- Total grants
- Total funders
- Total recipients
- Earliest award date
- 10 Apr 2001
- Latest award date
- 16 Jul 2018
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
Cremation Archive Cataloguing Project 25 Nov 2016
The principal objective of this project is to catalogue and make accessible for research archive material of the Cremation Society of Great Britain. This will provide an invaluable resource for academic research by various disciplines into cremation and society's disposal of its dead. The Cremation Society of Great Britain first deposited journals and part of its archive with Durham University in 1998. These were catalogued and made available for research. The Society then made a further substantial addition to that material in 2015, which now needs to be catalogued. The material covers all aspects of the Society's administration dating back to the late 19th century, the provision of its facilities for members, including funding schemes, and the development of the crematoria themselves. It also includes records of the International Cremation Society, particularly their annual conferences around the world. A professionally qualified archivist will be employed for six months to: 1. Sort and produce an online catalogue of the archival material to the current best practice ISAD(G) guidelines, overseen by similarly qualified professionals. 2. Package, box and label the material using the appropriate archival-quality materials to ensure long-term preservation and accessibility of the material, with the advice of professionally-qualified conservation staff.
Identification of Alternative Transcript Isoform Switches in Ageing and Senescene using Next Generation Sequencing (RNA-seq) 01 Apr 2016
During my project I aim to identify genes with alternatively expressed isoforms in mice when the individuals are subject to normal ageing, and/or under calorie restricted diet ageing. I will further study the selected candidate isoform switches, such as those predicted to regulate insulin signalling for mTOR pathways, in depth, with the intention of understanding their mechanism of regulation and how this causes the debilitating effects as so commonly associated with ageing. As the calorie-restricted diet has proved to significantly increase lifespans of mice I am personally interested to find isoforms and the mechanism that results in this drastic change between the two populations. Using the results of the bioinformatics analysis I will select candidate splice switches through filtering the data based on: statistical measure; relevance to ageing; relevance to restricted diet ageing. Once identified, the isoform switching regulatory mechanism will be studied using mini-gene constructs and designed primers to confirm the alternative events across ageing from mouse RNAs. In the future site directed mutagenesis will be used to identify the regulatory elements involved. These results could be used to target regulation of specific isoforms that may play roles in causing age-related cellular loss of function and cell senescence.
The project uses Law as a medium to inform, inspire and involve 16-18 year old students in exploring conceptual, social and ethical issues related to human cloning and stem cell research. Law represents one of the most important means by which society decides and communicates its values, so offers an ideal medium for debate. The project will deliver events in three streams: one on stem cell research in 2014; a second on human cloning in 2015; and a third involving dissemination in 2016. Stre ams 1 and 2 each comprise three days: one teacher preparation, one student preparation and one law-in-action workshop. Student preparation days will provide scientific background knowledge. Law-in-action workshops will involve student participation in a mock parliamentary debate (stream 1) and a mock court case (stream 2). Students' and teachers' understandings of the science and responses to events will be measured using education research methodologies. Stream 3 will disseminate outcomes via p ublication of research findings and CPD for teachers and lecturers, enabling replication of Stream 1 and 2 events. The principal objective is to develop young people's conceptual, ethical and social understanding of arguments/issues surrounding stem cell research and human cloning by providing insights into the means by which our legal system addresses and/or resolves controversies. This will be achieved by providing knowledge and opportunities to engage in constructive, structured debate and discussion. Participants will be better equipped as active members of a society in which these technologies may feature as sources for medical treatments.
The Hububb Hub at Wellcome Collection. 04 Mar 2014
The urge to be busy defines modern life. Rest can seem hard to find, whether in relation to an exhausted body, a racing mind or a hectic city. Should we slow down, or should we embrace intense activity? What effects do each of these states have on the health of our bodies and minds? Such questions frequently find their way into media reports and everyday conversations, but there has never been any sustained interdisciplinary attempt to answer them. In The Hubbub Hub, international experts investigating hubbub and rest at different scales will, for the first time, be gathered in a shared space – to breathe new life into the questions we ask about rest and busyness. Our ambitious project will be nourished by the unique resources available in Wellcome Collection and the noisy city beyond, and from the start the public and Wellcome Trust staff will be at its heart. The Hub is the uniquely versatile space we need to perform rigorous, creative research and to stage our scientific and artistic experiments, data-gathering and public events. While neuroscientists study the ‘resting’ brain, artists will explore the borders between signal, sound and noise, psychologists will track the activity of our bodies, and social scientists will map the city’s noise and silences. Our multidisciplinary team will transcend boundaries of scientific and artistic practice, leaving a rich legacy for academic and creative inquiry, clinical practice and public policy, and for the Hub’s future as a crucible for world-leading interdisciplinary research.
