- Total grants
- Total funders
- Total recipients
- Earliest award date
- 16 Jun 1998
- Latest award date
- 30 Sep 2018
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
1. 6th Annual General and Scientific Meeting (6th AGM) INDEPTH is an international network currently consisting of 37 demographic surveillance system (DSS) field sites in 19 countries that collectively monitor 2,000,000 people at a household level. The sites are currently located in Africa, Asia, Latin America and Oceania with the majority of sites located in sub-Saharan Africa. Each site operates in geographically defined populations, and conducts continuous, longitudinal, demographic monitoring, with timely production of data on all births, deaths, causes of death, and migration. This monitoring system provides a platform for the design and evaluation of a wide range of health care innovations as well as social, economic, behavioural and health interventions and research studies. Given their locations in different countries in the developing world, the INDEPTH Secretariat effectively uses email and telephone to communicate with its member sites. The Network identified the need for annual face-to-face meetings of its entire membership and hence made its Annual General and Scientific Meeting (AGM) an integral part of its governance structure. Full members of the INDEPTH Network, i.e., DSS sites represented by their site leaders or their designated representations of Demographic Surveillance System (DSS) sites attend, speak and vote at the AGM and receive all literature concerning the meetings. The Secretariat always determines a conference theme and subthemes for the session are determined by a scientific committee. The conference theme for 6th AGM is: Building Scientific Capacity for Health Surveillance and response in the Developing World. Subthemes that will be covered at this meeting are: Human Resources and Capacity Building for Health Surveillance DSS Supporting Public Health Policies DSS and Measuring Progress towards MDGs Human Resource Development and Research to Policy and Practice Ethics and Health Intervention Platforms Measuring Mortality and Morbidity of Poverty-related Diseases DSS Contribution to the monitoring and the response to the epidemic of HIV Technical Innovations for DSS Practitioners
Meeting: REVES 2006 Differential trends in health expectancy: implications for the future, Amsterdam, The Netherlands. May 29-31, 2006 The REVES (Réseau Espérance de Vie en Santé) International Network on Health Expectancy was set up in 1989 by the French Naitonal Institute of Health and Medical Research (INSERM, Montpellier, France), the Social Affairs Council, Quebec, Canada and the Center for Demographic Studies, Durham, United States. The ageing of the world population and the lengthening of life have been, and are, monitored by well-established demographic indicators such as the ageing ratio and life expectancy at birth. Similar indicators can measure healthy active ageing and changes in healthy active life to evaluate whether further increases in the quantity of life are accompanied by equivalent increases in quality of life. In other words, the interest is in determining whether or not additional years of life are years spent physically and mentally independent as well as socially integrated. Over the last twenty years, data collection and publication of ageing ratios and life expectancies by the UN have allowed governments, policy planners and other stakeholders to become aware of the ageing of the world population. In the next two decades, these should be supplemented by similar data collection and publication on healthy active life, as a fundamental resource for monitoring quality of life. It is envisaged that the topics covered at REVES 2006 will be similar to those covered at previous REVES meetings. Topics are likely to include: The study of health concepts; Methodological developments in population health; Disability, morbidity and mortality and their determinants; Health comparison among regions and social groups; The use of health expectancy as a policy instruments.
Graftings: Sex and Masculinity in Early-Modern France This book-length study focuses on grafting and transplantation in medical and botanical texts of the late 17th and early 18th centuries. I am especially interested in how grafting develops as a practice and as a metaphor, and what is tells us about shifting notions of scientific and cultural subjectivities. In an effort to explore the fluid contours of early-modern plant and human, my project focuses primarily on how discussions of grafting and transplantation serve to link the medical, botanical, and cultural realms as writers attempt to work through shifting notions of "otherness". How do writers understand intersections between the plant world and the human world? What do the descriptions of these intersections reveal about the larger cultural and political realities of the time? Given developing understandings of sexual difference in plants I am especially interested in examining what botanical knowledge and its frequent comparisons to the human body have to tell us about changing notions of gender and sexuality as we move toward the Enlightenment.
