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University of Cambridge
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Symposium on Drugs, Politics and Society in the Global South 30 Apr 2016

<p>The two-day symposium intends to tackle the issue of illicit drugs through an interdisciplinary, multi-sited approach, which is also peculiar to the tradition of St Antony&rsquo;s College and the Department of Politics and International Relations at Oxford. The objective is to bring together scholars whose interest in drug politics, <em>sensu lato</em>, and area expertise can contribute to triggering meaningful comparative debate. By focusing on several themes in two days, this would allow a comprehensive discussion of major aspects of drug policy around the world. One major contribution of this symposium would be to discuss the issue of drugs in those regions, which have often been left out of the international drug policy debate. Apart from scholars working on Latin American drug politics, the events will include participation of scholars working on the Middle East, Russia, Africa and China. This would fit the area studies vision that is peculiar to the hosting college, St Antony&rsquo;s, which is known to have a strong international perspective. Similarly, it will allow reserachers from the Department of Politics and International Relations to attend and participate in the event, thus injecting new analytical and investigative input into the ongoing themes of research existing in Oxford.</p>

Amount: £5,000
Funder: The Wellcome Trust
Recipient: University of Oxford

Evaluation of feasibility of assessing liver function during ex situ liver perfusion using microdialysis 01 Apr 2016

<p>Each year 15% of patients on the UK liver transplant waiting list die awaiting a donor liver, while a significant proportion of livers go unused because clinicians are&nbsp;unsure that the liver would provide life sustaining function. We are now able to perfuse a liver&nbsp;ex situ&nbsp;with oxygenated blood while evaluating markers of damage&nbsp;and function, enabling better assessment of organ viability.&nbsp;<br /><br />Microdialysis is a method in routine use in neurosurgery to evaluate brain metabolism following trauma, and involves passing a fine dialysis catheter into the brain parenchyma and perfusing it with an isotonic perfusate and examining the dialysate for metabolic markers such as glucose, lactate, and pyruvate. It can also be&nbsp;used to interrogate metabolism by introducing labeled substrates. &nbsp;Microdialysis has been used to study liver transplants post transplant, but has not been used to&nbsp;evaluate function&nbsp;ex situ&nbsp;where its relatively rapid readout may facilitate early and accurate decision making.<br /><br />This project will examine the feasibility of using microdialysis in perfused livers. &nbsp;Human livers that have been declined for transplantation will be studied and the&nbsp;optimal technique developed. Microdialysis results will be correlated with perfusate chemistry (lactate fall, maintenance of pH, ALT, AST) and metabolomic profile.</p>

Amount: £2,000
Funder: The Wellcome Trust
Recipient: University of Cambridge

Biomedical Vacation Scholarship Programme - University of Cambridge 30 Sep 2019

<p>This award is for 6 students per year for 5 years. It includes ?a salary at the national living wage plus holiday pay and national insurance or equivalent,?as well as?funds to cover or significantly subsidise accommodation and travel (&pound;1500 outside of London and up to &pound;2000 in London).??? It includes &pound;500 to each studentship towards research expenses.??? Unspent funds can be repurposed on further students or recruitment costs.&nbsp; Wellcome wishes to ensure a greater diversity of students (in relation to socio-economic background and ethnicity) progress to postgraduate research.&nbsp;<br> Over 5 years of the Programme we encourage organisations to aim for:&nbsp;&nbsp;<br> <br> -At least 50% of students recruited to the programme to be from underrepresented or disadvantaged groups, depending on priorities set by each organisation.&nbsp;&nbsp;<br> <br> -At least 50% of students recruited to the programme to be from non-Russell Group Universities. For the remaining 50%, organisations should consider how to recruit students from other universities as well as their own. Wellcome has included this recommended target as research indicates that most of the high-achieving STEMM graduates from minority ethnic backgrounds are located outside of Russell Group universities.&nbsp;&nbsp;</p>

