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Results

LifeLines 20 Apr 2016

This is the expansion of a project supporting volunteers aged 50 plus to run activities for vulnerable older people to improve health and well-being. These have previously included art classes, creative writing, yoga and computer club. The group will expand across the city, recruiting more volunteers, supporting more than 800 new people and establishing a Men’s Network to encourage older men to socialise regularly. It will also extend its HealthLink scheme to help older people get to medical appointments.

Kilkeel RBL - Saving Our Community Venue 22 Oct 2015

The group is a community and voluntary based organisation providing a range of services and activities to the local community. They received a grant of £10,000 to make improvements to their venue so that it can be used for more classes and activities.

Grant to Royal British Legion Tipton Branch 19 May 2016

Remembering Tipton's World War One Heroes

Grant awarded to The Royal British Legion (Forest Hall) Branch And Club (Tyne & Wear) 20 Nov 1998

Towards improving access and facilities for disabled people at the Forest Hall Ex-Servicemen's Institute.

Grant awarded to Community Service Volunteers (Training and Enterprise NE) (Tyne & Wear) 13 Jul 2004

To provide daycare services to older people living in high rise flats in Newcastle.

The attenuation of FMDV RNA replication. 07 Mar 2011

The body of research into FMDV is impressive; 150+ complete genome sequences, a map of polyprotein processing, full-length cDNA clones from which virus can be rescued ( infectious copies ), a non-infectious replicon cDNA system, characterisation of the virus receptor, atomic structures of the virus particle, L proteinase and 3D polymerase, characterisation of immune responses with detailed epitope mapping. There still remain, however, substantial and critical gaps in our knowledge as to how th is virus replicates so rapidly. Even cursory inspection of the FMDV genome reveals a number of features which are unique to aphthoviruses. Surprisingly, the function or contribution to RNA replication of these features is not understood and is not currently being investigated. Our hypothesis is that these unique genome features are critical targets for genetic modification(s) for vaccine development. Our proposed program of research focuses upon questions concerning the replication of v irus RNA and the molecular interactions between virus RNA/virus proteins with host-cell proteins using the (non-infectious) FMD replicon system. An essential element of this proposal is to harness the knowledge gained for the design of new, recombinant, forms of the genome to produce attenuated phenotypes: candidates for a new form of disease control live, attenuated, vaccines.

Amount: £94,000
Funder: The Wellcome Trust
Recipient: University of St Andrews

Biomedical Vacation Scholarship 14 Jun 2010

Not available

Amount: £5,760
Funder: The Wellcome Trust
Recipient: University of St Andrews

The interaction of paramyxoviruses with the interferon system. 02 Feb 2009

Whilst much has been learnt over recent years about how viruses interact with the interferon (IFN) system, there are still significant gaps in our knowledge. By building upon our extensive experience on the interaction of paramyxoviruses with the IFN system we propose to address some of these questions. More specifically, we will continue to characterise the nature of (paramyxo)virus inducers of IFN and how the IFN-induction cascade is activated and controlled, with particular reference to obser ved heterocellular nature of IFN induction. We will also identify the IFN-induced genes that affect the replication of paramyxoviruses (in particular PIV5), and detail how these viruses deal with cells in a pre-exisitng IFN-induced anti-viral state. In this regards, the importance of virus cytoplasmic bodies to the life-sytle of these viruses and their ability to establish prolonged/persistent infections will be examined. In addition, we will develop generalised methods for the rapid selection o f viruses that are either good inducers of IFN or cannot block IFN signalling, both for our fundamental studies and because such viruses may be developed as potential attenuated vaccine candidates. Such procedures may be particularly valuable for newly emerging viruses that pose an immediate threat to human and animal welfare.

Amount: £956,623
Funder: The Wellcome Trust
Recipient: University of St Andrews

New Disease Control Strategies for Foot-and-Mouth Disease. 13 Jul 2009

The body of research into FMDV is impressive; over 150 complete genome sequences, a map of polyprotein processing, full-length cDNA clones from which virus can be rescued ( infectious copies ), a non-infectious replicon cDNA system, characterisation of the virus receptor, atomic structures of the virus particle, L proteinase and 3D polymerase, characterisation of immune responses with detailed epitope mapping. There still remain, however, substantial and critical gaps in our knowledge as to ho w this virus replicates in two modes; (i) very rapid cell lysis (3-4hrs), or, (ii) establishment of persistent infections. Even a cursory inspection of the FMDV genome reveals a number of features which are unique to aphthoviruses. Surprisingly, perhaps, the function or contribution to RNA replication of these features is not understood and is not currently being investigated. Our proposed program of research focuses upon questions concerning the replication of virus RNA and the molecular interactions between virus RNA/virus proteins with host-cell proteins using the (non-infectious) FMD replicon system. An essential element of this proposal is to harness the knowledge gained for the design of new, recombinant, forms of the genome to produce attenuated phenotypes: candidates for a new form of disease control live, attenuated, vaccines.