The objectives of this training initiative are· To prepare clinical researchers from KEMRI, and those from Wellcome Trust fundTo establish a common level of expertise and understanding of clinical drug deTo prepare Kilifi for a future role as a centre that will initiate and coordinTo provide training of faulty drawn from East Africa to establish self-funding
Sex, sexuality and gender: Marking the 40th anniversary of 'Human Sexual Response' by Masters and Johnson 30 Aug 2006
Sex, sexuality and gender: Marking the 40th anniversary of Human Sexual Response by Masters and Johnson The Science Museum's Dana Centre proposes to mark the 40th anniversary of the publication of Masters and Johnson's groundbreaking book, Human Sexual Response, with a series of public engagement events exploring sex, sexuality and gender. As part of this series, we will develop and evaluate new SMS text technology, to drive and enhance audience engagement, as well as innovative and creative event formats; both of which will have a significant legacy for future events. The study of human sexuality is portrayed in the media largely through sensationalist articles which do not acknowledge the important research developments taking place in this, one of the most important biological human drives. The anniversary of Masters and Johnson's publication provides an ideal opportunity to raise the profile of the groundbreaking work currently taking place. The proposed events will examine why their work has achieved such lasting impact and how our understanding of sex, sexuality and gender has deepened and changed in the last 40 years. It will explore audience understanding and views on the ethical, moral, social and economic implications of these developments. Dealing with a subject widely considered personal and, by some, controversial and even taboo, these events present a significant opportunity to push the boundaries of science engagement by developing tools and formats to facilitate debate about potentially sensitive issues. We propose drawing on the Dana Centre's experience to develop and deliver events about a subject which will engage new audiences, and enhance dialogue through the piloting of new SMS technology and innovative formats.
Background: The National Eisteddfod is the premier cultural festival of Wales, held mainly in Welsh. It is an 8-day festival held annually in August, at different locations, Swansea in 2006 and Mold (Flintshire) in 2007. Total attendance at each festival usually exceeds 150,000. The site includes a main pavilion of capacity 3,500, with approximately 10 smaller satellite pavilions, including the Science Pavilion, all surrounded by some 300 commercial and other stands. A primary objective of the Eisteddfod is to develop and expand its Science Festival/Programme. General Objectives: 1. Provide opportunities for visitors to the Eisteddfod to become better informed about the nature of biomedical Science. [Thousands of pupils in Wales receive much (or all) of their science training in Welsh, and the Eisteddfod is the only major event, which allows them and their parents to experience science communication in Welsh.] 2. Presenting innovative exhibits, activities and shows at the 2006 and 2007 Eisteddfodau. Proposed themes are: 2006 - Asthma and Allergic Disorders, and 2007 - Neuroscience Target Audience: The main target audience are the visitors to the Eisteddfod. [Approximately 33,000 visited the Science Festival in 2005].
Analysis and decoding of the language of cells (A Royal Society exhibition) A proposal for the above exhibit has been selected for the Royal Society Summer Exhibition (July 2006) and the 2006 Glasgow Science Exhibition (September). There is no funding associated with acceptance for these prestigious events. Both events attract a large number of scientists, politicians, policy makers and members of the public. They represent a major annual opportunity to increase awareness of important scientific topics and breakthroughs. We will show how timelapse microscopy using proteins from fireflies and jelly fish has transformed cell biology. This will involve a luminescence practical demonstration and demonstrations using pictures and videos. We will use the NF-kappaB signalling system to demonstrate the problem that each mammalian cell has in sensing its environment and in making correct decisions regarding the cell's fate. We will show our new data that suggests that this signal works in a different way from that previously suspected. Rather than being a simple switch, we have found that NF-kappaB proteins move repeatedly (oscillate) between the cytoplasm and the nucleus of the cell. These oscillations control the switching on (and off) of a large number of genes. It now seems likely that the timing of these oscillations encodes the message. This concept, developed using systems biology approaches, changes the way that we think about cell signals suggesting that period (FM) may be as important as the amplitude of a signal (AM). We will demonstrate how this relates to cell division, cell death, cancer (particularly neurobalstoma in children) and inflammatory disease.
