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Search results (Displaying 98 grants)

Total grants
98
Total funders
1
Total recipients
1
Earliest award date
27 Feb 2006
Latest award date
06 Dec 2017
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Jeevan Shakti Mela - Funfair for lifeforce
<p>Type 2 Diabetes mellitus (T2DM) is often not well understood among marginalized populations, but its prevalence is increasing, particularly in low-income countries. We will address this challenge in rural plains Nepal, enabling female Maithil artists from the Janakpur Women&rsquo;s Development Centre (JWDC) to engage with communities about T2DM through research, drama, and a funfair. First, a … more
Amount: £75,000
Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Amount: £283,711
Computer-based analysis of early fibrosing lung disease
<p>Fibrosing lung disease (FLD) is an idiopathic condition, affecting older patients (median age=65 years) and smokers, accounting for 0.9% of all UK deaths in 2012. Unfortunately, despite newly available treatment options,&nbsp;FLD is typically diagnosed at an advanced stage with patients already markedly functionally&nbsp;impaired. Patient decline is often rapid.</p> <p>&nbsp;</p> <p>A constr… more
Amount: £1,034,494
Genetic background effects in human iPSCs and iPSC-derived cell types
<p>Human induced pluripotent stem cells (iPSC) have emerged as a key model system to study the function of genetic variants, as they provide access to relevant cell types and developmental lineages through cellular differentiation. However, while it has been shown that the genetic background of the donor individual has an effect on molecular phenotypes measured from iPSCs, it is currently not kno… more
Amount: £99,935
Investigation of protein CoAlation in the process of apoptosis
<p>CoAlation is a novel post-translational modification to proteins whereby Coenzyme A is covalently attached to proteins. It occurs as part of the oxidative stress response as an alternative mechanism to protein glutathionylation. It is specifically a modification of enzymes involved in cellular metabolism and protects catalytic thiol groups on active site cysteine residues from irreversible dam… more
Amount: £0
Amount: £2,850,000
Amount: £2,814,500
Prefrontal and hippocampal contributions to goal coding during navigation.
Keeping track of goals is vitally important for survival, particularly if the goals are locations in the world where we can find food or shelter. In order to navigate to these goals we need to know where we are and where the goals are. Whereas considerable evidence suggests that the hippocampus provides a signal for our current location, the neural coding of goal-relevant information is much less… more
Amount: £230,410
Physicke for mind, body and soul: the diagnosis, treatment and experience of melancholy in early modern England.
This research will explore the links between early modern medical and religious practices and their respective efforts to diagnose and treat psychological dysfunction associated with discontent and depression. Interdisciplinary in its scope, the thesis will draw upon contemporary medical, theological and literary works in an attempt to understand better early modern perceptions of human interiori… more
Amount: £76,648
KSHV manipulation of the B-cell differentiation programme to establish lytic and latent viral replication.
The human gamma herpesviruses, Kaposi s sarcoma associated herpesvirus (KSHV) and Epstein Barr Virus (EBV) maintain their latent life cycle in B-cells. Infectious virus is produced by lytic reactivation from latency to allow onward virus transmission despite a functioning immune system. To do this EBV is proposed to usurp B-cell developmental programmes and functional gene networks. We hypothesis… more
Amount: £327,041
Enhancing clinical research infrastructure at University College London and its associated NHS Trusts: Building Grant.
This proposal seeks funding for a unified Clinical Research Infrastructure at University College London (UCL) and its associated NHS Trusts. The key objective of the proposal is to help bridge the increasing gap between the successes of basic science and their translation into innovations that directly benefit patients. Establishing appropriate facilities within UCL will link the excellent and in… more
Amount: £250,000
Enhancing clinical research infrastructure at University College London and its associated NHS Trusts: Director's Discretionary Fund.
This proposal seeks funding for a unified Clinical Research Infrastructure at University College London (UCL) and its associated NHS Trusts. The key objective of the proposal is to help bridge the increasing gap between the successes of basic science and their translation into innovations that directly benefit patients. Establishing appropriate facilities within UCL will link the excellent and in… more
Amount: £250,000
A study of the functional anatomy of motor recovery after stroke.
Treatment of disability after stroke relies on the delivery of specific therapies in the setting of the multidisciplinary team, but lacks a clear neurobiological rationale. Work in animals suggests that the brain has a remarkable capacity to remodel its pathways and connections after injury, and that these changes correlate with improved function. In order to promote an understanding of the neu… more
Amount: £111,489
The Role Of Small-molecule Dietary And Non-dietary Antioxidants In Predicting And Preventing Respiratory Disease
<p>Respiratory diseases caused by smoking and pollution are increasing in prevalence across all continents. At present, there are no simple blood tests for predicting those at highest risk and few molecular targets for primary prevention. This work programme will use pre-collected data to answer the following: do antioxidant molecules found in blood (bilirubin, uric acid, alpha-tocopherol, ascorb… more
Amount: £284,626
Harnessing pre-clinical lung cancer patient models for precision immuno-oncology
<p>Only 16% of non-small cell lung cancer (NSCLC) patients survive for 5 years. Improvement in survival has been slow as the histological and genomic features of the disease are heterogeneous. Tumour heterogeneity poses a challenge for therapy development and suggests the importance of a personalised medicine approach. One approach is to expand the subset of tumour-infiltrating lymphocytes (TILs)… more
Amount: £250,000
Using modern causal inference methods and general population data to investigate the role of inflammation in the aetiology of eating disorders
<p>Eating disorders are severe psychiatric conditions with typical onset in adolescence and a complex aetiology. Epidemiological studies have shown that inflammation is potentially implicated in the aetiology of several psychiatric conditions. However, although the hypothesis is plausible, robust epidemiological evidence that inflammation is involved in the pathogenesis of eating disorders is lar… more
Amount: £250,000
Water resistance: a study of environmental justice, resilience and citizen science activism in Mexico City
<p>This research will explore resilience in the context of environmental justice, with a focus on water insecurity in Mexico City. The concept of resilience is central to public health and climate change discourse, but is rarely critiqued. Addressing this omission is crucial: resilience frameworks can conceal social inequalities, uphold political status quo, and overlook local experience. Equally… more
Amount: £96,532
Using new evidence synthesis techniques to explore health and care inequalities among Lesbian, Gay, Bisexual and Transgender people
<p>This proposal will utilise a developing approach to synthesising existing quantitative data in order to substantially enhance the evidence-base around health, wellbeing and care inequalities among Lesbian, Gay, Bisexual and Transgender (LGBT) people. The aims of this project are to:</p> <ul> <li>Review the potential of nationally representative UK datasets for individual participant data met… more
Amount: £50,239
Physiological and pathological regulation of calcium channel trafficking and function
<p>Voltage-gated Ca<sub>V</sub>2 calcium-channels are essential for presynaptic neurotransmitter release. &nbsp;Knowledge of factors governing the regulation in neurons of N-type (Ca<sub>V</sub>2.2) calcium-channel trafficking and properties is key to understanding their pathological role in neuropathic pain. &nbsp;Both Ca<sub>V</sub>2.2 and the auxiliary subunit alpha2delta-1, which is up-regula… more
Amount: £1,399,688