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Recipients:
University of Cambridge
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Results

Evaluation of feasibility of assessing liver function during ex situ liver perfusion using microdialysis 01 Apr 2016

<p>Each year 15% of patients on the UK liver transplant waiting list die awaiting a donor liver, while a significant proportion of livers go unused because clinicians are&nbsp;unsure that the liver would provide life sustaining function. We are now able to perfuse a liver&nbsp;ex situ&nbsp;with oxygenated blood while evaluating markers of damage&nbsp;and function, enabling better assessment of organ viability.&nbsp;<br /><br />Microdialysis is a method in routine use in neurosurgery to evaluate brain metabolism following trauma, and involves passing a fine dialysis catheter into the brain parenchyma and perfusing it with an isotonic perfusate and examining the dialysate for metabolic markers such as glucose, lactate, and pyruvate. It can also be&nbsp;used to interrogate metabolism by introducing labeled substrates. &nbsp;Microdialysis has been used to study liver transplants post transplant, but has not been used to&nbsp;evaluate function&nbsp;ex situ&nbsp;where its relatively rapid readout may facilitate early and accurate decision making.<br /><br />This project will examine the feasibility of using microdialysis in perfused livers. &nbsp;Human livers that have been declined for transplantation will be studied and the&nbsp;optimal technique developed. Microdialysis results will be correlated with perfusate chemistry (lactate fall, maintenance of pH, ALT, AST) and metabolomic profile.</p>

Amount: £2,000
Funder: The Wellcome Trust
Recipient: University of Cambridge

Biomedical Vacation Scholarship Programme - University of Cambridge 30 Sep 2019

<p>This award is for 6 students per year for 5 years. It includes ?a salary at the national living wage plus holiday pay and national insurance or equivalent,?as well as?funds to cover or significantly subsidise accommodation and travel (&pound;1500 outside of London and up to &pound;2000 in London).??? It includes &pound;500 to each studentship towards research expenses.??? Unspent funds can be repurposed on further students or recruitment costs.&nbsp; Wellcome wishes to ensure a greater diversity of students (in relation to socio-economic background and ethnicity) progress to postgraduate research.&nbsp;<br> Over 5 years of the Programme we encourage organisations to aim for:&nbsp;&nbsp;<br> <br> -At least 50% of students recruited to the programme to be from underrepresented or disadvantaged groups, depending on priorities set by each organisation.&nbsp;&nbsp;<br> <br> -At least 50% of students recruited to the programme to be from non-Russell Group Universities. For the remaining 50%, organisations should consider how to recruit students from other universities as well as their own. Wellcome has included this recommended target as research indicates that most of the high-achieving STEMM graduates from minority ethnic backgrounds are located outside of Russell Group universities.&nbsp;&nbsp;</p>

Amount: £166,500
Funder: The Wellcome Trust
Recipient: University of Cambridge

Wellcome Four Year PhD Programme in Stem Cell Biology and Medicine 24 Jul 2019

<p>Specialist post-graduate training in Stem Cell Biology and Medicine is essential to produce a stream of highly skilled and innovative investigators equipped with a deep understanding of stem cell science and its significance for future medicine. In this context, the Wellcome PhD Programme in Stem Cell Biology and Medicine is unique in the UK in focus and scope. The enduring popularity of the programme, which receives on average 200 applications per year, and the quality of research outputs and next destinations are testament to both the calibre of students we are able to recruit and to the high-quality training they receive. Our programme provides an environment that is intellectually rigorous and personally supportive for students, enabling them to set and attain research objectives. The programme is designed to develop analytical and critically-minded individuals. Since its inception in 2008, the PhD Programme has evolved in response to the expressed needs of students and continuous developments in modern Stem Cell Biology. Our overarching goal is to produce well-trained and rounded PhD graduates who have generated significant and original research findings and are fully prepared for an ambitious and challenging career, whether continuing in stem cell science or moving to another profession.<br> &nbsp;</p>

Amount: £6,051,821
Funder: The Wellcome Trust
Recipient: University of Cambridge

Adaptive Molecular Diagnostics 30 Sep 2019

<p>Our project will use genomic data and a detailed understanding of pathogen evolution to<br> deliver a robust, rapid, accurate and cost-effective pathogen detection kit for use in the field.</p> <p>Current methods are unsuitable for detection as they are slow, inaccurate and cannot be<br> field deployed. Our work has already changed the basic understanding of how cholera<br> spreads and identified high and low epidemic risks that are the cornerstones of disease<br> prevention. By making robust molecular indicator kits adapted to field settings we are able to<br> rapidly probe the likely behaviour of cholera strains and provide actionable data that can<br> make a direct contribution to a major human health challenge.</p>

