- Total grants
- Total funders
- Total recipients
- Earliest award date
- 10 Apr 2001
- Latest award date
- 16 Jul 2018
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
Grant awarded to Community Service Volunteers (Training and Enterprise NE) (Tyne & Wear) 10 Mar 2009
To provide support and mentoring to people with mental health problems to help them volunteer in Newcastle.
Grant awarded to Community Service Volunteers (Training and Enterprise NE) (Tyne & Wear) 13 Jul 2004
To provide daycare services to older people living in high rise flats in Newcastle.
Positive Futures London 18 Nov 2015
This project, based on a established youth-led volunteering model is expanding as a result of self-referrals and is being delivered in Hackney, Haringey and Tower Hamlets. It will support young people aged 13 to 25 to deliver volunteering and social action projects which they have identified to be of benefit to the local community. The aim of project is that all of the young people who are participating in it will develop key skills and have positive experiences that will shape their personal development.
Cremation Archive Cataloguing Project 25 Nov 2016
The principal objective of this project is to catalogue and make accessible for research archive material of the Cremation Society of Great Britain. This will provide an invaluable resource for academic research by various disciplines into cremation and society's disposal of its dead. The Cremation Society of Great Britain first deposited journals and part of its archive with Durham University in 1998. These were catalogued and made available for research. The Society then made a further substantial addition to that material in 2015, which now needs to be catalogued. The material covers all aspects of the Society's administration dating back to the late 19th century, the provision of its facilities for members, including funding schemes, and the development of the crematoria themselves. It also includes records of the International Cremation Society, particularly their annual conferences around the world. A professionally qualified archivist will be employed for six months to: 1. Sort and produce an online catalogue of the archival material to the current best practice ISAD(G) guidelines, overseen by similarly qualified professionals. 2. Package, box and label the material using the appropriate archival-quality materials to ensure long-term preservation and accessibility of the material, with the advice of professionally-qualified conservation staff.
Impressive reductions in malaria have occurred throughout sub-Saharan Africa over the past 12 years. However progress has not been geographically uniform and there are some high-burden countries where, despite good coverage with long lasting insecticide-treated nets (LLINs), the main preventative measure recommended by WHO, parasite prevalence rates and mortality from malaria remain obstinately high. Burkina Faso falls into this category. Despite two successful national LLIN distribution campaigns 60 % of children are persistently infected with malaria. Increased resistance to the pyrethroid insecticides used in LLINs and extensive transmission by mosquitoes biting outside the home, or at times when people are not protected by LLINs, are likely reducing the impact of LLINs but the relative importance of these poorly characterised vector factors, in relation to other human or health system factors has never been determined. This project will collect extensive empirical data and use models of malaria transmission to quantify the level of protection provided by LLINs in an insecticide resistant Africa. Via a detailed understanding of the factors limiting the efficacy of current tools we will identify the most cost effective, complementary interventions that would drive malaria transmission towards zero.
The Hububb Hub at Wellcome Collection. 30 Sep 2016
The urge to be busy defines modern life. Rest can seem hard to find, whether in relation to an exhausted body, a racing mind or a hectic city. Should we slow down, or should we embrace intense activity? What effects do each of these states have on the health of our bodies and minds? Such questions frequently find their way into media reports and everyday conversations, but there has never been any sustained interdisciplinary attempt to answer them. In The Hubbub Hub, international experts investigating hubbub and rest at different scales will, for the first time, be gathered in a shared space – to breathe new life into the questions we ask about rest and busyness. Our ambitious project will be nourished by the unique resources available in Wellcome Collection and the noisy city beyond, and from the start the public and Wellcome Trust staff will be at its heart. The Hub is the uniquely versatile space we need to perform rigorous, creative research and to stage our scientific and artistic experiments, data-gathering and public events. While neuroscientists study the ‘resting’ brain, artists will explore the borders between signal, sound and noise, psychologists will track the activity of our bodies, and social scientists will map the city’s noise and silences. Our multidisciplinary team will transcend boundaries of scientific and artistic practice, leaving a rich legacy for academic and creative inquiry, clinical practice and public policy, and for the Hub’s future as a crucible for world-leading interdisciplinary research.
With the support of the Wellcome Trust, the Durham Centre for Medical Humanities will become a nexus for world class medical humanities research. Spanning disciplines and periods, this research seeks to improve human health through an enhanced understanding of human experience. Over the next five years we will extend the significance and impact of existing medical humanities initiatives at Durham, while also fostering new ideas and projects within four distinct strands of work. Our central goals are to develop more effective ways of understanding human experience; to build interdisciplinary research projects that will enable us to influence clinical and health research, practice and policy; to transform views about and approaches to health care research by involving multiple stakeholders; and to promote and champion our approach across disciplinary, institutional and wider research contexts. Key to achieving these ambitious and longer-term goals will be an application for Wellcome Trust Centre status to continue our work beyond the period of this award.
