- Total grants
- Total funders
- Total recipients
- Earliest award date
- 26 Mar 2001
- Latest award date
- 26 Mar 2020
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
Development of an effective inactivated rotavirus vaccine (IRV) for developing countries: definition of rationale, business case, technical feasibility and overall development plan. 17 Sep 2012
Development of an effective inactivated rotavirus vaccine (IRV) for developing countries: definition of rationale, business case, technical feasibility and overall development planThis Pathfinder Award to Dr Audino Podda at the Novartis Vaccines Institute for Global Health in collaboration with Dr Jean-Pierre Amorij at InTraVacc in the Netherlands will provide pilot funding to assess the technical and commercial feasibility of developing a candidate inactivated rotavirus vaccine.The award will be used to assess if this candidate vaccine could provide advantages over existing live vaccines to offer a more effective and lower-cost solution for those most at risk of severe diarrhoea caused by rotavirus infection.
Developing a transformative therapy for inherited homocystinuria by correcting the misfolding of cystathionine beta synthase disease alleles 31 Aug 2012
This Pathfinder Award brings together world-class researchers from Pfizer Inc.’s Rare Disease Research Unit in Cambridge, MA (US), including Dr Christine Bulawa of Pfizer, and the Structural Genomics Consortium (SGC) in Oxford (UK), including Dr Wyatt Yue, to study cystathionine beta synthase (CBS) deficiency. CBS deficiency is a rare genetic disorder in which affected people cannot process the amino acid methionine. In many patients, a genetic defect causes the CBS enzyme to lose its optimal three-dimensional shape and prevents the enzyme from functioning properly. This leads to the build up of homocysteine in the body, causing an array of symptoms including early cardiovascular disease. The current standard of care is to reduce homocysteine levels by a methionine-restricted diet or supplementation with vitamin B6, a cofactor for the CBS enzyme. However, this does not treat the underlying cause of the disease, and many patients do not respond to these treatments. During the course of this collaborative research, scientists at Pfizer and SGC aim to develop biochemical and molecular tools to facilitate discovery of a potential drug that restores the optimal shape and function to the defective CBS protein, thereby treating the root cause of the disease.
Development of human induced pluripotent stem cells (iPSCs) in patients with neurodegeneration with brain iron accumulation (NBIA) 17 Sep 2012
A Pathfinder Award to Dr Michael Hutton at Eli Lilly, in partnership with Professor John Hardy at UCL, will provide pilot funding for this Industriy-Academic partnership to work on the rare disorders termed Neurodegeneration with brain iron accumulation (NBIA).This is a group of rare, severe neurological disorders that are characterised by parkinsonism, cognitive decline and dystonia. The Award will fund the development of human induced pluripotent stem cells (iPSCs) cells offers a way to develop in vitro models of these diseases in the laboratory, without exact knowledge of the disease mechanism(s). The cell characteristics will enable these models to be amenable to drug treatment from the array of therapeutic compounds held by Lilly going forward.
The Dewar Commission and the Highlands and Islands Medical Service: 100 years of state health services 25 Jun 2012
Guru Magazine is a social enterprise that publishes a free bi-monthly digital science periodical with accompanying online content. A science-lifestyle magazine, it presents research-based science in everyday language. Guru is a crowd-sourced project that prides itself on picking the very best science communicators to contribute articles. Launched in June 2011, Guru has provided content to meet the needs of a non-academically trained readership (male and female 25-35 year olds a hitherto poor ly catered-for population in science publishing). Guru Magazine provides relevant, interesting and topical adult reader entirely free of charge. The magazine also provides opportunities for new, emerging and passionate communicators to publish high quality content, accessible to all. After publishing five issues, Guru Magazine has received endorsements from the mainstream media and scientific community for its engaging content and original approach (1-5). It has featured the writing of prominent scientists, achieved an estimated 50,000 magazine downloads, and attracted an active social media following (Facebook and Twitter). To take the magazine forward and increase its goal of stimulating interest and excitement about science, funding is sought to enable the three founding members of Gurus to work part time, allowing them to dedicate time and resources to producing and promoting the magazine. Funding will be used to develop a free cross-platform mobile application (App) for smartp hones and tablets, promoted and published via mainstream digital outlets (Apples Newsstand, etc) and integrated with social media in order for us to develop and test new methods of engagement between the public and biomedical science.
