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Results

Illness as punishment, and community wellness, in nonconformist communities: a cognitive enactivist analysis. 30 Apr 2016

The goal of my proposal is to create an enactive model of illness as a punishment for transgression in early modern societies. I will examine the role that health plays in communities in which certain people do not conform to the behavioural norms of that community. I will focus the autobiography of Thomas Ellwood, who, as a Quaker, refused to genuflect or remove his hat when required by behavioural norms. As a result, he was punished with violence and the theft of his hat, resulting in an illness which he reflects on in spiritual terms as both a result of his nonconformism within society and a challenge from God. This project will deploy an enactive cognitive approach to explain Ellwood's reflections. Related to the notion of biological centrism, an enactive approach examines an organism's relation to its environment or community. I would present the research findings in an article, to be completed in late 2016, and as a conference paper at the international Cognitive Futures in the Humanities conference at Helsinki in June 2016 (I have already been invited to be part of a panel at this event, and our panel proposal has been accepted).

Amount: £639
Funder: The Wellcome Trust
Recipient: No Organisation

Experimental Stories: Oliver Emanuel 30 Sep 2015

What happens when a simple infection becomes life threatening? In a world where the effectiveness of antibiotics is diminishing, should we let certain people die to protect the rest?

Amount: £500
Funder: The Wellcome Trust
Recipient: No Organisation

Experimental Stories: Al Smith 30 Sep 2015

"Culture" 3 x 45’ plays

Amount: £500
Funder: The Wellcome Trust
Recipient: United Agents

Transnational Medical Activism against Nuclear Weapons in Britain in the Cold War. 15 Sep 2014

The proposed activity to be carried out during the tenure of a Small Research Grant consists of data collection in the newly opened Medact Archive at the Wellcome Library in London. For this purpose, I will travel to the Wellcome Library in London where I will spend five full days in the Medact Archive to look at materials relating especially to one of Medact's two predecessor organizations (the Medical Campaign againt Nuclear Weapons). This research will play a pivotal role in the completion of my current project on transnational medical activism against nuclear weapons in Britain in the Cold War.

Amount: £910
Funder: The Wellcome Trust
Recipient: Swansea University

Feminism and the body: an interdisciplinary conference. 30 Jan 2007

Feminism and the Body, an interdisciplinary conference 'Feminism and the Body, an interdisciplinary conference' will address issues that are at stake in the gendered politics of health and well being. Unique to this conference will be the range of research fields and disciplinary training that will converge on these issues. It will bring together scholars from the humanities, social sciences and medical sciences to share their expertise and disciplinary perspectives. In particular the event will promote critical discussions of the ways in which feminist theory has informed the research being presented, the ways that feminist engagements have shaped practices that relate to the body both historically and in the present, and the ways in which feminist thinking can best be developed as an analytic tool and an influence in the politics and practices of conceptualizing and engaging with bodies. Topics that will be covered by the conference include: ethical issues in antenatal screening technologies; the history of abortion; the impact of South Asian feminisms on women's health and well being; women's alcohol consumption in public space; experiences of domestic violence in pregnancy; the reproductive body and migration; representations of women's bodies in film, theatre and ballet; literary constructions of femininity and sexuality; child sexuality; the legacies of sexual difference feminism; feminist contributions to discussions of the ageing process; race and the different meanings of rape in Peru; issues of medico-legal ethics that arise where patients choose disability with pre-implantation genetic diagnosis; contemporary breastfeeding practices in Slovenia; cosmetic surgery; chemical treatments for vaginal secretions and skin whitening; decision making in relation to vasectomy; the historiography of rape and lynching in twentieth century America and eugenics in early twentieth-century Australia.

Amount: £540
Funder: The Wellcome Trust
Recipient: King's College London

More Humanity: Christine Borland's translation of empathy in medical anatomy and clinical practice and its incorporation in visual art. 14 Jun 2010

First, the proposed research will examine artist Christine Borland's methodology, focusing on notable artworks made during the last fifteen years. Second, it will analyse how contemporary artworks reference medical history and clinical practices towards providing a renewed direction to advanced artistic practice. The key goals are to record an in-depth interview with Christine Borland, with the production of an interview transcript, and to publish the research findings of the project in a peer review journal.

