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- 22 Nov 2005
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- 14 Dec 2005
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Preotease activated receptor-2 in pleural inflammation.
Protease Activated Receptor-2 in Pleural Inflammation Pleural diseases are common in clinical practice. Pleural inflammation is a crucial process underlying the pathogenesis of most pleural diseases, but the mechanisms governing pleural inflammation are poorly understood. Evidence that protease-activated receptor (PAR)-2, a novel seven-transmembrane G-protein-coupled receptor, holds a critic… more
The medical and scientific letters of Dr. David Livingstone online.
Interim (pilot) funding is required to sustain and develop a major online initiative whilst a full grant proposal is researched and written to publish the medical and scientific letters of Dr David Livingstone. The start-up funding (which ends in July) has been provided by the Wellcome Trust Centre for the History of Medicine at UCL and used to support Dr Michael Hawkins whose technical expertis… more
The role of growth factors in the formation and maintenance of central synapses.
We have shown that Wnt deficiency affects presynaptic differentiation in the mouse cerebellum. Conversely gain of function studies showed that Wnts increase presynaptic differentiation in cerebellar and hippocampal neurons. More recently we found that Wnt signalling also regulates neurotransmitter release. The presence of other growth factors such as FGFs and Shh during the synaptogenic period … more