BEANii Bodyscience Children's Theatre Project: 1837 vs 2012 is a series of creative learning workshops leading to presentations for families and teachers of participating children (aged 8-10), culminating in a public show. The project builds on BEANii's 10-weekly bodyscience course and community project of creative learning workshops which increase children's understanding of nutrition, exercise and psychology. The effectiveness of our methodology was demonstrated through an average score of 70% correct answers to bodyscience questions achieved by child participants. This project will extend content, reach and capacity of the existing programme for schools and communities in South Westminster initially, over two phases which complement but are independent of each other. Phase 1 will develop and deliver 2 sets x 1 school workshop to explore with 60 Year 4 & 5 children diets, lifestyle and psychology which affected childhood growth in 1837. The workshops will support curriculu m learning in science and history, leading to presentations for families and teachers (120 people). Phase 2 will develop and deliver 1 set x 12 community workshops for 30 children leading to a children's theatre show. The show will ask the audience (150 people) to decide whether early intervention based on current biomedical understanding of nutrition, exercise and positive psychology could have saved the life of Dickens' sister-in-law, Mary Hogarth, who died of heart failure in 1837, aged 17 . A project steering group will be established to facilitate collaboration between delivery team, scientists, historians and theatre professionals, ensuring quality and sustainability of the project.
Research.ms stage 2. 11 Jul 2012
Research.ms is striving to transform the way scientists communicate their work to the multiple sclerosis (MS) community; to reshape MS research by encouraging dynamic communication between people with MS (MSers) and researchers. The Research.ms team is applying for a second People Award to build on the success of the first. The Research.ms vision is to engage with researchers and MSers across the globe, using innovative, interactive online platforms. It enables user involvement in the design of research, using online platforms as direct feedback tools between MSers and researchers. Research.ms stage 2 will expand partnerships to other MS research centres across the UK and Northumbria Design School. The collaboration with Queen Mary University (QM) under Professor Gavin Giovannoni will continue. UCL Partners under Professor Alan Thompson will also collaborate. This is an exciting opportunity to ensure the public engage with world-leading research, and the project outputs are prof essionally designed. Outside the scope of this grant Research.ms also works with the Cambridge research team under Dr Alisdair Coles. Both UCL and Cambridge approached Shift.ms after hearing about Research.ms. The aim is to harness this growing reputation and work with more centres. The project will continue producing compelling online content across a broad spectrum of biomedical research, allowing researchers and MSers to communicate directly. It will also train the research teams in key communication skills, with and for the MS community. Researchers will be equipped with the skills to grow their own public engagement work and reach an audience beyond the Shift.ms community.
Science is for Parents Too. 11 Jul 2012
The project will promote adult engagement with biomedical sciences through a sustained learning programme for parents (with limited scientific education) of primary school children. As a result of this science enrichment initiative, parents will be better able to support their children's education and career options with regard to the sciences. Broadly aligned to the Key Stage 2 science curriculum, we will focus primarily on biomedical science, with elements of complementary chemistry, physics a nd maths through a biomedical lens to demonstrate the relationships between the sciences. Our proposition is that raising aspiration is best effected by cascading learning through the family, to ensure that education becomes recognised as a viable proposition for all within a household. The intention is to make an impact on both the adults who engage directly and their immediate family circle, in an attempt to make bioscience a topic for family conversation, encourage scientific questioning, and erode past negative experiences. The learning experience will be delivered in a creative and imaginative way, with practical demonstrations of concepts, complemented by science site visits and experiments which can be undertaken with the family. We perceive this as a pilot which will develop a sustainable teaching resource that could be deployed elsewhere. It will be delivered in partnership with the National Science Learning Centre which will host taught sessions; the possible longer-te rm ambition however is to upscale the project and deliver via the regional Science Learning Centres and NSLC partners in the devolved nations, to gain national coverage.