- Total grants
- Total funders
- Total recipients
- Earliest award date
- 17 Oct 2005
- Latest award date
- 18 Jun 2020
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
Improvement of livelihoods of the rural poor through education on health management and marketing of free range local chickens. 28 Feb 2006
The aim of the project is to use education on matters pertaining to keeping of local free range chickens to improve livelihoods of the poor poverty alleviation and economic empowerment of women and the youth.The activities include educating the animal health practitioners and chicken keepers in the villages in general aspects of management, disease prevention and marketing. Educational resources, formal training, radio, community meetings, drama with participatory approach will be used to transfer knolwedge to the target groups. The project tries to achieve creation of skilled enterprising chicken keepers who are backed with reliable animal health service providers. Forty-five veterinarians and 60 Village animal health service providers, will be updated on aspects of raising free range village chickens. 270 villagers (predominatly women) will be trained by the project on management, disease prevention and marketing of free range village chickens.The veterinarians will be selected from the 5 geographic zones of the country, while village animal health service providers and chicken keepers and will come from three regions, Morogoro, Tanga and Coast region of the Eastern zone. Community meetings and drama programmes will involve project members, animal health practitioners, contracted drama groups and village chicken keepers, with a target of reaching 15,000 people in the villages. Developed radio programmes on chicken keeping will be aired throughout the country.
Veterinary science, transboundary animal diseases and markets: pathways for policy in Southern Africa. 28 Feb 2006
Key to the future of livestock production in Africa - and constraints on meeting the high hopes of a 'livestock revolution' as a spur to stagnant agricultural sector growth - are the presence of transboundary animal diseases and the consequent escalating costs of regulation and meeting export standards. Focusing on the case of foot and mouth disease (FMD) in southern Africa - and specifically Botswana, Nambia, South Africa and Zimbabwe - this research will explore the economic, social and political trade-offs arising from disease control strategies focused on promoting commercial beef exports which are premised on the ability to separate a 'disease free' commercial sector from endemic areas through strictly enforced buffer and surveillance zones, and movement control. The key question is: given limited resources and capacities and growing costs, does it make sense to persist with this status quo and ensure disease freedom? Or are there alternatives that benefit a wider group of producers, are easier to implement, yet maintain access to important export markets and so foreign exchange revenues? Four country-based teams, coordinated by IDS and supported by project advisors, will investigate the policy processes in each country: how choices are made and by whom and with what criteria, to uncover the different scientific and economic arguments, policy actors and interest positions involved. The project will then bring the different players together in a series of policy dialogue workshops to explore different future policy scenarios (and their trade-offs), through a deliberative and participatory process. The main audience for both the analysis and methodological approach will be national and regional (SADC) level policymakers working on the intersections of animal health/disease control and marketing/trade policy. The policy dialogues will engage diverse stakeholders - livestock producers, regulators, processors, exporters and scientists - with a view to encouraging dialogue across usually divided sectors and across the region.
Bridging the intergenereational knowledge gap: measuring the diffusion of customary and formal livestock knowledge via multi-media tools for children. 28 Feb 2006
The overall aim of the project is to explore the inter-generational diffusion of livestock-related knowledge at the community and household levels utilising new methods (educational games) and alternate entry points (children). Therefore, the first objective is to create and test a range of computer-based technologies to teach children in India and Bolivia ages 8-12 about livestock care, management and health. The tools will be based upon Situated Learning Theory and as such, the focus will be on the development of problem solving skills applicable to the practical reality in which livestock keeping occurs. The second objective is to explore the diffusion rates of new knowledge across different age groups. While the intergenerational transfer of knowledge is widely recognised, transmission generally takes place from adults to children. With the access of children to new livestock-related knowledge, the study will test diffusion rates from children to adults. The games will focus on zoonotic diseases and those production constraints with readily identifiable and measurable behavioural changes. Hence, diffusion levels will be assessed in relation to the uptake of specific knowledge frames and via changes to farmer behaviour. The research will also explore the impact and influence of alterations to the 'authenticity' of the content on different age groups. Further, the effect on message transfer of linking animation levels to semantic content will be analysed. The final cross-cutting aim of the project is to engage global stakeholders in project outcomes. To meet this goal, participating schools in Bolivia and India will be linked to schools in Scotland and Denmark. Through video forums and technology sharing, the children involved will share their experiences of gaming and learning. In this manner, the project hopes to enhance global awareness and understanding among a new generation of development stakeholders.
