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Jeevan Shakti Mela - Funfair for lifeforce
<p>Type 2 Diabetes mellitus (T2DM) is often not well understood among marginalized populations, but its prevalence is increasing, particularly in low-income countries. We will address this challenge in rural plains Nepal, enabling female Maithil artists from the Janakpur Women’s Development Centre (JWDC) to engage with communities about T2DM through research, drama, and a funfair. First, a … more
Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Computer-based analysis of early fibrosing lung disease
<p>Fibrosing lung disease (FLD) is an idiopathic condition, affecting older patients (median age=65 years) and smokers, accounting for 0.9% of all UK deaths in 2012. Unfortunately, despite newly available treatment options, FLD is typically diagnosed at an advanced stage with patients already markedly functionally impaired. Patient decline is often rapid.</p> <p> </p> <p>A constr… more
Genetic background effects in human iPSCs and iPSC-derived cell types
<p>Human induced pluripotent stem cells (iPSC) have emerged as a key model system to study the function of genetic variants, as they provide access to relevant cell types and developmental lineages through cellular differentiation. However, while it has been shown that the genetic background of the donor individual has an effect on molecular phenotypes measured from iPSCs, it is currently not kno… more
Investigation of protein CoAlation in the process of apoptosis
<p>CoAlation is a novel post-translational modification to proteins whereby Coenzyme A is covalently attached to proteins. It occurs as part of the oxidative stress response as an alternative mechanism to protein glutathionylation. It is specifically a modification of enzymes involved in cellular metabolism and protects catalytic thiol groups on active site cysteine residues from irreversible dam… more
4 year PhD in Neuroscience
Macromolecular machines: interdisciplinary training grounds for structural, computational and chemical biology
UCL Wellcome Trust PhD Programme for Clinicians
Open access award 2012/13.
Transcriptional control of CNS myelination in development and maturity.
Most oligodendrocytes (OLs) are formed in the early postnatal period but myelin-forming OLs continue to be born throughout healthy adult life, possibly contributing to learning and memory. New OLs are generated from proliferating oligodendrocyte precursors (OPs), which can also generate astrocytes and perhaps even neurons in some contexts. If we could understand the genetic mechanisms that cont… more
Modelling barriers to drug delivery and response to therapy in solid tumours using non-invasive magnetic resonance imaging
During the growth of a tumour, high rates of cell proliferation lead to hypoxia and the upregulation of pro-angiogenic pathways. This results in a chaotic and disorganised vascular network that is typically poorly perfused, with highly permeable walls. Excessive fluid leakage through vessel walls leads to high interstitial fluid pressure (IFP) in most tumours which, alongside poor vascular perfus… more
Using deafness as a model system to inform literacy intervention and neurobiological models of language.
My previous work suggests that language processing in the brain is driven by linguistic structure rather than language modality. I have used this knowledge to develop a model of reading in deaf children. Since reading involves learning a visual representation of an auditory language, the majority of children born deaf find it extremely difficult to learn to read. In my model I propose that speech… more
The Conscious Phenotype.
The repertoire of physiological (and on longer timescales, anatomical) states in which an organism can survive is limited and these states define its phenotype. My research vision is to define the conscious phenotype - the set of states correlated with self-reported conscious experience of the external environment and its underlying basis in human brain anatomy and function. This will require a… more
An investigation into the defective termination and resolution of acute inflammation in ulcerative colitis
Ulcerative colitis (UC) is a chronic inflammatory disorder, associated with protracted acute inflammation after bacterial challenge. I postulate that this results from failure of the mechanisms that normally terminate inflammation. The skin window technique permits examination of acute inflammatory responses in vivo following tissue damage or applied immunomodulators. I will use this to investig… more
'Centre for Health service and Academic Partnership in Translational eHealth Research (CHAPTER)'
<p>UCL Partners is the largest AHSC in terms of population served (5m, ethnically diverse), and concentration of BRCs (n=5, £165m) and is the only AHSC with a system wide partnership model (n=14 NHS Trusts). Bringing together three of UCLP's academic partners UCL, LSHTM and QMUL, and the HPA, CHAPTER will integrate for the first time multiple areas of critical mass (>60 data sources and … more
A Phase I Clinical Trial of DARC
Preclinical development of a novel diagnostic for glaucoma. Glaucoma is the major cause (15 per cent) of irreversible blindness worldwide. A recent UK report suggested 10 per cent earlier detection of glaucoma would save £1billion/year in treatment costs alone.Professor Francesca Cordeiro and colleagues from the Institute of Ophthalmology at University College London, have been given Translation … more
Pre-clinical assessment of small diameter conduit made from nanocomposite polymer for coronary artery bypass graft application
Current synthetic grafts are largely based on polytetraluoroethane (PTFE) or Dacron perform adequately as large calibre grafts, but are not suitable for coronary artery bypass grafts (CABG) due to the small diameter of the coronary arteries, the low blood flow rates and high occlusion rates resulting in thrombosis and intimal hyperplasia. There is a clinical need for a smaller diameter CABG (<5m… more
The Secret Life of Proteins - Computational and Experimental Studies of Moonlighting Proteins.
The aim of the project is to further our understanding of protein moonlighting (multiple unrelatedfunctions of a single protein). During this project we will explore a number of questions that relate to the molecular mechanisms and properties that allow or enhance the moonlighting potential of a protein. the project will concentrate on computational approaches wit the aim of producing testable predictions, which we then hope to veryify with experimental studies.
InfeCtion respONse through vIrus genomiCs (ICONIC)
Viruses are a major cause of morbidity and mortality, with a high cost to the NHS. Viruses have significant genomic variation, which underpins pathogenicity, drug resistance, and transmission. Despite enormous advances in technology, we currently lack the systems, facilities and capacity to routinely capture full-length viral gene sequences, to monitor drug resistance at the granularity to optima… more
Biological determinants of ageing and late life health, and their pharmacological manipulation.
Age is the main risk factor for common, debilitating conditions including cancer, cardiovascular disease and neurodegeneration. Single gene mutations can extend healthy lifespan in laboratory animals. The mechanisms involved are evolutionarily conserved, with genetic and pharmacological inhibition of the nutrient-sensing insulin/insulin-like growth factor/TOR (IIT) signalling network extending he… more