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The National Lottery Community Fund (226,066) The Wellcome Trust (16,854) Co-operative Group (16,503) Sport England (15,905) The National Lottery Heritage Fund (10,201) Garfield Weston Foundation (6,126) Lloyds Bank Foundation for England and Wales (5,467) The Henry Smith Charity (4,590) Northern Rock Foundation (4,331) Community Foundation serving Tyne & Wear and Northumberland (4,320) Esmée Fairbairn Foundation (4,221) BBC Children in Need (4,183) Woodward Charitable Trust (2,767) Quartet Community Foundation (2,683) Department for Transport (2,577) The Tudor Trust (2,554) City Bridge Trust (2,480) Paul Hamlyn Foundation (2,367) Wolfson Foundation (2,210) Community Foundation for Surrey (1,987) Essex Community Foundation (1,891) Greater London Authority (1,846) Heart Of England Community Foundation (1,727) County Durham Community Foundation (1,659) The Robertson Trust (1,542) Comic Relief (1,442) Suffolk Community Foundation (1,428) Glasgow City Council (1,365) The Clothworkers Foundation (1,358) London Borough of Southwark (1,260) Somerset Community Foundation (1,259) Nesta (1,247) Guy's and St Thomas' Charity (1,230) Corra Foundation (1,184) London Catalyst (1,174) Oxfordshire Community Foundation (1,139) Birmingham City Council (1,103) CAF (1,004) Leeds Community Foundation (905) Masonic Charitable Foundation (895) Power to Change Trust (870) Sussex Community Foundation (852) Two Ridings Community Foundation (792) Trafford Housing Trust Social Investment (779) Ministry of Justice (774) National Churches Trust (760) Walcot Foundation (755) Devon Community Foundation (715) The Dulverton Trust (680) A B Charitable Trust (665) See Less

Results

Interrogating the past, present, and future of global health in Africa 30 Sep 2019

<p>Provoked and inspired by contemporary debates around engagement, epistemic justice, and the decolonization of science, the proposed project aims to begin to build a critically engaged global health studies in (and from) Africa and the global South. What might &lsquo;global&rsquo; health become, the project asks, if the power to shape it shifted to the South, into the hands of those often positioned as the objects of its interventions? Through critical dialogues and collaborative processes of participatory knowledge exchange, we hope to create space for new forms of critique and engagement to emerge from this more proximate positionality.&nbsp;</p> <p>The proposed project is structured into three stages, which explore the past, present, and future of global health in Africa. In the first stage, through critical reading and direct exchanges with prominent figures in the field, we will focus on understanding the &lsquo;genealogy&rsquo; of global health in Africa. In the second stage, we will look to the present moment, asking how postcolonial politics and critical social theory might disturb how we think about global health. The final stage will develop a collaborative vision for the&nbsp;future of critical global health studies in Africa and the global South.</p>

Amount: £27,746
Funder: The Wellcome Trust
Recipient: University of Stellenbosch

Health harms and altered health and wellbeing experiences associated with different types of violence 30 Sep 2019

<p>Violence has far-reaching impacts for people&rsquo;s lives. Being subject to violence causes physical and/or psychological health and wellbeing harms that lead to some degree of health loss, functional capacity loss and/or disability and which often endure across people&rsquo;s lives. The type of violence - its severity, whether it has a sexual element to it and the relationship between the victim and perpetrator will affect the scope of harms suffered and the health and wellbeing changes experienced. Research investment in violence as a public health issue over the last two decades means that there is a growing body of research about harms and altered health and wellbeing experiences associated with violence. This exploratory research project involves a systematic scoping review to identify, collate, chart and summarise the extent of our current knowledge of the harms and altered health and wellbeing experiences associated with contextually different types of violence. This new outline of the violence, health and wellbeing knowledge landscape will be shared with key stakeholder groups to shape and prioritise future directions of research and innovation to extend our knowledge so that victim/survivors receive the most appropriate care and intervention. &nbsp;</p>

Amount: £22,741
Funder: The Wellcome Trust
Recipient: University of Central Lancashire

