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Recipients:
University of Cambridge
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Results

Symposium on Drugs, Politics and Society in the Global South 30 Apr 2016

<p>The two-day symposium intends to tackle the issue of illicit drugs through an interdisciplinary, multi-sited approach, which is also peculiar to the tradition of St Antony&rsquo;s College and the Department of Politics and International Relations at Oxford. The objective is to bring together scholars whose interest in drug politics, <em>sensu lato</em>, and area expertise can contribute to triggering meaningful comparative debate. By focusing on several themes in two days, this would allow a comprehensive discussion of major aspects of drug policy around the world. One major contribution of this symposium would be to discuss the issue of drugs in those regions, which have often been left out of the international drug policy debate. Apart from scholars working on Latin American drug politics, the events will include participation of scholars working on the Middle East, Russia, Africa and China. This would fit the area studies vision that is peculiar to the hosting college, St Antony&rsquo;s, which is known to have a strong international perspective. Similarly, it will allow reserachers from the Department of Politics and International Relations to attend and participate in the event, thus injecting new analytical and investigative input into the ongoing themes of research existing in Oxford.</p>

Amount: £5,000
Funder: The Wellcome Trust
Recipient: University of Oxford

Evaluation of feasibility of assessing liver function during ex situ liver perfusion using microdialysis 01 Apr 2016

<p>Each year 15% of patients on the UK liver transplant waiting list die awaiting a donor liver, while a significant proportion of livers go unused because clinicians are&nbsp;unsure that the liver would provide life sustaining function. We are now able to perfuse a liver&nbsp;ex situ&nbsp;with oxygenated blood while evaluating markers of damage&nbsp;and function, enabling better assessment of organ viability.&nbsp;<br /><br />Microdialysis is a method in routine use in neurosurgery to evaluate brain metabolism following trauma, and involves passing a fine dialysis catheter into the brain parenchyma and perfusing it with an isotonic perfusate and examining the dialysate for metabolic markers such as glucose, lactate, and pyruvate. It can also be&nbsp;used to interrogate metabolism by introducing labeled substrates. &nbsp;Microdialysis has been used to study liver transplants post transplant, but has not been used to&nbsp;evaluate function&nbsp;ex situ&nbsp;where its relatively rapid readout may facilitate early and accurate decision making.<br /><br />This project will examine the feasibility of using microdialysis in perfused livers. &nbsp;Human livers that have been declined for transplantation will be studied and the&nbsp;optimal technique developed. Microdialysis results will be correlated with perfusate chemistry (lactate fall, maintenance of pH, ALT, AST) and metabolomic profile.</p>

Amount: £2,000
Funder: The Wellcome Trust
Recipient: University of Cambridge

Biomedical Vacation Scholarship Programme - University of Cambridge 30 Sep 2019

<p>This award is for 6 students per year for 5 years. It includes ?a salary at the national living wage plus holiday pay and national insurance or equivalent,?as well as?funds to cover or significantly subsidise accommodation and travel (&pound;1500 outside of London and up to &pound;2000 in London).??? It includes &pound;500 to each studentship towards research expenses.??? Unspent funds can be repurposed on further students or recruitment costs.&nbsp; Wellcome wishes to ensure a greater diversity of students (in relation to socio-economic background and ethnicity) progress to postgraduate research.&nbsp;<br> Over 5 years of the Programme we encourage organisations to aim for:&nbsp;&nbsp;<br> <br> -At least 50% of students recruited to the programme to be from underrepresented or disadvantaged groups, depending on priorities set by each organisation.&nbsp;&nbsp;<br> <br> -At least 50% of students recruited to the programme to be from non-Russell Group Universities. For the remaining 50%, organisations should consider how to recruit students from other universities as well as their own. Wellcome has included this recommended target as research indicates that most of the high-achieving STEMM graduates from minority ethnic backgrounds are located outside of Russell Group universities.&nbsp;&nbsp;</p>