Amount: £750,858
Funder: The Wellcome Trust
Recipient: University of Cambridge

Darwin Tree of Life 30 Sep 2019

<p>Life has evolved from a single origin to generate &gt;1.5 million eukaryotic species. Sequencing all species will provide an inventory of life, transform understanding of evolution, catalogue eukaryotic gene&nbsp;toolkits for biology and biotechnology, and enable monitoring of ecosystems under increasing stress. The Darwin Tree of Life (DToL) is a new initiative that will exploit long read technologies to sequence all 60000 species in the British Isles and play a leading role in the Earth BioGenome Project. This data resource will underpin bioscience for the coming century.</p> <p>We are a consortium of partners who will build and prove an end-to-end pipeline of sample collection, sequencing, genome assembly, annotation and data dissemination that can deliver this visionary project. We will:</p> <ul> <li> <p>Establish sample collection networks (to collect, record and voucher ~8000 species)</p> </li> <li> <p>Put in place large-scale sequencing and analytic processes (including for single cells and small-bodied taxa)</p> </li> <li> <p>Generate reference quality, deeply annotated genome assemblies for 2000 species</p> </li> <li> <p>Develop portals to disseminate the reference genomes, empowering wider scientific communities to embrace genomics in their future endeavours</p> </li> <li> <p>Share expertise in protocol development and informatics among the Darwin Tree of Life partners to strengthen institutional capacities across the consortium, and with the global EBP.</p> </li> </ul>

Amount: £264,009
Funder: The Wellcome Trust
Recipient: University of Cambridge

Biocontainment Level 2 high-parameter FACS: applications for the Cambridge biological sciences community 04 Jul 2019

<p><strong>Provision of cutting edge cell-sorter, with class II biocontainment to allow flexible workflows as applied to a broad range of studies within the Cambridge biomedical research community.</strong></p> <p>The acquisition of a CL2 high-parameter cell-sorter will provide critical ability to purify live-cell populations. This capability is desperately needed to match the explosive growth in high-parameter single-cell analysis in the Cambridge biomedical community (high-parameter flow-cytometry, CyTOF mass-spec, single-cell (sc)-RNA-seq). Parallel cell-sorting capacity of mouse and human live-cells is crucial for validation of findings, and in-depth exploration of the biology of highly purified cell populations. Currently, there is no capacity in Cambridge for high-parameter CL2-designated cell-sorting. This Wellcome Trust multi-user equipment grant application will provide a critical resource to the Cancer Research UK, Cambridge Institute (CRUK-CI), and wider Cambridge biomedical community.</p>

Amount: £479,450
Funder: The Wellcome Trust
Recipient: University of Cambridge

PomBase: A FAIR community resource advancing research from fission yeast to humans 04 Jul 2019

<p style="margin-left: 0cm; margin-right: 0cm">Because basic molecular mechanisms are shared universally, model organism databases are pivotal resources and drivers of research across species. We will enhance PomBase, the fission yeast model organism database, to place investigations using fission yeast in contexts that illuminate equivalent processes in other species, particularly human.</p> <p style="margin-left: 0cm; margin-right: 0cm">Through data stewardship, literature curation, and data integration, we will create emergent knowledge of eukaryotic cell biology, encompassing how proteins are connected into pathways, how pathways are connected to each other, what genes and pathways relate to human diseases, and what proteins remain unstudied across species.</p> <p style="margin-left: 0cm; margin-right: 0cm">We will develop generic open-source, modular, customisable tools to integrate diverse data types, thereby providing clear, user-responsive presentations of increasing volumes of complex data. We will continue to make substantial contributions to the development of shared infrastructures for semantic standardization of biology, supporting increased data propagation and re-use. We will engage closely with the research community through outreach activities.</p> <p style="margin-left: 0cm; margin-right: 0cm">Our proposal addresses four interconnected key objectives:</p> <p style="margin-left: 0cm; margin-right: 0cm">A1 Enabling fresh biological insights across organisms from quality-assured, standardised curation.</p> <p style="margin-left: 0cm; margin-right: 0cm">A2 Improving core infrastructure and providing innovative tools.</p> <p style="margin-left: 0cm; margin-right: 0cm">A3 Enhancing data acquisition, interoperability, and dissemination.</p> <p style="margin-left: 0cm; margin-right: 0cm">A4 Increasing outreach, community curation and promoting the fission yeast model system.</p>