Healthy Citizens? Migrant Identity and Constructions of Health in Post-War Australia. 05 Aug 2014

Psychological and epidemiological frames dominate studies of migrant health in Australia, resulting in understandings of migrants as either possessing a physical health advantage or a propensity to mental health disorders. However, this project sees Australia's unique post-war migration revolution, in which 3 million British and European people relocated to the other side of the world, as an opportunity to examine how constructions of health, migrant identity and national identity are intricatel y linked. It will investigate these connections through an analysis of migrants' life writings, held in Australian libraries, museums and community archives, as well as through oral history interviews and material culture. To contextualise these experiences the project will trace medical professionals' perspectives on migrants' psychological and bodily health between 1945 and 1970; evaluate how constructions of Australia as a 'healthful haven' were harnessed by government bodies to attract new a rrivals; and assess how the doctrine of assimilation pervaded the delivery of health care and advice to migrants. In doing so it will demonstrate how an interdisciplinary approach to the history of medicine, encompassing medical literature, oral history and material culture, can better explain popular attitudes to health in the mid-twentieth century.

Amount: £162,171
Funder: The Wellcome Trust
Recipient: University of Leicester

A Clinically Oriented Antimicrobial Resistance Surveillance Network (ACORN) 30 Sep 2019

<p style="margin-left: 0cm; margin-right: 0cm">Existing antimicrobial resistance (AMR) surveillance systems are based mostly on diagnostic microbiology laboratory antimicrobial susceptibility testing results alone, which limits direct assessment and subsequent modelling of the clinically relevant impacts and burden of drug resistant infections (DRI). Tools to capture and analyse AMR data in LMICs are scarce, which hinders engagement with and utilisation of available data.</p> <p style="margin-left: 0cm; margin-right: 0cm">To fill these gaps, the major aim of this project is to develop and test a comprehensive data capture system for patient-focussed AMR surveillance in LMIC settings. Data collected will expand on the pathogen-focussed WHO Global Antimicrobial Resistance Surveillance System to enable accurate classification of infection syndromes and outcomes. These data will be of critical importance to estimate syndromic and/or pathogen outcomes and associated costs: <em>i.e.</em> how many people die from DRIs and how much does it cost?</p> <p style="margin-left: 0cm; margin-right: 0cm">Project objectives are to:</p> <ul> <li>Establish a framework for patient-focussed DRI surveillance tailored to LMIC settings;</li> <li>Develop and refine tools for AMR data capture, verification, and interactive visualisation;</li> <li>Produce comprehensive diagnostic stewardship and surveillance training materials;</li> <li>Pilot surveillance at two sites in Southeast Asia;</li> <li>Prepare for wider roll out of surveillance at sites across the Wellcome Asia Programme network and beyond.</li> </ul>

Amount: £351,475
Funder: The Wellcome Trust
Recipient: University of Oxford

Shared Futures: Codeveloping Medical Humanities in China and the UK 30 Sep 2019

<p>The programme of exchange and networking proposed here aims to build on preliminary experiences of connecting and co-working between UK and Chinese institutions in order to:</p> <p>&nbsp;</p> <p style="margin-left: 0cm; margin-right: 0cm">i. Drive the Medical Humanities as a mature disciplinary field in China.</p> <p style="margin-left: 0cm; margin-right: 0cm">ii. Grow collaborative working between an expanding number of Chinese institutions and UK universities in the Medical Humanities.</p> <p style="margin-left: 0cm; margin-right: 0cm">iii. Establish a generation of scholars in the Medical Humanities with experience of research, training and teaching in both academic cultures and the capacity to build the field in China and elsewhere.</p> <p style="margin-left: 0cm; margin-right: 0cm">iv. Equip graduates of the programme with Medical Humanities knowledge and perspectives to enable them to engage in fresh ways with human health problems and challenges as they enter careers and sectors beyond academe around the world.</p> <p style="margin-left: 0cm; margin-right: 0cm">&nbsp;</p> <p style="margin-left: 0cm; margin-right: 0cm">It will connect the partners at the institutions above as they work together to enable:</p> <p style="margin-left: 0cm; margin-right: 0cm">&nbsp;</p> <p style="margin-left: 0cm; margin-right: 0cm">i. 18 M.Sc. students from SHU, SASS and Fudan to complete Masters degrees at the CSHHH Glasgow and the CHSTM at Manchester University.</p> <p style="margin-left: 0cm; margin-right: 0cm">ii. 9 one-year Early Career Researcher (ECR) Medical Humanities Fellowships at SHU, SASS and Fudan University.</p> <p style="margin-left: 0cm; margin-right: 0cm">iii. 6 Medical Humanities events (3 workshops in UK and 3 conferences in China) to showcase the network.</p> <p style="margin-left: 0cm; margin-right: 0cm">&nbsp;</p>

