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Results

Open Access Awards 2017/18 30 Sep 2018

Not available

Amount: £21,050
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Landscapes of Health: The Black Sea in the Socialist World. 25 Nov 2014

Landscapes of Health: The Black Sea in the Socialist World is a workshop with two main objectives. First, it seeks to develop our understanding of the role of Black Sea health resorts in socialist medical theory, practice, and culture. It highlights the importance of the sea, rest, environmental health, and natural healing to socialist ideas and practices of health. The workshop develops the idea of the Black Sea coastline of socialist Bulgaria, Romania and the Soviet Union as a shared zone of h ealth in the geography of the socialist world. Second, the workshop develops the idea of health resorts as international meeting places. The workshop marks the 70th anniversary of the Yalta conference (February 4-11, 1945), and brings to light the role of medicine and socialist ideas of health in Cold War diplomacy. Health resorts were showcases of the socialist world, in a Cold War contest fought publicly over welfare and standards of living. This workshop brings together for the first time scholars studying the health resorts of the Black Sea, with contributions from specialists in the history of medicine, history, film, architecture and urban planning, and scholars of both the Soviet Union and the Eastern Bloc.

Amount: £4,900
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Establishing objective measures for identifying children with Autism Spectrum Disorders using eye-tracking technology in the UK and India 09 Nov 2016

Autism Spectrum Disorders (ASD) contribute significantly to total years lived with disability globally. Most people with ASD in low-income countries are belatedly or never diagnosed, mainly due to the paucity of mental health specialists - hence critical years for treatment are missed. Objective measures for ASD detection are needed. Multiple cognitive markers of ASD have been identified using eye-tracking technology; testing these markers in combination holds promise for effective identification of children with ASD. This proposal aims to establish objective measures for identifying children with ASD using eye-tracking technology in high and low-income settings. Stage 1 will analyse existing eye-tracking data from the British Autism Study of Infant Siblings, to establish a combination of eye-tracking tasks that has the highest probability of identifying children with an ASD diagnosis. Stage 2 will be a case control pilot study to determine whether the same combination of markers identifies children with an ASD diagnosis in India. The feasibility and acceptability of these eye-tracking tasks will also be assessed in an Indian context. Establishing effective, acceptable and feasible methods for objectively identifying children with ASD will improve detection in these settings and translate into a greater number of children benefiting from early interventions worldwide.

Amount: £250,000
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Medicine and the Bishop in Medieval England, c.1100-c.1400. 04 Dec 2013

This project investigates the role of medicine in the life of the late medieval bishop, through an examination of three key themes. The bishop as a beneficiary of medical knowledge and treatment considers both medical provision within the episcopal household, and the role of preventative medicine (especially the six non-naturals) in protecting the bishop's health. The bishop's medical knowledge examines the medical knowledge of the late medieval episcopate: what medical knowledge did the bishop did, where did he obtain it from, and how did he use it? Understanding the bishop's body explores the role of medical knowledge in the formation of episcopal reputations, suggesting that medical interpretations of the episcopal body could be crucial in the formation of a reputation for sanctity or failure. Overall, the project aims to combine medical and ecclesiastical history in order to provide a detailed case study of the impact of medicine on a particular social group, and thus to improve ou r understanding of the links and potential tensions between spiritual and medical understandings of health and well-being as they existed in late medieval England.

Amount: £150,282
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Biomedical Vacation Scholarship 23 Jun 2014

Not available

Amount: £4,000
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Open access award 2013/14. 16 Sep 2013

Not available

Amount: £30,000
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Public health and outsiders': British responses to refugees in the twentieth century. 01 Dec 2011

This project uses public health policy towards refugees as a way into understanding the nature of health citizenship and belonging in twentieth century British society. The 1951 Refugee Convention implied a social contract between the receiving state and refugees over citizenship rights, including health citizenship. And yet experience has shown that through port-of-entry examinations, camps and the exclusion of asylum seekers from particular services, refugees have often been treated as outside the British community of health and subject to extraordinary measures. Public health policy has been enacted within two further contexts: the shifting geo-political landscapes of the Cold War, post-colonialist and post-Soviet eras, which created different waves of refugees; and the changing form and functions of the British state and welfare state which profoundly affected the influence and work of local health departments. Through using evidence from four case study groups - refugees from Naz ism in the 1930s; Displaced Persons relocated to Britain after 1945; Ugandan Asians in the 1970s and post-1991 refugees/asylum seekers the research will reconstruct public health policy towards refugees at different times and at different levels of the state, and reveal how public health was experienced by refugees themselves.