Amount: £1,200,000
Funder: The Wellcome Trust
Recipient: University of Cambridge

Living Assessment: measurement, thresholds and the health of disabled and at-risk children in England, 1989-present 29 Jan 2019

<p><em>Living Assessment </em>will explore two assessments of children in England since 1989: attempts to measure the support requirements of disabled children; and attempts to measure threats of harm to children&rsquo;s health and development in statutory social work practice. How have measurements been made about how and when state provision is necessary? How have thresholds for provision operated and been justified? How do people experience these assessments, and what are their concerns? These are important questions for understanding the role of health and measurement in welfare assessments of children, and for deepening and contextualising debates about the assessments, which have been intensified by austerity. To address these questions first we will study historical materials, drawing on new sources. Second, we will gather oral testimonies. Third, we will study patient records. Fourth, we will pursue action research, including a Parliamentary Inquiry, in collaboration with MPs and Lords from the All-Party Parliamentary Group for Children. We will work closely with three groups of Experts by Experience: disabled children and adolescents, adult care leavers, and parents who have experienced social work intervention. Experts by Experience will be involved in research design, interpreting findings, analysing transcripts, and co-designing and co-implementing the action research.<br> <br> &nbsp;</p>

Amount: £290,128
Funder: The Wellcome Trust
Recipient: University of Cambridge

Assisted Reproductive Technologies in the Islamic Republic: Infertility, Inequality and Masculinities in Iran 05 May 2019

<p>This research examines how (in)fertile&nbsp;couples, men in particular, can access and utilize assisted reproductive technologies (ARTs) in the socio-cultural, legal, religious and medical context of contemporary Iran. Iran is the only Muslim country in which ARTs, including the use of donor gametes and embryos, have been&nbsp;regulated by the state. Although the state&nbsp;partly subsidizes ARTs, they are not equally accessible&nbsp;to all. In Iran, infertility&mdash;a&nbsp;stigmatized condition&mdash;is&nbsp;considered a &lsquo;woman&rsquo;s problem&rsquo;; male infertility is hardly recognized&nbsp;in families, society or in social science. This ethnographic study will yield&nbsp;insights into male infertility and&nbsp;the use of ARTs in Iran and how this relates to dominant notions of masculinity. It will build on four core theoretical notions&mdash;&lsquo;reproductive navigation&rsquo;, &lsquo;(Islamic) biopolitics&rsquo;, &lsquo;stratified reproduction&rsquo; and &lsquo;emerging masculinities&rsquo;&mdash;and take an intersectional perspective considering gender, class and religion. Conducted in Tehran and Yazd, the research methods will include:&nbsp;observation in hospitals and in the mundane lives of (in)fertile couples; interviews with couples&nbsp;and&nbsp;religious authorities, medical professionals and policymakers. This research will further our understanding of how gender, class and religion inform disparities in the use of and access to ARTs, and speak to reproduction policies in Iran and countries with similar conditions.</p>

Amount: £120,829
Funder: The Wellcome Trust
Recipient: University of Cambridge

From Collection to Cultivation: Historical Perspectives on Crop Diversity and Food Security 30 Jul 2019

<p>Many experts agree that crop genetic diversity is essential to agricultural productivity, present and future, and therefore an important determinant of human health and well-being. Yet the routes through which this diversity is made valuable in agriculture, for example in breeding more disease-resistant or nutritious crops, remain underexplored. The dominant narrative credits plant breeders alone with generating value from crop diversity and has enabled breeders and seed companies to claim ownership over plant varieties. This in turn has encouraged a dramatic consolidation of the seed industry that many consider a threat to global food security.</p> <p><br> The narrative of breeder-generated value must be assessed and challenged. Through four historical case studies and a synthetic account, this project argues for a more encompassing view of how diverse materials give rise to the crops eaten around the world. It documents the contributions of researchers engaged in plant exploration, introduction, conservation, and utilisation. It charts efforts to locate disease-resistant varieties, prevent the spread of crop pathogens, ensure access to dietary diversity, and locate the genes that give rise to nutrient-rich varieties. By following neglected actors and methods, the project changes our understanding of how and by whom modern agricultural crops have been made.</p>

