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Recipients:
University of Cambridge
University of Oxford
Currency:
GBP
Award Year:
2016

Results

Symposium on Drugs, Politics and Society in the Global South 30 Apr 2016

<p>The two-day symposium intends to tackle the issue of illicit drugs through an interdisciplinary, multi-sited approach, which is also peculiar to the tradition of St Antony&rsquo;s College and the Department of Politics and International Relations at Oxford. The objective is to bring together scholars whose interest in drug politics, <em>sensu lato</em>, and area expertise can contribute to triggering meaningful comparative debate. By focusing on several themes in two days, this would allow a comprehensive discussion of major aspects of drug policy around the world. One major contribution of this symposium would be to discuss the issue of drugs in those regions, which have often been left out of the international drug policy debate. Apart from scholars working on Latin American drug politics, the events will include participation of scholars working on the Middle East, Russia, Africa and China. This would fit the area studies vision that is peculiar to the hosting college, St Antony&rsquo;s, which is known to have a strong international perspective. Similarly, it will allow reserachers from the Department of Politics and International Relations to attend and participate in the event, thus injecting new analytical and investigative input into the ongoing themes of research existing in Oxford.</p>

Amount: £5,000
Funder: The Wellcome Trust
Recipient: University of Oxford

Evaluation of feasibility of assessing liver function during ex situ liver perfusion using microdialysis 01 Apr 2016

<p>Each year 15% of patients on the UK liver transplant waiting list die awaiting a donor liver, while a significant proportion of livers go unused because clinicians are&nbsp;unsure that the liver would provide life sustaining function. We are now able to perfuse a liver&nbsp;ex situ&nbsp;with oxygenated blood while evaluating markers of damage&nbsp;and function, enabling better assessment of organ viability.&nbsp;<br /><br />Microdialysis is a method in routine use in neurosurgery to evaluate brain metabolism following trauma, and involves passing a fine dialysis catheter into the brain parenchyma and perfusing it with an isotonic perfusate and examining the dialysate for metabolic markers such as glucose, lactate, and pyruvate. It can also be&nbsp;used to interrogate metabolism by introducing labeled substrates. &nbsp;Microdialysis has been used to study liver transplants post transplant, but has not been used to&nbsp;evaluate function&nbsp;ex situ&nbsp;where its relatively rapid readout may facilitate early and accurate decision making.<br /><br />This project will examine the feasibility of using microdialysis in perfused livers. &nbsp;Human livers that have been declined for transplantation will be studied and the&nbsp;optimal technique developed. Microdialysis results will be correlated with perfusate chemistry (lactate fall, maintenance of pH, ALT, AST) and metabolomic profile.</p>

Amount: £2,000
Funder: The Wellcome Trust
Recipient: University of Cambridge

Burden of Zika virus in different South East Asian populations with febrile illness. 30 Sep 2016

<p>Our planned studies will identify if ZIKV is a current and neglected problem in three SE Asian populations located in Thailand, Vietnam and on the Thailand Myanmar border.&nbsp; Although ZIKV is reported to be endemic in Asia its prevalence and true significance in South East Asia is not well characterised.&nbsp; Transmission of ZIKV Myanmar has not yet been reported, there have only been two confirmed cases recently reported in Vietnam and there are only seven published confirmed cases of ZIKV infections in Thai residents (these were reported by the Thai Ministry of Public Health in 2015).&nbsp; There are several cases of confirmed ZIKV infections from travellers returning from Thailand, indicating that ZIKV is an under and/or misdiagnosed infection in this country.&nbsp; Further work is therefore urgently required. This is important not only for local public health planning, but also from a global health perspective as travellers to and from these regions may be at risk of infection with associated complications and/or pose a transmission risk to na&iuml;ve populations.</p>

Amount: £20,000
Funder: The Wellcome Trust
Recipient: University of Oxford

The Opie archive: exploring play in Britain from the 1950s to the 1980s 25 Nov 2016