Amount: £188,123
Funder: The Wellcome Trust
Recipient: University of St Andrews

Multifunctional molecular machines acting on DNA: the XPD and XPB helicases. 29 Jun 2010

Helicases are molecular machines that unwind and remodel DNA and RNA in a wide variety of essential cellular processes. To understand helicase function, we need to understand their molecular structures and the dynamic conformational changes central to their catalytic mechanisms. The DNA helicases XPD and XPB are the enzymatic components of the transcription factor TFIIH and are essential for the fundamental cellular processes of Nucleotide Excision Repair (NER) and transcription initiation. Euka ryal TFIIH is difficult to study at a molecular level and the archaeal homologues of XPD and XPB have proven to be important model systems. Building on our long track record studying the archaeal enzymes, we have brought together a number of cutting-edge technologies including crystallography, biochemistry, genetics, single molecule assays, EPR and biophysics. We aim to determine the structural changes inherent in XPD and XPB action, define the function of domains such as the Fe-S cluster domain of XPD and Thumb domain of XPB and gain an understanding of their mechanisms at a molecular level. These studies will provide valuable new insights relevant to human health and disease and provide an enhanced understanding of an important class of enzymes fundamental to human biology.

Amount: £923,998
Funder: The Wellcome Trust
Recipient: University of St Andrews

St Andrews University iGEM Team 28 Mar 2011

Not available

Amount: £9,000
Funder: The Wellcome Trust
Recipient: University of St Andrews

Core costs 18 Jan 2019

To support the work of the charity r.

Amount: £1,000
Funder: County Durham Community Foundation
Recipient: Royal British Legion

Equipment only grant for a MALDI Mass Spectrometer with MS/MS capabilities and associated equipment. 24 Apr 2006

A modern MALDI MS/MS mass spectrometer would underpin a major part of the research at the Centre for Biomolecular Sciences, University of St Andrews, a collaboration between the RAE Grade 5 Schools of Biology and Chemistry. These projects are described in this submission and collaborators forms. There is a strong theme of fighting infection by studying the molecular basis of disease and the identification of novel therapeutic targets. Projects requiring MALDI-TOF MS (MS/MS) include: (i) iden tification of host proteins interacting with viral proteins in adenovirus, bunyavirus, paramyxovirus and picornavirus infections, using immunoprecipitations and TAP-tag type strategies; (ii) investigation of the mode of action of anti-fungal peptides, by examining their synergy using a combined transcriptomics and proteomics approach; (iii) the Scottish Structural Proteomics Facility (SSPF), which is using high throughput gene expression, purification and crystallisation to elucidate the structu res of proteins involved in microbial pathogenesis, biosynthetic pathways and archaeal virus proteins; (iv) investigation of archaeal DNA damage protection, detection and repair mechanisms, by identification of the purified protein complexes involved and proteins whose expression levels change upon exposure to damage agents, and (v) definition of the SUMO and NEDD8 proteomes and quantification of changes in these post-translational modifications upon different stimuli.

Amount: £455,308
Funder: The Wellcome Trust
Recipient: University of St Andrews

RBL Portstewart Branching Out 26 Apr 2018

The group, based in Portstewart, are using a grant of £6,500 to replace their hall’s heating system and improve its insulation, making it more usable for community events.

Grant to Royal British Legion, Greenhithe & Swanscombe 23 May 2014

The impact of WW1 on Dartford and its residents

Grant to Royal British Legion, Downs Branch 15 Jul 2014

First Day Commemoration of World War I

Grant to Royal British Legion 19 Sep 2013

Events to commemorate the Centenary of the First World War in 2014

Grant to Royal British Legion Leiston Branch 13 Feb 2014

Commemorating Leiston in the Great War