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Your search ‘’ returned 25 results in ‘All grant fields’

Search results (Displaying 25 grants)

Total grants
25
Total funders
1
Total recipients
1
Earliest award date
12 Jan 2015
Latest award date
14 Dec 2015
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Amount: £24,959
Amount: £19,750
UCL / Wellcome Trust PhD programme for Clinicians; Investigating novel geneticassociations with ciliopathy in the zebrafish
<p>The primary cilium is present in almost all cells and plays an important role in the function of many organs, including the kidney, eye and brain. Ciliopathies result from dysfunction of the cilium. We have identified a family in which inherited lack of an enzyme that is involved in metabolism&nbsp; of dietary&nbsp; substrates&nbsp; is&nbsp; associated&nbsp; with&nbsp; kidney&nbsp; failure,&nb… more
Amount: £44,266
Investigation into LRRK2 vesicular trafficking pathways to provide further insight into Parkinson's disease pathogenesis.
<p>How do Parkinson&rsquo;s disease causing mutations in <em>LRRK2</em> impact vesicular trafficking within the trans-golgi network (TGN)? In addition, what is the functional nature of LRRK2- arfaptin-2 and ARL6IP1 interactions within this pathway?&nbsp;</p>
Amount: £80,000
Amount: £26,184
Global brain states and local cortical processing in awake behaving mice
<p>This project will study how cortical activity is coordinated at a global level in behaving mice.</p> <p>The brain's activity changes dramatically when animals perform active behaviors. In the cortex, this is manifested by a change in "cortical state", which is traditionally studied by recordings of the electroencephalogram. This project wil l use new experimental approaches to understand the n… more
Amount: £15,000
Medicine Corner - costed extension
This extension funding will cover the engagement by SNEHA of two consultants. One will assist with Dharavi Biennale activities as the project winds down. Both will work on Medicine Corner, the Wellcome Collection's programme of cultural activity exploring Indian medicine, health and wellbeing.
Amount: £6,300
THE PHYSIOLOGICAL ROLE OF CLATHRIN LIGHT CHAIN DIVERSITY IN VERTEBRATES.
<table> <tbody> <tr> <td>Clathrin-coated &nbsp; vesicles (CCVs) influence cell-cell interaction for all eukaryotic organisms &nbsp; by mediating membrane traffic pathways that control receptor expression and &nbsp; organelle formation. The biochemistry of how clathrin polymerizes into a &nbsp; lattice to form a CCV is understood at a basic level, but how CCVs meet the &nbsp; transport challenges … more
Amount: £51,200
AMARI: African Mental Health Research Initiative
<p>Mental, neurological and substance use (MNS) disorders are a leading, but neglected, cause of morbidity and mortality in sub-Saharan Africa [1]. MNS disorders account for &gt;25% of all years lived with disability globally, more than cardiac disease or cancer [2]. The treatment gap is vast, only 10% of people with MNS disorders in low-income countries access evidence-based treatments, compared… more
Amount: £49,068
A Community of One: Understanding The Social Core of Psychosis
<p>The delusions and hallucinations of psychosis are largely a social experience - typically involving the experience of illusory persecutors, conspirators and communicators - and yet evidence shows that current &lsquo;static&rsquo; measures of social cognition, at best, only weakly predict their presence and poorly explain these significant sources of distress and disability. Consequently, this … more
Amount: £96,779
Mechanisms of glia-derived neurogenesis
<table> <tbody> <tr> <td>Classic forward genetic screens in C.elegans have revealed many evolutionarily&nbsp;conserved genes required to generate individual terminal neuron types.&nbsp;However, little attention has been paid to the molecular and cellular&nbsp;mechanisms that act early during embryogenesis to specify neuronal lineages.&nbsp;The overall goal of this research is to characterise thes… more
Amount: £95,036
Supportive supervision of mid level health workers in rural Nepal for improved job satisfaction, motivation and quality of care.
<p>Many low-income countries are suffering from a shortage of health workers in rural areas. In response to this, tasks are being shifted to mid level cadres who are often working without adequate management and support mechanisms. These cadres require emotional and clinical support in order to develop and retain their skills, and an enabling environment to provide good quality care. The evidence… more
Amount: £33,367
High altitude adaptation and pregnancy outcome study (HAPS): investigating the influence of hypoxia on birth weight
A baby unable to grow to its full potential in the womb (intrauterine growth restriction, IUGR) results in low birth weight (LBW). Failure to adapt to a low-oxygen environment may impede placental growth and consequently, result in a LBW baby. LBW is especially common amongst newcomers to high altitude (HA) environments, however, populations with long HA residency are relatively protected, poten… more
Amount: £90,255
The impact of epigenetics on DNA-DNA interactions
It has become clear that DNA-DNA interactions are an important component of gene regulation and of complex trait genetics. The impact of DNA variation of these interactions is less well understood. This project will characterise two important loci, the Major Histocompatibility Locus (MHC) and the imprinted H19/Igf2 locus in mice. These loci play key roles in immunity and growth and serve as mode… more
Amount: £98,476
Non Invasive Prenatal Testing: A Comparative International Conference.
This 3-day workshop will bring together 23 multi-disciplinary international researchers and health care professionals to explore the ethical, legal, and social implications of the global expansion of non-invasive prenatal testing (NIPT) with an emphasis on including non-Western and low and middle income countries (LMIC). NIPT is a relatively new prenatal screening technology that became available… more
Amount: £10,000
Histories of sickle cell anaemia, race and health in postcolonial Britain, c.1950-1995 .
Following an extensive historiographical survey and archival research, I will complete an 80,000-100,000 word original thesis. This will be made up of an introduction, setting out historiographical and historical context and establishing my methodology and definitions, and five thematic chapters. The first chapter will deal with the genetic research undertaken on SCA by British scientists such as… more
Amount: £90,020
Wellcome Beit Prize 2014/2015- The population impact of delirium on long-term cognitive impairment.
<p>Delirium is one of the most common complications of acute illness in older adults yet it remains poorly understood. This fellowship will investigate prospectively population delirium incidence with cognitive outcomes. In parallel, I will test new methods for informatics-based delirium ascertainment for use in longitudinal studies. Hypothesis: Incident delirium is associated with changes in glo… more
Amount: £25,000
Public Engagement Provision
<p>Delirium is one of the most common complications of acute illness in older adults yet it remains poorly understood. This fellowship will investigate prospectively population delirium incidence with cognitive outcomes. In parallel, I will test new methods for informatics-based delirium ascertainment for use in longitudinal studies. Hypothesis: Incident delirium is associated with changes in glo… more
Amount: £25,468
Exploring the neurocomputational mechanisms of adaptive and pathological anxiety.
<p>At present the majority of people with anxiety fail to respond to their first treatment. Refining our understanding of the mechanisms underpinning anxiety, as well as the process by which adaptive anxiety becomes maladaptive is critical in order to improve diagnosis and treatment outcomes. To this end, the objective for this collaborative doctoral research project between UCL and the NIMH is t… more
Amount: £80,000