Amount: £886,718
Funder: The Wellcome Trust
Recipient: University of Cambridge

Cellular mechanisms of viral gene sensing and silencing 16 Jul 2019

<p style="margin-left: 0in; margin-right: 0in">Viruses depend on cellular machinery to express and replicate their genes. Viral RNA must therefore be delivered or generated in the cytosol. Some viruses also deliver genomic DNA into the nucleus, for integration into the host cell genome. The cell&rsquo;s principal innate defenses are to mount a potent inflammatory response upon sensing cytosolic viral RNA and to repress the transcription of integrated viral DNA. To be effective, these responses must be sensitive, specific and appropriately calibrated to minimize toxicity and autoinflammation. Our overarching goal is to gain a molecular understanding of how the cell recognizes cytosolic viral RNA and how it silences viral gene expression with the necessary sensitivity and specificity. In pursuit of this goal we are applying a complementary set of biophysical, biochemical and cell biological approaches, with a focus on using high-resolution structural information to obtain detailed mechanistic insights with atomic-level detail.&nbsp;<br> <br> <strong>Our key goals are to understand:</strong><br> <br> -how cells distinguish viral from endogenous nucleic acids;<br> -how the immune response against double-stranded RNA is generated and amplified;&nbsp;<br> -how cells recognize and silence integrated viral DNA;<br> <br> This will provide invaluable insights on&nbsp;fundamental principles of&nbsp;host-pathogen recognition, chromatin regulation and host-virus coevolution.</p>

Amount: £2,740,933
Funder: The Wellcome Trust
Recipient: University of Cambridge

Genome regulation across developmental trajectories 16 Jul 2019

<p>To understand how the genome directs development, we need to know the cell-to-cell changes in genomic activity at individual loci and how changes are regulated. Advances in single-cell profiling provide a new ability to determine the regulatory configuration of individual cells genome-wide through profiling gene expression and chromatin accessibility. However, determining the connections between mother and daughter cells remains difficult. The invariant and known cell lineage of <em>C. elegans</em> solves this problem, making it possible with single-cell profiling to determine locus-specific activity in every cell from the zygote to the differentiated state. In Aim 1 we study the early events of genome quiescence, zygotic genome activation (ZGA), and lineage commitment by profiling all cells from the zygote to the 26-cell stage, and germ cells through their later ZGA. In Aim 2 we use the 20-cell intestine as a paradigm to study progression through a complete developmental trajectory. We will investigate mechanisms of key transitions and further study the relationship of activity patterns to genome 3D structure. In Aim 3, we focus on the impacts and regulation of active and PRC2/Polycomb chromatin domains. Our work will impact understanding of core principles of genome regulation relevant across animals.&nbsp;<br> &nbsp;</p>

Amount: £2,423,363
Funder: The Wellcome Trust
Recipient: University of Cambridge

The complete interaction between Trypanosoma brucei and mammalian host proteins 16 Jul 2019

<p style="margin-left: 0in; margin-right: 0in">African trypanosomes have remarkable cell surfaces which mediate their interactions with the molecules of infected mammals. These surfaces are packed with a dense layer of the variant surface glycoprotein (VSG), allowing a population survival strategy based on antigenic variation. Within thisVSG coat operate receptors for mammalian ligands such as transferrin and haptoglobin-haemoglobin. We have shown how these receptors have evolved to bind ligands while minimising exposing of the trypanosome to the adaptive immune system. We have also shown that trypanosome receptors bind to complement components, identifying and characterising receptors for factor H and complement C3. This latter work validated a bioinformatics screen that identified a further 25 putative receptors. The aim of this proposal is to now identify the complete receptor repertoire used by&nbsp;<em>Trypanosoma brucei</em>to exploit and survive within its host. We will assess whether receptors are virulence factors and whether they represent new biology. We will understand the molecular basis for their action. We will also determine what causes the distribution and dynamics of different receptor types within the cell.&nbsp;&nbsp;This will produce detailed mechanistic insight into the cell and molecular biology of trypanosome receptors, yielding a greater understanding of both the trypanosome and the disease.</p>

Amount: £1,706,361
Funder: The Wellcome Trust
Recipient: University of Cambridge

Molecular mechanisms controlling CTL killing: from genes to secretion 16 Jul 2019