Assessment of optimal channels of communication for effective message delivery on nagana and human sleeping sickness in Uganda. 28 Feb 2006
The project will assess optimal channels for communication of targeted messages, designed to translate key findings, that highlight the animal health and public health risks posed to rural peoples and their livestock from zoonotic trypanosomiasis and nagana. The focus will be the transition zone between areas affected by zoonotic T.b.rhodesiense and T.b.gambiense (Tororo, Soroti, Kaberamaido, Lira, Apac and Gulu Districts). An informed human health and animal health service, and an informed population, will be key in minimising the severe impact of a crossover between these two diseases. The existing knowledge base among all sectors of the community potentially affected by trypanosomiasis and HAT (human African trypanosomiasis) will be evaluated in districts recently affected by outbreaks in terms of awareness of HAT symptoms and treatment availability; clinical signs in domestic animals, treatment options and mechanisms for avoidance of nagana in livestock. Knowledge gaps will be closed through design of messages, which will be developed through engagement of stakeholders with a) scientific expertise directly relevant to trypanosomiasis in affected regions, e.g. veterinary and public-health professionals b) professional media and messaging skills, c) a high level of community knowledge, e.g. farmers groups, local community representatives, and d) policy makers and representatives of the broader community, to emphasise the danger of the two forms of HAT becoming sympatric; the link between livestock and HAT; disease presentation and appropriate treatment in livestock and humans, benefits of treating cattle with trypanocidal drugs and insecticides, disease risk factors and measures for risk avoidance. Best-bet communication channels for delivery and dissemination of information, will be identified, appropriate for target audiences comprising policy makers, cattle keepers and non-cattle keepers in the affected districts, and the broader community including civil society and the private sector. The project will disseminate information and monitor and evaluate the uptake and impact of messaging.
Although the aetiology of attention-deficit/hyperactivity disorder (ADHD) is uncertain, it is frequently found to be associated with prenatal exposure to nicotine and alcohol. It is difficult to determine whether the association is due to direct effects of the drugs on development or is a consequence of exposure to a postnatal environment characterised by parental alcohol abuse and smoking. This project will address the issue with a well-established method for assessing attention in rats to investigate attentional effects of prenatal exposure to alcohol (in the laboratory in Brazil) and nicotine (in the laboratory in UK). The work will extend use of the chosen task to studyingthe effects of prenatal drug exposure on cognitive function in adulthood. It is argued that the proposed procedures might serve as a model for ADHD with higher face, construct and predictive validity than the few models available so far. The goals of the proposed research are to test the hypotheses that prenatal exposure to alcohol and nicotine produces behavioural deficits that resemble those seen in ADHD and that these deficits can be reversed by drugs
Impact of avian influenza and its control measures on village livestock keepers, traders and consumers in Viet Nam. 28 Feb 2006
The Highly Pathogenic Avian Influenza (HPAI) epidemic in Viet Nam has had a high socio-economic impact through the death and destruction of poultry and disruption of poultry product markets. It has also been responsible for 42 human deaths. In response, the Vietnamese government is considering control and risk reduction strategies that involve changes in poultry husbandry and marketing systems. The proposed project is a collaboration between VEERU and the Viet Nam Ministry of Agriculture and Rural Development (MARD) to develop and test epidemiological and socio-economic analyses of HPAI control measures in order to identify potential conflicts of interest, public and private roles in control programmes and, hence, help to increase the success and sustainability of such programmes. The main objectives of the research are to: 1. Assess the epidemiological justification for current and proposed control strategies. 2. Evaluate the socio-economic impact of HPAI and its control strategies on stakeholders affected, with a particular focus on smallholder commercial and backyard producers. 3. Assess livelihood and health risk perceptions of smallholder commercial and backyard producers with regards to HPAI. 4. Determine the needs of key stakeholders that will assist them to adjust and adapt to changes brought about by HPAI and its control measures. 5. Suggest adjustments to control strategies and government actions based on the epidemiological and socio-economic assessments that will be brought together with value chain analysis and new institutional economic analysis. 6. Disseminate the project findings (information and methodologies) within Viet Nam and in the neighbouring countries also affected by HPAI. The project will collect data, using focus group workshops and key informant interviews of stakeholders, at all levels of poultry production and marketing in the most severley affected Vietnamese provinces. Data will also be collected from consumers. MARD will be a collaborator and a target audience for project outputs.
