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Search results (Displaying 97 grants)

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Earliest award date
24 Jan 2017
Latest award date
03 Dec 2019
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Jeevan Shakti Mela - Funfair for lifeforce
<p>Type 2 Diabetes mellitus (T2DM) is often not well understood among marginalized populations, but its prevalence is increasing, particularly in low-income countries. We will address this challenge in rural plains Nepal, enabling female Maithil artists from the Janakpur Women&rsquo;s Development Centre (JWDC) to engage with communities about T2DM through research, drama, and a funfair. First, a … more
Amount: £75,000
Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Amount: £283,711
Computer-based analysis of early fibrosing lung disease
<p>Fibrosing lung disease (FLD) is an idiopathic condition, affecting older patients (median age=65 years) and smokers, accounting for 0.9% of all UK deaths in 2012. Unfortunately, despite newly available treatment options,&nbsp;FLD is typically diagnosed at an advanced stage with patients already markedly functionally&nbsp;impaired. Patient decline is often rapid.</p> <p>&nbsp;</p> <p>A constr… more
Amount: £1,034,494
Gender, health and the afterlife of colonialism. Engaging new problematisations to improve maternal and infant survival.
<p style="margin-left: 0cm; margin-right: 0cm">I will work at the intersection of public health, decolonisation theory and feminist ethnography to generate evidence and promote gender responsive strategies aimed at improving maternal and infant survival.</p> <p style="margin-left: 0cm; margin-right: 0cm">Historical gender and ethnic inequalities underlie low rates of skilled birth attendance and… more
Amount: £446,111
Our Planet, Our Health award: Complex Urban Systems for Sustainability and Health
<p style="margin-left: 0cm; margin-right: 0cm">Three work streams will address participatory local action (outcomes 1-3), national media (outcome 4), and global communication (outcome 5). After two years, we will have stimulated local discussion and co-designed and implemented public engagement interventions for urban environmental sustainability and health &ndash; centred on waste management - w… more
Amount: £248,615
Amount: £2,000,000
Genetic background effects in human iPSCs and iPSC-derived cell types
<p>Human induced pluripotent stem cells (iPSC) have emerged as a key model system to study the function of genetic variants, as they provide access to relevant cell types and developmental lineages through cellular differentiation. However, while it has been shown that the genetic background of the donor individual has an effect on molecular phenotypes measured from iPSCs, it is currently not kno… more
Amount: £99,935
Investigation of protein CoAlation in the process of apoptosis
<p>CoAlation is a novel post-translational modification to proteins whereby Coenzyme A is covalently attached to proteins. It occurs as part of the oxidative stress response as an alternative mechanism to protein glutathionylation. It is specifically a modification of enzymes involved in cellular metabolism and protects catalytic thiol groups on active site cysteine residues from irreversible dam… more
Amount: £0
Amount: £2,850,000
Amount: £2,814,500
Inhibitory control of visually-guided behaviour
The brain utilises cortical and subcortical pathways to transform sensory information into action, giving rise to learned and instinctive sensory-guided behaviours. How these pathways interact to generate flexible behaviour, allowing animals to react differently to the same environmental stimuli depending on circumstance, remains poorly understood. We propose that inhibitory circuits in the thala… more
Amount: £2,249,535
Neuro-computational mechanisms of information acquisition and integration in social contexts
Understanding the social cognitive mechanisms that enable people to learn from and interact with others has been of considerable interest to psychologists and neuroscientists for decades. Yet, the mechanisms underlying our ability to gather information from other people and to learn from them by integrating this information into our beliefs remain to be elucidated. Here, I proposed to use a neuro… more
Amount: £300,000
Understanding and predicting individual differences in cannabis-induced psychosis-like experiences
Acute pharmacological challenge and observational studies in humans have shown that cannabis can induce psychosis-like experiences. However, not all individuals exhibit adverse experiences, implicating individual differences in cannabis-sensitivity. While a number of studies implicate a genetic contribution to cannabis-sensitivity, such evidence relies on genetic variables of limited interpretab… more
Amount: £300,000
UCL Wellcome 4-year PhD in Mental Health Science
<p style="margin-left: 0cm; margin-right: 0cm">Mental illness is a major public health problem, with poorly understood causes and highly variable treatment outcomes. While mental health research training has strength within disciplines, these typically operate in parallel, greatly impeding progress in improving clinical outcomes. The <strong>UCL Wellcome 4-Year PhD in Mental Health Science</stron… more
Amount: £5,757,810
RNA metabolism in developing neurons
<p>Understanding how neurons translate extracellular cues into specific patterns of gene expression is amongst the major goals of modern neurobiology. Efforts to unravel the molecular basis of localised gene expression have mostly focused on transcriptional control and mRNA transport. However, post-transcriptional mRNA processing is increasingly recognised as an essential step in the propagation … more
Amount: £2,119,443
Mechanisms of perceptual decision-making in premotor cortex
<p style="margin-left: 0cm; margin-right: 0cm">Decisions require integration of sensory evidence and prior knowledge before committing to a chosen action, but the neural mechanisms of decision-making remain poorly understood, partly because they involve the interaction of multiple brain structures and timescales. We have developed a change-detection task in mice, which separates covert antecedent… more
Amount: £2,781,976
Synaptic, Cellular and Neural Circuit Dysfunction in Down Syndrome
<p style="margin-left: 0cm; margin-right: 0cm">Down syndrome (DS) is a common genetic disorder resulting from an extra copy of human chromosome 21 (Hsa21). This gene dosage disorder is characterised by cognitive deficits and early-onset neurodegeneration. It causes significant impact on the quality and longevity of life. Presently, there are no therapies.</p> <p style="margin-left: 0cm; margin-r… more
Amount: £2,444,366
Applying causal inference methods to investigate the impact of adverse childhood experiences on mental health
<p style="margin-left: 0cm; margin-right: 0cm">Children exposed to abuse, neglect, and dysfunctional home environments (e.g., parental substance abuse, mental illness, domestic violence) have an elevated risk of developing costly and impairing mental health problems. However, as highlighted in a recent report by the UK Science and Technology Select Committee, the extent to which these adverse chi… more
Amount: £300,000