A school's matinee of Darwin's Dream to be held at the Royal Albert Hall on 20th March 2006 with a series of related schools' workshops and a two week exhibiton for the general public. 23 Jan 2006
A schools' matinee of Darwin's Dream to be held at the Royal Albert Hall on 20th March 2006 with a series of related schools' workshops and a two week exhibition for the general public In order to maximise the potential of Darwin's Dream and to extend access to a further 1,500 school children and teachers, the Royal Albert Hall would like to make available a schools' matinee at the Hall. The Hall would also like to closely engage four schools from disadvantaged local areas, via a series of weekly half day workshops six weeks prior to the performances. Groups of 25-30 children in three of these schools will work with professional animators to develop the three interludes for both the matinee and evening performance at the Hall. The fourth school will devise additional music and drama for the Fanfare and Carnival and Big Bang sections. On each visit, two animators (including either a scientist, an artist/maker or a theatre director) will help the children understand the element of science that their interlude represents; work with them to create costumes/props; and help them prepare to stage their interlude. The project's Composer and Artistic Director, Graham Treacher will also visit each school to ensure that the children understand the full nature of the project, and have gained an understanding of evolution and natural selection. In order to extend the project to the general pubic, the Hall would also like to mount an exhibition in a main public foyer which would be viewed, not only by those attending both performances, but by the general public visiting the Hall in the two week period either side of the production.
Sleeping beauties. 14 Dec 2005
Sleeping Beauties Sleeping Beauties (working title) is a development process for a theatre script and workshop programme concerned with: Chronic Fatigue Syndrome/ME How doctors and patients communicate with each other (or don't) Coping with the certainty of illness experience in the context of uncertainty about its biomedical basis Understanding the contemporary role of biomedical explanations of disease in a setting notable for their absence The 'art' of medicine, thus needed to complement and support the (emerging) science. An initial and successful exploratory workshop, involving the applicants and two actors, was conducted as part of the Theatre Royal Plymouth's Theatre of Science project. A presentation of two first draft scenes from this workshop was presented at the Association of Medical Humanities Conference in July 2005. This received very positive response: including its ability to convey swiftly some key issues about the illness and its impact on patients, carers and professionals; and the veracity of the portrayals in the script from an experienced clinician and a qualified researcher whose doctorate involved interviews with over 200 such patients. We now intend to: Develop a first-draft script written by Simon Turley, with dramaturgical and workshop input from Jeff Teare and clinical and scientific input from Tony Pinching. Run workshops with medial students (part of a special study unit at the Peninsula Medical School - PMS) CFS sufferers and their carers (through local and national CFS/ME Groups, clinicians and actors. Create a presentation based on this work to be shown as part of the national conference marking the roll-out of the new CFS/ME clinical services in March 2006. The presentation, or its material, will then be offered to other training workshops for health professionals and patients/carers. A public reading of the full script will then be staged in London before an intended professional production in late 2006.