Amount: £887
Funder: The Wellcome Trust
Recipient: Northumbria University

Student Elective Prize for Mr Matthew J Martin 29 Aug 2008

An in-vitro study of the enhancement of carotid plaque echogenicity with the use of thrombus-targeted microbubbles'

Amount: £960
Funder: The Wellcome Trust
Recipient: University of Leicester

The millennium lecture series. 14 Dec 2005

The Millennium Lecture Series The Millennium Lecture Series has been running for six years. The lecture series usually comprises of around 10 lectures from prominent scientists and runs from October to May. These lectures are free to students and the general public. The aim is to promote awareness of various sciences to the community and schools. This year's lectures boast another set of excellent speakers, including two eminent popularisers of science, Philip Ball and Marcus du Sautoy, and a Nobel Prize winner (Jean-Marie Lehn). This year we are also pleased to say that we have two very distinguished speakers in the field of the medical biosciences, Professor Richard Evershed, from the University of Bristol, and Professor Anthony Campbell, of the University of Wales College of Medicine. Professor Evershed will be giving a lecture on bioarchaeology on 21st November 2005. Professor Campbell will be giving a lecture on deep sea bioluminescence and its application to modern medicine on 12th December 2005. In the following two years we hope to attract equally distinguished scientists in biomedicine. Past speakers have included Sir Alec Jeffreys, Lord Robert Winston and Frances Ashcroft. Overall, the lecture series provides insight into a variety of science areas and the issues surrounding them, and encourages a wide range of people from disparate areas to participate in discussion of scientific issues and appreciate how science can be both interesting and valuable to modern society.

Amount: £680
Funder: The Wellcome Trust
Recipient: University of Bath

Understanding mechanisms of stress hyporesponsiveness in lactating females. 26 Apr 2006

Lactating females show attenuated neuroendocrine and behavioural responses to stress, thereby providing an innate model of stress hyporesponsiveness. We propose that understanding the mechanisms by which neuroendocrine responses to stress are naturally reduced, such as in lactating females, will provide the basis to develop treatments for stress and strategies to avoid stress. We hypothesise that attenuated stress responses during lactation are due to reduced synthesis and secretion of corticotrophin releasing hormone (CRH) and/or arginine vasopressin (AVP) from the hypothalamus as a result of increased negative feedback by cortisols. We also propose that oxytocin produced in the brain facilitates these mechanisms. Previous studies have examined mRNA levels as an index of response, but no-one has measured secretion of CRH and AVP. To test our hypothesis, we will directly measure steady-state levels of CRH and AVP mRNA and secretion of CRH and AVP in lactating and non-lactating females under basal and stress-induced conditions. Furthermore, we will establish the efficacy of cortisol feedback on CRH and AVP synthesis and secretion and will ascertain if oxytocin acts centrally to attenuate neuroendocrine responses to stress.

Amount: £862
Funder: The Wellcome Trust
Recipient: University of Bristol

De-N-acetylation of cell wall chitin/pepitdoglycan as a defence mechanism against the mammalian immune system - structures, mechanisma and inhibitor development. 19 Jul 2006

One of the primary defences of the innate mammalian immune system against microbial pathogens is secretion of cell wall-targeted lytic glycoside hydrolases. Some of these enzymes, lysozymes (degrading peptidoglycan) and chitinases (degrading chitin), heavily depend on the presence of the N-acetyl side chains on N-acetylglucosamine for substrate recognition. Recent research has suggested that bacteria, fungi and microsporidia possess carbohydrate esterases ("family 4 carbohydrate esterases", CE-4) that partially de-N-acetylate cell wall peptidoglycan and chitin, thereby conferring microbial resistance against these mammalian glycoside hydrolases. Bacterial knockout studies of CE-4 esterases have shown that deletion of these genes results in hypersensitivity to lysozyme and dramatic reduction in virulence in a mouse model. This proposal aims to study the structure and molecular mechanism of action of microbial CE-4 esterases, screen small molecule libraries for inhibitors and synthesize potential leads using a combination of the resulting hits and rational design. These leads will then be tested in bacterial, fungal and microsporidian cultures in terms of resistance against lysozymes/chitinases and ultimately evaluated (through collaborations) in appropriate mouse models. Specifically, we will study the peptidoglycan deacetylases of the Streptococcus pneumoniae and the oral pathogen Streptococcus mutans, fungal chitin deacetylases from the pathogen Aspergillus fumigatus and the microsporidian chitin deacetylase from the pathogen Encephalitozoon cuniculi.

