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Search results (Displaying 55 grants)

Total grants
55
Total funders
1
Total recipients
1
Earliest award date
24 Jan 2017
Latest award date
06 Dec 2017
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Jeevan Shakti Mela - Funfair for lifeforce
<p>Type 2 Diabetes mellitus (T2DM) is often not well understood among marginalized populations, but its prevalence is increasing, particularly in low-income countries. We will address this challenge in rural plains Nepal, enabling female Maithil artists from the Janakpur Women&rsquo;s Development Centre (JWDC) to engage with communities about T2DM through research, drama, and a funfair. First, a … more
Amount: £75,000
Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Amount: £283,711
Computer-based analysis of early fibrosing lung disease
<p>Fibrosing lung disease (FLD) is an idiopathic condition, affecting older patients (median age=65 years) and smokers, accounting for 0.9% of all UK deaths in 2012. Unfortunately, despite newly available treatment options,&nbsp;FLD is typically diagnosed at an advanced stage with patients already markedly functionally&nbsp;impaired. Patient decline is often rapid.</p> <p>&nbsp;</p> <p>A constr… more
Amount: £1,034,494
Genetic background effects in human iPSCs and iPSC-derived cell types
<p>Human induced pluripotent stem cells (iPSC) have emerged as a key model system to study the function of genetic variants, as they provide access to relevant cell types and developmental lineages through cellular differentiation. However, while it has been shown that the genetic background of the donor individual has an effect on molecular phenotypes measured from iPSCs, it is currently not kno… more
Amount: £99,935
Investigation of protein CoAlation in the process of apoptosis
<p>CoAlation is a novel post-translational modification to proteins whereby Coenzyme A is covalently attached to proteins. It occurs as part of the oxidative stress response as an alternative mechanism to protein glutathionylation. It is specifically a modification of enzymes involved in cellular metabolism and protects catalytic thiol groups on active site cysteine residues from irreversible dam… more
Amount: £0
Amount: £2,850,000
Amount: £2,814,500
The Role Of Small-molecule Dietary And Non-dietary Antioxidants In Predicting And Preventing Respiratory Disease
<p>Respiratory diseases caused by smoking and pollution are increasing in prevalence across all continents. At present, there are no simple blood tests for predicting those at highest risk and few molecular targets for primary prevention. This work programme will use pre-collected data to answer the following: do antioxidant molecules found in blood (bilirubin, uric acid, alpha-tocopherol, ascorb… more
Amount: £284,626
Harnessing pre-clinical lung cancer patient models for precision immuno-oncology
<p>Only 16% of non-small cell lung cancer (NSCLC) patients survive for 5 years. Improvement in survival has been slow as the histological and genomic features of the disease are heterogeneous. Tumour heterogeneity poses a challenge for therapy development and suggests the importance of a personalised medicine approach. One approach is to expand the subset of tumour-infiltrating lymphocytes (TILs)… more
Amount: £250,000
Using modern causal inference methods and general population data to investigate the role of inflammation in the aetiology of eating disorders
<p>Eating disorders are severe psychiatric conditions with typical onset in adolescence and a complex aetiology. Epidemiological studies have shown that inflammation is potentially implicated in the aetiology of several psychiatric conditions. However, although the hypothesis is plausible, robust epidemiological evidence that inflammation is involved in the pathogenesis of eating disorders is lar… more
Amount: £250,000
Water resistance: a study of environmental justice, resilience and citizen science activism in Mexico City
<p>This research will explore resilience in the context of environmental justice, with a focus on water insecurity in Mexico City. The concept of resilience is central to public health and climate change discourse, but is rarely critiqued. Addressing this omission is crucial: resilience frameworks can conceal social inequalities, uphold political status quo, and overlook local experience. Equally… more
Amount: £96,532
Using new evidence synthesis techniques to explore health and care inequalities among Lesbian, Gay, Bisexual and Transgender people
<p>This proposal will utilise a developing approach to synthesising existing quantitative data in order to substantially enhance the evidence-base around health, wellbeing and care inequalities among Lesbian, Gay, Bisexual and Transgender (LGBT) people. The aims of this project are to:</p> <ul> <li>Review the potential of nationally representative UK datasets for individual participant data met… more
Amount: £50,239
Physiological and pathological regulation of calcium channel trafficking and function
<p>Voltage-gated Ca<sub>V</sub>2 calcium-channels are essential for presynaptic neurotransmitter release. &nbsp;Knowledge of factors governing the regulation in neurons of N-type (Ca<sub>V</sub>2.2) calcium-channel trafficking and properties is key to understanding their pathological role in neuropathic pain. &nbsp;Both Ca<sub>V</sub>2.2 and the auxiliary subunit alpha2delta-1, which is up-regula… more
Amount: £1,399,688
Arts, Society and Public Health: An Exploration of the Major UK Cohort Studies
<p>This fellowship will explore the impact of arts and cultural engagement on health and wellbeing at a population level, using the outstanding longitudinal cohort data that have been collected in the UK. Research will examine the effects of (i) cultural engagement (e.g. attending concerts/museums/galleries/cinemas/theatre); (ii) active arts participation (e.g. music/dance/crafts/drama); (iii) pa… more
Amount: £241,889
Somatic adaptation and sex differences in human endocrine development and disease
<p>Our work focusses on new genetic mechanisms affecting human adrenal and reproductive function. We have recently described a multisystem growth restriction disorder caused by gain-of-function of SAMD9, where somatic adaptation can modify phenotype and mask detection of the genotype. In parallel, we developed a transcriptomic atlas of human adrenal and gonad development, mapping out sex-specific… more
Amount: £1,561,134
Assessment of placental function in complicated pregnancy using advanced MRI
<p>Placental insufficiency underlies the major obstetric syndromes of fetal growth restriction (FGR) and pre-eclampsia and accounts for one third of stillbirths in high-income countries. There is an unmet clinical need for a method to properly characterise placental perfusion and determine if and when a placenta is likely to fail.&nbsp;The objective of this work is to develop&nbsp;an imaging meth… more
Amount: £99,804
Dynamical modelling of somatic genomes
<p>Cancers are complex and chaotic systems.&nbsp;It is becoming apparent that no two cells in a cancer are genetically identical or follow the same evolutionary trajectory.&nbsp;Chromosomal instability (CIN)&nbsp;is one way that cells generate this complexity and is&nbsp;a hallmark of all&nbsp;cancer and ageing. &nbsp;In cancer, it increases the level of variation available to cells and gives ris… more
Amount: £1,273,968
Enhancing emotion-regulation in adolescence: A developmental window of opportunity
<p>Adolescence is an emotionally challenging developmental stage. Adolescents frequently experience negative affect and rapid fluctuations in affective states. Difficulty in regulating these emotions is associated with a range of psychopathology. Successful emotion-regulation relies on executive control, the ability to attend and respond to goal-relevant information, while inhibiting responses to… more
Amount: £250,000
Amount: £123,300