- Total grants
- Total funders
- Total recipients
- Earliest award date
- 20 Nov 1998
- Latest award date
- 17 Apr 2020
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
An Analysis of Health Behaviour Modifications in Alleviating Fear of Cancer Recurrence (FCR) 01 Apr 2016
Cancer afflicts a considerable number of people and may have significant impact on them, such as heart problems and infertility. Distressful emotions, including loneliness and Fear of Cancer Recurrence (FCR) might be experienced. FCR is extrememly common among cancer survivors to varying degrees. In addition, high levels have been associated with depression, hopelessness and other undesirable consequences . As a highly prevalent unmet need of cancer survivors, such implications on their quality of life reveal the importance of research into FCR to improve care for cancer survivors. This research project aims to further investigate the relationship between loneliness, distress and FCR. In particular, it also seeks to study whether modifications in health behaviours can alleviate FCR. Research suggests that diet and physical activity may be key factors in reducing cancer risk. Furthermore, it is thought that FCR might motivate health behavior modifications in cancer survivors. However, more research is needed to delineate this relationship. Moreover, a theoretical understanding of if and how changing health behaviours may help the survivors manage their fears is not available. Therefore, the project will explore the relations between health behaviour modifications and FCR through interviews and surveys to attain both qualitative and quantitative data.
We have established that bacterial cells require cellular homeostasis for growth and survival in diverse niches. Ion channels play major roles in cellular homeostasis, as exemplified by our previous work on mechanogated (MscS & MscK) and electrophile-activated (KefC) channels. We have made considerable progress in understanding the gating of these two channel types and the future programme will concentrate specifically on the gating transitions in the channels. Additionally, we will pursue high resolution structures for the closed state of both MscS and MscK and assess important regions of the KefC structure in order to link them to function. The team members have become expert in electrophysiology, molecular genetics and protein biochemistry and they have made significant contributions to understanding the mechanisms and physiological roles of bacterial ion channels. The programme builds on these core skills, which will be augmented by strategic structural and biophysical collaborations (Naismith & Perozo). The key objectives will be: Detailed understanding of the gating transition of the MscS and MscK channels. Closed structures for MscS and MscK. Structural analysis of KefC - definition of the ion translocation pathway and the gating transition.
This grant application requests funding to support a one-week archival visit to Oxford. I wish to make a detailed study of a single fifteenth-century manuscript, Oxford, Bodleian Library, MS Rawlinson c. 299. This manuscript contains a collection of medieval medical recipes written in English. The hand-written collection comprises about 150 recipes in total, including some charms and a uroscopy. A unique point of interest is that the manuscript had a known owner and location in the sixteenth-cen tury. My investigation will consider this later owner's use of this medieval medical material by charting the exact nature of his annotations and interractions in the manuscript.
Cell Block Science 13 Jan 2016
Funding is sought to facilitate the delivery of a programme of public engagement with science activities in the prison learning centres of HMP YOI Cornton Vale and HMP Shotts. Activities will be designed and delivered by scientists from the Biomedical Sciences Research Centre (BSRC), St Andrews University with assistance from their public engagement officer, Mhairi Stewart. The BSRC is uniquely placed to cover many STEM subjects including Biology, Chemistry, Physics and Medicine. The programme will launch with Univeristy of St Andrews researchers visiting the prison learning centres and the establishment of a science library in the centres. The project officer (to be appointed) along with the named applicants will use these visits to evaluate the areas of most interest and widen the programme to include a series of science based projects delivered at differing levels of challenge that prisoners can undertake in the prison environment. Our aims are to engage prisoners with STEM subjects and provide opportunities for skill development including problem solving, communication skills, independent learning, and teamwork. Researchers will receive communication skills training and practice through the programme. This project will also contribute to knowledge on best practice in informal science learning within prison environments.
The interferon (IFN) system is a major component of vertebrate innate anti-viral immunity. It is so powerful that most (if not all) viruses have evolved IFN antagonists1. Whilst there has been an explosion in our knowledge of this subject in the last 10-15 years(1), there are still many unanswered questions about how viruses interact with the system. Our aim is tobuild up a comprehensive understanding of this interaction by focusing on paramyxoviruses; our studies will determine how paramyxovirus infections trigger IFN production, whether overstimulation of the system (and other innate responses) exacerbates disease processes, how IFNcontrols paramyxovirus infections and influences virus host range, pathogenicity and
Human stem cells bring a great promise for personalized regenerative medicine, in vitro studies of patient-specific human diseases and new generation of effective drug-screening methods. In the last years, patient-derived induced pluripotent stem cells (iPSC) have been increasingly used in clinical trials of novel therapies and more fundamental studies on the genetic neuronal disorders. However, the great variability and heterogeneous behaviour of patient-derived iPSC lines has been recognized as a major obstacle in their clinical applications and in conclusive interpretation of in vitro studies and drug screening assays. Their functional electrical properties responsible for the neural function are particularly important for the success of neuroregenerative stem cell treatment. However, they are extremely difficult to study using traditional electrode-based methods and the selection of functionally optimal transplant cell line is currently unfeasible. In this project, we will apply our recently developed experimental system capable of rapid functional analysis of living neural cells to human iPSC-derived neurons. Using our light-based optogenetics approach we will aim to demonstrate an efficient methodology for selection of the optimal transplant iPSC line for neuroregenerative therapy based on its electrophysiological characteristics. Our non-invasive approach will enable complete electrophysiological characterization of hundreds of cells within each sample.
The mammalian spinal cord contains all the neural machinery required to generate locomotor activity, even in the absence of descending and sensory input. Neuromodulation is an important component of this system, allowing locomotor activity to be modulated to suit different states or behaviours. Nitric Oxide (NO) is a potentially critical neuromodulator, about which almost nothing is known in the context of mammalian locomotion. We therefore aim to elucidate the role of NO in the control of mamma lian locomotion. We will initially determine the neuronal sources of NO in the mouse spinal cord using NADPH-d histochemistry and nNOS immunohistochemistry to reveal nitric oxide synthase expression, and DAF-2DA labelling to reveal NO production. Next, using electroneurographic recordings from ventral roots and whole-cell patch-clamp recordings from neurons in spinal cord preparations which can elicit locomotor activity, we will examine the effects of NO-mediated signalling on locomotor networks and determine underlying cellular and synaptic mechanisms. Patch-clamp analyses will concentrate on nitrergic neurons, revealed by DAF-2DA labelling, and motoneurons, the output cells of motor systems. Data obtained will address an important gap in our knowledge of spinal motor networks and provide novel information regarding NO-mediated signalling which should be applicable to other neuronal systems.