Amount: £166,500
Funder: The Wellcome Trust
Recipient: University of Cambridge

Biomedical Vacation Scholarship Programme - University of Oxford 30 Sep 2019

<p>This award is for 6 students per year for 5 years. It includes ?a salary at the national living wage plus holiday pay and national insurance or equivalent,?as well as?funds to cover or significantly subsidise accommodation and travel (&pound;1500 outside of London and up to &pound;2000 in London).??? It includes &pound;500 to each studentship towards research expenses.??? Unspent funds can be repurposed on further students or recruitment costs.&nbsp; Wellcome wishes to ensure a greater diversity of students (in relation to socio-economic background and ethnicity) progress to postgraduate research.&nbsp;<br> Over 5 years of the Programme we encourage organisations to aim for:&nbsp;&nbsp;<br> <br> -At least 50% of students recruited to the programme to be from underrepresented or disadvantaged groups, depending on priorities set by each organisation.&nbsp;&nbsp;<br> <br> -At least 50% of students recruited to the programme to be from non-Russell Group Universities. For the remaining 50%, organisations should consider how to recruit students from other universities as well as their own. Wellcome has included this recommended target as research indicates that most of the high-achieving STEMM graduates from minority ethnic backgrounds are located outside of Russell Group universities.&nbsp;&nbsp;</p>

Amount: £166,500
Funder: The Wellcome Trust
Recipient: University of Oxford

Consolidating practice in social science research for Ebola, DRC. 30 Sep 2019

<p style="margin-left: 0cm; margin-right: 0cm">The response to the Ebola epidemic in North Kivu and Ituri provinces, Democratic Republic of Congo has been described as one of the most complex that national and international communities have had to face.Given the complexity of this protracted epidemic, social science research has become a critically important part of the response in order to help contextualise strategies, investigate social determinants of infection, and inform understanding and reception of interventions employed for outbreak control. To routinely generate this intelligence,&nbsp;&nbsp;an innovative solution has emerged in the form of the Cellule d&rsquo;Analyse en Sciences Sociales. UNICEF-funded, this group is made up predominantly of local and national social scientists.&nbsp;&nbsp;Other ad hoc social science research is also being conducted in the field. Through this proposal we aim to consolidate learning and articulate what is needed to replicate similar initiatives in future outbreaks. We will provide remote technical support, conduct structured critical appraisal of the field experience, capture lessons learned, and develop guidance and tools for the current and for future outbreaks. Our vision is to contribute to better outbreak prevention and response through excellence in social and behavioural science research, integrated into current and future responses to infectious disease threats.&nbsp;</p>

Amount: £75,161
Funder: The Wellcome Trust
Recipient: University of Oxford

Public Involvement in the Governance of Population Level Research 31 Aug 2019

<p style="margin-left: 0cm; margin-right: 0cm">Population-level research governance is at a critical juncture. Traditional governance tools, like informed consent and expert committee review processes, have been stretched beyond their ability to function in an effort to accommodate research at scale. While consensus on the importance of involving the public&nbsp;in governance exists, there is little agreement on what such involvement means in practice, when it should be undertaken, and what the primary justifications for it are. There is also little understanding of how involvement approaches integrate with other legal and regulatory structures to effectively inform governance.</p> <p style="margin-left: 0cm; margin-right: 0cm">Primary aims:</p> <ul> <li>Conduct scoping work which examines:</li> </ul> <ol> <li>How should we characterise the range of governance and regulatory challenges that confront us with respect to population-level biomedical research?</li> <li> <p style="margin-left: 0cm; margin-right: 0cm">What approaches are currently being used to address these challenges and how, if at all, do these techniques incorporate elements of public involvement?</p> </li> <li> <p style="margin-left: 0cm; margin-right: 0cm">Where are potential areas that public involvement might be introduced to meet these governance challenges?</p> </li> </ol> <ul> <li>Build an international network which focuses on the intersection of governance and societal involvement in the context of population-level biomedical research</li> <li>Develop a larger research proposal that will address the role of societal involvement in governance challenges in this context.</li> </ul>