'Frissure': a book about a scar. 16 Jul 2012
Following a diagnosis of breast cancer and resulting mastectomy the poet, Kathleen Jamie approached artist, Brigid Collins, 'to be her eyes'. The ensuing sittings and conversations between poet and artist began as an exploration of line, initially Kathleen's mastectomy scar line, but they also became a 'laying down of layers', of reciprocity, of experience and, ultimately, of transformation. These sittings prepared the ground from which a significant body of work began to emerge, consist ing of a series of prose poems and of artworks. At its heart lies a consideration of a particular way of looking. It contrasts the artist's looking with the 'medical gaze'. In these works the subject: the scar, or line, is not the end of the story, but instead it leads out of loss, and back into the natural world, and the beautiful. This work has been developed in association with discussions during Kathleen's fellowship at Durham University's Centre for Medical Humanities which is supp orting the development of an art book entitled 'Frissure'. The book combines the prose poems and the images to create an object of beauty that is intended to explore the disruption of the body and its transformation as a result of surgery.
Identity and role of integral membrane proteins of Nuclear Envelope Precursor Vesicles in Membrane Fusion and Nuclear Pore Assembly. 10 Nov 2008
Two distinct Nuclear Envelope Precursor (NEP) vesicles in Xenopus eggs, NEP-A and NEP-B, are essential for Nuclear Envelope (NE) assembly. Recently, we showed that fusion between NEP-A and NEP-B initiates the formation of Nuclear Pore Complexes (NPCs). This might be because essential components of NPCs are segregated between each NEP and can only interact following vesicle fusion. Alternatively, remodelling of membranes during fusion might topologically favour NPC assembly. The proposed investig ations will test these hypothesise. Our first objective is to use a proteomic approach (MudPIT) to identify NEP-A and NEP-B specific proteins. Our second objective is to use a rational bioinformatics approach to identify those proteins in NEP-A that could be involved in NPC assembly (we already know which NEP-B proteins are involved in NPC assembly). Our third objective is to use immunogold E.M, live confocal imaging and protein-protein interaction assays to further refine the list of NEP-A prot eins likely to be involved in NPC assembly (because they are located within NPC assembly intermediates and/or interact with NPC proteins). Our final objective is to use functional assays to determine whether, within a final list of candidate proteins, some or all are necessary for NPC assembly.
To support the development of the WASSUP project.
Volunteer Britain 14 Jul 2005
Community Service Volunteers (CSV) works to reconnect people to their community through volunteering and training and to enrich people?s lives. This project will produce short audio and visual clips on volunteer's experiences, produced by the volunteers themselves. CSV will showcase the clips in order to recognise their efforts and promote volunteering to others, through radio, TV and at local community events. This will be done in conjunction with the 'Year of the Volunteer' campaign.
Lampton Community Gardens 15 Sep 2006
CSV Environment (Bristol) will promote and develop the community gardens and establish a volunteer community management group to sustain it for the benefit of all local residents.
Cole Haven 07 May 2007
This group will develop area of woodland located within the heart of Birmingham's inner city, and create an outdoor education available to local schools and the wider community.
Operation Strongbow 13 Feb 2008
This project in Stockton-on-Tees, based on successful previous work in Middlesbrough, is a volunteer-led initiative to support older people at risk of distraction burglary. Volunteers will visit vulnerable and older people in their homes, or in community settings such as day centres, to empower them to avoid doorstep crime. Older people will be alerted to the types of tricks used, simple steps they can take to avoid being victims, and the importance of reporting any incidents to the police.
CSV Vocal Project 15 Aug 2012
This grant will expand the volunteer project for people with learning disabilities into new parts of the county, offering a programme of training, volunteering and supported employment using community mentors. Called the Vocal Project, participants work with community volunteers who help them to access training and social events. As their confidence around people and skills develop, they will then gradually move into volunteering placements either in a group or an individual setting._x000B_