<p>This project focuses on the archive of internationally renowned folklorists Iona (b. 1923) and Peter Opie (1918-1982). The Opies' landmark publications were based on information contributed by some 20,000 children from schools all over Britain, in response to three surveys (c.1950&ndash;80), supplemented by the Opies&rsquo; own in-depth observation and sound recording, of a wide variety of games and forms of play. The Opie archive at the Bodleian includes the survey responses, correspondence, and the Opies&rsquo; loose-leaf research files. At present, this collection can only be searched by physically looking through the papers. It is consequently little used, even by specialists. At the same time, even limited use results in wear and tear of a collection which is vulnerable to the possibility of damage through mishandling or misfiling.</p> <p>Our goal is threefold:</p> <ul> <li>One, to unlock this archive's full potential by creating a catalogue, and physically preparing the archive for a future digitisation project, which will permit creative uses of the content without endangering the original materials.</li> <li>Two, to publicise the archive in its usable form to a wide range of audiences and encourage increased and diverse use.</li> <li>Three, detailed scoping of digitisation possibilities in collaboration with intrerested academic partners<em>.</em></li> </ul>

Amount: £102,382
Funder: The Wellcome Trust
Recipient: University of Oxford

An advanced cryoEM instrument for the University of Cambridge 07 Dec 2016

<p>We seek support to consolidate an advanced electron cryo-microscopy (cryo-EM) facility dedicated to structural studies of biological macromolecular assemblies. The facility would provide a revolutionary new tool to the large structural biology community in the University that would enable acquisition of critical data in support of a wide and diverse range of projects tackling fundamental problems in molecular biology relevant to human health. Currently, the named applicants primarily use X-ray crystallography to study large assemblies, but many of these samples cannot be readily crystallised. The recent development of a new generation of direct electron detectors, together with sophisticated data-processing software, has dramatically improved cryo-EM analysis, which now achieves routinely sub-nanometer resolution. Until recently, researchers in the university did not have access to cryoEM, but this has changed with the recent Wellcome Trust award to purchase a cryo-EM instrument&nbsp;for sample screening and intermediate resolution structure determination. We are building on this support, to develop the second phase of our strategy and seek funding for an&nbsp;advanced microscope capable of&nbsp;high resolution structure determination to complement and extend our existing instrumentations.</p>

Amount: £3,000,000
Funder: The Wellcome Trust
Recipient: University of Cambridge

Urban animals, human livelihoods and health in the global south: a trans-species approach 10 Nov 2016

<p>Many of the urban poor in the global south rely on animals for their livelihoods.&nbsp; Yet complex relations between animals, informal livelihoods and health have received scant systematic theoretical and applied attention in the social sciences.</p> <p>&nbsp;</p> <p><em>Urban Animals</em> questions why the urban poor believe they need to keep animals, hypothesizing that these needs are structured by social, spatial and economic forces.&nbsp; It explores health implications emerging from these trans-species arrangements and the management responses they provoke.</p> <p>Combining ethnographic enquiry with analytics of comparative urbanisms, its goal is to develop concepts for understanding human-animal relations in megacities and their health implications in the global south.&nbsp; Central to this goal is to adopt a novel trans-species approach, moving away from anthropocentric leanings of urban studies and public health.&nbsp;</p> <p>&nbsp;</p> <p>This Seed Award will be used to conduct pilot and feasibility studies in New Delhi and Cape Town; collect preliminary data to underpin conceptual, methodological and comparative development; build/consolidate international academic and stakeholder partnerships; and develop collaborative research capacity.&nbsp;Its outputs will be a cross-continental interdisciplinary research consortium which will have generated concepts and evidence for a Wellcome Collaborative Award.</p>

Amount: £49,845
Funder: The Wellcome Trust
Recipient: University of Oxford

Targeting malaria hotspots in Myanmar: An individual-based modeling approach 22 Nov 2016

<p>The epidemiology of malaria in Myanmar has been changing with its decreasing incidence in Myanmar, while there is also an urgent need to address emerging resistance to artemisinin. Current malaria control strategies are no longer enough to achieve elimination. New strategies, like targeting of malaria hotspots where transmission intensity exceeds the average, have been suggested both by studies and the WHO.</p> <p>Such targeted strategies has been implemented in Kayin, Myanmar. However, detection of hotspots using qPCR has been limited to randomly selected villages because of the financial and operational constraints. This could be optimized by a simulation model.</p> <p>The proposed project will develop an individual-based mathematical model to:</p> <p>- Understand/model the changing epidemiology of malaria as its incidence declines in Myanmar</p> <p>- Derive cost-effective strategy to identify and treat malaria hotspots&nbsp;in Kayin, Myanmar</p> <p>As inputs, the model will have census data, population movement, and malaria data from relevant sources to create a dynamic, synthetic population. Simulated individuals will have their own risk of infection, health behaviour and response to treatment which will influence the overall disease transmission dynamics. A corresponding mosquito model will drive the force of infection for humans. Several detection methods and treatment strategies will be simulated.</p>