Amount: £29,320
Funder: The Wellcome Trust
Recipient: University of Oxford

Building a social science research agenda to explore the local contexts of viral hepatitis 31 Aug 2019

<p style="margin-left: 0cm; margin-right: 0cm">Viral hepatitis is a global health threat that contributes to more annual deaths than HIV&nbsp;or malaria. Hepatitis B virus can be prevented by early vaccination or treated with antiviral drugs and hepatitis C virus can be cured safely and effectively with direct acting antivirals, yet screening, diagnosis and treatment remain low on a global scale. The way hepatitis is experienced and managed is context specific, making public health programmes dependent on an understanding of local knowledge and practices. Despite this, viral hepatitis is, generally, underfunded and understudied from a social science perspective.</p> <p style="margin-left: 0cm; margin-right: 0cm">The goal of this specific application is two-fold. First, to build upon an international platform of social science researchers working on research related to infectious disease threats to include a specific working group focused on viral hepatitis. Second, to create a core team of researchers from multiple contexts in East Africa, West Africa, and Southeast Asia to develop and prepare a larger collaborative research agenda<strong> </strong>related to viral hepatitis that will be implemented in low- and middle-income countries. We will host two meetings: one to discuss past and ongoing research and the second to develop a protocol for submission for a collaborative award.</p>

Amount: £27,800
Funder: The Wellcome Trust
Recipient: University of Oxford

Mesh Community Engagement Network 30 Sep 2019

<p>Mesh Community Engagement Network (<u>www.mesh-ce.org</u>) is a collaborative open-access webspace and networking project for people involved in community&nbsp;engagement with global health research (CE). Building on a successful pilot, we propose a new three-year strategic approach with a&nbsp;focus on measuring impact, using a <em>Theory of Change</em>&nbsp;to provide clarity on how we expect to make a difference to global health by supporting better research.</p> <p style="margin-left: 0cm; margin-right: 0cm">We have&nbsp;three aims: To ensure the value of CE is recognised by a diversity of global health stakeholders and is considered an integral part of research; to generate and strengthen leadership and capacity; and to increase outcomes-focussed, innovative CE. Mesh&rsquo;s vision for the future is that all global health research incorporates high-quality CE built on evidence, good practice and strong networks.</p> <p style="margin-left: 0cm; margin-right: 0cm">Capitalising on the project&rsquo;s impressive reach, geographical spread and high-level partnerships, we will secure a small&nbsp;team and move management from Wellcome to embed the project at The Global Health Network. A robust monitoring and evaluation plan will allow for greater agility and adjustments to the strategy and project delivery, increasing efficiency and leading to the development of Mesh as a low-cost and high-impact project in the future.<br> <br> Intro film (1min 43sec):&nbsp;<u>https://youtu.be/1jCHxbPLPlA</u></p>

Amount: £243,993
Funder: The Wellcome Trust
Recipient: University of Oxford

Inaugural Meeting of the Ebola Data Platform Data Access Committee 30 Sep 2019

<p>The Ebola Data Platform (EDP) strengthens knowledge and capacity across the health, research and humanitarian communities to reduce the impact of Ebola through responsible data reuse. The Data Access Committee (DAC) is a key pillar of the Platform&rsquo;s governance framework, facilitating access to data from the Platform for equitable research and to&nbsp;help tackle the most pressing challenges in the global response to Ebola.</p> <p>IDDO and the Data Access Committee Chair seek to&nbsp;convene the full DAC membership in person for an inaugural meeting in West Africa later in 2019. Key outputs expected from&nbsp;the meeting:</p> <ul> <li>Develop Data Access Guidelines for the EDP and finalise the DAC Terms of Reference.</li> <li>Strengthen the EDP plans to support research capacity across Ebola-affected countries.</li> <li>Align the EDP data access policies with other initiatives across West Africa and the continent.</li> <li>Provide feedback to the EDP Steering Committee on research priorities, issues in data access and promoting equity in data use.</li> </ul> <p>This application requests funding for travel, accommodation and subsistence&nbsp;during the two-day meeting for the 10 members of the DAC and two members of the Secretariat. The current DAC membership is mostly comprised of members from&nbsp;low-income countries, including those directly affected by Ebola.</p> <p>&nbsp;</p>

