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Search results (Displaying 126 grants)

Total grants
126
Total funders
1
Total recipients
1
Earliest award date
04 Feb 2009
Latest award date
06 Dec 2017
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Jeevan Shakti Mela - Funfair for lifeforce
<p>Type 2 Diabetes mellitus (T2DM) is often not well understood among marginalized populations, but its prevalence is increasing, particularly in low-income countries. We will address this challenge in rural plains Nepal, enabling female Maithil artists from the Janakpur Women&rsquo;s Development Centre (JWDC) to engage with communities about T2DM through research, drama, and a funfair. First, a … more
Amount: £75,000
Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Amount: £283,711
Computer-based analysis of early fibrosing lung disease
<p>Fibrosing lung disease (FLD) is an idiopathic condition, affecting older patients (median age=65 years) and smokers, accounting for 0.9% of all UK deaths in 2012. Unfortunately, despite newly available treatment options,&nbsp;FLD is typically diagnosed at an advanced stage with patients already markedly functionally&nbsp;impaired. Patient decline is often rapid.</p> <p>&nbsp;</p> <p>A constr… more
Amount: £1,034,494
Genetic background effects in human iPSCs and iPSC-derived cell types
<p>Human induced pluripotent stem cells (iPSC) have emerged as a key model system to study the function of genetic variants, as they provide access to relevant cell types and developmental lineages through cellular differentiation. However, while it has been shown that the genetic background of the donor individual has an effect on molecular phenotypes measured from iPSCs, it is currently not kno… more
Amount: £99,935
Investigation of protein CoAlation in the process of apoptosis
<p>CoAlation is a novel post-translational modification to proteins whereby Coenzyme A is covalently attached to proteins. It occurs as part of the oxidative stress response as an alternative mechanism to protein glutathionylation. It is specifically a modification of enzymes involved in cellular metabolism and protects catalytic thiol groups on active site cysteine residues from irreversible dam… more
Amount: £0
Amount: £2,850,000
Amount: £2,814,500
Collaborative community studies of Swine Origin Influenza Virus (SOIV) H1N1
To provide timely information on The occurrence of ILI and of PCR confirmed influenza in different population subgroups. Clinical illness in symptomatic patients including range, duration and severity of symptoms and sensitivity and specificity of symptoms and fever. Access to care and treatment (experience of helplines, access to antivirals, treatment with antibiotics) Effectiveness of antiviral… more
Amount: £1,044,824
collaborative community studies of swine origin infuenza virus H1N1
To provide timely information on The occurrence of ILI and of PCR confirmed influenza in different population subgroups. Clinical illness in symptomatic patients including range, duration and severity of symptoms and sensitivity and specificity of symptoms and fever. Access to care and treatment (experience of helplines, access to antivirals, treatment with antibiotics) Effectiveness of antiviral… more
Amount: £78,376
Open access award.
Not available
Amount: £150,000
Understanding the folding, misfolding, and polymerization of a1-antitrypsin using NMR spectroscopy
A. Assess the structural and dynamical characteristics of the native state of a1-antitrypsin at a residue specific level using NMR spectroscopy and mass spectrometry. B. Using NMR spectroscopy, examine the folding pathway of AAT at a residue specific level and structurally characterize partially folded intermediate states that are formed during this process. C. Understand the folding of AA T as i… more
Amount: £152,244
Manipulating Iron metabolism through synthesis of Hepcidin analogues.
There is a strong connection between iron metabolism and healthy living, particularly in the elderly and obese where it is found that iron levels can decrease- affected by the level of hepcidin -a small peptide that controls iron homeostasis.[1, 2] Hepcidin binds to, and induces degradation of Ferroportin (an iron efflux protein) involved in intestinal iron absorption, maternal fetal iron transpo… more
Amount: £152,244
Computational & experimental studies of riboswitches.
This project aims to combine computational and experimental methods to further our understanding of how riboswitches interact with their cognate ligands, and how we can use sequence, structural and genomic context information to predict riboswitches in genomic sequences. Objectives of this project include: a) The development of a computational method to identify candidate sequences for new classe… more
Amount: £152,244
Mass Spectrometry Studies of Type IV Secretion Systems.
The emergence of methicillin-resistant Staphylococcus aureus (MRSA), responsible for difficult to treat infections in humans has led to the identification of broad-host-range plasmids carrying antibiotic resistance, conjugated through Type IV Secretion Systems (T4SSs). The T4SS is one of several types of secretion systems that mediates the transport of macromolecules across cellular membranes [1-… more
Amount: £152,244
Development of a novel high throughput screen for cytoplasmic entry of cell penetrating peptides.
In our opinion, none of the current methods for assessing uptake of proteins by CPPs are able to give a rapid, accurate, and quantitative measure of cytosolic uptake. Our aims are therefore: (i) Generation of a high throughput, quantitative assay for the transport of proteins into the cytoplasm of mammalian cells by cell penetrating constructs. Our proposed assay is based on monitoring the cytopl… more
Amount: £152,244
Does increased household income among the poor contribute to reversal of the social gradient of obesity in Egypt?
The global obesity epidemic is spreading rapidly in developing countries with a social distribution that varies according to level of economic development. In urban Egypt, obesity appears to have become more common among poor women compared to the rich which is the reverse of the expected social distribution of obesity at Egypt s stage of economic development. Observational data suggest that inc… more
Amount: £180,817
The impact of HIV and antiretroviral therapy on the cardiovascular system in HIV-infected children.
HIV and some antiretroviral (ARV) drugs are associated with impaired cardiac and vascular function in adults, but little is known about the impact in HIV-infected children. This project will explore the relationships between HIV infection, immune activation and cardiovascular phenotype in HIV infected children living in Africa recruited to a funded pharmacokinetic study of different nucleoside r… more
Amount: £371,694
Crossing the boundaries of mind and medicine: Carl du Prel (1839-1899) and his network in the history of dynamic psychiatry
The proposed research aims to a) detail du Prel's philosophical-psychological system in the context of emerging mechanistic, monistic, and other theories of mind and body, especially pertaining to issues related to the mental causation of physical and mental health, b) reconstruct the genesis of knowledge claims of opponents of late nineteenth- to early twentieth century psychical research, who h… more
Amount: £80,951
A systematic investigation into the pathogenesis and course of Parkinson's syndrome.
In this ambitious proposal we have assembled a group of world-leading clinical and basic science researchers possessing complementary expertise to identify and tackle the causes of Parkinson's Disease (PD). The overall goal will be a fuller understanding of the molecular pathogenesis of PD as well as improved clinical assessment of the disease prodrome. The main goals of the project are: 1. To un… more
Amount: £5,952,982