cytokines IL-1ß and IL-18 and a form of inflammatory cell death called pyroptosis. Inflammasome-mediated processes are important during microbial infections and also in regulating both metabolic processes and mucosal immune responses. Recent evidence links the cellular cytoskeleton that spatially and temporally organizes host immune responses, to inflammasome activation and regulation. Here, the involvement of cytoskeleton in the regulation of inflammasome signaling will be studied in NLRP1 and NLRP3 inflammasome activation. We will perform a microscopy-based high throughput RNA interference screen in cultured human THP-1 cells where genes connected to thecytoskeletal network are knocked out and the effect on inflammasome activation

Amount: £153,367
Funder: The Wellcome Trust
Recipient: University College Dublin

MA in Medical History 16 Sep 2008

Not available

Amount: £21,698
Funder: The Wellcome Trust
Recipient: University College Dublin

Regulation of human colonic UT-B urea transporters 06 Jul 2010

This project will investigate the regulation of UT-B urea transporters within the human colon. Tissue samples will be surgically obtained from the four different subsections of the colon (i.e. ascending, transverse, descending and sigmoid). Using RT-PCR analysis, all UT-B urea transporters present will be cloned and sequenced. UT-B urea transporter protein expression will be investigated using two previously characterised antibodies, with additional isoform-specific antibodies being produced as required. Protein investigations will involve western blotting and immunolocalisation using frozen cryo-sections of colonic tissue. To detail urea transport regulation, several stable MDCK cell lines will be produced - each one expressing a single UT-B isoform (e.g. MDCK-hUT-B1). In addition, the Caco-2 intestinal cell model will also be utilised. After cellular localisation has been confirmed, the relevant 14C-labelled urea flux experiments will be performed to investigate urea transport functi on (e.g. phloretin and dimethylurea inhibition). Further studies will investigate the regulation of UT-B-mediated transport both by intracellular pathways (e.g. cAMP) and by extracellular factors (e.g. short chain fatty acids). Finally, further cell lines expressing UT-B isoforms with mutated glycosylation sites will also be produced and investigated. Through these pioneering studies, we will determine the precise functional regulation of human colonic UT-B urea transporters.

Amount: £39,302
Funder: The Wellcome Trust
Recipient: University College Dublin

MA in the Social and Cultural History of Medicine. 31 Aug 2007

The 1940s were a watershed in the development of the Irish health system. The fuel and food shortages caused by WWII and the compulsory medical inspections of Irish immigrants to Britain from 1943 drew attention to the continuing deficiencies in the health of the nation. There ensued a debate on the future of the Irish health system. Various alternatives to the system in place were proposed and resisted by interest groups, most notably the Catholic Church, the government and the medical profession. Central to this discourse was the question of how much power the state should have over the lives and health of families, whose primacy was enshrined in the constitution. This thesis will examine how this debate impacted on the health and welfare of Irish Travellers. In this period the perception and status of Irish Travellers was changing due to modernisation and the strains of post war Ireland. This process culminated in the perception of Travellers as an 'itinerant problem' that needed to be fixed. Hitherto Travellers operated on the margins of the state. This had serious health implications for Travellers who experienced with high birth rates, high infant mortality rates, high suicide rates and low life expectancy. The change in the perception of Travellers in the post war period culminated in the appointment of a Commission on Itinerancy in 1960 to investigate the rehabilitation, education and health of Travellers.

Amount: £20,258
Funder: The Wellcome Trust
Recipient: University College Dublin

An investigation into the regulation of virulence factors by DNA supercoiling in gastrointestinal pathogens 16 Jul 2012

DNA supercoiling is a global regulator that plays a critical role in the regulation of virulence factors in many gastrointestinal pathogens including S. Typhimurium. Studies of Campylobacter jejuni have revealed that there is a strong correlation between DNA Supercoiling and the regulation of different virulence genes. However C. jejuni displays an absence of many of the classic regulators of virulence found in S.Typhimurium including nucleoid associated proteins. It has recently been demonstrated that DNA supercoiling affects the regulation of motility and invasion of epithelial cells by C.jejuni. The overall aim of this project is to investigate the regulation of virulence factors by DNA Supercoiling in these two key gastrointestinal pathogens. Transcriptional profiles will be generated for S.Typhimurium and C.jejuni by RNA-seq in response to changes in DNA topology. Bioinformatic analysis of these transcriptional profiles will lead to the identification of potential DNA supercoiling regulons as well as aid the design of predictive models for identifying genes in other pathogens which are regulated by changes in DNA topology. Finally in vitro infection assays will be used to validate and functionally characterise novel supercoiling regulons identified in this analysis.