Amount: £166,500
Funder: The Wellcome Trust
Recipient: University of Cambridge

Biomedical Vacation Scholarship Programme - University of Oxford 30 Sep 2019

<p>This award is for 6 students per year for 5 years. It includes ?a salary at the national living wage plus holiday pay and national insurance or equivalent,?as well as?funds to cover or significantly subsidise accommodation and travel (&pound;1500 outside of London and up to &pound;2000 in London).??? It includes &pound;500 to each studentship towards research expenses.??? Unspent funds can be repurposed on further students or recruitment costs.&nbsp; Wellcome wishes to ensure a greater diversity of students (in relation to socio-economic background and ethnicity) progress to postgraduate research.&nbsp;<br> Over 5 years of the Programme we encourage organisations to aim for:&nbsp;&nbsp;<br> <br> -At least 50% of students recruited to the programme to be from underrepresented or disadvantaged groups, depending on priorities set by each organisation.&nbsp;&nbsp;<br> <br> -At least 50% of students recruited to the programme to be from non-Russell Group Universities. For the remaining 50%, organisations should consider how to recruit students from other universities as well as their own. Wellcome has included this recommended target as research indicates that most of the high-achieving STEMM graduates from minority ethnic backgrounds are located outside of Russell Group universities.&nbsp;&nbsp;</p>

Amount: £166,500
Funder: The Wellcome Trust
Recipient: University of Oxford

Biomedical Vacation Scholarship Programme - University College London 30 Sep 2019

<p>This award is for 6 students per year for 5 years. It includes ?a salary at the national living wage plus holiday pay and national insurance or equivalent,?as well as?funds to cover or significantly subsidise accommodation and travel (&pound;1500 outside of London and up to &pound;2000 in London).??? It includes &pound;500 to each studentship towards research expenses.??? Unspent funds can be repurposed on further students or recruitment costs.&nbsp; Wellcome wishes to ensure a greater diversity of students (in relation to socio-economic background and ethnicity) progress to postgraduate research.&nbsp;<br> Over 5 years of the Programme we encourage organisations to aim for:&nbsp;&nbsp;<br> <br> -At least 50% of students recruited to the programme to be from underrepresented or disadvantaged groups, depending on priorities set by each organisation.&nbsp;&nbsp;<br> <br> -At least 50% of students recruited to the programme to be from non-Russell Group Universities. For the remaining 50%, organisations should consider how to recruit students from other universities as well as their own. Wellcome has included this recommended target as research indicates that most of the high-achieving STEMM graduates from minority ethnic backgrounds are located outside of Russell Group universities.&nbsp;&nbsp;</p>

Amount: £197,340
Funder: The Wellcome Trust
Recipient: University College London

talking funny - sounding different 30 Sep 2019

<p>In Talking Funny, Sounding Different we will create a performance lab within the HUB, to experiment with, innovate and empower humans and their &lsquo;funny&rsquo; voices, from the written word to live theatre, from beat boxing to comedy. We will study the performance of the human voice as a potential source of anxiety and difficulty, and as a route to confidence and social contact. We will work with people with clinical voice issues, scientists, clinicians and artists to explore new art, new therapies and apply cutting edge neuroscience to our understanding of the voice and its effect on the audience. For this discretionary award, we are asking for funding for:</p> <p>meetings between the main collaborators, patient groups, &nbsp;and relevant artists and&nbsp;performers</p> <p>live events and rehearsal time to plan and develop the live events: these events will explore the possibilities of vocal performances across different groups of people, with an emphasis on people who 'sound funny' with an emphasis on voices that are rarely heard.</p>

Amount: £10,000
Funder: The Wellcome Trust
Recipient: University College London

Consolidating practice in social science research for Ebola, DRC. 30 Sep 2019

<p style="margin-left: 0cm; margin-right: 0cm">The response to the Ebola epidemic in North Kivu and Ituri provinces, Democratic Republic of Congo has been described as one of the most complex that national and international communities have had to face.Given the complexity of this protracted epidemic, social science research has become a critically important part of the response in order to help contextualise strategies, investigate social determinants of infection, and inform understanding and reception of interventions employed for outbreak control. To routinely generate this intelligence,&nbsp;&nbsp;an innovative solution has emerged in the form of the Cellule d&rsquo;Analyse en Sciences Sociales. UNICEF-funded, this group is made up predominantly of local and national social scientists.&nbsp;&nbsp;Other ad hoc social science research is also being conducted in the field. Through this proposal we aim to consolidate learning and articulate what is needed to replicate similar initiatives in future outbreaks. We will provide remote technical support, conduct structured critical appraisal of the field experience, capture lessons learned, and develop guidance and tools for the current and for future outbreaks. Our vision is to contribute to better outbreak prevention and response through excellence in social and behavioural science research, integrated into current and future responses to infectious disease threats.&nbsp;</p>