Amount: £923,235
Funder: The Wellcome Trust
Recipient: University of Strathclyde

Fibrin films at the crossroads of haemostasis, infection control and wound healing 24 Apr 2019

<p>We have recently shown that fibrin forms a continuous film covering the air-blood interface of external wounds, and that these film form an almost instantaneous barrier protecting the wound against infection for at least 12 hours. This discovery is potentially paradigm-shifting in haemostasis presenting a new area of research with novel translational opportunities. I propose that fibrin films help prevent wound infection for 24-48 hours by providing a barrier across the surface of an external wound. In turn, this preclusion of infection aids the wound healing process by preventing prolonged inflammation at the site of injury. To investigate this I will assess the role of the film in preventing the proliferation and dissemination of bacteria in murine models of dermal infection over 72 hours, and explore if fibrin films can prevent infection from becoming blood-borne. I will go on to investigate how this prevention of infection influences wound healing using a murine wound healing model, and study how fibrin films influence white blood cell and fibroblast infiltration. These lines of investigation will bring together the fields of haemostasis, infection and tissue repair, uncovering new pathways to target in the treatment of dermal and blood borne infections and wound healing.</p>

Amount: £300,000
Funder: The Wellcome Trust
Recipient: University of Leeds

Diet on Microbiome interactions for better Immune Outcomes (DoMInO) study) 30 Sep 2019

<p style="margin-left: 0cm; margin-right: 0cm">Severe growth faltering leading to stunting and undernutrition remains highly prevalent in low- and middle-income countries (LMICs) and is estimated to play a role in 45% of under-5 deaths. However, despite many decades of research, the precise aetiology of this growth faltering remains obscure. The <u>D</u>iet <u>o</u>n <u>M</u>icrobiome interactions for better <u>I</u>mmu<u>n</u>e <u>O</u>utcomes (DoMInO) consortium brings together multidisciplinary research scientists with expertise in nutrition, breast-milk bioactives, gut microbiome and immunity to:</p> <ol> <li>Advance our understanding of the interactions between diet, gut microbiome and human immunity, especially in LMIC settings.</li> <li>Conduct a small study (20 mother-infant pairs) to:</li> </ol> <ol style="list-style-type: lower-roman"> <li>Test systems and methods for the detailed assessment of diet on microbiome interactions and infant vaccine responses, as a proxy for infant immune responses.</li> <li>Develop a package of robust methods and assessment protocols for integration into future research proposals.</li> <li>Obtain variance metrics from all assays to be used as a basis of power calculations for a substantive future study.</li> </ol> <p style="margin-left: 0cm; margin-right: 0cm">Together, this work will underpin the development of future large research grant applications led by the DoMInO consortium.</p>

Amount: £49,954
Funder: The Wellcome Trust
Recipient: King's College London

Metabolic Dysregulation in Skeletal muscle and Adipose Following allogeneic haematopoietic stem cell transplant in children, teenagers and young adults 30 Sep 2019

