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Search results (Displaying 339 grants)

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Earliest award date
22 Nov 2005
Latest award date
30 Sep 2020
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From vision to action: Systems analysis of sensorimotor circuitry controlling visually-guided behaviour
<p style="margin-left: 0cm; margin-right: 0cm">Despite the emergence of technologies to record from thousands of neurons during animal behaviour, two major issues are currently limiting the transfer and utilisation of ultra-high-dimensional datasets between neuroscience groups. First, raw data files are often enormous, making data transfer inconvenient and expensive. Second, there is no common fo… more
Amount: £48,349
Global Health 50/50: Towards accountability for gender equality in global health
<p>We propose to establish <em>Global Health 50/50</em>, a new initiative seeking to advance action and accountability for gender-equality in global health.&nbsp;</p> <p>Gender is a key driver of power to exercise the right to health, including exposure to risks of poor health, health seeking behaviours, and access to quality health care. Gender inequalities continue to define and drive career p… more
Amount: £29,764
Amount: £50,000
Jeevan Shakti Mela - Funfair for lifeforce
<p>Type 2 Diabetes mellitus (T2DM) is often not well understood among marginalized populations, but its prevalence is increasing, particularly in low-income countries. We will address this challenge in rural plains Nepal, enabling female Maithil artists from the Janakpur Women&rsquo;s Development Centre (JWDC) to engage with communities about T2DM through research, drama, and a funfair. First, a … more
Amount: £75,000
Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>We will have achieved a comprehensive understanding of not only the most appropriate ways and times to discuss inclusion in a SUDIC registry with bereaved families but how we can better inform and support them through the death of their child and the multi-disciplinary investigation that follows a sudden death. We will have established:</p> <ul> <li>What families understand now about the pro… more
Amount: £16,000
Vacation Scholarships 2017 - University College London
<p>Vacation Scholarships 2017 - University College London</p>
Amount: £25,500
Genetic background effects in human iPSCs and iPSC-derived cell types
<p>Human induced pluripotent stem cells (iPSC) have emerged as a key model system to study the function of genetic variants, as they provide access to relevant cell types and developmental lineages through cellular differentiation. However, while it has been shown that the genetic background of the donor individual has an effect on molecular phenotypes measured from iPSCs, it is currently not kno… more
Amount: £99,935
Investigation of protein CoAlation in the process of apoptosis
<p>CoAlation is a novel post-translational modification to proteins whereby Coenzyme A is covalently attached to proteins. It occurs as part of the oxidative stress response as an alternative mechanism to protein glutathionylation. It is specifically a modification of enzymes involved in cellular metabolism and protects catalytic thiol groups on active site cysteine residues from irreversible dam… more
Amount: £0
How do cells integrate signals? Roles of timing in neural induction
<p>During embryonic development cells have to integrate up to eight molecular pathways in order to choose between alternative fates or behaviours. However, even in combination, these eight pathways cannot provide enough information to specify the many (perhaps as many as 10<sup>4</sup>) cell types that comprise the adult body. Timing seems to be important. One of the earliest fate decisions in em… more
Amount: £12,700
Harnessing Diversity Generating Retroelements (DGRs) for in vivo evolution
<p>The goal of the project is to express the reverse transcriptase (RT), central to the Bordertella phage BPP-1 diversity generating retroelement (DGR), and test it for synthetic nucleic acid (XNA) synthesis as well as reverse transcription. In addition, I will focus on cloning the BPP-1 DGR elements into E. coli, creating a circuit where DGR function can activate a selectable marker (e.g. kanR).… more
Amount: £2,000
Probing the synaptic mechanisms of human genetic neurological disorders
<p>We are interested in how mutations that lead to human neurological disorders (particularly epilepsy) impact neuronal function. Much of our previous work has focused on how mutations change intrinsic neuronal excitability, but epilepsy is increasingly being associated with genes which are also predicted to perturb synaptic activity, and the aim of this project is to probe whether a subset of mu… more
Amount: £5,805
Amount: £24,959
Amount: £19,750
UCL / Wellcome Trust PhD programme for Clinicians; Investigating novel geneticassociations with ciliopathy in the zebrafish
<p>The primary cilium is present in almost all cells and plays an important role in the function of many organs, including the kidney, eye and brain. Ciliopathies result from dysfunction of the cilium. We have identified a family in which inherited lack of an enzyme that is involved in metabolism&nbsp; of dietary&nbsp; substrates&nbsp; is&nbsp; associated&nbsp; with&nbsp; kidney&nbsp; failure,&nb… more
Amount: £44,266
Public Engagement Provision
The James Lind Alliance recently identified their 'Top 10' research prioritiesaccording to what stroke patients and their carers want. Cognitive therapies, long-term consequences of stroke and aphasia therapy were the top three priorities. My proposal will address all of these. Stroke patients with anomia and their families will be therefore be the main public beneficiaries of knowledge arising f… more
Amount: £4,500
Investigation into LRRK2 vesicular trafficking pathways to provide further insight into Parkinson's disease pathogenesis.
<p>How do Parkinson&rsquo;s disease causing mutations in <em>LRRK2</em> impact vesicular trafficking within the trans-golgi network (TGN)? In addition, what is the functional nature of LRRK2- arfaptin-2 and ARL6IP1 interactions within this pathway?&nbsp;</p>
Amount: £80,000