- Total grants
- Total funders
- Total recipients
- Earliest award date
- 20 Nov 1998
- Latest award date
- 18 Jan 2019
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
LifeLines 20 Apr 2016
This is the expansion of a project supporting volunteers aged 50 plus to run activities for vulnerable older people to improve health and well-being. These have previously included art classes, creative writing, yoga and computer club. The group will expand across the city, recruiting more volunteers, supporting more than 800 new people and establishing a Menâ€™s Network to encourage older men to socialise regularly. It will also extend its HealthLink scheme to help older people get to medical appointments.
Kilkeel RBL - Saving Our Community Venue 22 Oct 2015
The group is a community and voluntary based organisation providing a range of services and activities to the local community. They received a grant of Â£10,000 to make improvements to their venue so that it can be used for more classes and activities.
Towards improving access and facilities for disabled people at the Forest Hall Ex-Servicemen's Institute.
Grant awarded to Community Service Volunteers (Training and Enterprise NE) (Tyne & Wear) 13 Jul 2004
To provide daycare services to older people living in high rise flats in Newcastle.
Defining signalling pathways that control neurovascular interactions in the brain and retina. 10 May 2011
Mentalizing and social conformity: Pharmacological manipulations and underlying mechanisms. 12 Jul 2011
The proposed research project focuses on the neurobiology of social behaviour.Neuroimaging experiments will be combined with pharmacological manipulations to better understand the mechanisms and computations underlying social information processing. We recently developed a paradigm to modulate participant's preferences in an intertemporal choice task (Garvert et al., in preparation). This paradigm is apotentially powerful tool for conceptualizing and quantifying the implicit effects mentalizing exerts on decision making. l aim to use this task to studythe biological mechanisms underlying behaviour of individuals placed in socialsituations by investigating the brain regions that support task performance and the effect played by neuromodulators known to be involved in social behaviour (e.g. oxytocin). Furthermore, it will be investigated whether a similar social conformity effect can be observed in other areas of decision making. Elucidating these mechanisms is highly relevant for understanding psychiatric disorders associated with social dysfunction, such as autism. In
Characterisation of genes regulated by S-nitrosylation of HDAC2 during radial neuron migration. 12 Jul 2011
The generation of the laminar structure of the cerebral cortex relies on the radial migration of post mitotic neurons. This proceeds under the control of extremely precise regulatory networks requiring input from multiple extracellular signalling pathways and the co-ordinated expression of nuclear factors that result in specific programmes of gene expression. Recently, in the Riccio lab, we have shown that S-nitrosylation of HDAC2 is required for polarization and radial migration of cortical neurons during the formation of the cerebral cortex. A screen was carried out to identify genes regulated by S-nitrosylation of HDAC2 during cortical neuron migration. Druing this project, 2 candidate genes identified by this screen will be selected and their role in cortical development will be characterised. Key goals which have been set in order to achieve this include the following: 1) Verifying that these genes are upregulated in response to HDAC2 S-nitrosylation. 2) Characterisation of candidate genes expression in vivo 3) Analysis of candidate gene promoter and interaction with HDAC2 4) Characterisation of the function of the candidate genes in cortical neuron polarization and migration, which will include the generation of 2 knockout mouse lines.
The role of flavin-containing monooxygenase 5 (FMO5) in regulating age-related increases in plasma cholesterol and glucose and in body weight 30 Nov 2010
Control of proliferation and developing differentiation of NG2 cells in the developing and adult brain. 21 Feb 2011
This project will investigate how hippocampal dentate gyrus granule cells process synaptic inputs from the medial and lateral entorhinal cortex (MEC and LEC). I will determine how particular activity patterns in MEC and LEC are translated into granule cell population activity in vitro by selectively activating neurons in MEC and LEC using optogenetic stimulation of presynaptic neurons. The results of these experiments will be used to help us interpret subsequent in vivo recordings from granule cells in awake mice navigating in a virtual reality (VR) environment. Both in vitro and in vivo data will be used to construct models to help us to understand the link between cellular processing and behavioural pattern separation.
