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Search results (Displaying 99 grants)

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Earliest award date
28 Jan 2013
Latest award date
06 Dec 2017
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Jeevan Shakti Mela - Funfair for lifeforce
<p>Type 2 Diabetes mellitus (T2DM) is often not well understood among marginalized populations, but its prevalence is increasing, particularly in low-income countries. We will address this challenge in rural plains Nepal, enabling female Maithil artists from the Janakpur Women&rsquo;s Development Centre (JWDC) to engage with communities about T2DM through research, drama, and a funfair. First, a … more
Amount: £75,000
Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Amount: £283,711
Computer-based analysis of early fibrosing lung disease
<p>Fibrosing lung disease (FLD) is an idiopathic condition, affecting older patients (median age=65 years) and smokers, accounting for 0.9% of all UK deaths in 2012. Unfortunately, despite newly available treatment options,&nbsp;FLD is typically diagnosed at an advanced stage with patients already markedly functionally&nbsp;impaired. Patient decline is often rapid.</p> <p>&nbsp;</p> <p>A constr… more
Amount: £1,034,494
Genetic background effects in human iPSCs and iPSC-derived cell types
<p>Human induced pluripotent stem cells (iPSC) have emerged as a key model system to study the function of genetic variants, as they provide access to relevant cell types and developmental lineages through cellular differentiation. However, while it has been shown that the genetic background of the donor individual has an effect on molecular phenotypes measured from iPSCs, it is currently not kno… more
Amount: £99,935
Investigation of protein CoAlation in the process of apoptosis
<p>CoAlation is a novel post-translational modification to proteins whereby Coenzyme A is covalently attached to proteins. It occurs as part of the oxidative stress response as an alternative mechanism to protein glutathionylation. It is specifically a modification of enzymes involved in cellular metabolism and protects catalytic thiol groups on active site cysteine residues from irreversible dam… more
Amount: £0
Amount: £2,850,000
Amount: £2,814,500
Albumin to prevent infection in Acute-on-Chronic Liver Failure (ATTIRE)
Liver disease is the 5th commonest cause of death in the UK and the only one of the top 10 currently rising. Approximately 110,000 patients with symptoms of advanced cirrhosis, (commonly related to alcohol excess) e.g. jaundice, confusion and bleeding from the stomach, were admitted to UK hospitals in 2011-12. The most common cause of death in these patients is infection. These patients have a we… more
Amount: £1,288,480
Amount: £163,023
4 Year PhD in Neuroscience.
<table> <tbody> <tr> <td><span style="font-size: medium;"><span style="font-size: medium;"></span></span> <p>The molecular mechanisms that control the formation and growth of synapses are well understood. However, much less is known about how synapses are maintained in the adult brain and how synapse loss and dysfunction is triggered in neurodegenerative conditions, such as Alzheimer's disease (A… more
Amount: £163,023
Amount: £163,023
Developing Novel Antimicrobials by Synthetic Biology
<p>Current problems with increasing antimicrobial resistance mean the discovery of novel antimicrobials is becoming increasingly important. Therefore, antimicrobial drug discovery has been selected as a model to investigate the feasibility of using synthetic biology to create azol(in)e modified peptide libraries and select mutants with biological activity. The library of azol(in)e modified peptid… more
Amount: £163,023
Sulfonium Salts as Precursors for 18F-labelling of Small Molecule PET Tracers.
Positron emission tomography (PET) has become an invaluable tool for diagnostic imaging and medical research as it allows quantification of biochemical processes in vivo with unsurpassed sensitivity and specificity. Due to its near ideal physicochemical properties fluorine-18 is the radioisotope of choice for imaging applications with PET, yet the lack of efficient and practical methods for the i… more
Amount: £163,023
Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present.
Modern patterns of human health and disease have been shaped by cultural, demographic and ecological changes over the last 10,000 years, particularly in association with the transition to agriculture and subsequent increases in urban settlement, population density and mobility, and reduction in dietary breadth to a few key staples. These changes will, in turn, have led to increased carbohydrate c… more
Amount: £360,819
Infection and immunity from a life course perspective: Life Study enhancement pilot study
We aim to understand how interactions between microorganisms, both pathogenic and the colonising microbiota, the immune system and clinical, social and behavioural factors during pregnancy, birth, infancy and childhood influence health throughout life. We therefore propose an Infection and Immunity Enhancement to Life Study, a large national birth cohort study that aims to recruit 90,000 particip… more
Amount: £1,140,387
The Role Of Small-molecule Dietary And Non-dietary Antioxidants In Predicting And Preventing Respiratory Disease
<p>Respiratory diseases caused by smoking and pollution are increasing in prevalence across all continents. At present, there are no simple blood tests for predicting those at highest risk and few molecular targets for primary prevention. This work programme will use pre-collected data to answer the following: do antioxidant molecules found in blood (bilirubin, uric acid, alpha-tocopherol, ascorb… more
Amount: £284,626
Harnessing pre-clinical lung cancer patient models for precision immuno-oncology
<p>Only 16% of non-small cell lung cancer (NSCLC) patients survive for 5 years. Improvement in survival has been slow as the histological and genomic features of the disease are heterogeneous. Tumour heterogeneity poses a challenge for therapy development and suggests the importance of a personalised medicine approach. One approach is to expand the subset of tumour-infiltrating lymphocytes (TILs)… more
Amount: £250,000
Using modern causal inference methods and general population data to investigate the role of inflammation in the aetiology of eating disorders
<p>Eating disorders are severe psychiatric conditions with typical onset in adolescence and a complex aetiology. Epidemiological studies have shown that inflammation is potentially implicated in the aetiology of several psychiatric conditions. However, although the hypothesis is plausible, robust epidemiological evidence that inflammation is involved in the pathogenesis of eating disorders is lar… more
Amount: £250,000
Water resistance: a study of environmental justice, resilience and citizen science activism in Mexico City
<p>This research will explore resilience in the context of environmental justice, with a focus on water insecurity in Mexico City. The concept of resilience is central to public health and climate change discourse, but is rarely critiqued. Addressing this omission is crucial: resilience frameworks can conceal social inequalities, uphold political status quo, and overlook local experience. Equally… more
Amount: £96,532