<p style="margin-left: 0in; margin-right: 0in">The aim of my research is to understand the molecular mechanisms that control cytotoxic T lymphocyte (CTL) polarized secretion and killing.&nbsp;<br> <br> In a recent screen of single gene deletion mice we identified novel genes that are required for CTL killing and implicate important roles for organelles including mitochondria and peroxisomes.&nbsp; During the course of these studies we also developed advanced (high-throughput) assays for CTL killing and a detailed map of events leading to CTL secretion.&nbsp; &nbsp;<br> <br> Our specific aims over the next five years will be to<br> <br> (i) Identify the roles of the newly discovered genes, and the organelles they implicate, in CTL killing using a combination of biochemical, genetic and high-resolution imaging approaches. &nbsp;<br> <br> (ii) Determine how&nbsp;transcriptional&nbsp;control fine-tunes&nbsp;CTL killing, combining&nbsp;gene deletion and cell biological approaches (eg micro-patterning) with single cell transcriptomics to ask how CTL modulate their responses in order to modulate their killing.<br> <br> (iii) Broaden the range of genetic diseases for studying CTL function and make use&nbsp;of emerging genomic data to identify new causal&nbsp;genes&nbsp;in immunodeficiency.</p> <p style="margin-left: 0in; margin-right: 0in">With the combination of genetic and cell biological approaches that we take, we aim to bridge the current gap between genes and function in CTL.&nbsp;</p>

Amount: £3,292,176
Funder: The Wellcome Trust
Recipient: University of Cambridge

Developmental Mechanisms of Motor Network Tuning 16 Jul 2019

<p>Activity is required for correct development of neural circuits and emergence of appropriate behaviour. At early stages activity is spontaneously generated, and then superseded by patterned network activity as sensory afferents become active. A period of maximal plasticity, termed critical period, generally spans these two phases. Significantly, aberrant activity during neural circuit development, especially when occurring in the critical period, can lead to network errors that become &lsquo;locked in&rsquo; and may contribute to neurological disorders in later life. Whilst a requirement for activity is universal for circuit development, important questions remain unanswered. We have identified a comparable requirement for activity in the development of the motor circuit of <em>Drosophila</em> larvae. Notably, perturbation of activity leads to permanent and significant errors in circuit function. This system is composed of identifiable, tractable neurons of defined connectivity. These advantages allow us to study fundamental questions in ways not possible in higher organisms. Exploiting this exceptional level of resolution, our overall goal is:</p> <p style="margin-left: 0cm; margin-right: 0cm"><strong>to generate detailed understanding of the cellular and molecular processes that underlie normal network tuning and lead to errors following early activity perturbation; further, to determine in this tractable circuit the capability of homeostatic mechanisms to compensate for early induced perturbations.</strong></p>

Amount: £956,398
Funder: The Wellcome Trust
Recipient: University of Cambridge

Cambridge Events in History of Medicine 02 May 2019

<p>This application is to enable the Cambridge Department of History and Philosophy of Science, a major centre of research in history of medicine and health, and the leading international centre for history of reproduction, to continue the annual Cambridge Wellcome Lecture in the History of Medicine and to maintain and enhance our seminar series now that Wellcome core-funding awards have ended. The public lecture is the highlight of our year, an opportunity to showcase work, draw together a large community and invite advisors from Wellcome to speak to prospective and existing grantholders. The seminars, which alternate between &lsquo;early medicine&rsquo;, &lsquo;modern medicine and biology&rsquo; and &lsquo;generation to reproduction&rsquo;, are an important forum for training, exchange and networking and the main intellectual focus for the department&rsquo;s expanding group of historians of medicine and health. We will increase the value of the seminars&nbsp;by more routinely inviting colleagues from continental Europe, and by increasing access through covering the full cost of dinners. The reproduction theme develops our leadership role in that field; the other strands ensure intellectual breadth and provide space for new areas of special strength to emerge.</p>

