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Search results (Displaying 103 grants)

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Earliest award date
24 Jan 2017
Latest award date
05 Dec 2018
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Amount: £50,000
A Hotbed for Liver Cancer: Biomedicine, Exposure and Uncertainty in West Africa
<p>Incidence rates of primary liver cancer vary strikingly across the globe. West Africans are more likely than most populations to develop and die from it. Focusing on Senegal and The Gambia, my project investigates how this association between place and <em>intensity of susceptibility</em> to liver cancer has been understood, and how it has been maintained by gaps in protection from risky expos… more
Amount: £301,612
Developing novel gene therapy technology for treatment of glycine encephalopathy
"Glycine encephalopathy, also known as non-ketotic hyperglycinaemia (NKH), is a life limiting inherited neuro-metabolic disease which presents soon after birth and leads to severe neurological outcomes including epilepsy and profound developmental delay. Current treatments for NKH are neither effective long-term, nor curative. Glycine encephalopathy is characterized by accumulation of glycine and… more
Amount: £365,837
Lancet Countdown: Tracking Progress on Health and Climate Change
<p>Please see the Executive Summary of the attached document for a summary of the proposal.</p> <p>&nbsp;</p>
Amount: £5,528,492
Jeevan Shakti Mela - Funfair for lifeforce
<p>Type 2 Diabetes mellitus (T2DM) is often not well understood among marginalized populations, but its prevalence is increasing, particularly in low-income countries. We will address this challenge in rural plains Nepal, enabling female Maithil artists from the Janakpur Women&rsquo;s Development Centre (JWDC) to engage with communities about T2DM through research, drama, and a funfair. First, a … more
Amount: £75,000
Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Amount: £283,711
Computer-based analysis of early fibrosing lung disease
<p>Fibrosing lung disease (FLD) is an idiopathic condition, affecting older patients (median age=65 years) and smokers, accounting for 0.9% of all UK deaths in 2012. Unfortunately, despite newly available treatment options,&nbsp;FLD is typically diagnosed at an advanced stage with patients already markedly functionally&nbsp;impaired. Patient decline is often rapid.</p> <p>&nbsp;</p> <p>A constr… more
Amount: £1,034,494
Wellcome Centre for Human Neuroimaging
<p>The Research Enrichment fund will enable us to embed public engagement (PE) into our Wellcome Centre research process.&nbsp;If funded, we will have achieved the following at the end of the proposed Research Enrichment programme:</p> <p>(1) &nbsp;Established a cultural change within our Centre where PE is integrated into all of our research programmes, with more researchers doing PE than not.&… more
Amount: £266,960
Auditory structured sequence learning on multiple timescales
<p>Regularities play an important role in analysing auditory scenes; for example, by exploiting the predictable sounds of the car engine, a driver can effortlessly ignore this irrelevant noise, freeing cognitive resources to focus on the road. Regularities also play an important role in language, dictating the relationship between syllables in word or the order words in a sentence, and have been … more
Amount: £300,000
Neurobiological foundations of flexible social behaviour
<p>A core aspect of healthy social function is the ability to map our private beliefs onto those that we express publicly according to the social context. It may be socially appropriate to express gratitude for a gift we do not want, or remorse for an action we do not regret. My goal is to understand the neurocognitive mechanisms supporting context-appropriate social behaviours and how they are a… more
Amount: £300,000
Genetic background effects in human iPSCs and iPSC-derived cell types
<p>Human induced pluripotent stem cells (iPSC) have emerged as a key model system to study the function of genetic variants, as they provide access to relevant cell types and developmental lineages through cellular differentiation. However, while it has been shown that the genetic background of the donor individual has an effect on molecular phenotypes measured from iPSCs, it is currently not kno… more
Amount: £99,935
Investigation of protein CoAlation in the process of apoptosis
<p>CoAlation is a novel post-translational modification to proteins whereby Coenzyme A is covalently attached to proteins. It occurs as part of the oxidative stress response as an alternative mechanism to protein glutathionylation. It is specifically a modification of enzymes involved in cellular metabolism and protects catalytic thiol groups on active site cysteine residues from irreversible dam… more
Amount: £0
Amount: £2,850,000
Amount: £2,814,500
The typology and function of an integrated spatial and visual cortical system
<p style="margin-left: 0cm; margin-right: 0cm">When we move within an environment, our visual system is bombarded with visual stimulation from the outside world while, at the same time, the head and eyes are also moving. The brain is nonetheless able to integrate these competing inputs into a stable perception of the world. I will investigate two brain regions that are likely to be key players in… more
Amount: £2,126,007
Adaptive myelination in learning and memory
<p>We found that production of new oligodendrocytes (OLs) is stimulated by, and required for, motor skill learning in mice. &nbsp;New OL production was required within 2-3 hours of mice engaging with the motor task, seemingly too soon for full myelin wrapping. We will therefore investigate&nbsp;how, at the cellular level, OLs contribute to early-stage&nbsp;learning, by&nbsp;interfering geneticall… more
Amount: £1,305,661
Information-seeking in health and disease
<p style="margin-left: 0in; margin-right: 0in">People spend a substantial amount of time seeking out information (e.g., reading, asking questions, internet browsing). It is theorized that common psychiatric conditions, including depression and anxiety, are characterized by abnormal information-seeking patterns. These patterns could potentially be measured and used to facilitate diagnosis and trea… more
Amount: £1,622,804
The Long and Winding Road: Connecting Cortex to Cortex Through the Thalamus.
<p>Our current model of the thalamus as a modulator and transmitter of sensory information is difficult to reconcile with the connectivity and physiology of the high-order thalamic nuclei (HOn). The dominance of cortical over peripheral input, variety of cortical areas providing modulation&nbsp;and cell-to-cell diversity in cortical projection targets have made the HOn difficult to understand. I … more
Amount: £300,000