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LifeLines 20 Apr 2016

This is the expansion of a project supporting volunteers aged 50 plus to run activities for vulnerable older people to improve health and well-being. These have previously included art classes, creative writing, yoga and computer club. The group will expand across the city, recruiting more volunteers, supporting more than 800 new people and establishing a Men’s Network to encourage older men to socialise regularly. It will also extend its HealthLink scheme to help older people get to medical appointments.

Kilkeel RBL - Saving Our Community Venue 22 Oct 2015

The group is a community and voluntary based organisation providing a range of services and activities to the local community. They received a grant of £10,000 to make improvements to their venue so that it can be used for more classes and activities.

Grant to Royal British Legion Tipton Branch 19 May 2016

Remembering Tipton's World War One Heroes

Grant awarded to The Royal British Legion (Forest Hall) Branch And Club (Tyne & Wear) 20 Nov 1998

Towards improving access and facilities for disabled people at the Forest Hall Ex-Servicemen's Institute.

Grant awarded to Community Service Volunteers (Training and Enterprise NE) (Tyne & Wear) 13 Jul 2004

To provide daycare services to older people living in high rise flats in Newcastle.

Salience network and coordination of brain circuits in schizophrenia. 20 Jun 2011

Structural and functional brain changes have been documented extensively in schizophrenia. Emergence of psychosis during adolescence is a well-established feature of schizophrenia. Aberrant neurodevelopment leading to disrupted coordination of brain circuits has been proposed as a putative cause. Glutamatergic dysfunction has been proposed to underlie this dysconnectivity. During normal adolescence pruning of focal brain circuits leads to the emergence of longer-range connections even in the absence of direct anatomical connectivity. A paralimbic network called Salience Network (insula and anterior cingulate) has been identified as a key circuit that matures in connectivity during adolescence. This network is thought to mediate switching between default-mode and task-active brain states by modulating the recruitment of the relevant large-scale networks, in healthy adults. Objectives: To study the nature of short-range and long-range structural and functional connectivity in sch izophrenia and to demonstrate impaired Salience Network modulation of task-related recruitment of brain circuits, using fMRI. Functional connectivity will be related to glutamate levels in insula and anterior cingulate (measured using spectroscopy). Independent Component Analysis, Graph Networks and Dynamic Causal Modeling will be employed to study functional connectivity. Tractography will be used to analyse structural connectivity. Surface-based morphometry will be employed to study struc tural covariance complementing functional connectivity.

Amount: £195,294
Funder: The Wellcome Trust
Recipient: University of Nottingham

Does quorum sensing diversity affect cell-cell communication, biofilm fitness and susceptibility to antimicrobials?. 09 Jul 2009

If our ability to treat infection effectively is to continue, our understanding of the mechanisms through which current antibiotic therapies are subverted must be improved. Chronic lung infection with Pseudomonas aeruginosa (PA) is primarily responsible for the accelerated decline in lung function and mortality in patients with cystic fibrosis. Quorum sensing (QS) is a cell-cell communication system used by PA to regulate virulence and biofilm maturation: an attractive target for novel antim icrobial therapies. However, it is known that QS mutants arise during chronic lung infection. How phenotypically diverse are these mutants and do they influence the clinical status of the patient? This multidisciplinary proposal will utilise a combination of molecular techniques, animal models and social evolution theory to (1) determine the level of QS diversity in patients; (2) explore the effect of QS diversity on biofilm formation, pathogenesis in chronic lung infection and antimicrobial susceptibility; (3) develop and empirically test evolutionary theory to determine why this diversity arises and (4) assess the potential of QS as an antimicrobial target. The insights this work will provide could be instrumental in guiding future development and use of novel antimicrobials that disrupt PA virulence, thus increasing the efficacy of old and new antibiotics.

Amount: £287,073
Funder: The Wellcome Trust
Recipient: University of Nottingham

Open Access Awards. 16 Sep 2008

Not available

Amount: £30,000
Funder: The Wellcome Trust
Recipient: University of Nottingham

The market for healers and the ethics of biomedicine in Burkina Faso. 05 Jun 2008

There has been considerable normative debate about the applicability of international bioethical thinking to medical practice and research in developing countries. Little is known about how this plays out empirically, particularly about the interaction between indigenous and international bioethical thinking. It is also acknowledged that international writing on bioethics has tended to be dominated by Anglophone values and models of research and medical practice, whose universality is contested. This empirical study of the ethics of medical practice in Burkina Faso will: describe how practitioners deal with the potentially competing claims of local and international ethical expectations; examine the influence of a francophone context and its different traditions of ethical analysis. WP1 A literature review covering international bioethics, the sociology of the professions and the anthropological study of indigenous healers; archival work on the institutional foundations of European medicine in Burkina Faso. WP2 The role of international organizations and NGOs in shaping the contemporary organisation of health services in Burkina Faso, particularly the ethical expectations embedded within their interaction with the state. The approach of regulators. WP3 The bioethics of indigenous practice and the standards adopted by local healers in interaction with consumers. WP4 The European-style medical practitioners and the ethical standards that they adopt in interactions with their consumers and their regulators. WPS PhD thesis and journal articles in French and English, together with an accessible web summary of the main findings. WP1 & WP5 will be mainly completed in Nottingham; WP2-4 will be completed in Burkina Faso.