Amount: £31,827
Funder: The Wellcome Trust
Recipient: University of Cambridge

Orphan GPR35 controls the quintessential sodium-potassium pump 10 Mar 2019

<p>We discovered that GPR35 interacts with the&nbsp;&alpha;1-chain of the sodium/potassium ATPase (Na/K- ATPase) and thereby controls its pump and signalling function. GPR35<sup>T108M</sup>, which confers genetic risk for ulcerative colitis and primary sclerosing cholangitis, increases Na/K-ATPase's pump function by 25%, while deletion of Gpr35 decreases it by 30%. GPR35 also activates Na/K-ATPase-dependent Src signalling, and&nbsp;<em>Gpr</em>35<sup>&ndash;/&ndash;</sup>&nbsp;mice are protected from developing tumours.&nbsp;Considering Na/K-ATPase&rsquo;s quintessential role in maintaining the electrochemical gradient of a cell, we will (1) address the structural basis of GPR35&rsquo;s unique interaction with Na/K-ATPase. We will use molecular biological, biochemical, and structural (cryo-EM) methods to address this. (2) We will elucidate the role of GPR35 in innate and adaptive immunity and its dependency on Na/K-ATPase. GPR35 is expressed in immune and intestinal epithelial cells. Albeit endothelial cells do not express GPR35, we observed changes in vascularisation in tumour tissue and aortic rings.&nbsp;This prompted&nbsp;us to (3) study the role of GPR35 in angiogenesis. We will test how&nbsp;GPR35 modulates the interaction of macrophage, fibroblasts and endothelial cells and the consequent&nbsp;effects on vascularisation and therefore tumour growth and size.&nbsp;</p> <p>&nbsp;</p>

Amount: £1,216,814
Funder: The Wellcome Trust
Recipient: University of Cambridge

Tethered exosomes and their role in MHC-II presentation 12 Jun 2019

<p style="margin-left: 0cm; margin-right: 0cm">Peptide-loaded MHC-II (pMHC-II) is presented at the surface of antigen presenting cells and it has historically been assumed that pMHC-II is localised on the plasma membrane. However, immunofluorescence data reveals pMHC-II localised to patches rather than uniformly distributed. The loading of peptide onto MHC-II occurs within MVBs, specifically on ILVs. In order for pMHC-II to be subsequently incorporated into the plasma membrane, ILVs would be required to &lsquo;back-fuse&rsquo; with the limiting membrane of the MVB. This back-fusion step represents an ambiguous fusion event. I have recently shown that exosomes can be physically tethered to the cell surface by tetherin. Tetherin is highly expressed in antigen presenting cells and these cells display clusters of exosomes at their surface. Using biochemistry, immuno-electron microscopy and functional assays I wish to test the hypothesis that surface-tethered exosomes present pMHC-II at the surface of antigen presenting cells.</p> <p style="margin-left: 0cm; margin-right: 0cm">I will establish the molecular machinery which traffics tetherin to ILVs/exosomes, and define the residues on tetherin that are required for this trafficking. Finally, I will explore where and how exosomes fuse to recipient cells, and use a screening approach to identify molecules involved in exosomes &ndash; plasma membrane fusion.</p>

Amount: £1,066,222
Funder: The Wellcome Trust
Recipient: University of Cambridge

The role of FUS phase transition in axonal mRNA localisation and translation 24 Apr 2019

<p>The neuropathological hallmark of the two closely related neurodegenerative diseases, ALS and FTD, is the presence of poorly soluble intracellular protein aggregates consisting of low-complexity domain-bearing RNA-binding proteins (RBPs). Intriguingly, these proteins are also key components of liquid-like ribonucleoproteins (RNPs) mediating diverse physiological processes, including transporting mRNAs to distal neurites to promote local protein synthesis (LPS). Interestingly, LPS in disease-affected neurons is often perturbed raising the possibility that the phase transition property of RBPs is critical for regulating the local supply of proteins that promote axon maintenance. Using the ALS/FTD-associated protein FUS as an example, I will investigate the effects of liquid-liquid phase separation and liquid-to-solid phase transition on axonal mRNA localisation, LPS and axon maintenance. <em>Xenopus</em> retinal neurons and mouse cortical neurons will be used as complementary models, in combination with optogenetic tools to achieve precise spatiotemporal control of localised FUS phase transition. A major goal is to understand the mechanisms by which aberrant intra-axonal phase transition of FUS leads to impaired LPS and axon degeneration. As effective treatments for ALS/FTD are currently unavailable, identifying differential mRNA interactors of physiological and pathological FUS and determining their translational status in axons may provide insights for clinical therapeutic options for ALS/FTD.</p>

Amount: £300,000
Funder: The Wellcome Trust
Recipient: University of Cambridge