Amount: £179,171
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Institutional Strategic Support Fund Phase2 FY2014/16 27 Oct 2014

The Wellcome Trust has recently awarded the University of Aberdeen £600,000 in funding to support a range of strategic research activities that fall within the Wellcome Trust's remit. Projects must fall within the remit of the Wellcome Trust and be within the strategic remit of the Aberdeen ISSF including; Infection, Immunity and Inflammation, particularly Medical Mycology Understanding the molecular basis of obesity for the development of interventions Applied Health Sciences, particularly through our Chief Scientist Office-funded Health Economics Research Unit and Health Services Research Unit. The support strategy for the fund is to: Facilitate more interdisciplinary research across the schools and institutes Enhance research impact through its translation into practice and dissemination through public engagement Enhance our Career Development Support in biomedical research

Amount: £600,000
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Biomedical Vacation Scholarship 25 Jun 2012

Not available

Amount: £4,560
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Three-dimensional imaging of Chlamydia infectious cycle 04 Aug 2011

This project is concerned with molecular and cellular aspects of protein quality control. We will carry out structural analyses of molecular chaperones at different stages of protein folding or disaggregation by cryo electron microscopy and single particle analysis. To understand the mechanism of assisted folding and the structural basis for substrate selectivity in bacterial and archaeal chaperonins, proteins trapped or folding inside chaperonin complexes will be imaged. We will also investigat e complexes of the yeast chaperone Hsp104 with model and physiological substrate proteins. Hsp104 is one of a unique group of chaperones capable of dissolving aggregates, and is essential for the propagation of yeast prions. A new approach initiated by the PI s sabbatical is cryo electron tomography of vitrified cell sections to study the three-dimensional structure of yeast prions in situ. In parallel, biochemically isolated prion aggregates will be examined by tomography, along with prion fi brils reconstituted with the Hsp100 and the Hsp70 system chaperones involved in their propagation. We will then apply these methods to neuroblastoma cells stably infected with mouse prions, the causative agent of transmissible encephalopathies. The approaches developed should eventually be applicable to vitrified sections of brain tissue of animal models of neurodegenerative disease.

Amount: £199,377
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Visualising Illness and Pain. 31 Mar 2016

Drawing on the varied perspectives of artists, historians, art therapists, curators, clinicians and social scientists, the proposed workshop will explore a series of questions relating to the visual representation of illness. Focusing specifically on contemporary works made in response to first-person encounters with illness, the workshop will consider what issues are at stake in reading these artefacts as subjective expressions of pain and suffering. The event will comprise two parts. The fi rst, taking place on a Friday afternoon and evening, will be open to the public, and will include a keynote address by Joanna Bourke and a panel discussion between artist Deborah Padfield, clinician Joanna Zakrzewska and social psychologist Alan Radley. The second, taking place the following day, will take the form of a series of panel discussions involving practitioners from different disciplines, with the aim of addressing a number of clearly defined research questions. We hope that the w orkshop will ultimately function not just as a one-off event, but also as a scoping exercise for a larger collaborative project. One of its likely outcomes will be the planning of an exhibition (with accompanying catalogue) that will be displayed both online and in the Peltz Gallery, Birkbeck.

Amount: £719
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

The reception and application of degeneration theory and the concept of atavism in Scandinavian racial sciences, literature, cultural debate, and satire, 1880-1922 10 May 2016

The objective of my doctoral thesis will be to examine how degeneration theory, as both a scientific and cultural concept, was received and disseminated into Scandinavian racial biology and anthropology, literature, cultural debate, and satire. I will contend that degeneration theory may be viewed as a prism reflecting the relationship between nineteenth- and early twentieth-century science and culture: culture popularising science through periodicals, satire, and literature, and science examining and diagnosing culture. Furthermore, this project aims to broaden the geographical and cultural scope of degeneration studies by delineating the unique character of Scandinavian degeneration theory, strongly emphasising heredity over environment as the main cause of degeneration. I will also juxtapose the notion of late nineteenth-century British, French, German, and Italian degenerationist thought as closed systems of knowledge with a wider, more inclusive network of mutual contributions between European scientists, critics and authors. I will be focusing on the time period between 1880 and 1922, as the spectre of degeneration began to emerge in Scandinavian debate in the 1880s, and the study will conclude with the founding of the Swedish National Institute for Eugenics in 1922, which positioned Scandinavia at the forefront of European research into the mechanisms of racial heredity.