To investigate the types of AMPA receptor auxiliary proteins that regulate targeting of the receptors to axonal and presynaptic sites, to determine whether these differ from auxiliary proteins involved in receptor targeting at postsynaptic sites, and to understand their role in the regulation of transmitter release.
Synaptic and neuronal determinants of network function: Application of new optical and computational tools. 02 Jun 2011
Developing a mechanistic understanding of brain function is a central aim of neuroscience. I will investigate how synaptic and neuronal properties, together with network structure, control network synchrony and perform rapid information processing in the cerebellar cortex. To do this I will take advantage of powerful new optical and computational methods that I have developed, together with anatomical, electrophysiological and genetic approaches. The initial focus will be on properties of synap tic signaling in inhibitory interneurons, because they are poorly understood and my recent work suggests that electrical synapses between interneurons play a key role in desynchronizing network activity. I will build on this by examining why electrical signalling is excitatory in some cells and inhibitory in others. High-speed 3D 2-photon imaging will be used to measure network synchrony and investigate how it is controlled. By characterizing the input-output properties of synapses and neurons I will also determine the computations performed on sensory information. Biologically detailed network models will then be used to link neuronal computations and network structure to information processing at the network level. Key predictions from these network models, about the way information is represented and processed, will be tested by imaging the cerebellar cortex of intact animals.
Pain intensity, pain location and pain modulation: a combined neurophysiological and psychophysical approach. 03 Mar 2011
Pain is a complex subjective experience, most often caused by the activation of the nociceptive system. This project aims to investigate the neural bases of three cardinal aspects of pain perception: where it is (spatial localization), how much pain there is (intensity) and how it can be modulated by other somatosensory input (touch-pain interactions). Previous work on pain perception has been limited by poor control of pain stimuli and unreliable psychophysical techniques. We will resolve these problems by applying new fast, feedback-controlled laser stimulation, and improved subjective judgement methods, in a series of experiments with healthy volunteers. First, by investigating spatial acuity of pain, we will ask whether pain is more profoundly spatial than classically thought. By comparing its spatial precision to that of touch, we explore the possibility of shared spatial representations between the two senses. Second, we will develop improved pscyhophysical methods for reporting pain intensity, and then use these to better identify neural correlates of pain intensity using modern neuroimaging techniques. Finally, we combine this knowledge about spatial and intensity aspects of pain, to invest how nearby touch can inhibit pain. This basic understanding of pain mechanisms will have direct implications for clinical pain treatment.
Without intervention, complete DiGeorge syndrome (DGS) results in fatal immunodeficiency, as a result of absent thymic stromal function. Recent therapies focus on transplantation of non-MHC-matched thymic epithelium. This project will investigate the importance of MHC-restriction in immune reconstitution and self-tolerance in DGS patients treated with transplantation of thymic epithelium. To test if appropriate MHC expression in thymic epithelial transplants is necessary for efficient T-cel l immunity and tolerance-induction, we will compare the ability of T-cells from DGS transplant patients to activate and proliferate in response to MHC (+antigen) of host- or donor-origin. We will also establish in vitro and mouse in vivo models to address this question. We will compare tolerance induction in human thymus reaggregate cultures in which the epithelial and haematopoietic components are either MHC-matched or mismatched. To assess the impact of MHC-matching on immune reconstitution i n vivo, we will generate models in which athymic mice reconstituted with human haematopoietic stem cells, are transplanted with human thymic epithelium, expressing either MHC matched or non-matched to the haematopoietic component. In addition, to test if a gene-therapy approach to MHC-matching would be beneficial, we will test if we can improve reconstitution by lentiviral-transduction of matched MHC into thymic epithelial cells.