Amount: £75,161
Funder: The Wellcome Trust
Recipient: University of Oxford

Public Involvement in the Governance of Population Level Research 31 Aug 2019

<p style="margin-left: 0cm; margin-right: 0cm">Population-level research governance is at a critical juncture. Traditional governance tools, like informed consent and expert committee review processes, have been stretched beyond their ability to function in an effort to accommodate research at scale. While consensus on the importance of involving the public&nbsp;in governance exists, there is little agreement on what such involvement means in practice, when it should be undertaken, and what the primary justifications for it are. There is also little understanding of how involvement approaches integrate with other legal and regulatory structures to effectively inform governance.</p> <p style="margin-left: 0cm; margin-right: 0cm">Primary aims:</p> <ul> <li>Conduct scoping work which examines:</li> </ul> <ol> <li>How should we characterise the range of governance and regulatory challenges that confront us with respect to population-level biomedical research?</li> <li> <p style="margin-left: 0cm; margin-right: 0cm">What approaches are currently being used to address these challenges and how, if at all, do these techniques incorporate elements of public involvement?</p> </li> <li> <p style="margin-left: 0cm; margin-right: 0cm">Where are potential areas that public involvement might be introduced to meet these governance challenges?</p> </li> </ol> <ul> <li>Build an international network which focuses on the intersection of governance and societal involvement in the context of population-level biomedical research</li> <li>Develop a larger research proposal that will address the role of societal involvement in governance challenges in this context.</li> </ul>

Amount: £29,320
Funder: The Wellcome Trust
Recipient: University of Oxford

Building a social science research agenda to explore the local contexts of viral hepatitis 31 Aug 2019

<p style="margin-left: 0cm; margin-right: 0cm">Viral hepatitis is a global health threat that contributes to more annual deaths than HIV&nbsp;or malaria. Hepatitis B virus can be prevented by early vaccination or treated with antiviral drugs and hepatitis C virus can be cured safely and effectively with direct acting antivirals, yet screening, diagnosis and treatment remain low on a global scale. The way hepatitis is experienced and managed is context specific, making public health programmes dependent on an understanding of local knowledge and practices. Despite this, viral hepatitis is, generally, underfunded and understudied from a social science perspective.</p> <p style="margin-left: 0cm; margin-right: 0cm">The goal of this specific application is two-fold. First, to build upon an international platform of social science researchers working on research related to infectious disease threats to include a specific working group focused on viral hepatitis. Second, to create a core team of researchers from multiple contexts in East Africa, West Africa, and Southeast Asia to develop and prepare a larger collaborative research agenda<strong> </strong>related to viral hepatitis that will be implemented in low- and middle-income countries. We will host two meetings: one to discuss past and ongoing research and the second to develop a protocol for submission for a collaborative award.</p>