The imminent closure of the Coventry and Warwickshire Hospital in Coventry city centre, and relocation to a purpose-built 'super hospital' on the city's outskirts, marks a significant moment in the history of the NHS. We are currently preparing a programme of public activities to engage the local community in the contemporary and historical issues arising from this event. To this end we have committed funds from our operating budget to employ a Research Assistant at 50% for nine months. His duties will include collecting oral testimony and writing a brief synthetic history for the project website. The purpose of this application (for funds to make the RA full-time and provide equipment) is to add three academic goals to a programme otherwise directed towards public engagement: 1. To extend the quantity, range, and depth of the oral history so that it is of greater academic significance; 2. To develop a more sophisticated contemporary history of the closure based on original archival sources and oral testimony and set within a national context; 3. To communicate the research findings to the academic community in the form of two articles in refereed journals in the history of medicine.
This proposal requests a third phase of Wellcome Support to the Social Research Center. The third phase is intended to consolidate the success of the previous two phases. The program activities will retain but modify the previous components of training programs and research internships and will include two additional components of institutional support and regional partnerships for health equity. I. Training Program and Research Internships · Further development of the Research Training Program to achieve better recognition of health equity as a development challenge in the Arab region. · More effective support for trainees to develop a research project addressing health equity concern in their country. · Training internships to be allocated to researchers working in the area of health equity. II. Development of Research Capacity of a Select Number of Institutions In response to the shortcomings in both teaching and performance of educational and research institutions, two types of institutional support are planned. a. Improvement of teaching skills and curriculum in relevant departments of major universities in the region. b. Supporting the research capacity and performance of promising research units in the region. III. Partnership for Health Equity Regional networking and partnerships to build a critical mass of researchers and to consolidate knowledge on health equity: - Support better documentation of the magnitude of health inequities and the burden of ill health born by different social groups. - Increase understanding of the nature of social factors and the mechanism of their contribution to health. - Encourage the adoption of policies and programs aiming to reduce inequities.
The Greek medical papyri from Graeco/Roman Oxyrhynchus: An edition of 60 unpublished texts from a centre of learning and scholarship in middle Egypt. 09 Mar 2006
The project which is being proposed here is truly interdisciplinary. It brings together scholars in the field of the history of medicine and papyrologists who are trained to decipher the most difficult texts. The aim of this project is to publish the Greek papyri of medical content which were excavated among many others in the town of Oxyrhynchus in Middle Egypt. While poetic and prose texts of all kinds, as well as documents, have been published in great numbers, the medical pieces have remained nearly untouched by scholars. Oxyrhynchus was a hellenized city with a high living standard; scholars from Alexandria spent their leisure time there. Studying papyri found in Oxyrhynchus enables us to have at least a glance into the holdings of the lost library at Alexandria. It is time finally to address this gap. These papyri, which range from recipes to fragments of learned treatises, some perhaps by famous names from Alexandria and elsewhere, show at which level medical care was offered and received by people living in this place in which the Greek and Egyptian cultures met. The texts will be edited, along with translation and commentary, in one or two volumes in the Oxyrhynchus Papyri series.
The role of the immunoglobulin superfamily proteins in the coordination of morphogenesis. 21 Feb 2006
The coordinated interaction of different cell types is required for tissue morphogenesis and organ formation. Our labs have uncovered interactions between distinctive cell populations during myogenesis and nephrogenesis. In both tissues the immunoglobulin (Ig) domain protein superfamily mediates signalling between different cell types and these interactions lead to specific morphogenetic movements. We aim to understand, at the molecular level, how signalling through this pathway acts to coordinate the activity of different cell types to produce distinctive morphogenetic responses.The Ig domain superfamily of proteins interact in specific partnerships to alter eachother's activity, leading to the recruitment and activation of cytoplasmic targets. However, the outcome in terms of cell differentiation is widely divergent depending on the developmental context, ranging from cell fusion, neuronal pathfinding, synaptogenesis, cell intercalation, cell sorting and apoptosis. By focusing on two developmental contexts in a genetically manipulable organism, Drosophila melanogaster, we aim to establish interactions, partners and targets common to this pathway as well as to pinpoint those that lead to the specificity of the cell response.Adopting genetic, biochemical and cell biological approaches will allow us to confirm known interactions, to identify new partners and to establish the function of specific binding partnerships.
