- Total grants
- Total funders
- Total recipients
- Earliest award date
- 20 Nov 1998
- Latest award date
- 18 Jan 2019
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
LifeLines 20 Apr 2016
This is the expansion of a project supporting volunteers aged 50 plus to run activities for vulnerable older people to improve health and well-being. These have previously included art classes, creative writing, yoga and computer club. The group will expand across the city, recruiting more volunteers, supporting more than 800 new people and establishing a Menâ€™s Network to encourage older men to socialise regularly. It will also extend its HealthLink scheme to help older people get to medical appointments.
Kilkeel RBL - Saving Our Community Venue 22 Oct 2015
The group is a community and voluntary based organisation providing a range of services and activities to the local community. They received a grant of Â£10,000 to make improvements to their venue so that it can be used for more classes and activities.
Towards improving access and facilities for disabled people at the Forest Hall Ex-Servicemen's Institute.
Grant awarded to Community Service Volunteers (Training and Enterprise NE) (Tyne & Wear) 13 Jul 2004
To provide daycare services to older people living in high rise flats in Newcastle.
There is increasing recognition of the clinical importance of red blood cell (RBC) ageing and clearance, including in transfusion medicine, but the consequences of disposal remain poorly understood. Several mechanisms of recognition and immune clearance of aged RBC have been described, but their effects, particularly on the immune system, and relevance to disease need urgently to be determined. This will be the first comprehensive programme to characterise the immune consequences of effete RBC clearance in health and disease. The specific goals are to define the consequences of RBC uptake on phagocyte and immune responses; establish how storage of blood collected for transfusion modifies these responses; determine the age-related changes to RBC that mediate immune effects; identify the sites and cells mediating clearance in vivo; and ascertain the effects of abnormal clearance in exemplar inherited and acquired diseases. This timely application assembles sophisticated techniques av ailable locally and through key external collaborations, and builds on an ongoing partnership between the University of Aberdeen and the Scottish National Blood Transfusion Service. The results will be of direct clinical relevance to many diseases affecting RBC lifespan, and the conclusions will inform knowledge of cell turnover more generally.
Pattern recognition receptor co-stimulation and chronic fungal infection in chromoblastomycosis. 05 Oct 2010
Fonseca pedrosoi is a causative agent of chromoblastomycosis, a chronic disfiguring disease of the skin and subcutaneous tissues which is very difficult to treat. Virtually nothing is known about the immunology underlying this disease or why it causes chronic infections. Using murine models, we have discovered that the chronicity of the systemic disease is due to a defect in innate recognition. We found that although the pathogen was recognised by an unidentified Fc(gamma)-coupled receptor, it did not co-activate the Toll-like receptor pathway, which resulted in an insufficient pro-inflammatory response. Excitingly, infection could be cured in vivo by artificially co-stimulating the TLR-pathway, suggesting a possible route for treatment of this disease in humans. In this application, we wish to verify that this form of treatment would work without undesirable side-effects in a murine subcutaneous infection model, which would more closely resemble the human disease, and to explore the possibility of using topically applied TLR agonists as a form of treatment. We also propose to characterise the innate mechanisms involved in the recognition of F. pedrosoi, by identifying the pattern recognition receptor(s) involved and by characterising the cell wall of this organism.
454 sequencing - dental calculus 13 Apr 2010
Ancient or historic human dental calculus has yet to be explotited as a DNA source for oral bacteria. We attempted to extract oral bacteria from dental caclulus using Anglo Saxon remains for a preliminary study, and utilised two approaches for identifying the bacteria: a) Specific primers designed to identify oral bacteria associated with peridontitis and diet type. b) Universal primers (16S rDNA) to investigate the diversity of oral bacteria within the calculus deposits. Presently, only a) has been performed on the Anglo Saxon remains as further measures are necessary to totally remove the background bacterial contamination in laboratory consumables before b) can be efficiently performed. This process is currently underway.
Defining the role of vascular endothelial growth factor (VEGF-A) in commissural axon guidance at the optic chiasm. 26 Jun 2008
The co-ordinated patterning of nerves and blood vessels is essential for normal physiological function. This functional integration has its basis in development, but the mechanisms that control the co-patterning of nerves and vessels remain poorly understood. The overarching aim of this proposal is to elucidate the contribution of the archetypical angiogenesis factor vascular endothelial growth factor (VEGF-A) and blood vessels to axon guidance in the central nervous system. Our pilot data p rovides convincing evidence that the VEGF-A isoform VEGF164 and its receptor neuropilin 1 (NRP1) play an essential role in retinal ganglion cell (RGC) axon pathfinding at the optic chiasm, where RGC axons decussate to set up the binocular visual pathways. These findings provide the first evidence for a role of VEGF-A in axon guidance in vivo and identify a classical vascular growth factor as a major player in the establishment of contralateral visual projections. We now wish to extend these fi ndings to establish the precise role of VEGF-A at the optic chiasm. In particular, we wish to determine if VEGF-A acts directly on the growth cones of RGC axons or if physical interactions between nerves and blood vessels underlie the role of VEGF-A in axon guidance.