Amount: £128,087
Funder: The Wellcome Trust
Recipient: University of Oxford

Regulatory T cell-neutrophil interaction in the development and maintenance of secondary pneumonia 06 Dec 2016

<p>Secondary pneumonia following influenza infection is common, with considerable associated morbidity and mortality. Strikingly, secondary infections tend to arise from bacteria which live otherwise asymptomatically in the oropharynx.&nbsp;</p> <p>Based on existing data, I hypothesise that the development of secondary streptococcal pneumonia is dependent on a key immune-cell molecular pathway, namely Phosphoinsitol-3-Kinase delta (PI3K&delta;), and that inhibition PI3K&delta; will be protective via the following mechanisms.</p> <p>1)&nbsp;&nbsp;&nbsp; Influenza-induced expansion of immunosuppressive regulatory T-cells (T<sub>reg</sub>) which depend on PI3K&delta; for suppressive functioning</p> <p>2)&nbsp;&nbsp;&nbsp; Viral and T<sub>reg</sub> mediated suppression of neutrophil function</p> <p>3)&nbsp;&nbsp;&nbsp; A change in the lung microbiome as a result of the effects 1 and 2, leading to established infection by <em>Streptococcus pneumoniae</em>.</p> <p>&nbsp;</p> <p>The goals are:</p> <p>1) To determin whether PI3K&delta;-null animals are resistant to secondary streptococcal pneumonia.</p> <p>2) To use tools including T<sub>reg</sub> depleted animals, conditional knockout animals and small molecule PI3K&delta; inhibitors to explore mechanisms of resistance.</p> <p>3) To develop a more clinically relevant murine model secondary pneumonia, using a streptococcal colonisation model which when exposed to influenza will develop secondary pneumonia.</p> <p>4) To characterise the respiratory microbiome of animals at various stages will be characterised, looking for factors that may facilitate or militate against development of secondary pneumonia.&nbsp;</p>

Amount: £516,560
Funder: The Wellcome Trust
Recipient: University of Cambridge

Livestock, Environment and People (LEAP) 06 Oct 2016

<p>Changes in the amount and type of animal-sourced food (ASF) we consume, and in the way they are produced, are critical drivers of global human health and environmental quality.&nbsp; The project will develop novel policy tools and interventions to allow more informed and effective action to be taken to maximise the health and environmental co-benefits of changes in ASF consumption.&nbsp; We shall build a quantitative food system model incorporating economic, health and environmental modules that will allow the effects of existing drivers and novel policy interventions to be assessed. We shall exploit unique epidemiological resources to provide new evidence about how different types of ASF affect health, and conduct experiments to develop new interventions to influence the consumption of ASFs and ASF substitutes.&nbsp; A social-science component will research how social norms and political economic factors affect the practicality and acceptability of interventions, and how this may be changed. &nbsp;The effects of different types of ASF production on climate change, water use and quality, and ecosystem functions will be measured and brought together for the first time.&nbsp; The project will develop a distinct work stream in China and engagement with multiple audiences will be integral to all its activities.</p>

Amount: £4,391,572
Funder: The Wellcome Trust
Recipient: University of Oxford

Future of Animal-sourced Foods (FOAF) 06 Oct 2016

<p>Changes in the amount and type of animal-sourced food (ASF) we consume, and in the way they are produced, are critical drivers of global human health and environmental quality.&nbsp; The project will develop novel policy tools and interventions to allow more informed and effective action to be taken to maximise the health and environmental co-benefits of changes in ASF consumption.&nbsp; We shall build a quantitative food system model incorporating economic, health and environmental modules that will allow the effects of existing drivers and novel policy interventions to be assessed. We shall exploit unique epidemiological resources to provide new evidence about how different types of ASF affect health, and conduct experiments to develop new interventions to influence the consumption of ASFs and ASF substitutes.&nbsp; A social-science component will research how social norms and political economic factors affect the practicality and acceptability of interventions, and how this may be changed. &nbsp;The effects of different types of ASF production on climate change, water use and quality, and ecosystem functions will be measured and brought together for the first time.&nbsp; The project will develop a distinct work stream in China and engagement with multiple audiences will be integral to all its activities.</p>