Amount: £19,879
Funder: The Wellcome Trust
Recipient: University of Oxford

Chemistry in Cells – New Technologies to Probe Complex Biology and Medicine. 24 Jul 2019

<p>This Programme will provide unique training for a new generation of scientists focusing on the quantification of biologically-important molecular interactions in physiologically-relevant settings. It is currently impossible to accurately and directly quantify interactions of molecules, and their consequences, in the complex physiological settings relevant to diagnosis and treatment of disease. To address this unmet need, we will harness physical science-based approaches to develop technologies that will underpin research across the spectrum of cell biology and biomedical science<br> <br> Scientific goals:</p> <ul> <li>Collaborative research outputs (papers, patents) using innovative approaches to provide new insights into biomedicine.</li> <li>Adoption of our technologies by the broad biomedical research community to study fundamental biology/diseases including Alzheimer&rsquo;s, schizophrenia and cancer.</li> </ul> <p><br> We have developed an innovative framework for our training programme, promoting a diverse and positive research culture change that we aim to propagate across Oxford and the UK.<br> <br> Culture-change goals:</p> <ul> <li>Promotion of a positive research culture in Oxford demonstrated by uptake of our practices across the University.</li> <li>Communication of our strategies&nbsp;<em>via&nbsp;</em>lectures on graduate education and publications in educational journals.&nbsp;</li> </ul> <p><br> These ambitious goals provide an exceptional basis for a multidisciplinary programme that trains scientist equipped as problem solvers for a diverse range of 21<sup>st</sup>century workplaces.&nbsp;</p>

Amount: £5,685,862
Funder: The Wellcome Trust
Recipient: University of Oxford

Genomic Medicine and Statistics 24 Jul 2019

<p>Genomic Medicine and Statistics (GMS) is a four-year doctoral training programme at the University of Oxford, established in 2008. Over the next 5-year funding period our goal is to train future leaders in the application of genomics to advance human health, equipping them with skills sets spanning experimental and analytical genomic science to address current roadblocks by innovating and realising the potential of genomics. We will do this through a cross-disciplinary approach addressing core themes including genomic and -omic technologies, functional genomics, genome biology, population genetics, evolution, pathogen genomics, genomics of disease, genomic analysis, and application of genomics for drug development, diagnostics, precision medicine and therapy. We will recruit students from diverse backgrounds with a track record of academic excellence and enthusiasm for this field. The first year will provide necessary core skills through taught modules with a minimum of two three-month rotations to gain exposure and training in different research environments prior to deciding on the topic of doctoral research, with additional training tailored to the needs of individual students. We will build a strong cohort, deliver a student-focused training experience with world-class training, supervision and pastoral support and actively manage student transitions including established internships with partner organisations.</p>

Amount: £5,685,862
Funder: The Wellcome Trust
Recipient: University of Oxford

Cellular Structural Biology 24 Jul 2019

<p>Structural biology continues to provide one of the most important toolsets for molecular biosciences. It also underlies many crucial industries, supporting biomedical advances in drug and vaccine development and molecular engineering. It continues to develop at pace. The recent electron cryo-microscopy revolution has been transformative and advances in tomographic methods prove likely to soon bridge the gap between molecular and cellular levels. It is essential that we train cohorts of students with these tools.&nbsp;<br> <br> We aim to provide outstanding broad training in structural biology methods, while students conduct exciting research projects. We expect these cohorts to contain future academic research leaders, who apply structural biology to important cellular systems and/or contribute to development of methodologies. We aim to train future leaders of industry, equipping them for research and development. Our program will also prepare students for a wide range of other future careers, providing project management experience, programming skills, and the experience of working in a precise and numerically rigorous scientific field. We will equip and support our students to transition to careers in academia, industry and beyond, while ensuring that we train a cohort to continue to apply and to develop structural biology into the future.</p>