Assuring the future of medical humanities in the UK: a post-graduate conference Embodied understandings . 11 Feb 2013
Funding is requested to enable free participation in the first dedicated conference for post-graduates in Medical Humanities: Understanding human flourishing: a postgraduate medical humanities conference. 16-17 May 2013, Durham University. Front page Costs include catering and the expenses of three visiting speakers. Medical Humanities is growing rapidly with several new interdisciplinary university centres across the UK. Ensuring this continued growth and future research excellence in Medi cal Humanities requires recognition and intellectual support for the burgeoning community of postgraduates associated or self-affiliating with these new initiatives. The conference is timely in bringing together these postgraduate researchers to explore and exchange their interdisciplinary perspectives and methods on health, illness and human flourishing and to build networks and collaborative relationships for the future. A panel discussion on academic publishing will provide information and ad vice for those embarking on a career in medical humanities. The keynote speaker is Professor Stuart Murray, director of the new Centre for Medical Humanities at Leeds University. Panellists are Professor Brian Hurwitz from the Wellcome-supported Centre for Humanities and Health at Kings College, London and Dr. Deborah Kirklin, editor of the BMJ Medical Humanities journal, London, who join Professor Martyn Evans, co-director of Wellcome-supported Durham Centre for Medical Humanities
Trust, risk and uncertainty in medicinal transactions in Sub-Saharan Africa: Integrating Behavioural Game Theory and Ethnography to develop a robust analytical framework to address a major global public health challenge. 18 Sep 2015
Medicines are at the centre of a major global public health crisis. Widespread counterfeiting and unprecedented global traffic of pharmaceuticals have created significant trust problems for patients and others, particularly where regulation is weak, with serious risks for individual and public health. We propose to develop a robust analytical framework to understand the mechanisms that foster the production of trust in medicinal transactions in sub-Saharan Africa. Our question is: how, under con ditions of uncertainty and informational asymmetry, do actors (consumers and providers) come to trust and distrust particular medicines, and how does this shape practice? Our goal is to bring together the richness of ethnographic enquiry with the powerful analytical approaches offered by Behavioural Game Theory in order to address this pressing global public health problem. This seed award application, to support the development of a full Wellcome Collaborative proposal, would be used to conduct a pilot and feasibility study in Ghana and Tanzania; collect preliminary data to underpin theoretical and methodological development; build/consolidate international academic and stake-holder partnerships; and develop local research capacity. This is particularly important given the theoretically-novel and ambitious nature of the proposed larger study and the new international, inter-disciplinary research consortium we are building.
Funding is requested to support a conference to be held at Durham University in September 2015, aimed at new and emerging researchers in the field of mad studies. Titled Making Sense of Mad Studies, this meeting will provide a vital opportunity for early-career (postgraduate and postdoctoral) researchers working in and around mad studies to explore critical new directions in researching madness and to forge the connections and collaborations required for the development of a thriving new genera tion of mad studies scholars. The conference emerges out of and draws from the successes of the nationally recognized North East Mad Studies Forum, founded by postgraduate members of the Durham University Centre for Medical Humanities in 2013 (now proposed chairpersons for this event). This proposal represents the second international postgraduate conference to emerge from the postgraduate community at the Durham Centre for Medical Humanities, following the symposium on Human Flourishing, funded by the Wellcome Trust in 2013. Confirmed keynote speakers include Prof Peter Beresford (Brunel), Prof Brendan Stone (Sheffield University), Dr Helen Spandler (University of Central Lancashire) and Dr Kathryn Church (Ryerson University, Toronto). In keeping with the ethos of mad studies, participation from non-academic/service-user communities will be integral to the conference design.
'Frissure': a book about a scar. 16 Jul 2012
Following a diagnosis of breast cancer and resulting mastectomy the poet, Kathleen Jamie approached artist, Brigid Collins, 'to be her eyes'. The ensuing sittings and conversations between poet and artist began as an exploration of line, initially Kathleen's mastectomy scar line, but they also became a 'laying down of layers', of reciprocity, of experience and, ultimately, of transformation. These sittings prepared the ground from which a significant body of work began to emerge, consist ing of a series of prose poems and of artworks. At its heart lies a consideration of a particular way of looking. It contrasts the artist's looking with the 'medical gaze'. In these works the subject: the scar, or line, is not the end of the story, but instead it leads out of loss, and back into the natural world, and the beautiful. This work has been developed in association with discussions during Kathleen's fellowship at Durham University's Centre for Medical Humanities which is supp orting the development of an art book entitled 'Frissure'. The book combines the prose poems and the images to create an object of beauty that is intended to explore the disruption of the body and its transformation as a result of surgery.
