- Total grants
- Total funders
- Total recipients
- Earliest award date
- 01 Jan 2018
- Latest award date
- 31 Dec 2018
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
Art with a Heart Craft and Chat 13 Feb 2018
to run free regular craft and chat session in Art with a Heart once a month increasing to fortnightly as the attendance grows. All art materials will be supplied for those attending
Building Operational Capacity 16 Apr 2018
This project aims to develop operational capacity in the organisation to make best use of the volunteers, premises and equipment that we have at our disposal. We aim to do this by recruiting a part-time coordinator to manage the activities set out in the purposes of our Charitable Incorporated Organisation (CIO registration 1172658).
Space Cadet Journey 18 Apr 2018
our project reaches out to children & young people for them to get involved in our hands-on STEM workshops and take part in project-led events through weekly, monthly and quarterly activity sessions. Currently this is biweekly at Broomwood, Timperley, Altrincham with monthly “taster” science shows delivered in the other Trafford locations: Sale, Stretford, Urmston & Old Trafford.
Pickering Lodge Education Signage Artwork 03 May 2018
Completion of erection and completeion of artwork of lecturn sign for a nature trail sign and history trail sign to provide education material on the Pickering Lodge Park
My Best Life 07 Aug 2018
We have engaged with the young people in our specified area and out of that sample group we identified they would be interested in projects that utilise music, media and the arts so the "My Best Life" project is a collaboration of TMZM, St Johns Centre, Groundworks, Limelight Centre and Alchemy Arts This focuses on raising the general well-being of youth
to expand what we offer to Autistic kids by providing 3 classes including the original animation class that is self funding, a new animation class and starting a new class, entitled Technically Brilliant.
I will use a life-course epidemiological approach to investigate determinants and prevention of violence, based on four population-based birth cohort studies (N > 4,000 in each) started in 1982, 1993, 2004, and 2015 in Pelotas city, southern-Brazil. My goals are to: 1) investigate early life-mechanisms hypothesised to cause persistent child aggression leading to violence; 2) investigate reasons for the rapid increases in violence during the course of the studies; and 3) evaluate two early interventions to prevent child behaviour problems leading to violence, in a randomised-control trial nested in the youngest cohort study (2015). With respect to early-life determinants, new psychological assessments of child socio-cognitive functioning (including self-control, verbal skills, and empathy) and parenting factors (sensitivity, harsh and inconsistent parenting) will be introduced in the youngest cohort, and a biological indicator of chronic stress (cortisol from hair samples) will be measured in the 2015 and 2004 cohorts. A four-arm randomised trial will be used to evaluate the effects of two parenting interventions: 1) parent-training in book-sharing to promote parental sensitivity and child cognitive development – key protective factors against aggression and violence; 2) parent-training that targets a reduction in harsh discipline and maltreatment – also key risk factors for problem behaviour.
This proposal addresses two factors important in obesity-related disease, namely determinants of healthy adipose remodelling in chronic positive energy balance, and mechanisms linking insulin resistance to disease. Two rare, informative human disorders will first be dissected, one featuring subcutaneous lipodystrophy due to heterozygous loss of DNA polymerase delta activity and the second a mixture of lower body fat loss and dramatic upper body adipose hyperplasia due to a missense mutation in mitofusin 2, involved in mitochondrial fusion and other processes. Physiological, tissue and cellular studies of humans and mouse models will address the role of DNA replication/repair and mitochondrial dynamics in depot-specific human adipose remodelling, and will test both mitigating strategies and relevance for common disease. The second part of the project will exploit emerging techniques for saturation mutagenesis coupled to downstream functional assays to develop "look up" tools for stratification of genetic variants by functional consequence. Saturating mutation libraries and such derived tools have myriad applications, including genetic diagnosis of rare disease, patient stratification for experimental medicine studies, and linking of functional perturbations to lifecourse human phenotypes in genotyped cohorts. The approach will be applied first to the insulin receptor, and thence other genes involved in insulin signal transduction.