Amount: £5,685,862
Funder: The Wellcome Trust
Recipient: University of Oxford

Wellcome Four Year PhD Programme in Stem Cell Biology and Medicine 24 Jul 2019

<p>Specialist post-graduate training in Stem Cell Biology and Medicine is essential to produce a stream of highly skilled and innovative investigators equipped with a deep understanding of stem cell science and its significance for future medicine. In this context, the Wellcome PhD Programme in Stem Cell Biology and Medicine is unique in the UK in focus and scope. The enduring popularity of the programme, which receives on average 200 applications per year, and the quality of research outputs and next destinations are testament to both the calibre of students we are able to recruit and to the high-quality training they receive. Our programme provides an environment that is intellectually rigorous and personally supportive for students, enabling them to set and attain research objectives. The programme is designed to develop analytical and critically-minded individuals. Since its inception in 2008, the PhD Programme has evolved in response to the expressed needs of students and continuous developments in modern Stem Cell Biology. Our overarching goal is to produce well-trained and rounded PhD graduates who have generated significant and original research findings and are fully prepared for an ambitious and challenging career, whether continuing in stem cell science or moving to another profession.<br> &nbsp;</p>

Amount: £6,051,821
Funder: The Wellcome Trust
Recipient: University of Cambridge

Adaptive Molecular Diagnostics 30 Sep 2019

<p>Our project will use genomic data and a detailed understanding of pathogen evolution to<br> deliver a robust, rapid, accurate and cost-effective pathogen detection kit for use in the field.</p> <p>Current methods are unsuitable for detection as they are slow, inaccurate and cannot be<br> field deployed. Our work has already changed the basic understanding of how cholera<br> spreads and identified high and low epidemic risks that are the cornerstones of disease<br> prevention. By making robust molecular indicator kits adapted to field settings we are able to<br> rapidly probe the likely behaviour of cholera strains and provide actionable data that can<br> make a direct contribution to a major human health challenge.</p>

Amount: £750,858
Funder: The Wellcome Trust
Recipient: University of Cambridge
Amount: £12,456
Funder: The Wellcome Trust
Recipient: University of Oxford

Good Financial Grant Practice/Global Grant Community 30 Sep 2019

<p style="margin-left: 0cm; margin-right: 0cm">The African Academy of Sciences (AAS) is strengthening financial management of grants by developing a good financial grant ecosystem, that whilst developed in Africa is applicable to the Global Grant Community.&nbsp; By being applicable across borders, geographical regions and sectors, it will help ensure buy in and adoption by global funding agencies and grantors.</p> <p style="margin-left: 0cm; margin-right: 0cm">Wellcome have supported the development of the Global Grant Community &ndash; Good Financial Grant Practice by providing the initial &nbsp;&pound;0.5m funding, which catalysed GFGP and additional funding from other funders of circa &pound;3m and supporting Genny to provide advisory and operational support to AAS, Michael Kilpatrick who is based in Nairobi at the AAS and the initiative, initially for one day a week, while Genny was seconded to Sanger as their CFO and for the past year on a full time basis.</p> <p style="margin-left: 0cm; margin-right: 0cm">The requested funding will enable Genny to continue to work with the AAS in the development of this initiative alongside the new role as CFO of the OUCRU as an employee of Oxford University.</p>