A travelling interactive exhibition entitled 1001 Inventions: Muslim heritage in our World. 14 Dec 2005
A travelling interactive exhibition entitled 1001 Inventions: Muslim Heritage in our World, that will feature a thematic hospital pod demonstrating the vast Muslim contributions to Medicine, Surgery and Pharmacy via a hand-on 'edutainment' approach 1001 Inventions: Muslim Heritage in our World is a unique UK based educational project that aims to bridge the gap in understanding the rich heritage that the Muslim community share with other communities in the UK and Europe. 1001 Inventions is a non-religious and non-political project that will allow the positive aspects of progress in science and technology to act as a unifying theme in understanding the interdependence of communities throughout human history. A groundbreaking exhibition has been planned to generate awareness and appreciation of the scientific discoveries Muslims have made over a time-span of 1000 years. The lasting legacy of Muslim inventiveness and scholarship can still serve to inspire and motivate the youth of today. The project will emphasise how Muslims working harmoniously alongside people of different faiths and races across Europe were able to contribute extensively to many fields including science, and medicine, thus demonstrating the concept of enduring interconnectivity between Muslims and non-Muslims in Europe which can still exist today. The exhibition will have universal appeal that will engage all sections of the public although the exhibition will principally impact Black and Minority Ethnic (BME) communities and be particularly significant to British Muslim students. The exhibition will be a decisive tool in altering negative perceptions towards Muslims and in boosting the self-esteem of young Muslims in a positive and constructive way. The exhibition is envisaged to inform the public and ultimately encourage young Muslims and young BME members to pursue HE studies and take up careers in biomedical sciences.
The millennium lecture series. 14 Dec 2005
The Millennium Lecture Series The Millennium Lecture Series has been running for six years. The lecture series usually comprises of around 10 lectures from prominent scientists and runs from October to May. These lectures are free to students and the general public. The aim is to promote awareness of various sciences to the community and schools. This year's lectures boast another set of excellent speakers, including two eminent popularisers of science, Philip Ball and Marcus du Sautoy, and a Nobel Prize winner (Jean-Marie Lehn). This year we are also pleased to say that we have two very distinguished speakers in the field of the medical biosciences, Professor Richard Evershed, from the University of Bristol, and Professor Anthony Campbell, of the University of Wales College of Medicine. Professor Evershed will be giving a lecture on bioarchaeology on 21st November 2005. Professor Campbell will be giving a lecture on deep sea bioluminescence and its application to modern medicine on 12th December 2005. In the following two years we hope to attract equally distinguished scientists in biomedicine. Past speakers have included Sir Alec Jeffreys, Lord Robert Winston and Frances Ashcroft. Overall, the lecture series provides insight into a variety of science areas and the issues surrounding them, and encourages a wide range of people from disparate areas to participate in discussion of scientific issues and appreciate how science can be both interesting and valuable to modern society.
Timebomb 08 Feb 2006
The main objective of this project is to examine the many cultural, social and bioscientific issues around hepatitis C and its treatment in the UK and thereby raise awareness. The hepatitis C virus (HCV) is highly infectious, little understood, and largely unheard of. Some 9 out of 10 of the 500,000 people infected in the UK remain undiagnosed. If nothing is done, the next 10 years will see an epidemic of people turning up in A & E with end-stage liver disease. It has been rightly called 'the viral time-bomb'. The project is a documentary for the general public structured around the strong personal narrative of the year-long journey through treatment of one young woman, Gemma Peppe, and examines amongst other things: The increasing prejudice against pharmaceutical products and in favour of untested alternative therapies The difficult decision to undertake the treatment (it has many side-effects and only a 50% chance of success) Other reasons why only 3,000 patients a year get treatment in the UK compared with 10-20,000 in comparable European countries Why so many people of South Asian origin are being diagnosed too late and dying unnecessarily as a result The enormous stigmatisation of HCV and consequent discrimination in healthcare, employment, in the social arena and even in the law courts The lack of political will to address the issue The film features other patients, clinicians, politicians, alternative therapists and patient advocates. Underlying everything is the question: will Gemma's treatment work?
