Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

Current Filters

Currency:
GBP
Recipients:
Volunteering Matters
Medical Research Council

Filter By

Recipient Organizations (clear)
University of Oxford (1,569) University of Cambridge (1,282) University College London (1,143) Imperial College London (748) University of Edinburgh (718) Guy's and St Thomas' NHS Foundation Trust (565) King's College London (519) University of Manchester (443) University of Bristol (420) London School of Hygiene & Tropical Medicine (391) University of Glasgow (335) University of Dundee (312) University of Liverpool (307) The Royal British Legion (300) Newcastle University (299) University of Birmingham (298) Cardiff University (259) University of Leeds (235) King's College London (218) Queen Mary University of London (190) University of Warwick (182) University of York (177) Liverpool School of Tropical Medicine (173) University of Nottingham (173) University of Sheffield (171) Merched Y Wawr (161) University of Exeter (153) University of Leicester (149) Barnardo's (141) The Guide Association (139) The Scout Association (131) University of Southampton (125) Alzheimer's Society (115) Cruse Bereavement Care (113) University College Dublin (108) Church of England Children's Society (107) University of Aberdeen (107) Institute of Cancer Research (100) Birkbeck University of London (96) The National Trust for Places of Historic Interest or Natural Beauty (95) The National Childbirth Trust (90) Queen's University Belfast (89) University of Sussex (88) St George's University of London (87) Wellcome Trust Sanger Institute (86) Education Services - Headquarters (85) Volunteering Matters (83) University of St Andrews (78) Medical Research Council (73) National University of Ireland Galway (72) See Less

Results

Molecular mechanisms of neural circuit function 28 Nov 2017

I aim to (i) discover molecular and cellular mechanisms that underpin neuronal properties; (ii) elucidate how these properties shape neural circuit activity to generate behaviour. C. elegans offers special opportunities to address these questions. C. elegans kept at 21% O2 adopt a different state from animals kept at 2. We are deconstructing the tonically signalling circuit that coordinates this state change via fast and slow-acting mechanisms. To achieve this, we isolated 583 mutants defective in escape from 21% O2. I propose to elucidate the function of several conserved protein complexes highlighted by these mutants. These include: 1) An interleukin-17 signalling pathway that changes circuit gain; 2) Membrane proteins of unknown function that I speculate promote biogenesis of many ion channels; 3) An ER complex promoting biogenesis of GPCRs; 4) A pan-neuronally expressed calmodulin-binding transcription factor controlling neural excitability. These studies combine genetics, biochemistry and cell biology, and integrate in vivo C. elegans work with studies in mammalian cells. To complement the genetics, we will use RNA-seq of FACS-sorted C. elegans neurons to study circuit plasticity, and adapt a platform developed for pan-neuronal imaging of freely-moving zebrafish larvae to freely-moving C. elegans, to provide a more comprehensive phenotypic readout.

Amount: £1,620,093
Funder: The Wellcome Trust
Recipient: Medical Research Council

Zika funding- WT-MRC-DFID partnership 30 Sep 2016

Not available

Amount: £1,000,000
Funder: The Wellcome Trust
Recipient: Medical Research Council

Operating costs 30 Sep 2015

Not available

Amount: £135,600
Funder: The Wellcome Trust
Recipient: Medical Research Council

Biomedical Vacation Scholarship 23 Jun 2014

Not available

Amount: £2,000
Funder: The Wellcome Trust
Recipient: Medical Research Council

A randomized trial of therapy shortening for minimal tuberculosis with new WHO-recommended doses and FDC drugs in African/indian HIV+/HIV- children. 12 Jun 2013

1) To determine whether treatment of minimal TB disease in children for 4 months results in 18-month disease-free survivalthat is non-inferior to treatment for 6 months, both with standard, but recently increased doses (WHO recommendation) ofanti-TB regimens of isoniazid and rifampicin supplemented by pyrazinamide for the first 2 months and ethambutol in areasof high HIV prevalence.2) To determine via nested PK substudies:a) The plasma PK of Isoniazid, rifampicin and pyrazinamide taken as daily new paediatric fixed-dose dispersible tabletcombinations in African and Indian HIV-infected and uninfected children across different ages according to weight-baseddosing tables. Results would be compared to values following administration of single drugs (within child) and to historicaldata in adults and children.b) To describe the effect of rifampicin on the PK of key antiretroviral drugs (efavirenz at standard doses in children olderthan 3 years; ritonavir-boosted lopinavir (with additional ritonavir boosting), nevirapine in fixed dose combinations withadded neviripine; zidovudine and abacavir in triple nucleoside regimens.c) to evaluate the association between PK and adverse drug effects and to response to anti-TB drugs.d) Using PK modeling, to simulate dosing approaches in different groups of children (race, age, nutritional status, cotreatmentwith ART).

Amount: £634,398
Funder: The Wellcome Trust
Recipient: Medical Research Council

RNA-binding proteins in health and disease. 10 May 2011

Our research focus on the role of RNA-binding proteins (RNABPs) in gene expression at different levels during the RNA processing cascade from splicing in the nucleus to translation in the cytoplasm. RNAs in cells associate with RNABPs to form ribonucleoprotein (RNP) complexes. There is a great variety of RNABPs, each with unique RNA-binding activity giving rise to a unique RNP for each RNA. They have a profound impact on cellular gene expression networks, affecting processes as diverse astranscription, pre-mRNA splicing, microRNA (miRNA) biogenesis and function andtranslation.