Amount: £947,700
Funder: The Wellcome Trust
Recipient: University of Oxford

Obesity: Exploiting Genomes for Novel Insights 06 Dec 2016

What are the mechanisms by which genes influence an individuals propensity to obesity. I study animal models to find answers to that question. I will study the link between genes and obesity in two complementary research streams. Firstly, I will build on my recent discovery of an obesity-associated POMC mutation in animal models which disrupts hypothalamic leptin-melanocortin signalling. Deep phenotyping of eating behaviour and physiology in the absence and presence of a synthetic MC4R agonist with the goal of defining the contribution of POMC-derived peptides to energy homeostasis. Secondly, I will use genome-wide association studies in animals to find further genetic determinants of obesity. Their relevance to humans will be tested in large patient cohorts with both rare, severe obesity and common obesity, and putative obesity loci studied in relevant cell models. Preliminary data has shown this approach is successful.

Amount: £415,141
Funder: The Wellcome Trust
Recipient: University of Cambridge

The role of BMP signalling in diseases of the motor unit 06 Dec 2016

<p>Spinal and bulbar muscular atrophy (SBMA) is an X-linked, adult-onset, neuromuscular disease characterized by lower motor neuron degeneration as result of misfolding and accumulation of mutant Androgen Receptor (AR). In recent years this scenario of selective neuronal vulnerability has been challenged by the discovery that in SBMA, as in other diseases of the motor unit, skeletal muscle, rather than being a mere bystander of motor neuron degeneration, is primarily affected and therapies exclusively targeting muscle ameliorate the pathology in motor neuron while preventing the development of a neuromuscular phenotype in animal models. My goal is to elucidate the molecular mechanisms underlying the intrinsic contribution of skeletal muscle in SBMA pathogenesis. I will investigate the role of the Bone Morphogenetic Protein (BMP) signalling pathway in SBMA pathophysiology, testing the central hypothesis that failure to activate the protective BMP pathway in SBMA muscle in response to denervation causes primary muscle atrophy and affects motor neuron ability to cope with the stress posed by mutant AR. The rationale is to provide a molecular basis for the cell-autonomous and non-cell autonomous roles of muscle in the mechanisms of toxicity in SBMA and other diseases of the motor unit and to identify novel therapeutic targets.</p>

Amount: £1,048,938
Funder: The Wellcome Trust
Recipient: University of Oxford

Adaptive decision templates in the human brain 30 Nov 2016

<p>Interacting with the surrounding environment depends on our ability to extract meaningful patterns from incoming streams of sensory information. Learning and experience are known to facilitate this skill; yet, we know little about how the brain extracts structure and generalises this knowledge to novel settings. Here, I propose to test the brain mechanisms underlying structure learning using contrasting tasks that involve learning structure in space vs. time at different levels of complexity (simple vs. complex feature contingencies). I will use computational modelling to interrogate the processes involved in learning behaviourally-relevant structures (i.e. decision templates). I will relate this system-level insight to multimodal neuroimaging to provide converging evidence for brain mechanisms that mediate learning specialisation and generalisation. I will exploit high-field imaging to test fine-scale decision templates in the visual cortex. I will combine 7T imaging with human electrophysiology (MEG/EEG) and interventions (TMS) to test for local and larger-scale brain circuits that retune decision templates through feedback and inhibitory interactions. Finally, I will test whether these mechanisms support our ability to generalise previous experience to novel contexts and tasks. This integrated approach will advance our understanding of the brain&rsquo;s capacity for adaptive and resilient behaviour with implications for promoting lifelong learning.</p>