Amount: £153,645
Funder: The Wellcome Trust
Recipient: University College Dublin

The evolution of riboregulation in mycobacterial pathogens and its role in host-pathogen interactions 16 Jul 2012

In the past decade, non-coding RNAs (ncRNAs), including antisense RNAs (asRNAs), small intergenic RNAs (sRNAs), and elements within the untranslated regions (UTRs) of genes, have emerged as widespread and important regulators of bacterial gene expression. The genus Mycobacterium contains a number of clinically relevant lineages, including the slow-growing members of the M. tuberculosis complex (MTBC), such as M. tuberculosis and M. bovis; facultativepathogens such as M. marinum; and the rapidly growing, multidrug resistant, opportunistic pathogen M. abscessus. Although ncRNAs are known to exist in a number of mycobacteria, their roles are still largely unclear. Using comparative transcriptomic analyses and host cell infection models, thisproject seeks to further understand the prevalence, distribution and functionsof ncRNAs in mycobacteria. Key goals are: " To compare the ncRNA transcriptional patterns of an obligate intracellular pathogen (M. bovis) with those of a closely related facultative pathogen (M. marinum) using computational methods. " To understand the roles of sRNAs in the infection process via RNA-seq analysis of M. abscessus during infection of THP-1 cells. " To uncover the targets of selected sRNAs via experimental approaches. " To offer an insight into the mechanistic aspects of target recognition by searching for sRNA chaperone proteins.

Amount: £153,645
Funder: The Wellcome Trust
Recipient: University College Dublin

Computational analyses of TB pathogens to decipher adaptations to transmission 24 Jun 2013

Mycobacterium tuberculosis (MTB), causative agent of tuberculosis (TB), is oneof the most successful pathogens in the world. MTB is an obligate human pathogen, having no known reservoir outside of the human host. However, the related clinically relevant smooth tubercle bacilli (STB), such as Mycobacterium canettii, seems to survive in an unidentified environmental niche. Genome sequencing has revealed great diversity across STB compared to MTB, with large numbers of single nucleotide polymorphisms (SNPs) and insertion/deletions. This raises questions about the evolution of pathogens, their adaptation to pathogenic or opportunistic lifestyles and comparative analyses across these species offer an ideal opportunity to explore these phenomena. Our hypothesis is that by studying the transcriptomic response of MTB and STB to environmental stimuli we will shed light on the evolution of these pathogens and niche adaptation. We will incorporate transcriptome data with genome data of these species to see whether there is evidence for selection of

Amount: £155,242
Funder: The Wellcome Trust
Recipient: University College Dublin

'An awfully ignorant mob' or 'Embryo doctors'?: Dissecting medical student culture and the shaping of medical professional identity in Ireland, c.1800-1950. 25 Mar 2013

This application seeks funding to visit relevant archives in London as part of a wider postdoctoral study I am undertaking on the history of Irish medical students' experiences, c.1800-1950. I will produce a public outreach blog post on the use of medical memoirs as a genre and on the importance of the Wellcome Library collections to Irish medical history. The research grant will also make a significant contribution to the outputs of the wider project which are a monograph and three peer-reviewe d journal articles. The postdoctoral study, funded by an Irish Research Council postdoctoral fellowship (2012-14) assesses how Irish medical schools inculcated students with the hallmarks of medical professional identity and whether there was anything distinctive about Irish medical students' educational experiences in the period. The fellowship does not provide funds for travel and a Wellcome Trust Research Expenses grant would enable me to undertake vital research at the British Library, W ellcome Library and Royal College of Surgeons Library, drawing upon relevant contemporary lecturers' addresses, student magazines, diaries, lecture notes, and student guides. These sources, many of which are archival in nature, are not available at Irish libraries and it is vital that they are viewed in person.

Amount: £1,455
Funder: The Wellcome Trust
Recipient: University College Dublin

Children and medicine; ethics, autonomy and regulation. 17 Oct 2012

A two-day workshop that examines the philosophical and ethico-legal problems associated with assessing and respecting the autonomy of children within the context of medical treatment and medical research. Participants will be from different disciplines (philosophy, law, medicine, education) and different legal jurisdictions (England, Scotland, Northern Ireland, Republic of Ireland). We will discuss, compare, and criticise the latest developments in law, policy and practice in both countries, as well as examine and challenge some of the ethical and philosophical presuppositions behind the latest developments. The workshop will comprise seven papers, with ample discussion time, together with a final roundtable. The papers cover important areas such as the problem of defining consent and best interests, the problem of parents disagreeing with physicians, the problem of assessing and communicating risk, and the problem of evaluating and treating adolescent mental health. All 17 particip ants listed in the proposal have agreed to attend the workshop; and all 7 presenters listed as giving papers have provided titles and abstracts for their papers. After the workshop, the organisers will collect revised submissions into a volume for publication. This would further increase the impact of the workshop on policy and practice in both countries.

Amount: £3,187
Funder: The Wellcome Trust
Recipient: University College Dublin

Core costs 18 Jan 2019

To support the work of the charity r.

Amount: £1,000
Funder: County Durham Community Foundation
Recipient: Royal British Legion

RBL Portstewart Branching Out 26 Apr 2018

The group, based in Portstewart, are using a grant of £6,500 to replace their hall’s heating system and improve its insulation, making it more usable for community events.

Grant to Royal British Legion, Greenhithe & Swanscombe 23 May 2014

The impact of WW1 on Dartford and its residents