Amount: £27,800
Funder: The Wellcome Trust
Recipient: University of Oxford

One for All, All for One? 12 Sep 2019

<p style="margin-left: 0cm; margin-right: 0cm">How people think about vaccines is a global concern<u><sup>1</sup></u>. <em>&lsquo;One for All?&rsquo;</em> asks: &ldquo;How does engagement with herd immunity influence attitudes to immunisation?&rdquo;. By working in close partnership with communities, researchers, artists, healthcare professionals, experts by experience, policy-makers and creative engagement practitioners in Africa and the UK, we will co-create a range of graphic-based, online and print resources focused on herd immunity. Developing, testing, evaluating and sharing <em>&lsquo;One for All?&rsquo;</em> resources will</p> <ul> <li>Empower people who make decisions about immunisation (e.g. parents, guardians, community leaders, influencers, older children) to: <ul style="list-style-type: circle"> <li>Make informed choices about vaccination, informed by a set of resources based on robust research, common concerns and in context;</li> <li>Contribute actively and meaningfully to future research.</li> </ul> </li> <li>Enable researchers, fieldworkers, practitioners, policy-makers and healthcare professionals to &lsquo;do&rsquo; engagement with vaccines, based around concepts of herd immunity through the use of our creative, accessible and transferable resources;</li> <li>Inform research and engagement practice by testing and evaluating our central question and sharing our learning;</li> <li>Potentially reach further global audiences through strategic branding, campaigning and stakeholder engagement.</li> </ul> <p style="margin-left: 0cm; margin-right: 0cm"><em>&lsquo;One for All?&rsquo;</em> ultimately contributes to the goal of decreasing vaccine hesitancy and increasing vaccine uptake by contributing to the learning and practice of engagement with immunisation.</p>

Amount: £166,802
Funder: The Wellcome Trust
Recipient: University College London

Mesh Community Engagement Network 30 Sep 2019

<p>Mesh Community Engagement Network (<u>www.mesh-ce.org</u>) is a collaborative open-access webspace and networking project for people involved in community&nbsp;engagement with global health research (CE). Building on a successful pilot, we propose a new three-year strategic approach with a&nbsp;focus on measuring impact, using a <em>Theory of Change</em>&nbsp;to provide clarity on how we expect to make a difference to global health by supporting better research.</p> <p style="margin-left: 0cm; margin-right: 0cm">We have&nbsp;three aims: To ensure the value of CE is recognised by a diversity of global health stakeholders and is considered an integral part of research; to generate and strengthen leadership and capacity; and to increase outcomes-focussed, innovative CE. Mesh&rsquo;s vision for the future is that all global health research incorporates high-quality CE built on evidence, good practice and strong networks.</p> <p style="margin-left: 0cm; margin-right: 0cm">Capitalising on the project&rsquo;s impressive reach, geographical spread and high-level partnerships, we will secure a small&nbsp;team and move management from Wellcome to embed the project at The Global Health Network. A robust monitoring and evaluation plan will allow for greater agility and adjustments to the strategy and project delivery, increasing efficiency and leading to the development of Mesh as a low-cost and high-impact project in the future.<br> <br> Intro film (1min 43sec):&nbsp;<u>https://youtu.be/1jCHxbPLPlA</u></p>

Amount: £243,993
Funder: The Wellcome Trust
Recipient: University of Oxford

Inaugural Meeting of the Ebola Data Platform Data Access Committee 30 Sep 2019

<p>The Ebola Data Platform (EDP) strengthens knowledge and capacity across the health, research and humanitarian communities to reduce the impact of Ebola through responsible data reuse. The Data Access Committee (DAC) is a key pillar of the Platform&rsquo;s governance framework, facilitating access to data from the Platform for equitable research and to&nbsp;help tackle the most pressing challenges in the global response to Ebola.</p> <p>IDDO and the Data Access Committee Chair seek to&nbsp;convene the full DAC membership in person for an inaugural meeting in West Africa later in 2019. Key outputs expected from&nbsp;the meeting:</p> <ul> <li>Develop Data Access Guidelines for the EDP and finalise the DAC Terms of Reference.</li> <li>Strengthen the EDP plans to support research capacity across Ebola-affected countries.</li> <li>Align the EDP data access policies with other initiatives across West Africa and the continent.</li> <li>Provide feedback to the EDP Steering Committee on research priorities, issues in data access and promoting equity in data use.</li> </ul> <p>This application requests funding for travel, accommodation and subsistence&nbsp;during the two-day meeting for the 10 members of the DAC and two members of the Secretariat. The current DAC membership is mostly comprised of members from&nbsp;low-income countries, including those directly affected by Ebola.</p> <p>&nbsp;</p>