Amount: £108,070
Funder: The Wellcome Trust
Recipient: University of Nottingham

In vitro reconstitution and study of Bacillus subtilis DNA replication. 29 Jun 2010

Most of what we know about DNA replication initiation and the organization of the replication fork has emerged from studies of the E. coli system where the replication process has recapitulated in vitro. Little is known about the B. subtilis system because of the lack of a complete in vitro system and the crucial differences in initiation and the organization of the replication fork. Yet the B. subtilis replication is more similar to eukaryotic replication with two polymerases PolC and DnaE act ing on the leading and lagging strand analogous to pol delta and pol alpha, respectively. This proposal aims to recapitulate the oriC-driven B. subtilis complete replication process in vitro. My lab has been working in this area and we are now in possession of all the proteins required as well as unique tools, resources and expertise to achieve this task. Initially we will use it to reveal the molecular mechanism of oriC-replication initiation by the DnaA-DnaD-DnaB proteins and then the molecula r details that underpin the two-polymerase organization of the replication fork. The development of this in vitro system will also be an invaluable tool for future studies of several other crucial differences between B. subtilis and E. coli replication.

Amount: £187,674
Funder: The Wellcome Trust
Recipient: University of Nottingham

Inflammatory mediators as modulators of decidual calcium channel expression and function. 08 Jul 2008

Proinflammatory pathways have been implicated in the initiation of term and preterm labour. However the specific molecular mechanisms mediating their actions have not been fully elucidated. Our earlier studies have demonstrated the differential expression of decidual potassium and calcium currents with the onset of labour and their modulation by uterotonic agents including oxytocin. We aim to extend our research to test the hypothesis that decidual calcium channels play a key role in integrating cellular signals in preparation for labour and are targets of proinflammatory mediators through which decidual function may be linked to the onset of labour. The unique electrical and immune characteristics of decidual stromal cells as well as their location at the materno-fetal interface suggest that they have key roles in determining uterine function. A combination of molecular techniques and electrophysiology will be utilised to identify and characterise the interaction between voltage-gate d calcium channels and their transcriptional regulation by proinflammatory mediators, in human decidua obtained before and after the onset of labour, These studies will illuminate our understanding of the interplay between complex inflammatory networks and ion channels in the intitiation of spontaneous labour.

Amount: £278,309
Funder: The Wellcome Trust
Recipient: University of Nottingham

Open Access Award. 31 Oct 2006

Not available

Amount: £20,000
Funder: The Wellcome Trust
Recipient: University of Nottingham

Masters Degree. 28 May 2007

Rationing decisions in health care in Burkina Faso The health system in Burkina Faso has been extensively restructure since 1990. One important dimension of this is the introduction of referral system that reflects conventional international practice: primary care at a district level, secondary care at a regional level and tertiary care in a single national hospital, with a progressive increase in the degree of specialization and complexity of the medical work involved. It is important not to identify these tiers with their equivalents in more developed countries: Burkina Faso is one of the poorest countries in the world (204/232 in the CIA World Factbook) with GDP of about $1,200 per head and life expectancy at birth of less than 50 years. There is a growing problem with HIV/AIDS and a high risk of infectious disease. As with a number of other poor countries, then, the health system has added a fourth tier, providing state-funded referrals to health facilities outside the country where local services are unable to cope. Eligibility for international referral is defined and guaranteed in law, although not matched by the availability of resources to fund referrals in every case. A committee of doctors has been set up in the national tertiary centre to determine which patients should actually be referred for treatment outside the country. This study will concentrate on the workings of the review committee. It will look at the two main issues: the response of the members to the constraints on traditional medical autonomy represented by the legal definitions of eligibility for health care in another country, and the basis on which committee members adjudicate between the competing claims of different patients who satisfy the criteria in a situation where resources are insufficient to offer the treatment to all of them. Although both of these are familiar issues to both social scientists and bioethicists, they have been little studied in the context of the poorest countries, where the challenges may be more sharply posed.