Amount: £89,829
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Value in People Award. 29 Mar 2010

Not available

Amount: £200,000
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Protein quality control: Chaperone-substrate interactions and cellular aggregates. 26 Jun 2009

This project is concerned with molecular and cellular aspects of protein quality control. We will carry out structural analyses of molecular chaperones at different stages of protein folding or disaggregation by cryo electron microscopy and single particle analysis. To understand the mechanism of assisted folding and the structural basis for substrate selectivity in bacterial and archaeal chaperonins, proteins trapped or folding inside chaperonin complexes will be imaged. We will also investigat e complexes of the yeast chaperone Hsp104 with model and physiological substrate proteins. Hsp104 is one of a unique group of chaperones capable of dissolving aggregates, and is essential for the propagation of yeast prions. A new approach initiated by the PI s sabbatical is cryo electron tomography of vitrified cell sections to study the three-dimensional structure of yeast prions in situ. In parallel, biochemically isolated prion aggregates will be examined by tomography, along with prion fi brils reconstituted with the Hsp100 and the Hsp70 system chaperones involved in their propagation. We will then apply these methods to neuroblastoma cells stably infected with mouse prions, the causative agent of transmissible encephalopathies. The approaches developed should eventually be applicable to vitrified sections of brain tissue of animal models of neurodegenerative disease.

Amount: £1,062,536
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Biomedical vacation scholarship. 29 May 2009

Not available

Amount: £3,040
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Open Access Awards. 16 Sep 2008

Not available

Amount: £20,000
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

In Pursuit of the Nazi Mind: The Deployment and Development of Psychoanalysis in the Allied Struggle against Germany. 12 Jun 2008

'In Pursuit of the Nazi Mind' demonstrates how models of the unconscious and cognate clinical techniques contributed to and were reshaped by the Allied struggle against the Third Reich. Important studies of Nazi psychology, centred on the concept of the superego, were mobilised in military intelligence, post-war planning and policy recommendations. My goal is to contextualise and critically assess medico-psychiatric and psychoanalytical endeavours to grasp the irrational wellsprings of N azism, and to show their significance more widely for the history of psychology in western culture. A panoramic survey will cover the emergence of new Freudian approaches to politics in the 1920s, their apotheosis in the 1940s and disintegration in and beyond the 1960s. Five accompanying core cases, for which extensive documentation exists, are designed to illustrate the varied roles and influences of applied psychoanalysis around the war: 1. Testimony of Hess s doctors, in Britain 1941-45, an d at Nuremberg. 2. Studies of Hitler, commissioned by the US Office of Strategic Services in 1941. 3. Experiments conducted upon Nazi sympathisers through the Allied Control Commission, 1945-6. 4. Psychoanalytic materials furnished to the UNESCO project, Tensions Affecting International Understanding' , 1947-51. 5. Clinical evaluations of imprisoned Nazi murderers psychic lives, 1945-1970.

Amount: £103,358
Funder: The Wellcome Trust
Recipient: Birkbeck University of London

Structural basis of the cell stress response. 27 Feb 2007

The purpose of the proposed sabbatical project is to take advantage of recent developments in cryo electron tomography and vitrified cell sectioning, in order to examine the structure of yeast cells during and after heat stress. Itwill enable me to combine our previous mechanistic work on individual molecular chaperones with studies of aggregate formation and clearance in vivo. A network of heat shock proteins has been implicated in the prevention and reversal of protein aggregation, but the details of aggregate structure and interaction with chaperones are poorly understood. With the facilities andexpertise now available at EMBL, I will be able to observe the three-dimensional arrangement of large macromolecular assemblies and organelles in yeast cells during the stress response. I will follow the courseof aggregation and examine the involvement of the cytoskeleton, ER, Golgi and lysosomes in processing aggregates through the proteasomal and autophagy pathways. As an extension of my existing collaboration with Prof B Bukau at the ZMBH, Heidelberg, I will be able to compare the processing of aggregates in wild-type cells with that in chaperone deletion mutants, with over expression of aggregation-prone polypeptides, and/or in prion strains, depending on the outcome of initial work.

Amount: £12,300
Funder: The Wellcome Trust
Recipient: Birkbeck University of London