How does the pathogen Candida albicans sense heat and activate the thermal adaptation mechanisms that promote infection?. 23 May 2011
The major fungal pathogen of humans, Candida albicans, is frequently exposed to temperature changes in host niches. This pathogen must sense and adapt to these thermal fluctuations to establish infections. Therefore, my first goal is to determine how C. albicans cells sense changes in ambient temperature by defining the thermal sensor. In parallel, my second goal is to characterise the biological thermostat i.e. the mechanism(s) by which cells fine-tune the degree of thermal adaptation to the thermal fluctuation. I recently showed that key signalling pathways contribute to thermal adaptation in C. albicans: i.e. the Mkc1, Hog1 and Cek1 pathways. Therefore, my third goal is to establish how these pathways contribute to thermotolerance, in part through modulation of global gene expression patterns. These mechanisms are likely to be conserved in other eukaryotic systems. Therefore, my fourth goal is to test whether other pathogenic fungi such as Cryptococcus neoformans (which occup ies diverse niches in the environment as well as in humans), sense temperature through analogous mechanisms. My fifth goal is to determine how specific thermal adaptation pathways contribute to fungal virulence. By addressing these goals this project will dramatically advance our understanding of eukaryotic thermal adaptation mechanisms.
This project will determine the neuroprotective role of the counter-inflammatory cytokine Interleukin-10 (IL-10) in human African trypanosomiasis (HAT) and evaluate the potential of this cytokine as a therapeutic and diagnostic tool. Our core hypothesis is that IL-10 plays the key role in reducing neuroinflammatory responses in HAT, thereby prolonging survival. The hypothesis leads to the following predictions, which we will test: 1. IL-10 administration parenterally in a mouse model wil l ameliorate neuropathology, and may delay or restrict invasion of the brain parenchyma by trypanosomes. 2. Blocking IL-10 signalling in astrocytes in trypanosome-infected mice will exacerbateCNS neuropathology 3. IL-10 levels in the CSF of HAT patients will inversely correlate with disease severity. Further to these predictions, the proposed project aims to answer the following questions: 1. Does IL-10 administration prevent the neuroinflammatory reaction in the mouse model? 2. What is th e cellular source of IL-10 in the CNS? 3. Is the pattern of trypanosome invasion of the CNS altered following IL-10 administration? 4. Is the astrocyte the key cell type through which IL-10 modulates the CNS inflammatory reaction? 5. Are IL-10, and astrogliosis marker levels in the serum and CSF of trypanosomiasis patients dignostic for disease severity and potential staging tools?
Architecture of the genome: a genetic investigation of chromosome-positioning mechanisms. 16 May 2007
The intranuclear organization of chromosomes is critical for many aspects of genome function, affecting gene expression, DNA repair, and the organization of DNA replication. It is therefore imperative that we understand the mechanisms and cellular components that control chromosome architecture. We have pioneered a screening method that combines advanced imaging with yeast genetics to identify cellular components important for chromosome positioning, using a microscope system funded by a recent Wellcome Trust Equipment grant. Our pilot analysis has identified the chromatin assembly factor Asf1 and the Ctf18 ring-loading complex as crucial for correct positioning of the chromosome ends or telomeres. The first objective of this research programme is to use genetic, genomic, and proteomic approaches to understand the mechanisms by which Asf1 and Ctf18 affect telomere positioning. Second, we will undertake a genome-scale survey of the cellular components responsible for positioning and organizing telomeres. The information gained will contribute to the third part of the programme, in which we will analyse the localisation of non-telomeric chromosome domains, and identify the molecular components involved in global chromosome positioning. Overall, this research programme forms a cutting-edge investigation of the mechanisms controlling eukaryotic chromosome architecture.
'Varieties of Cultural History: Theory and Practice in the Cultural Histories of Medicine, Science and Literature and the Arts' conference to be held at the University of Aberdeen from 5 - 8 July 2007. 23 Mar 2007
Varieties of Cultural History: Theory and Practice in the Cultural Histories of Medicine, Science, Literature and the Arts Cultural History is a diverse field, drawing inspiration from many disciplines beyond conventional history: thus, the question 'What is Cultural History?' is one that cultural historians regularly encounter both at research and teaching levels. By providing a forum for creative interchange among practitioners of cultural history, in and beyond the spheres of medicine and health, this conference provides an opportunity to reflect upon and identify characteristics, approaches, methods and ambitions. Cultural historians of medicine and health have consistently played major roles in debates over such questions, their work repeatedly providing some of the most provocative, innovative, or otherwise effective examples of what the approaches, methods and ambitions of cultural history may achieve. In light of this, the organisers have foregrounded 'medicine' in the list of 'varieties of cultural history' that the conference will explore. Our wish is that at this conference, cultural historians of medicine will disseminate their own research to a more extended community of scholars; and, reciprocally, that scholars beyond the conventional limits of cultural history of medicine (in science, literature and the arts) will highlight the resonances between medicine, health and wider culture. The first two full days of the conference will consist of parallel sessions and keynote papers; the morning of the third day will consist of the discussion of varieties of cultural history teaching, in the research contexts of different institutions. During the afternoons of 6 and 7 July there will be four commissioned sessions of three papers, two of which will cover the cultural history of medicine, and six keynote papers, one of which will be by a cultural historian of medicine. The other commissioned sessions will cover 'Science and Literature' and 'Methodological Problems in the Cultural History of Science'.
RBL Portstewart Branching Out 26 Apr 2018
The group, based in Portstewart, are using a grant of £6,500 to replace their hall’s heating system and improve its insulation, making it more usable for community events.
The impact of WW1 on Dartford and its residents
Grant to Little Newcastle Community Association in conjunction with Royal British Legion, Pembrokeshire 30 May 2014
Interpreting World War 1 through Commemoratives