<p>Disease and under-nutrition in children can exert profound effects on&nbsp;growth and development&nbsp;and have adverse later effects that continue into adulthood. The treatments used in the management of disease can&nbsp;also exert effects which although curative have immediate short-term effects on nutritional state and metabolism but also persist into later life with increased morbidity and mortality. At the heart of many of these disease and treatment-induced changes in metabolic regulation and control are attributable to&nbsp;a limited number of cellular processes relating to cellular bioenergetics, redox/antioxidant state and inflammation.&nbsp;&nbsp;Within this paradigm, we seek support to develop a program of work to better understand how these processes contribute to&nbsp;an overt example of accelerated ageing/metabolic dysregulation seen in&nbsp;Children, teenagers and young adults(CTYA) surviving Acute Lymphoblastic Leukaemia(ALL) treated with allogeneic haematopoietic stem cell transplantation(HSCT) and intervene through targeted nutritional and exercise interventions.&nbsp;Our key&nbsp;goals are to i) build a multi-disciplinary team&nbsp;with complimentary capabilities to explore and explain the clinical and biological consequences of HSCT from the molecular to the whole body level, ii) synthesise the available evidence and case-identification, and iii) develop methodology, to&nbsp;work together to construct a high quality research program application for follow-on funding.&nbsp;</p>

Amount: £49,412
Funder: The Wellcome Trust
Recipient: University of Southampton

Pilot Study of the utility of text mining and machine learning tools to accelerate systematic review and meta-analysis of findings of in vivo research 30 Sep 2016

<p>Firstly we will convene an expert panel to establish "required" and "desired" performance thresholds for the performance of text mining and machine learning tools. Then, for each of the three tasks of identifying and retrieving relevant publications, extracting meta-data from identified publications, and extracting outcome data from relevant publications we will (1) where not already performed, conduct a systematic review to identify all candidate approaches; (2) implement the most promising approaches using existing systematic review datasets; and then (3) prospectively validate these approaches in ongoing systematic reviews. These tasks will be conducted by a team which brings together expertise in text mining and machine learning as applied to systematic review (Thomas, Ananiadou) and in the conduct of systematic reviews of in vivo data <span style="font-family: Arial; font-size: small;"><span style="font-family: Arial; font-size: small;"><span style="font-family: Arial; font-size: small;"></span></span></span></p> <p>(Sena, Rice, Macleod), supported by external collabortators.</p> <p>The development datasets are (1) a systematic review of in vivo studies in neuropathic pain, (2) a systematic review of in vivo publications from leading UK institutions, and (3) a selection of in vivo publications describing different outcome measures curated on the CAMARADES database. For the validation datasets we will use a systematic review of in vivo models of depression. For each, we will ascertain the sensitivity, specificity and where relevant the accuracy of the text mining/ machine learning approach, and the reduction in human work (eg number of articles needed to screen) possible whilst maintaining performance at the "desired" threshold.</p> <p><span style="font-family: Arial; font-size: small;"><span style="font-family: Arial; font-size: small;"></span></span></p> <p>&nbsp;</p>

Amount: £176,397
Funder: The Wellcome Trust
Recipient: University of Edinburgh

Applying food science to inform diet choices and improve health 30 Sep 2019

<p>Our&nbsp;aim is to develop a research proposal addressing the&nbsp;nutritional value of weaning foods across the entire food pathway; from crop variation to individual effects on metabolism and the microbiome. In order to achieve this, some method development and preliminary data will need to be generated. The key objectives for this pump priming funding are to:</p> <ol> <li>Identify potential sources of staple food crops that are commonly available in developing countries, for the purpose of weaning infants</li> <li>Explore cooking and processing methods that exist within communities</li> <li>Research and develop analytical methods for identification and quantification of key phytonutrient&nbsp;and anti-nutrient compounds in the crops of interest (maize, rice, cassava)</li> <li>Develop&nbsp;<em>in vitro&nbsp;</em>model protocols for assessment of&nbsp;gut microbiome composition and immunology</li> <li>Scout for possible cohort communities within developing countries</li> <li>Arrange a collaborative sandpit meeting to bring together additional expertise, and host a workshop to develop ideas for a follow-on application</li> </ol>

Amount: £50,000
Funder: The Wellcome Trust
Recipient: University of Reading

NUDGES to Metabolically Characterise Nutritionally Compromised Individuals 30 Sep 2019