Amount: £1,344,200
Funder: The Wellcome Trust
Recipient: University of Cambridge

Circuit principles of memory-based behavioral choice 30 Nov 2016

We aim to elucidate the circuit mechanisms underlying three key computations essential for memory-based behavioral choice: 1) updating valences attached to sensory cues, when actual and expected outcomes differ; 2) computing the “value” for each action, based on multiple, conflicting cues; and 3) selecting one action and suppressing other physically incompatible competing actions. One obstacle to progress in this field has been the problem of identifying underlying circuits with synaptic resolution, and causally relating structural motifs to their proposed function. Both insects and vertebrates have evolved cerebellar-like higher-order parallel-fiber systems specialized in forming large numbers of associative memories and in guiding memory-behavioral choice. However, no synapse-resolution wiring diagram of any such system has been available to guide analysis and inspire understanding.    We have recently mapped the synaptic-resolution wiring diagram of one such system, the insect mushroom body, in Drosophila larva, which reveals multiple novel circuit motifs and provides clues about learning and decision-making models and their neuronal implementation. An exquisite genetic toolkit available in this model system allows selective manipulation of individual neuron types to establish causal relationships between their activity and behavior. We are now in a unique position to causally relate the identified structural motifs to their function.

Amount: £1,737,376
Funder: The Wellcome Trust
Recipient: University of Cambridge

The complete synaptic-level connectome of a nervous system and experimental connectomics 30 Nov 2016

<p>Animals sense the local environment, learn and remember past events, predict future ones, and combine current and past information to choose appropriate motor responses. Underlying these capabilities is the nervous system, which continuously integrates multiple sources of information and chooses one response in exclusion to all others. Our vision is to study neural circuit function on the basis of known synaptic-level wiring diagrams. In Aim #1, we propose to map the complete wiring diagram of an insect, the <em>Drosophila</em> larval central nervous system, using serial electron microscopy. With the knowledge of the circuits formed by the identified and genetically accessible larval neurons we can study how circuits change either by experience or in disease. In Aim #2 we propose to read out the engrams, the persistent yet reversible structural circuit patterns that form in response to learning and that underlie long-term memories, using associative memory in the larval mushroom bodies as the model system. For circuits to assemble correctly while remaining plastic, hundreds of genes need to work in concert. In Aim #3, we will study the effects of mutations in select genes associated with neural diseases on the synaptic-level circuit structure, causing the disease phenotype.</p>

Amount: £1,763,361
Funder: The Wellcome Trust
Recipient: University of Cambridge

Characterising extreme innate immune response phenotypes informative for disease using a functional genomics approach 30 Nov 2016

<p>The overall aim is to define and characterise extreme innate immune response phenotypes in order to gain insights into the functional alleles driving such differences between individuals; biological consequences in terms of gene regulation, cellular function and disease; and opportunities for therapeutic intervention. Key goals are (1) to analyse existing transcriptomic and expression quantitative trait mapping datasets for primary monocytes activated by lipopolysaccharide (endotoxin) or interferon-gamma from a large cohort of healthy volunteers to identify extreme responders (aggregated and gene level), using genetics to resolve functional alleles then validate and establish functional consequences including through chemical probes; (2) to use genome editing to conduct high-throughput screens in human induced pluripotent stem cell derived monocytes complementing the genetic data; (3) to define key nodal genes and networks for drug target discovery and prioritisation; and (4) to characterise prioritised genes and functional alleles modulating gene transcription and epigenetic regulation relevant to disease. Anticipated outcomes are improved understanding of pathophysiology in immune-mediated disease notably sepsis; exemplars to the field of how to establish mechanism for functional alleles involving regulatory genetic variants; improved interpretation of genome-wide association studies; novel nodal points involving TLR and related pathways as drug targets; and better drug target prioritisation.</p>

Amount: £1,575,666
Funder: The Wellcome Trust
Recipient: University of Oxford

Using parasite population genomics to improve understanding of malaria epidemiology 30 Nov 2016

<p>This collaborative project will use genomic approaches to characterise demographic flux and evolutionary trends in the malaria parasite population.&nbsp; Using novel methods for parasite genome sequencing that are suitable for large-scale field applications, we will perform longitudinal studies of parasite population genomics at multiple locations with different transmission intensities in Africa and Southeast Asia, and we will examine the clinical and epidemiological correlates of population genomic variables under a range of ecological settings.&nbsp; We will develop statistical and computational approaches to use longitudinally sampled genome sequencing data to construct spatial maps of parasite demography and examine how this changes over time. We will promote collaboration between experts on population genomics, geospatial mapping and mathematical modelling to use these data to inform and improve epidemiological models of malaria transmission. &nbsp;Our overarching goal is to establish the practical and analytical foundations to use parasite genome sequencing to investigate the causes of epidemiological events such as resurgence and emerging drug resistance, and thus to assist in planning effective interventions.&nbsp;</p>