The role of the immmunoglobulin superfamily proteins in the coordination of morphogenesis. 21 Feb 2006
The coordinated interaction of different cell types is required for tissue morphogenesis and organ formation. Our labs have uncovered interactions between distinctive cell populations during myogenesis and nephrogenesis. In both tissues the immunoglobulin (Ig) domain protein superfamily mediates signalling between different cell types and these interactions lead to specific morphogenetic movements. We aim to understand, at the molecular level, how signalling through this pathway acts to coordinate the activity of different cell types to produce distinctive morphogenetic responses. The Ig domain superfamily of proteins interact in specific partnerships to alter each other's activity, leading to the recruitment and activation of cytoplasmic targets. However, the outcome in terms of cell differentiation is widely divergent depending on the developmental context, ranging from cell fusion, neuronal pathfinding, synaptogenesis, cell intercalation, cell sorting and apoptosis. By focusing on two developmental contexts in a genetically manipulable organism, Drosophila melanogaster, we aim to establish interactions, partners and targets common to this pathway as well as to pinpoint those that lead to the specificity of the cell response. Adopting genetic, biochemical and cell biological approaches will allow us to confirm known interactions, to identify new partners and to establish the function of specific binding partnerships.
Disease and Culture in Early Modern Italy. 10 Nov 2005
The pilot study will investigate the wide variety of cultural responses to large-scale epidemic disease, principally in Italy and against the backdrop of plague during the sixteenth century. The study will question generally accepted ideas (William McNeill, Alfred Crosby, and others) that epidemic catastrophe brought on widespread pessimism, otherworldly philosophies, and the decline of vigorous state formations). For the most catastrophic plague wave of the sixteenth century, 1575-7, the relationship was more nearly the reverse. The principal source for viewing this relationship will be the plague tract as it developed and multiplied through the sixteenth century. Written by university doctors, practicing medics, members of newly established health boards, and parish priests, these sources provide not only changing attitudes toward medical practice; they express fears and hopes and devise means for combating their hidden enemy from ritual purges to social policy. Around three hundred of them survive for sixteenth-century Italy, scattered through rare book rooms and archives; less than handful are available in modern editions. Along with demographic sources, chronicles, and literary works (novelle), this pilot study will explore these largely untapped sources to chart psychological and cultural reactions to epidemic disease from periods of low plague mortalities to the catastrophic years, 1575-7.
Sci.dentity 19 Dec 2005
1) Sci.dentity: Engaging with the Science of Sexes and Gender Project Aims: To increase public engagement with medical and biochemical knowledge of what male/female "sex" is and how sex is assigned, i.e., chromosomally, hormonally etc. To develop and extend creativity and expression through an inter-disciplinary arts project with young people in order to engage with complex ideas of sexed and gendered identities. To establish a forum for discussion around bioethical concerns related to issues of sex determinism. To carry out embedded, participative evaluation. The 12 month project has four phases: 1) Lead-in; 2) Workshops & Exhibition; 3) Reflection & Development; 4) Outreach programme The two main creative engagements are: A Performing and Visual Arts project with a group of young transsexual people will explore their understandings of the relationship between the science of sex and sexed identities. This will produce: i) a multimedia and performance art exhibition/event of young trans people's art work; ii) a short film that will document the creative workshops, present interviews with medical experts and practitioners in the field and incorporate the multimedia/art work produced by the young people. A Community Outreach Programme: participatory workshops using the film as a stimulus, with school and college groups in relation to aspects of AS/A Level Biology (Human), and AS/GCSE Citizenship curricula; workshops/post-show discussions with Lesbian, Gay, Bisexual and Transsexual (LGBT) youth groups; dissemination of the film and supporting information package to regional and national LGBT organisations and film festivals.