Amount: £19,879
Funder: The Wellcome Trust
Recipient: University of Oxford

Optical Biology 24 Jul 2019

<p>The &lsquo;Optical Biology&rsquo; PhD programme will train future research leaders to answer fundamental questions in biology by exploiting and developing state-of-the-art optical techniques. The programme brings together life scientists, physicists, chemists and computational scientists at UCL, with world-leading industrial and academic partners, to deliver an integrated training programme in the most advanced optical methods and analysis tools. This would be the first UK PhD programme offering multidisciplinary training in the major&nbsp;advanced light-based methods that are transforming all areas of biomedical research. The programme will be based at UCL, a world-leading environment where many major advances in optical techniques for biology have been developed, including ultra-fast 3D 2-photon microscopy, targeted 2-photon optogenetics, low power super-resolution imaging and whole-brain optical mapping. It will also offer students outstanding opportunities to undertake internships and training with our industrial and academic partners, promoting their career development and providing them with attractive post-PhD prospects.&nbsp;<br> <br> <em>Key programme goals:</em><br> <br> 1. To train researchers capable of developing and using state-of-the-art optical methods and associated analysis techniques.<br> <br> 2. To train researchers to use these methods to address fundamental biological problems.<br> <br> 3. To create researchers who engage, communicate and collaborate effectively with both industry and academia across disciplinary boundaries.</p>

Amount: £6,066,810
Funder: The Wellcome Trust
Recipient: University College London

Chemistry in Cells – New Technologies to Probe Complex Biology and Medicine. 24 Jul 2019

<p>This Programme will provide unique training for a new generation of scientists focusing on the quantification of biologically-important molecular interactions in physiologically-relevant settings. It is currently impossible to accurately and directly quantify interactions of molecules, and their consequences, in the complex physiological settings relevant to diagnosis and treatment of disease. To address this unmet need, we will harness physical science-based approaches to develop technologies that will underpin research across the spectrum of cell biology and biomedical science<br> <br> Scientific goals:</p> <ul> <li>Collaborative research outputs (papers, patents) using innovative approaches to provide new insights into biomedicine.</li> <li>Adoption of our technologies by the broad biomedical research community to study fundamental biology/diseases including Alzheimer&rsquo;s, schizophrenia and cancer.</li> </ul> <p><br> We have developed an innovative framework for our training programme, promoting a diverse and positive research culture change that we aim to propagate across Oxford and the UK.<br> <br> Culture-change goals:</p> <ul> <li>Promotion of a positive research culture in Oxford demonstrated by uptake of our practices across the University.</li> <li>Communication of our strategies&nbsp;<em>via&nbsp;</em>lectures on graduate education and publications in educational journals.&nbsp;</li> </ul> <p><br> These ambitious goals provide an exceptional basis for a multidisciplinary programme that trains scientist equipped as problem solvers for a diverse range of 21<sup>st</sup>century workplaces.&nbsp;</p>

Amount: £5,685,862
Funder: The Wellcome Trust
Recipient: University of Oxford

UCL Wellcome 4-year PhD in Mental Health Science 24 Jul 2019

<p style="margin-left: 0cm; margin-right: 0cm">Mental illness is a major public health problem, with poorly understood causes and highly variable treatment outcomes. While mental health research training has strength within disciplines, these typically operate in parallel, greatly impeding progress in improving clinical outcomes. The <strong>UCL Wellcome 4-Year PhD in Mental Health Science</strong> is an interdisciplinary, student-centred programme, which aims to train the next generation of research and policy leaders to succeed within mental health research fields, and foster greater cross-disciplinarity in future researchers. It leverages UCL&rsquo;s outstanding mental health research environment across three broad Themes: Mechanism, Population Mental Health, and Intervention. In Year 1, students will obtain experience in these different Themes through short rotation projects and courses, including areas outside their academic background; through this they will be exposed to new concepts and techniques, learn to &ldquo;speak the language&rdquo; of the different disciplines, and spot the synergistic connections between them. For the main PhD project in Years 2-4, students will select a supervisory team and Thesis Committee across all three Themes, enabling interdisciplinary mentorship. A strong emphasis will be placed on developing a distinct and supportive cohort identity, with continual skills development and preparation for transition following the Programme, whether within or outside academia.</p>

Amount: £5,757,810
Funder: The Wellcome Trust
Recipient: University College London