Identity and role of integral membrane proteins of Nuclear Envelope Precursor Vesicles in Membrane Fusion and Nuclear Pore Assembly. 10 Nov 2008
Two distinct Nuclear Envelope Precursor (NEP) vesicles in Xenopus eggs, NEP-A and NEP-B, are essential for Nuclear Envelope (NE) assembly. Recently, we showed that fusion between NEP-A and NEP-B initiates the formation of Nuclear Pore Complexes (NPCs). This might be because essential components of NPCs are segregated between each NEP and can only interact following vesicle fusion. Alternatively, remodelling of membranes during fusion might topologically favour NPC assembly. The proposed investig ations will test these hypothesise. Our first objective is to use a proteomic approach (MudPIT) to identify NEP-A and NEP-B specific proteins. Our second objective is to use a rational bioinformatics approach to identify those proteins in NEP-A that could be involved in NPC assembly (we already know which NEP-B proteins are involved in NPC assembly). Our third objective is to use immunogold E.M, live confocal imaging and protein-protein interaction assays to further refine the list of NEP-A prot eins likely to be involved in NPC assembly (because they are located within NPC assembly intermediates and/or interact with NPC proteins). Our final objective is to use functional assays to determine whether, within a final list of candidate proteins, some or all are necessary for NPC assembly.
Our programme will build upon our studies of the MtrCDE multi-drug pump from Neisseria gonorrhoeae. We have overproduced MtrC, D and E; and established via pull-down assays, chemical cross-linking and microcalorimetry that MtrD and MtrE can interact with MtrC and with one another. Our aims are to map the sites of interaction by proteolytic-fragmentation and mass-spectrometry fingerprinting of the cross-linked proteins. This will enable us to model the docking of the proteins as a guide to the in sertion of cysteines for cross-linking to stabilise the ternary-complex for imaging by AFM. Ultimately, our aim is to build an atomic-resolution model of the assembly by docking the high-resolution structures of the individual proteins into the AFM topographs. Towards this end, we have already obtained crystals of each protein that diffract to around 7-8 that will be further optimized for high-resolution diffraction. As an alternative strategy we will undertake the crystallisation and structure determination of the binary- and ternary-complexes. We will utilise our docking models and/or structures to identifying residues that can stabilize the ternary-complex; mutate these residues and test for pump assembly (via pull-down assays, microcalorimetry and by monitoring the interaction of fluorophore-labelled proteins by fluorescence-energy-transfer) and function (via resistance assays).
Pseudomonas aeruginosa is an opportunistic pathogen that causes acute infections (sepsis) predominantly in victims with large or burn wounds, chronic infections in immuno-compomised patients such as people in cancer chemotherapy and chronic pulmonary infections and inflammation in cystic fibrosis patients. While a large number of virulent factors expressed and secreted by the pathogen are known, the precise cellular and molecular mechanisms of these remain largely elusive. PlcHR from P. aerugino sa, a complex extracellular toxin represents a major virulence factor that has been shown to be selectively cytotoxic to mammalian endothelial cells that line the interior surface of all blood vessels. They play key roles in thrombosis, inflammation and the formation of new blood vessels. It has therefore been suggested that PlcHR is directly involved in the cellular mechanisms responsible for the vascular lesions and poor wound healing associated with P. aeruginosa septicemia and sepsis. Furth ermore, PlcHR has been shown to exhibit strong anti-angiogenic attributes that could be exploited for example in the treatment of tumors. Deciphering the molecular basis of PlcHR activity is therefore of major medical importance.
Open Access award. 31 Oct 2006
Grant Proposal under the Value in People Award scheme, to cover the cost of open access publishing any research paper resulting from Trust funding that has been accepted for publication in an open access journal or a journal that offers authors an open access choice for the payment of a fee (sometimes known as page processing charges).
Community Healthy Living Advisor Volunteers 22 Jun 2006
The Manchester branch of Community Service Volunteers runs a range of projects that encourage people to take up learning via its Media Clubhouse. With this award it will deliver workshops, led by a qualified nutritionist, aimed at individuals who want to become volunteer healthy living advisors. The volunteers will be recruited from groups with multiple disadvantages as well as minority groups based in and around the City Centre.