Amount: £1,477,149
Funder: The Wellcome Trust
Recipient: Medical Research Council

ThinkOutreach Podcasts 11 Jan 2012

Not available

Amount: £1,558
Funder: The Wellcome Trust
Recipient: Medical Research Council

Dendritic integration in the ventromedial nucleus of the hypothalamus. 11 Jun 2012

The main goal of this project is to investigate the input-output function of single neurons in the ventromedial nucleus of the hypothalamus (VMH), and test whether dendritic computations can contribute to information processing in these neurons, in particular in the circuit that controls aggressive behaviour. There are three initial key questions: (1) How do dendrites in VMH neurons integrate excitatory synaptic input? (2) What is the distribution of excitatory synapses from different inpu t pathways on VMH dendrites? (3) How do VMH neurons integrate information arriving from specific brain areas? These questions will be addressed in actute brain slices, using whole-cell recordings, 2-photon glutamate uncaging, and optogenetics together with calcium imaging. Specific brain regions will be targeted by stereotaxic injections, and axons and synapses visualized with genetic and immunohistochemistry methods. These experiments will be done in the ventrolateral VMH subdivision (VM Hvl), which control aggressive and sexual behaviour, and will identify the repertoire of dendritic computations of the VMHvl, as well as how they might be engaged by activation of specific projection areas. The final goal is to use immediate-early genes and viral tracing of VMH projections to target the neurons involved in aggression, and investigate dendritic information processing in this specific cell population.

Amount: £859,949
Funder: The Wellcome Trust
Recipient: Medical Research Council

Proteases in egress of the malaria parasite from its host red blood cell. 02 Feb 2009

Approximately 40% of the world s population is at risk from malaria, and with the increasing prevalence of drug resistance, the need for novel, effective drugs against this pathogen is increasingly urgent. The most virulent form of malaria is caused by waves of replication of the unicellular parasite Plasmodium falciparum within an intraerythrocytic parasitophorous vacuole (PV). At 48-hour intervals, rupture of the infected erythrocyte releases merozoites (a process called egress) which invade f resh erythrocytes to repeat the cycle. Egress is governed by the release of an essential parasite serine protease called SUB1 from maturing merozoites into the PV space. SUB1 initiates a cascade which involves the proteolytic processing of a papain-like enzyme family called SERA. At least two members of this family, SERA5 and SERA6, are essential for parasite viability. SERA5, and likely the other SERAs, is then further processed by another, as yet unidentified protease (which we refer to as the P50C protease). The purpose of this project is to investigate the role of the SERA proteins in parasite egress; verification of the enzymatic activity of the SERAs and identification of their substrates and of the P50C protease will provide new targets for the development of antimalarial drugs.

Amount: £177,006
Funder: The Wellcome Trust
Recipient: Medical Research Council

Facility costs 16 Sep 2008

Not available

Amount: £400,000
Funder: The Wellcome Trust
Recipient: Medical Research Council

Music From the Worm Farm. 02 Jul 2008

MUSIC FROM THE WORM FARM will be a six-month research and development residency in the Nurrish Lab within MRC Cell Biology Unit, University College London, exploring a new and experimental collaboration between composer Keith Johnson and neurobiologist Stephen Nurrish. The deep questions at the heart of both our interests are those that concern the brain and the body, what we think and what we do, and the mysterious middle ground between them. The residency will be documented and disseminated via a website; including written and visual material alongside original musical works, and a public presentation.

Amount: £13,289
Funder: The Wellcome Trust
Recipient: Medical Research Council

Biomedical Vacation Scholarship 14 Jun 2010

Not available

Amount: £1,520
Funder: The Wellcome Trust
Recipient: Medical Research Council

Grant to Volunteering Matters 20 Dec 2013

Great War pop-up exhibition

Amount: £9,700
Funder: The National Lottery Heritage Fund
Recipient: Volunteering Matters
Region: North East
District: County Durham

Women Against Sexual Exploitation and Violence Speak Up Project (WASSUP) 11 Dec 2017

To support the development of the WASSUP project.

Amount: £20,000
Funder: Suffolk Community Foundation
Recipient: Volunteering Matters

Volunteer Britain 14 Jul 2005

Community Service Volunteers (CSV) works to reconnect people to their community through volunteering and training and to enrich people?s lives. This project will produce short audio and visual clips on volunteer's experiences, produced by the volunteers themselves. CSV will showcase the clips in order to recognise their efforts and promote volunteering to others, through radio, TV and at local community events. This will be done in conjunction with the 'Year of the Volunteer' campaign.

Amount: £49,056
Funder: The Big Lottery Fund
Recipient: Volunteering Matters
Region: London
District: Islington London Boro

Lampton Community Gardens 15 Sep 2006

CSV Environment (Bristol) will promote and develop the community gardens and establish a volunteer community management group to sustain it for the benefit of all local residents.

Amount: £9,724
Funder: The Big Lottery Fund
Recipient: Volunteering Matters
Region: South West
District: City of Bristol

Cole Haven 07 May 2007

This group will develop area of woodland located within the heart of Birmingham's inner city, and create an outdoor education available to local schools and the wider community.

Amount: £9,991
Funder: The Big Lottery Fund
Recipient: Volunteering Matters
Region: West Midlands
District: Birmingham District

Country Parks for All 09 Feb 2007

A project to take a group of young people on a residential weekend in the countryside by this group in Birmingham.

Amount: £3,227
Funder: The Big Lottery Fund
Recipient: Volunteering Matters
Region: West Midlands
District: Birmingham District