Genomic Medicine and Statistics 24 Jul 2019

<p>Genomic Medicine and Statistics (GMS) is a four-year doctoral training programme at the University of Oxford, established in 2008. Over the next 5-year funding period our goal is to train future leaders in the application of genomics to advance human health, equipping them with skills sets spanning experimental and analytical genomic science to address current roadblocks by innovating and realising the potential of genomics. We will do this through a cross-disciplinary approach addressing core themes including genomic and -omic technologies, functional genomics, genome biology, population genetics, evolution, pathogen genomics, genomics of disease, genomic analysis, and application of genomics for drug development, diagnostics, precision medicine and therapy. We will recruit students from diverse backgrounds with a track record of academic excellence and enthusiasm for this field. The first year will provide necessary core skills through taught modules with a minimum of two three-month rotations to gain exposure and training in different research environments prior to deciding on the topic of doctoral research, with additional training tailored to the needs of individual students. We will build a strong cohort, deliver a student-focused training experience with world-class training, supervision and pastoral support and actively manage student transitions including established internships with partner organisations.</p>

Amount: £5,685,862
Funder: The Wellcome Trust
Recipient: University of Oxford

Cellular Structural Biology 24 Jul 2019

<p>Structural biology continues to provide one of the most important toolsets for molecular biosciences. It also underlies many crucial industries, supporting biomedical advances in drug and vaccine development and molecular engineering. It continues to develop at pace. The recent electron cryo-microscopy revolution has been transformative and advances in tomographic methods prove likely to soon bridge the gap between molecular and cellular levels. It is essential that we train cohorts of students with these tools.&nbsp;<br> <br> We aim to provide outstanding broad training in structural biology methods, while students conduct exciting research projects. We expect these cohorts to contain future academic research leaders, who apply structural biology to important cellular systems and/or contribute to development of methodologies. We aim to train future leaders of industry, equipping them for research and development. Our program will also prepare students for a wide range of other future careers, providing project management experience, programming skills, and the experience of working in a precise and numerically rigorous scientific field. We will equip and support our students to transition to careers in academia, industry and beyond, while ensuring that we train a cohort to continue to apply and to develop structural biology into the future.</p>

Amount: £5,685,862
Funder: The Wellcome Trust
Recipient: University of Oxford

Wellcome Four Year PhD Programme in Stem Cell Biology and Medicine 24 Jul 2019

<p>Specialist post-graduate training in Stem Cell Biology and Medicine is essential to produce a stream of highly skilled and innovative investigators equipped with a deep understanding of stem cell science and its significance for future medicine. In this context, the Wellcome PhD Programme in Stem Cell Biology and Medicine is unique in the UK in focus and scope. The enduring popularity of the programme, which receives on average 200 applications per year, and the quality of research outputs and next destinations are testament to both the calibre of students we are able to recruit and to the high-quality training they receive. Our programme provides an environment that is intellectually rigorous and personally supportive for students, enabling them to set and attain research objectives. The programme is designed to develop analytical and critically-minded individuals. Since its inception in 2008, the PhD Programme has evolved in response to the expressed needs of students and continuous developments in modern Stem Cell Biology. Our overarching goal is to produce well-trained and rounded PhD graduates who have generated significant and original research findings and are fully prepared for an ambitious and challenging career, whether continuing in stem cell science or moving to another profession.<br> &nbsp;</p>

Amount: £6,051,821
Funder: The Wellcome Trust
Recipient: University of Cambridge

Adaptive Molecular Diagnostics 30 Sep 2019

<p>Our project will use genomic data and a detailed understanding of pathogen evolution to<br> deliver a robust, rapid, accurate and cost-effective pathogen detection kit for use in the field.</p> <p>Current methods are unsuitable for detection as they are slow, inaccurate and cannot be<br> field deployed. Our work has already changed the basic understanding of how cholera<br> spreads and identified high and low epidemic risks that are the cornerstones of disease<br> prevention. By making robust molecular indicator kits adapted to field settings we are able to<br> rapidly probe the likely behaviour of cholera strains and provide actionable data that can<br> make a direct contribution to a major human health challenge.</p>

Amount: £750,858
Funder: The Wellcome Trust
Recipient: University of Cambridge
Amount: £12,456
Funder: The Wellcome Trust
Recipient: University of Oxford