- Total grants
- Total funders
- Total recipients
- Earliest award date
- 20 Nov 1998
- Latest award date
- 25 Jan 2019
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
Sodium channels are responsible for mediating ion permeability in nerve and cardiac cells; different isoforms are responsible for either producing a voltage potential essential to neurotransmission or creating the initial upstroke of the action potential seen in electrocardiograms. A number of neurological and cardiovascular diseases involving sodium channel mutations have been identified, and these channels are good potential targets for rational drug design. In preliminary work we have isolated, purified, and structurally- and functionally- characterised sodium channels from electric eels, which have a high sequence identity with the human sodium channels, and which can be prepared in sufficient quantities for 2D crystallisations. Furthermore we have developed a circular dichroism spectroscopic assay that enables us to distinguish between the various functional states, inactivated, open, closed, etc., of the channels. This project will use 2D crystallography and electron microscopy to provide 3D structural information on this pharmacologically-important membrane protein. The use of drugs and toxins to stabilise, or 'trap', channel molecules in conformations associated with specific functional states (as monitored by Cd spectroscopy) should provide information that improves the homogeneity of the population, thereby improving the crystal order, and should aid in the understanding of the structural basis of these different states.
Kinesin motor proteins in malaria. 10 Jul 2008
Kinesins are microtubule-based, ATP-dependent molecular motors that have many essential roles in eukaryotes including in cell division, cell motility and intracellular transport. Elimination of kinesin function often proves fatal because essential cell processes are compromised. The malaria genome encodes ten putative kinesin motors, about which little is known, and the proposed research will aim to characterise them biochemically, structurally and within the parasite. Key goals: Assessment of kinesin expression in parasites by RT-PCR Clone and express Plasmodium kinesins, particularly their motor domains which contain microtubule and ATP-binding sites. Begin with four kinesins with homologues in humans. Biochemical characterisation of microtubule-stimulated ATPase activity, providing insight into likely functions Visualisation of the kinesin motor-microtubule interaction by cryo-electron microscopy and 3D reconstruction Generate pseudo-atomic models of the motor-microt ubule interaction using homology models and dock these into the EM-derived molecular envelope Expression of GFP-tagged motors in vivo to determine their location and assess their possible roles in vivo Use of electron tomography to visualise the morphology of parasite microtubules and correlate this with kinesin localisation Combine in vitro and in vivo assays to set up drug screens to look for kinesin-specific inhibitors
In Pursuit of the Nazi Mind: The Deployment and Development of Psychoanalysis in the Allied Struggle against Germany. 12 Jun 2008
'In Pursuit of the Nazi Mind' demonstrates how models of the unconscious and cognate clinical techniques contributed to and were reshaped by the Allied struggle against the Third Reich. Important studies of Nazi psychology, centred on the concept of the superego, were mobilised in military intelligence, post-war planning and policy recommendations. My goal is to contextualise and critically assess medico-psychiatric and psychoanalytical endeavours to grasp the irrational wellsprings of N azism, and to show their significance more widely for the history of psychology in western culture. A panoramic survey will cover the emergence of new Freudian approaches to politics in the 1920s, their apotheosis in the 1940s and disintegration in and beyond the 1960s. Five accompanying core cases, for which extensive documentation exists, are designed to illustrate the varied roles and influences of applied psychoanalysis around the war: 1. Testimony of Hess s doctors, in Britain 1941-45, an d at Nuremberg. 2. Studies of Hitler, commissioned by the US Office of Strategic Services in 1941. 3. Experiments conducted upon Nazi sympathisers through the Allied Control Commission, 1945-6. 4. Psychoanalytic materials furnished to the UNESCO project, Tensions Affecting International Understanding' , 1947-51. 5. Clinical evaluations of imprisoned Nazi murderers psychic lives, 1945-1970.
Hadleigh Great War Centenary Project
Provide Walls of Honour for the fallen in the Town Memorial Park
Weekend D-Day celebration event 25 Jun 2004
The Gateshead branch of the Royal British Legion has been awarded a grant towards their weekend of celebrations in commemoration of the D-Day landings. This will involve a church service as well as entertainments and refreshments. The event is open to all residents in the Gateshead area.
The Legion's hall is used for a variety of clubs and individuals. As part of an ongoing refurbishment project they will extend and develop the front hall to include disabled toilets and baby-changing facilities.
Brass Band Concert 25 May 2005
The Baschurch and District Branch of the Royal British Legion have been awarded a grant to hold a church service and parade to commemorate the 60th anniversary of the end of the Second World War. A Brass Band concert and reception will also be held.
Service 25 May 2005
The Royal British Legion Gwent County Committee have been awarded a grant to hold a Drumhead Service of Thanksgiving to mark the 60th anniversary of the cessation of hostilities of World War Two. The event will be attended by many ex-services and veterans groups and will cover five county authorities in Wales.
60th Anniversary Event 11 May 2005
The Ladybarn and district branch of the Royal British Legion will use their award to hold a celebration of the 60th anniversary of the end of the Second World War. The celebration will involve entertainment from local group who will play music from the period.