<p style="margin-left: 0cm; margin-right: 0cm">Sarcopenia, defined as a loss of muscle mass and function, develops in the context of many disease states. Malnutrition in early childhood, which is still highly prevalent in low- and middle-income countries (LIMC), is associated with a loss of muscle mass; similarly, in the elderly and, interestingly, obesity has also been found to be related to sarcopenia. The study of the mechanisms to reverse muscle wasting is key in treating sarcopenia. There is a lack of understanding of the mechanisms that can drive the reverse of muscle wasting.</p> <p style="margin-left: 0cm; margin-right: 0cm">An obvious approach to understand muscle homeostasis would be to use a myriad of &lsquo;omics technologies, often called &ldquo;deep-phenotyping&rdquo;. However, deep-phenotyping based on one sample per participant is very noisy and challenging to interpret. This makes it difficult to apply in malnutrition. It is imperative that we have a paradigm shift in deep-phenotyping. We propose serial &ndash;omics analyses with an actual perturbation of metabolic homeostasis. These perturbations or &ldquo;nudges&rdquo; as defined by short acute metabolic challenges allow us to study the adaptability in muscle loss and regeneration in various sarcopenic populations.</p> <p style="margin-left: 0cm; margin-right: 0cm">We will organise two workshops, one on methods for evidence synthesis and one closed to develop a large collaborative proposal.</p>

Amount: £49,948
Funder: The Wellcome Trust
Recipient: University of Cambridge

Establishing systemic policy engagement at OUCRU: a pilot project 21 Jan 2019

<p style="margin-left: 0in; margin-right: 0in">The aim of this project is to pilot a system within OUCRU whereby projects are assessed for their potential policy impact; policy-making stakeholders&rsquo; interests&rsquo; are acknowledged and incorporated into project designs; and we have the infrastructure and expertise in place to support policy engagement, thereby ensuring that opportunities for policy impact are fully realized. If this pilot system is successful, we will be able to expand the scope of this initiative to support systemic policy engagement across the breadth of all our work.</p> <p style="margin-left: 0in; margin-right: 0in">There are three components to the proposed project:</p> <p style="margin-left: 0in; margin-right: 0in"><strong>Component one: Strengthening our understanding of how policy engagement operates in Vietnam and within OUCRU.</strong> This includes an external policy-mapping project, and an internal policy engagement review.&nbsp;</p> <p style="margin-left: 0in; margin-right: 0in"><strong>Component two: Implementing a pilot programme of systemic policy engagement. </strong>In this component we will develop a policy engagement plan and establish a Policy Stakeholder Advisory Board (PSAB) to create opportunities for continuous stakeholder engagement beyond the life of this project.</p> <p style="margin-left: 0in; margin-right: 0in"><strong>Component three: Monitoring and evaluation</strong>. In this component we will develop a theory of change, and we will conduct evaluations of the policy engagement plan, and of the PSAB in line with that theory of change to inform the next steps.</p>

Amount: £70,133
Funder: The Wellcome Trust
Recipient: University of Oxford

Global Access for Monoclonal Antibodies - Landscape Report 30 Sep 2019

<p>Monoclonal antibodies (mAbs) are safe, effective treatments for many chronic<br> diseases and have had a transformational impact on human health and<br> medicine. However, access to mAb products is limited mostly to developed<br> countries and/or private retail markets. In parallel, the potential for mAbs has<br> expanded to passive immunization and therapy for infectious diseases. Many<br> antibody-based candidates are being tested in clinical studies, but they have an<br> unclear path to broad, affordable global access. The Wellcome Trust has<br> commissioned the International AIDS Vaccine Initiative (lA VI) to prepare a landscape<br> report on the challenges and investment opportunities for affordable global access to<br> mAbs for prevention and therapy in low- and middle-income countries, with an<br> analysis of opportunities to broaden access in high-income countries as a secondary<br> goal. This report will include case studies for marketed antibodies and an application<br> of these learnings to antibodies in development for multiple diseases, including<br> infectious diseases.</p>