I propose to undertake further research into the subject of my MD thesis 'Control and the therapeutic trial 1918 - 1948', awarded earlier this year, in order to publish the work as a book. My thesis offered a novel assessment of the genesis and hegemony of today's 'controlled trial' though an historical analysis of the rhetorical associations of the term 'controlled' and their exploitation, in particular, by the Medical Research Council (MRC.) My analysis has considerable implications for current medical research and evidence-based practice. Although I briefly discussed these implications in my thesis, I intend to expand this analysis, including an overview of the use of the rhetoric of the 'controlled trial' from 1948 to the end of the 20th century (outside the scope of my original thesis) and further discussion of the extent to which its rhetorical function is implicit in current research and lay discourse. This would involve analysis of medical journals and textbooks, lay newspapers and magazines covering the latter half of the twentieth century, together with further reading of secondary sources which largely fell outside my original thesis. I also intend to explore further, notions of 'control' during the earlier twentieth century.
Vascularisation of the Xenopus limb during development and regeneration Regeneration is the ability of a fully developed organism to replace lost tissues, organs and appendages by growth or remodelling of somatic tissue. The most remarkable examples of regeneration in vertebrates occur in amphibians, which are able to regenerate many complex structures. For example these animals are able to regenerate limbs and tails following amputation. Following amputation, epithelial cells begin to migrate as a sheet to cover the exposed mesenchymal tissues; this sheet is known as the wound epidermis. After wound closure the tissue undergoes extensive histolysis and cellular dedifferentiation, whereby the cells lose their differentiated characteristics and become undifferentiated proliferating blastemal cells. The cells contribute to the formation of the blastema; a self-organising cellular mass that forms at the distal end of the amputated stump. The fact that the blastema is comprised of this mass of undifferentiated, proliferating, mesodermal cells likens it to a benign tumour which raises the question as to whether the blastema, like a tumour, requires a vasculature for initiation and continuation of outgrowth. There have been few studies on vasculature formation during regeneration. Early studies in the regenerating limb utilising Prussian blue and Indian ink, led to the conclusion that capillary sprouting begins during wound healing and dedifferentiation stages from vessels in the stump, especially those of the dermis, but that the new capillaries avoid the growing blastema during the early stages of regeneration and only begin to invade the blastema proximally with the onset of histogenesis. Later studies have documented the stages of vessel morphogenesis in regenerating fins, using TG (fli1:EGFP)y1 transgenic zebrafish, as well as the use of a small molecule inhibitor of the VEGF receptor to exert precise control over blood vessel regeneration. This project hopes to elucidate the molecular and cellular mechanisms behind neovascularisation in the developing and regenerating Xenopus limb.
Interactions of HIV-gp120 with sensory neurones. 19 Jul 2006
I will investigate gp120-associated neuropathic pain by assessing the capacity of gp120 to interact with different cell types within the peripheral nerve and the ensuing induction of intermediaries associated with the development of neuropathic pain. This will be achieved by a combination of in vivo and in vitro studies that will explore the interactions of gp120 with the two chemokine receptors CCR5 and CXCR4 on a molecular level, and the interactions via these receptors with Schwann cells, macrophages and neurones directly, on a cellular level. These investigations aim to elucidate 1) the relative importance of the co-receptors, CCR5 and CXCR4, in AASN pathology; 2) to identify the cell type(s) through which gp120 acts and whether these interactions are directly related to the establishment of neuropathic pain; and 3) to identify the components released by these cells in response to gp120 binding.
A change in intracellular free Ca2+ concentration is an important signalling mechanism that regulates diverse cellular processes. One mechanism for increased Ca2+ entry into cells occurs in response to the emptying of ER Ca2+ stores and involves the ER Ca2+ sensing protein STIM1 and its translocation to the plasma membrane. The first objective is to examine if STIM1 translocation can be observed in HeLa cells in response to store depletion and ATP depletion and to determine whether it inserts into the plasma membrane. The second objective is to investigate the mechanism through which STIM1 moves to and inserts into the plasma membrane. The third objective is to identify novel STIM1-interacting partners that may be involved in translocation or regulation of STIM1. The fourth objective is to examine the dynamic interaction between STIM1 and Orai1.