This proposal will study the mechanisms that control the trafficking of the energy providing mitochondria within neurons, and how this relates to neuronal development and connectivity. Using imaging, molecular and cell biological techniques, combined with mouse transgenic approaches we will determine the molecular mechanisms underlying the activity-dependent subcellular positioning of mitochondria in neurons. We will examine how the mitochondrial calcium-sensing GTPase Miro1 acts as a molecul ar switch to regulate mitochondrial movement and distribution. How Miro1-dependent mitochondrial trafficking regulates neuronal migration and morphogenesis will also be determined in addition to the role of Miro1 in regulating the formation and maintenance of synapses and dendritic spines. A key goal will also be to determine if different roles exist for constitutive versus activity-dependent control of mitochondrial transport by Miro1 in these processes. These studies will significantly adv ance our understanding of the molecular mechanisms that control mitochondrial localisation in neurons and the role that activity-dependent mitochondrial trafficking plays in regulating neuronal morphogenesis and connectivity.
Imaging Pain in the Developing Human Brain. 22 Jun 2011
The aim of this research is to understand the development and plasticity of human pain processing, with a particular translational focus on improving clinical assessment and treatment of infant pain. When and how the human brain begins to process pain is fundamental to our basic understanding of human development and to paediatric clinical care. The key goals of this proposal are: (i) Undertsand the neuro-developmental mechanisms that underlie the beginning of human pain perception (ii ) To use fMRI to identify cortical and subcortical structures activated by noxious stimulation in the developing human brain? (iii) To investigate how noxious-evoked brain activity, spinal cord activity, and behavioural and autonomic responses are developmentally regulated? (iv) To establish whether morphine is an effective analgesic for procedural pain in newborn infants?
The project aims to elucidate the relationship between mental capacity and criminal responsibility in order to explore moral issues concerning the way people with a psychiatric diagnosis are treated between these two legal contexts. The project will develop a framework that both clarifies and evaluates current practices in the assessment of capacity and culpability in English law. The descriptive element of the project will use legal and philosophical analysis to identify the features of age ncy centrally, features of belief systems, motivational systems and control that are currently held to be relevant in determinations of capacity and culpability in English law, with a focus on drawing out the points of difference between the two. The normative element of the project will be concerned with evaluating moral, political or other potential justifications for the identified differences in assessments of capacity and culpability. By bringing attention to this question, and producin g a framework that makes recommendations for these areas of law, the project aims to have an impact on the way that features of mental disorder are taken into account in judgments regarding capacity and criminal responsibility.
The primary goal of the proposed research will comprise an up-to-date edition of the corpus of the gynaecological cuneiform texts from 1st millennium BC Mesopotamia, consisting of transliterations, translations and a philological commentary. The text edition will form the basis for a comparative and context analysis of the corpus: the specific features and contents of the gynaecological corpus will be investigated, but also internal and external references and information for the socio-cultural contexts in which the gynaecological texts were written down and used, and the factors that have contributed to their form and features, will be analysed. Here, the position of gynaecological texts within the 'stream of tradition' of Mesopotamian medicine, the cultural belief system and social practice, will be investigated, concentrating on a) the specialists, healers and practitioners involved in treating women who contributed to the formation and transmission of the gynaecological texts, b) the concepts of the female body, the functional processes of the female sexual organs, and the specific gynaecological complaints and problems found in these texts, c) the ways of treating and healing women described in these texts.
The ultimate aim of this research is to reduce the number women delivering prematurely. The study has two aspects that are of particular clinical relevance: (1) it seems likely that early identification of women who are at risk of bacteria triggered PTB will be essential to intervening in a timely fashion ? phenotyping maternal antimicrobial defences at an early gestation offers a logical way to do this; (2) the idea of therapeutically augmenting cervical antimicrobial activity using vector mediated gene delivery to cervical epithelium is a highly novel approach that has the potential to prevent ascending bacterial colonization of the placenta and membranes. As such, the project is poised at the interface of clinical and basic science and may make a significant contribution to reducing the risk of preterm birth and subsequently both neonatal morbidity and mortality, and the serious long term disability associated with prematurity.