Amount: £243,591
Funder: The Wellcome Trust
Recipient: International AIDS Vaccine Initiative

Economic and Social Dimensions of Health and Morbidity 30 Sep 2019

<p style="margin-left: 0cm; margin-right: 0cm">The proposal is to build a substantive, international research agenda, delving into several, hitherto under-researched, dimensions of health outcomes through the creation and&nbsp;consolidation of a network of active researchers with a specific Southern focus. The proposed research agenda on economic and social determinants of health and morbidity&nbsp;will fill several knowledge gaps, as well as contribute specific inputs into policy and advocacy.&nbsp;</p> <p style="margin-left: 0cm; margin-right: 0cm">The team is interested in developing a research agenda along the following broad themes. The research would either&nbsp;&nbsp;be cross-national or focus on a specific country; however, the issues are broad enough to have wide ranging international implications. The broad themes are:&nbsp;</p> <p style="margin-left: 0cm; margin-right: 0cm"><strong>1. Socioeconomic Status, Stigma and Health: Racial and Caste Disparities&nbsp;</strong>&nbsp;</p> <p style="margin-left: 0cm; margin-right: 0cm"><strong>2. Women&rsquo;s Health: Son Preference, Breastfeeding and&nbsp;Participation in Paid Work</strong></p> <p style="margin-left: 0cm; margin-right: 0cm"><strong>3. The Origins of Health Disparities: The Importance of Early Childhood</strong></p> <p style="margin-left: 0cm; margin-right: 0cm">4.&nbsp;<strong>Intersecting Identities: Gender, Caste and Class</strong></p> <p style="margin-left: 0cm; margin-right: 0cm"><strong>5. &nbsp;Improving Measurement and Policy: Understanding Demand and Supply of Health Services</strong></p> <p style="margin-left: 0cm; margin-right: 0cm">The plan is for the core researchers to participate in three closed-door workshops of 2-3 days each over 12 months. At the end of this period, we hope to be successful in building a coherent proposal for a research programme subsuming multiple linked projects.&nbsp;</p> <p style="margin-left: 0cm; margin-right: 0cm">&nbsp;</p> <p style="margin-left: 0cm; margin-right: 0cm">&nbsp;</p>

Amount: £29,885
Funder: The Wellcome Trust
Recipient: Ashoka University

Continuous Blood Pressure Monitoring by a Wearable Ultrasonic Patch 28 Feb 2019

<p>This research will develop a method for continuous, accurate, and non-invasive blood pressure waveform measurement using a stretchable ultrasound device worn on the human skin. Continuous blood pressure waveform monitoring provides critical diagnostic clues to pathological cardiovascular conditions, and can raise patient awareness, help preventive care, and serve as the basis for personalised medicine. This research is distinct from other blood pressure waveform measurement methods because it provides blood pressure waveform data with a non-invasive device that does not constrict natural body movement or cause discomfort. The use of a soft, stretchable platform that matches the softness of the human skin will make a key difference in patient acceptance in high-risk populations and wellness monitoring for the general public, with a direct impact on clinical and preventive care practices.</p>

Amount: £398,949
Funder: The Wellcome Trust
Recipient: University of California, San Diego

Discovery of anti-DENV Antibodies Using Artificial Intelligence 28 Feb 2019

<p>Dengue virus (DENV) is a viral pathogen of global health significance: in 390 million<br> cases worldwide, 96 million exhibited clinical symptoms and resulted in 21 thousand<br> deaths. Currently, there are no therapeutic treatments against DENV. DENV is<br> composed of four similar but serologically different viruses (DENV 1-4). Cross-reactive,<br> neutralizing antibodies to all four DENV serotypes may provide an effective passive<br> treatment against severe DENV disease.<br> A large number of potentially successful antibody candidates remain undiscovered due<br> to the complexity of the natural immune response (theoretical antibody repertoire of<br> 10140 potential antibodies). We aim to apply network analyses and machine learning to<br> investigate large amounts of raw high-throughput sequence data from antibody<br> repertoires, resulting in detection of rare, under-represented DENV-specific antibodies.<br> This project aims to discover and develop new neutralizing antibodies for therapeutic<br> treatment of dengue infection and inform vaccine design.</p>