Amount: £500
Funder: The Wellcome Trust
Recipient: University of Bath

Oxford history of chemistry seminar series to be held in Oxford on 9 and 23 February 2011 17 Jan 2011

Intellectual historians can hardly disregard the role played by alchemical practices (experiments, theories, circulation of books and manuscripts, constitution of networks covering the entire European continent and several early colonial settlements) in the agenda of Early Modern learning. Equally, studies published over the last twenty years have much contributed to the appreciation of the role of chemistry in the constitution of research practices in science, technology and medicine, and to the key social and intellectual role played by practitioners of chemistry during the XVIII and XIX centuries. Finally, business historians or historians of innovation (including therapeutic innovation) can hardly escape confronting the complex interactions between university and industrial research on a continental and intercontinental level throughout the XX century. The main goal of the Oxford History of Chemistry Seminar series, which is in its 4th year this year, has been to assert the centrality of the history of chemistry to a variety of research areas dealing with the social, intellectual and economic history of Europe (and beyond) over the last five centuries.

Amount: £525
Funder: The Wellcome Trust
Recipient: Oxford Brookes University

The history of monastic bloodletting as revealed in medieval monastic account rolls and visitation records 16 Sep 2008

The main purpose of this trip is to carry out research necessary to complete a monograph on the function of periodic bloodletting in medieval monastic life. I will be looking primarily at account rolls from monasteries and cathedral abbeys in order to determine the actual dates on which religious were bled. This is important because preliminary investigations indicate that the bleeding sometimes coincided with days deemed perilous in medical tests; I need to learn whether my initial findings are representative or anomalous. Examining the days when religious were bled may also be one way of determining changes in the practice over time; in addition, it may shed light on differences in bleeding practices between religious orders. Bloodletting appears not only in account rolls; it is also a subject mentioned in many episcopal visitation records and in the General Chapter statutes of the Cistercian and Carthusian orders. This research will provide an opportunity to examine those records more closely to determine concerns associated with the time of bloodletting. The complaints may help to reveal more about the perceived importance of regular bloodletting, its perceived function, as well as anxieties about potential lapses in discipline during the period of convalescence.

Amount: £882
Funder: The Wellcome Trust
Recipient: Misc United States

Arts and Crafts Equipment 01 Apr 2011

Arts and Crafts Equipment

Therapy & Counseling 01 Apr 2011

Therapy & Counseling Foundation Programme in Solution Focused Practice

Allergy clinic improvements 29 Oct 2014

Fit for the future, Allergy clinic improvements

Leveraging genetic variation in the social partners to investigate effects of the social environment on behaviour 16 Jun 2018

I have been invited to speak at a workshop that brings together experts from statistics, genetics, and computer science in order to discuss current and future challenges in my field (http://web.cs.ucla.edu/~ehalperin/bcb2018/). I am however expecting a baby for the middle of June and based on my experience attending conferences after I had my first child, I have decided to take my new baby, who will be 3 months old at the time of the conference, with me. I indeed found it difficult to be separated from my first child for a week when I attended ICQG5 in June 2016, and struggled to keep breastfeeding after this week-long separation. Because I want to make the most of my time at the conference, I have asked my mother to accompany me to babysit and she has accepted. Her coming with me will incur extra costs, for which I am submitting this application. Attending this conference will allow me to develop my research at the leading edge of the field, based on the presentations and discussions I will see/have at the conference. It will also allow me to make my research known to a broad set of excellent researchers, which is particularly important given the relative youth of my field (social genetic effects) and its relevance across the board of disciplines and species. Finally, it will give me the opportunity to meet key people to start discussing my next position, which I would like to be independent group leader.

Amount: £700
Funder: The Wellcome Trust
Recipient: European Bioinformatics Institute