The Body in Motion. 19 Dec 2005
The Body in Motion Body in Motion is a cross curricular project, which combines the PE (Dance) and Science national curriculum modules. It will involve eight primary schools and up to 280 students within the Leeds area in an initiative, which will culminate in a dance performance for the schools involved and the local community. Phoenix's Education Team will work with Year 5 & 6 pupils on a weekly basis, over 6 weeks to deliver the initiative, which will take its theme from the human body, its structure and ways in which it functions. This theme will be examined and explored through the medium of dance with the aid of digital technology. Each session will focus on a different aspect of the working body i.e., the function of the skeleton, muscles, heart, lungs and nervous system, and through this, sections of the overall dance will be shaped. The main objectives of the project are to: Provide a stimulating experience using dance and digital technologies to explore Key Stage 2 science units 4A and 5A Provide high quality participatory arts provision from specialists in the dance field Improve understanding of scientific principles, within the parameters ascribed in the national curriculum
Resonance. 19 Dec 2005
Resonance Resonance is a music and bio-medicine project for young people focussing on music composition and post-genomic science, specifically Nuclear Magnetic Resonance (NMR) spectroscopy. It is a collaboration between Birmingham Contemporary Music Group (BCMG), String Quartets from Scratch (SQFS) and the Henry Wellcome Building for Biomolecular NMR Spectroscopy (HWB-NMR). Aims To: Engage young people with cutting-edge science and music. Enable scientists, composers and BCMG musicians to engage with each other's disciplines. Explore connections between music and NMR spectroscopy. Create contemporary music for young people to perform. Deepen young people's composition skills through composing music inspired by NMR spectroscopy. Engage BCMG's audience in bio-medical research and surrounding social and ethical issues. Enable scientists to share their work with a wider audience. Short-term Objectives To: Commission and publish three string quartets inspired by NMR spectroscopy from today's leading composers for young string players. Run a series of workshops for young musicians in Birmingham exploring experimentation and process in NMR spectroscopy and music composition. Run a series of workshops/rehearsals with young string players from Birmingham coached by BCMG musicians. Long-term Objectives To produce: A music and science performance with visuals and discussion in the CBSO Centre by young musicians, BCMG musicians and scientists. Three published string quartets for use by young string players worldwide and BCMG on tour. A secondary school resource book linking NMR spectroscopy with music composition including a CD of images which would also accompany performances of the quartets.
In Vivo, in Vitro, in Form. 19 Dec 2005
In vivo, in vitro, in form This project raises awareness to biomedical developments in the design, manufacture and use of artificial and organic replacement and regenerated body parts through the medium of artistic expression. It will enable scientists to engage with young people to inform and inspire their art work and performance. This art work will be used to inform other young people about the science: 'science inspired art informing young people'. A digital artist will work with secondary students and primary pupils from Wirral schools to design and produce robotic puppets with unusual abilities for use in animation and performance. Students will also produce futuristic digital images of designer replacement limbs and animations that will stimulate discussion and story telling. Inspiration for this work will come from meeting amputees, scientists, prosthetists, robotic engineers and inspiring role models. Five artists in residence at local secondary schools will provoke debate through art: Perfection/Imperfection. Through selective choice of materials and styles, students' work will reveal a person that some people might describe as imperfect, as 'perfect'. We intend to exhibit these sculptures individually in public places to provoke reaction. Work-in-progress will form a walkthrough installation in the Wirral schools art exhibition. The year long project will culminate in eight innovative and experimental life performances communicating the history of prosthetics and future advancements in regenerative biomedical research to a young audience. Challenging and thought provoking debates through live, video conference and web-based formats will cover the controversial issues raised by this project.
Colour Coded. 19 Dec 2005
Colour Coded The project aims are to: Explore how people feel about their particular skin pigmentation - from pride to distress, and what they do when dissatisfied - lightening, bleaching, tanning. Work with young black people as they find out what factors affect skin pigmentation. Produce an educational tool which can be used in science and PSHE lessons. Celebrate our varied skin tones and change attitudes. The project objectives are to: Raise awareness of the processes involved in determining skin colour and tone. Engage young people from the black community in the West Midlands in the project. Develop scientific understanding of those participating. Develop film-making and marketing skills of those involved. What we plan to do: We plan to work with a group of young people from Handsworth and the surrounding area to make a DVD on skin colour. The young people will work with dermatologist Celia Moss, and her team, and two community film-makers to create a series of short films. These will be screened regionally and also made available to schools and colleges via a sell-through DVD (priced to cover duplication and costs). The intended outputs are: A DVD of short films; A screening in the West Midlands; Publicity throughout the West Midlands and beyond. Our target audiences are: Young people in the West Midlands; Young people throughout the UK.