BioImaging UK Community Network 30 Sep 2019

<p>Development of a national network to support Imaging Scientists to enable to UK to remain at the forefront of biomedical research.</p>

Setting the 2019 Mental Health Agenda 30 Sep 2019

<p style="margin-left: 0cm; margin-right: 0cm">This proposal is to complement and build on the work United for Global Mental Health (United GMH) is currently undertaking as part of a Wellcome grant. It aims to deliver a plan of action for the first four months of 2019 to shift the scale of ambition and sustain lasting activity on mental health.</p> <p style="margin-left: 0cm; margin-right: 0cm">The proposal plans activities covering four streams:</p> <ol> <li><strong>Catalysing commitment at Davos 2019</strong>: spurring greater action within the growing global movement and launching WEF&rsquo;s new programme area</li> <li><strong>Further amplification of the Lancet Report</strong> to new audiences</li> <li><strong>Maintaining the Drumbeat </strong>using the Friendship Bench</li> <li><strong>Sustaining work of the Blue Print Group</strong> through to the end of April 2019</li> <li><strong>Operational support</strong> for United for Global Mental Health</li> </ol> <p style="margin-left: 0cm; margin-right: 0cm">The United GMH team will leverage support from Wellcome to mobilise partners, and the wider global mental health community, to maintain the momentum built since July to raise mental health further up the global political agenda in 2019. We are requesting &pound;106,895 from Wellcome to further this work.</p>

Amount: £106,895
Funder: The Wellcome Trust
Recipient: Global Campaign for Mental Health

Mobile phone-based screening tools to accelerate malaria eradication 28 Feb 2019

<p>Malaria is one of the deadliest infectious diseases in the world, with 219 million infections<br> and 435,000 deaths in 2017. A crucial step towards achieving malaria elimination is reducing<br> malaria transmission by identifying and treating the asymptomatic transmission reservoir.<br> Malaria ROTs are the most commonly used tests to detect malaria infection; however, they<br> rely on blood sampling which limits their practicality for mass screening and routine<br> surveillance.<br> We will evaluate the utility of interstitial fluid and saliva for blood-free detection of PfHRP2,<br> an established biomarker of malaria infection. We will also develop mobile phone-based<br> screening tools for sensitive measurements of PfHRP2 in interstitial fluid and saliva, and<br> evaluate their effectiveness for identifying asymptomatical/y infected individuals in Malawi.<br> The simplicity, portability and bloodless nature of these tools will likely make them more<br> readily accepted, especially among asymptomatic individuals. Improved surveillance of this<br> group will reduce malaria transmission and accelerate malaria eradication.</p>

Amount: £790,359
Funder: The Wellcome Trust
Recipient: Rice University

SP3: Scalable Software for Pathogen Reads to Clinical Results using Next Generation Sequencing 28 Feb 2019

<p>Scalable Pathogen Pipeline for turning Next Generation Sequencing Pathogen data into<br> Clinical Results<br> Recently, technology has developed which allows us to read the DNA blueprint of microbes<br> rapidly. This technology is now being widely used on bacteria, both to decide optimal<br> treatments, and to track the transmission of infection. A key requirement is the need for<br> integrated software to turn DNA sequence data into a microbial identification and a prediction<br> of resistance, and into a usable depiction of microbial transmission.<br> Existing software solutions work and improve on conventional laboratory methods, but are<br> difficult to deploy and validate outside the University settings where they were<br> created. However, there is global demand for similar, readily deployed, high quality services.<br> The Scalable Pathogen Pipeline (SP3) project will address this demand. Building on a range<br> of proven existing tools, it will provide a sustainable, open source, software framework,<br> together with validation data, to clinical and research settings. It will be deployable without the<br> need for extensive software or genomics expertise.</p>

Amount: £1,029,833
Funder: The Wellcome Trust
Recipient: Cardiff University