Twenty-five years after its discovery, human immunodeficiency virus type 1 (HIV-1) and its related illnesses still have a major health and socio-economic impact, particularly in developing countries. Over 40 million people world-wide are currently infected with HIV-1 and an estimated 12,000 new infections occur each day (UNAIDS/WHO 2006). For this reason HIV infection is important to study and there is a wealth of information available for secondary analysis. However, much - if not the majority - of this valuable data is "locked" in the published literature. As a result this information is time-consuming to study and is inaccessible to data mining projects. Computational Biology offers us the opportunity to extract data from the published literature for analysis. Here we are concerned with the molecular interactions that occur between a virus and its host. HIV, like all viruses, subjugates and exploits host cells in order to propagate. To achieve this, the virion must first bind to a host cell, enter it and then hijack the cell's 'machinery'. This is accomplished via an intricate network of protein-protein interactions both intra-virion and pathogen-host. The host subsequently responds to the virus and its protein products via host-pathogen interactions. There is therefore a complex interplay of host ("good") and viral ("bad") mediated protein-protein interactions.
WT Studentship for Miss Nazan Saner: 4-year PhD studentship in Molecular and Cellular Biology Replication of DNA is initiated from defined origins on chromosomes and proceeds with replication forks travelling bi-directionally from the origins. The timing of DNA replication initiation from various origins is highly coordinated; some origins fire early and others late during S phase. Moreover, inside nuclei, the bulk of DNA replication is physically organized in replication factories, intranuclear foci consisting of DNA polymerases and other replication proteins. Each factory processes several (2-100) active replication forks. The adjacent replicons along a chromosome might be organized for replication in the same replication factory. However, it is not yet clear what determines the groups of replicons that replicate at individual replication factories. We have been studying duplication of chromosomal DNA using budding yeast Saccharomycces cerevisiae as a model organism. Many basic mechanisms of DNA replication are similar in yeast and human cells. It is therefore likely that results form the yeast system will be of direct relevance to DNA replication mechanisms in human cells. In budding yeast, we can utilize amenable genetics and advanced knowledge in proteomics. In particular, the location of replication origins on chromosomes and the time of their firing have been well studied in this organism. We propose to investigate the spatial and temporal organization of DNA replication in budding yeast using a range of live-cell imaging techniques that have been recently developed in the lab. In particular, we will address which groups of replicons are processed in individual replication factories, how this grouping is determined and how this process is organized.
The investigation of nucleosome dynamics using site directed spin labelling and electron paramagnetic resonance. 19 Jul 2006
WT Studentship for Mr Andrew J Bowman: 4-year PhD studentship in Molecular and Cellular Biology When nuclesomes were first discovered, it was thought they were static bodies, rigid complexes whose function was to package the genome into cellular dimensions. Contrary to this, within the last 15 years or so, nucleosomes have been shown to be highly dynamic entities. Widom and colleagues have shown that DNA wrapped around the histone octamer undergoes spontaneous, transient unwrapping, allowing access to DNA binding proteins. Studies carried out by the Prunell and Victor labs have indicated structural changes in the histone core, particularly in the (H3-H4)2-tetramer. In agreement with this, studies carried out by Cleveland and colleagues on the H3 variant CENP-A showed that certain regions of the tetramer have greater dynamicity. During my rotation project I employed the technique of Site-Directed Spin Labelling (SDSL) and Electron Paramagnetic Resonance (EPR) to further investigate the structural dynamicity of the (H3-H4)2-tetramer. The tetramer is a likely nucleosome folding intermediate, first associating with DNA to form a tetrasome, followed by the binding of H2A-H2B to form the nucleosome proper. However, there is no structural information on the tetramer or tetrasome as a free entity. Another region of the nucleosome which is lacking structural information, though of great biological importance, are the histone tails. It is the general consensus that histone tails are devoid of secondary structure, protruding from the nucleosome into solution as a random coil. In the crystal structures of nucleosomes all but one of the histone tails do not reside in defined positions, the exception making inter-nucleosomal contracts, and thus are not resolved.