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Search results (Displaying 16 grants)

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Earliest award date
07 Mar 2018
Latest award date
15 Nov 2018
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From vision to action: Systems analysis of sensorimotor circuitry controlling visually-guided behaviour
<p style="margin-left: 0cm; margin-right: 0cm">Despite the emergence of technologies to record from thousands of neurons during animal behaviour, two major issues are currently limiting the transfer and utilisation of ultra-high-dimensional datasets between neuroscience groups. First, raw data files are often enormous, making data transfer inconvenient and expensive. Second, there is no common fo… more
Amount: £48,349
Amount: £50,000
An Open-Source Database for Predicting Pharmacokinetics
<p>A free public web resource will be created for academic and industry pharmacometric modellers and data scientists to share standard big datasets and code for the purpose of generating reproducible studies. The ultimate goal is to encourage open research practices through provision of resources needed to facilitate machine learning and mechanism-based approaches for modelling of dose-concentrat… more
Amount: £49,758
The genetics of depression in diverse populations
<p>Major depressive disorder (MDD) is common and has an immense burden of disease. Genetic variants associated with MDD have been identified. However, most previous studies were based on European ancestry samples.</p> <p>&nbsp;</p> <p>Our aim is to establish a global study resource to investigate the genetic basis of depression in diverse ethnic groups. Due to the high prevalence of MDD, the ri… more
Amount: £99,995
Cellular mechanisms underlying the morphogenetic biomechanics of mammalian neural tube closure
<p>Primary neurulation is a biomechanical process whereby the flat neural plate folds into a closed neural tube (NT). Closure initiates at the hindbrain/cervical boundary and &ldquo;zippers&rdquo; bi-directionally to form the cephalic and spinal NT. Failure of NT closure results in defects including spina bifida, which continue to affect 1:1,000 pregnancies. Despite advances in delineating its ge… more
Amount: £25,000
The role of 3' UTR variation in the molecular pathogenesis of motor neuron disease
<p>UV cross-linking and immunoprecipitation (CLIP) is a commonly used method to profile endogenous protein-RNA interactions by sequencing RNA fragments that copurify with a selected RNA-binding protein (RBPs). Integrative analysis of available CLIP data is hampered by the lack of a unified CLIP data resource. 27 variants of the method have already been developed, and these have been used in over … more
Amount: £49,995
Developing antisense oligonucleotide therapeutics to target gain-of-function mutations in childhood neurology
<p style="margin-left: 0cm; margin-right: 0cm">The aim of this project is to develop an antisense oligonucleotide (AON) therapeutic approach to target selected gain-of-function mutations that cause childhood neurological disorders. We have selected KCNT1-related infant epilepsy as the primary target disease in this proposal due to the following reasons: 1) this is one of the most frequent genetic… more
Amount: £94,290
Quantitative evaluation of gene dosage effects in the Ras/ERK and PI3K/mTOR pathways on metastatic transformation of oesophageal cancer
<p>Distant metastases account for ~90% of cancer-related deaths, but our understanding of the determinants of this process is limited. I propose to elucidate early genomic mechanisms that enable cells to acquire a metastatic phenotype, with focus on allelic imbalance resulting from copy number changes and the underlying genomic instability. I have previously characterized the implications of geno… more
Amount: £99,983
The Future of Maternity Care: challenges and opportunities to achieve person-centred care in the NHS
<p>I propose to review up-to-date research and evidence regarding new developments in technology and health education that aim to&nbsp;improve maternity care in the UK, particularly through improving&nbsp;women&rsquo;s access to information,&nbsp;services, and their own medical records.&nbsp;Parliamentarians will require a balanced and&nbsp;concise summary&nbsp;of the evidence behind these new te… more
Amount: £6,514
Politics, Philosophy and Economics of Health
<p>This project will examine benefits sharing for the provision of genetic information in the creation of medical treatments for infectious diseases. Networks to enable the international sharing of genetic material are a cornerstone of pandemic preparedness initiatives. Countries with the highest disease burdens share their isolated virus strains, that are&nbsp; utilised by pharmaceutical compani… more
Amount: £27,140
Visualising the spatial range of neuropeptide action
<p>Our moods and our memories arise from a form of chemical communication in our brain termed neuromodulation. Neuromodulators are diffusible neurotransmitters, such as monoamines and neuropeptides, that can act at a distance and potentially reach many different circuits in the brain. Traditionally, neuropeptides have been thought to act on all receptor-expressing neurons within the brain. Howeve… more
Amount: £99,949
Investigating the effect and impact of binding RSV-G protein on pneumococcal growth and antibiotic sensitivity
<p>The pneumococcus (<em>Streptococcus pneumoniae</em>) is a global pathogen associated with high mortality rates in young children and the elderly. My research has shown that pneumococci rapidly increase their virulence by binding to the G protein encoded by human respiratory syncytial virus (RSV), the leading cause of viral pneumonia. This is thought to be mediated by the pneumococcal receptor … more
Amount: £99,958
Understanding how nNOS signaling in the gut influences the development, maintenance and function of interstitial cells of Cajal.
<p>Loss of neuronal nitric oxide synthase (NOS1, a.k.a nNOS) neurons has been implicated in a range of gastrointestinal motility disorders including Achalasia, Gastroparesis and Diabetes. Recent studies have demonstrated that global knockout of <em>Nos1</em> results in reduced populations of interstitial cells of Cajal (ICC). This key population is crucial for pacemaker function and neurotransmis… more
Amount: £99,580
Politics, medical knowledge and development: from Israel to Ethiopia and Eritrea (and back)
<p>This project will critically study how the circulation of medical knowledge and practices of developing health programs between Israel, Ethiopia and Eritrea, shape regional politics, immigration dynamics and racialization processes in Africa and the Middle East. Specifically, how political instrumentalisation&nbsp;of medical knowledge affects three interrelated dynamics: Constructing&nbsp;heal… more
Amount: £29,330
Exploring glial roles in sculpting brain development
<p>&nbsp; &nbsp; Although two broad cell types, neurons and glia, compose the brain, neurobiologists have tended to focus on neurons, the electrically excitable cells that process information. Glia were thought of primarily as neuronal support cells. Recent work challenges this view and shows that glia play essential roles not just in supporting neuronal function but also in instructing their dev… more
Amount: £25,000