Amount: £120,000
Funder: The Wellcome Trust
Recipient: University of Oxford

Understanding mental health 11 Jun 2019

<p style="margin-left: 0cm; margin-right: 0cm">My proposed secondment project will assess the situation and understanding of mental health in OECD countries. Health systems have not yet adequately responded to the burden of mental disorders, resulting in a wide&nbsp;gap between the need for treatment and its provision.&nbsp;The key&nbsp;goals are to: (1)&nbsp;summarise&nbsp;the different methods of measuring mental health across the 36 OECD member countries; (2) understand the drivers and social determinants of mental health over the life cycle, including prenatal, early years, working age and older age; (3)&nbsp;explore the&nbsp;poorly understood relationship between mental health and subjective wellbeing; (4)&nbsp;explore different treatment methods for mental health, both at the&nbsp;micro level including&nbsp;therapy, medication,&nbsp;and complementary and alternative therapies, and at the macro level including mental health resources, policies, programs and interventions available in OECD countries.&nbsp;</p> <p style="margin-left: 0cm; margin-right: 0cm">This project will&nbsp;provide the most up to date and reliable qualitative and quantitative evidence on what is currently known about mental health and ways to effectively tackle its increasing burden.&nbsp;This will provide cross-country learning and sharing of best practices between OECD members and will be extremely useful to inform policy-making around the world.</p> <p style="margin-left: 0cm; margin-right: 0cm">Key words: mental health, determinants, measurements, treatments, well-being</p>

Amount: £13,435
Funder: The Wellcome Trust
Recipient: University of Oxford

Establishing global ethical norms on Minimally Invasive Autopsy 11 Jun 2019

<p>Uncertainty about causes of death and unregistered mortality patterns in low-middle income countries (LMICs) are limitations to planning and evaluation of health programmes. Funding bodies such as the Gates Foundation have advocated Minimally Invasive Autopsy (MIA) to address these important kinds of uncertainty and to minimise sensitivities. MIA involves using hollow needles to sample a number of organs without actually having to open the deceased body - as a possibly more acceptable alternative and less invasive to full autopsy.<br> <br> The conduct of MIA in practice presents a number of ethical and social challenges. While the global development and introduction of MIA is growing, little attention has been paid to these problems or to the development of global ethical&nbsp;norms. The World Health Organisation (WHO) &ndash; a key international actor in the context of global health - is particularly well placed to form global ethical norms on MIA.<br> <br> The aim of my project is to provide an overview of key ethical issues associated with designing and deploying MIA globally. I intend to develop a preparatory document for a WHO consultation meeting on establishing global ethical norms, with the aim to inform the development of MIA guideline.<br> <br> <strong>minimally invasive autopsy, ethics, WHO</strong><br> &nbsp;</p>

Amount: £29,500
Funder: The Wellcome Trust
Recipient: University of Oxford

Darwin Tree of Life 30 Sep 2019

<p>Life has evolved from a single origin to generate &gt;1.5 million eukaryotic species. Sequencing all species will provide an inventory of life, transform understanding of evolution, catalogue eukaryotic gene&nbsp;toolkits for biology and biotechnology, and enable monitoring of ecosystems under increasing stress. The Darwin Tree of Life (DToL) is a new initiative that will exploit long read technologies to sequence all 60000 species in the British Isles and play a leading role in the Earth BioGenome Project. This data resource will underpin bioscience for the coming century.</p> <p>We are a consortium of partners who will build and prove an end-to-end pipeline of sample collection, sequencing, genome assembly, annotation and data dissemination that can deliver this visionary project. We will:</p> <ul> <li> <p>Establish sample collection networks (to collect, record and voucher ~8000 species)</p> </li> <li> <p>Put in place large-scale sequencing and analytic processes (including for single cells and small-bodied taxa)</p> </li> <li> <p>Generate reference quality, deeply annotated genome assemblies for 2000 species</p> </li> <li> <p>Develop portals to disseminate the reference genomes, empowering wider scientific communities to embrace genomics in their future endeavours</p> </li> <li> <p>Share expertise in protocol development and informatics among the Darwin Tree of Life partners to strengthen institutional capacities across the consortium, and with the global EBP.</p> </li> </ul>

Amount: £762,584
Funder: The Wellcome Trust
Recipient: University of Oxford