Crime Scene 19 Dec 2005
Crime Scene Two groups from Harlaw Academy aged 12-15 years will work alongside a Forensic Scientist, and staff from the City Councils Museums and Galleries/Cultural Services Teams, with support from Grampian Police Partnership Development Officer, to create a site specific art installation piece on the theme of forensic science. The aim of the project will be to inform and engage young people in forensic science, explore its role and subsequent implications on contemporary culture in western society. This will be done in a variety of ways relying heavily on the expertise of the forensic anthropologists, archaeologists and police who will relate their experiences in the field and use local examples of criminal cases which were resolved using forensic techniques. The artists from the Arts Development team, part of the Cultural Services Team at Aberdeen City Council, will guide the groups from Harlaw Academy in their exploration of forensic science and create work which will cover anatomy, physiognomy, anthropology, osteology and archaeology. The groups will also work with a storyteller/creative writer to devise their own story which the forensic installation site will be based around and installed in Aberdeen Art Gallery. Whilst working with the artists the groups will continue to interact with police, archaeologists and scientists so that their expertise is ongoing. Amongst the techniques the groups and artists will use are glass (for casting/slumping 3D models) and photography (both documentary and forensic). Curatorial Staff from Aberdeen Art Gallery will facilitate the groups in the curation of the subsequent exhibition, and an event will be held to show and publicise which larger numbers of young people will be invited to participate in. The work will be available to the Wellcome Trust for exhibition in related venues.
Sensitive (Allergens and Everyday Lives) 19 Dec 2005
Sensitive (Allergens and Everyday Lives) In collaboration with artists from Phoenix Arts Association's established outreach program, Artist Anna Dumitriu and Professor Helen Smith (Brighton and Sussex Medical School) propose to work with secondary school children from Varndean School in Brighton to develop an understanding of the impact of allergies on young people's lives through the creation of a series of artworks located throughout the school environment. Allergies affect everyone on a personal level, if not at first hand, through friends and family. But there is a huge amount of misunderstanding about how allergic reactions actually happen, what effects they have physically and emotionally and the best ways of dealing with them. Anna Dumitriu has been making and exhibiting art about medicine and microscopy for over 10 years, Professor Helen Smith is the author of "Allergy - Your Questions Answered" and an artist in her own right. Phoenix Arts Association has an established education programme and experience of organising outreach projects. We will undertake a series of short talks, discussions and workshops and the students will be asked to write about how allergies have affected their own lives. Helen and Anna will discuss the scientific background and then we will use microscopes to observe samples of allergens so the students have an opportunity to draw them from life. The drawings, discussions and written work will be used as the basis for a series of both large and small scale interventions around the school, incorporating digital or video projections, installation, craft based techniques and live art performance.
The Greater Black Krait (Bungarus niger) in Bangladesh: ecology, epidemiology and management of envenoming bites. 15 Feb 2006
Key Goals: 1) To determine the medical importance of B. niger in Chittagong District, Bangladesh. 2) To define the clinical features of envenoming by this species. 3) To modify guidelines for clinical management.Research: A survey of snakebite in Chittagong District showed that more than 300 of 800 documented bites resulted in severe envenoming. In approximately 10% of cases, all with severe neurotoxic envenoming, the biting species remained unknown after immunodiagnosis. In five cases the snakes responsible for the bites had been killed and brought to the clinic. Based on morphological and DNA evidence from the five snakes, we suspect that the biting species in this series was B. niger, a snake never previously reported in Bangladesh. We will collect specimens of B. niger in Chittagong District, using molecular and morphological methods to confirm species identity and to validate diagnostic features. Venom will be collected to characterise its biological activity and neutralization by polyvalent antivenoms, and to raise high-titre antisera for the detection of venom in the blood of victims of undiagnosed neurotoxic snake bite. We will analyze geographical information, behavioural, ecological, and socioeconomic parameters to estimate the distribution of this species, and to identify the human population at risk. Based on these data, we will generate avoidance guidelines for local people, and protocols for the long-term captive husbandry of B. niger, to facilitate sustainable venom collection and specific antivenom production.