Amount: £22,600
Funder: The Wellcome Trust
Recipient: University of Nottingham

Transcriptional control of inflammatory gene expression in asthma. 03 Jul 2007

Recent work by our group and others suggests that airway smooth muscle (ASM) cells play a central role in chronic inflammation and airway remodelling in asthma by production of lipid mediators, chemokines, matrix metalloproteinases and growth factors. There is also evidence that airway smooth muscle (ASM) cells have intrinsic abnormalities in these synthetic pathways. Our preliminary studies show that ASM cells obtained from bronchial biopsies in asthmatic subjects produce more eotaxin, IL-8 and VEGF than cells from non-asthmatic subjects. We have shown that these genes are transcriptionally regulated in ASM cells by specific transcription factors and histone H4 acetylation and have started to identify the histone acetyl transferases responsible and the regulatory mechanisms involved. Furthermore we have found that histone acetyltransferase activity is increased in cells from asthmatic subjects. We will extend these studies to determine 1. which co-activator HATs stimulate inflam matory gene expression and how they and their co-repressor HDACs are regulated? 2. which aspects of transcriptional regulation are abnormal in asthma? 3. the effect of existing (beta-2 agonists and glucocorticoids) and novel (PPARgamma agonists, PKCbeta inhibitors) asthma therapies on these processes in normal and asthmatic cells. These studies will provide information regarding new therapeutic targets for chronic asthma.

Amount: £716,801
Funder: The Wellcome Trust
Recipient: University of Nottingham

Core costs 18 Jan 2019

To support the work of the charity r.

Amount: £1,000
Funder: County Durham Community Foundation
Recipient: Royal British Legion

The use of race/ethnicity in applied population genetics research: implications of scientific practice, public health and access to health care. 19 Oct 2005

The development of novel diagnostics, therapeutics and health services is increasingly predicated on the search for significant biological differences within and between populations. This has led to the creation of large-scale scientific projects that map genetic variation, including human genetic databases focused on populations defined according to geography, nationality, race/ethnicity or disease. However, comparisons of genetic differences between populations raise important scientific, social, ethical and policy questions. This is an empirical study of how the categories of race/ethnicity are used in applied population genetics research and the implications this may have for scientific practice, public health and access to health care. The research is focussed on a detailed analysis of two case studies (the aetiology of common diseases and the pharmacogenetics of drug metabolism) and is designed around four discreet, but intersecting, 'workpackages' that explore the conceptual, practical and policy implications in commercial, scientific and health policy settings. Primary data will be mainly derived from 60-70 UK interviews. The research will firstly analyse how concepts of race/ethnicity have been used in the scientific literature covering the two case study areas. It will also explore more general debates about the use of these categories in genetics and biomedical research. The project will then examine how concepts of race/ethnicity are used in the two case studies of applied population genetics and analyse their influence on research agendas, study design and scientific findings, as well as their social, ethical and policy implications. This will be followed by an assessment of the potential implications of applying the findings of population genetics research, based on the use of racial/ethnic categories, in health policy, the development of NHS services and the provision of healthcare. Finally, the project will identify 'good practice' for the use of racial/ethnic categories in both population genetics research and health policy, planning and practice with the aim of improving the acuity of research and promoting equity in health.

Amount: £3,000
Funder: The Wellcome Trust
Recipient: University of Nottingham

An investigation of the role of cortico-striato-thalamo-cortical circuits in the regulation of inter-temporal choice behaviour in rats. 20 Oct 2005

Inter-temporal choice is choice between rewards that differ in their sizes and delays. It is believed that an abnormality of inter-temporal choice (predeliction for 'impulsive choice') may contribute to the behavioural disturbance seen in some clinical conditions. It is suggested that this abnormality of inter-temporal choice may arise from dysfunction of cortico-striato-thalamo-cortical (CSTC) circuits. To date there have been no systematic investigations of the effects of manipulating CSTC function on inter-temporal choice in animals. The project will use behavioural methodology based on a mathematical theory of inter-temporal choice developed by the applicants. A series of experiments will examine the effects of disrupting the function of three putative CSTC circuits (designated by their cortical components, as orbital prefrontal, ventromedial prefrontal and dorsomedial prefrontal) on performance on inter-temporal choice schedules. The effects of lesions of the cortical component of the circuits will be examined, followed by examination of the effects of disconnecting the cortical component from its striatal target, and selective dopamine depletion in these regions. Hypotheses will be derived from these experiments about effects of the lesions on processes believed to underlie inter-temporal choice (delay-discounting, sensitivity to reinforcer size). These hypotheses will be addressed using quantitative single-operandum operant schedules.

Amount: £297,929
Funder: The Wellcome Trust
Recipient: University of Nottingham


Not available

Amount: £200,000
Funder: The Wellcome Trust
Recipient: University of Nottingham

RBL Portstewart Branching Out 26 Apr 2018

The group, based in Portstewart, are using a grant of £6,500 to replace their hall’s heating system and improve its insulation, making it more usable for community events.

Grant to Royal British Legion, Greenhithe & Swanscombe 23 May 2014

The impact of WW1 on Dartford and its residents