Amount: £3,989,275
Funder: The Wellcome Trust
Recipient: University of Oxford

The translational potential of mass spectrometry and next-generation sequencing in patients with central nervous system infections in Vietnam 22 Nov 2016

<p>Central nervous system (CNS) infections are devastating conditions worldwide, especially in low- and middle-income counties (LMIC). Clinical outcomes are dependent upon the rapid identification of the causative agent and instituting effective antimicrobial therapy, although the causative agent is only identified in &lt;50% of patients. Furthermore, Southeast Asia is highly susceptible to the emergence of novel and drug resistant pathogens. New diagnostic techniques are urgently required for rapid response to future outbreaks, and to improve patient outcomes.</p> <p>This Fellowship will focus on the translational potential of mass spectrometry and next-generation sequencing (NGS) in clinical diagnostics of CNS infections in Vietnam, and has three key goals:</p> <ol> <li>To determine whether Mass spectrometry of cerebrospinal fluid (CSF) will identify protein/peptide signatures associated with different infectious aetiologies.</li> <li>To determine whether NGS-based metagenomic analysis will identify a broad range of known/unknown pathogens in the CSF and improve upon current standard laboratory assays.</li> <li>To determine whether NGS can provide rapid, whole genome sequence-based prediction of antimicrobial susceptibility for <em>Mycobacterium tuberculosis</em> and <em>Streptococcus pneumoniae</em>. &nbsp;</li> </ol> <p>I aim to provide proof-of-principle that CSF proteomics- and NGS-based methods can improve upon the diagnostic assays currently available in hospital settings, especially in LMIC, and thereby potentially improve patient outcomes.</p>

Amount: £685,086
Funder: The Wellcome Trust
Recipient: University of Oxford

Neuronal reward mechanisms 30 Nov 2016

We investigate neuronal reward and economic decision signals in behavioural tasks with designs from learning and economic decision theories, supplemented by selected, closely related neuroimaging experiments. We study the main components of the brain's reward system, including dopamine neurons (reward prediction error), orbitofrontal cortex (economic decision variables), striatum (so far insufficiently characterised reward signals) and amygdala (short- and long-term rewards). We search for reward and decision signals that provide explanations and hardware implementations for the constructs of reward and economic theories. We need to know these fundamental neuronal signals before focussing on cellular and molecular mechanisms, which differs from work on sensory and motor systems whose signals are better characterised.  We state three aims:  Aim 1: We characterise neuronal processing of skewness-risk, arguably the most frequent risk form.  Aim 2: We identify neuronal signals for utility and test formal axioms for utility maximisation, which is supposedly the goal of 'rational' agents. Utility is THE basic economic decision variable that explains most economic choices.  Aim 3: We assess neuronal representations of preferences, and bridge the gap between biologically necessary rewards and tradable economic goods, by testing basic assumptions of revealed preference theory.

Amount: £4,413,529
Funder: The Wellcome Trust
Recipient: University of Cambridge

Transient Complex Formation in Nanodroplets 09 Nov 2016

<p>Networks of molecular complexes play a fundamental role in biology. Transient interactions often regulate these networks and thus targeted interference offers possibilities for therapeutical intervention.</p> <p>Capturing these elusive complexes is far from trivial. Many are only present at low concentrations because of low-affinity, low solubility or high toxicity. Only a few have been captured and characterised.</p> <p>The physical chemistry of nanodroplets offers a way to enhance the formation of such biological complexes. Droplet populations can be created containing copies of different molecules and combinations of molecules in a statistical distribution. Controlled shrinkage of the droplets by evaporation slowly increases the effective concentration and drives energetically favoured interactions between trapped molecules. The complexes can then be structurally characterised by mass spectrometry, electron microscopy, and flash imaging with X-ray free-electron lasers. I plan to study two complexes: the poorly understood Rubisco - Rubisco-activase complex at the centre of plant carbon fixation, and the FANC core complex, where mutations cause DNA repair malfunctions, resulting in cytopenia, developmental defects, and tumor predisposition.</p> <p>The nanodroplet technology I will develop will make such hitherto difficult to study transient complexes of medical and biotechnological importance accessible to structural analysis.</p>

Amount: £250,000
Funder: The Wellcome Trust
Recipient: University of Oxford