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Search results (Displaying 58 grants)

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Earliest award date
06 Feb 2007
Latest award date
06 Dec 2017
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Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Amount: £283,711
Amount: £350,000
Electrophysiological and imaging studies of hite mechanisms underlying brain white matter pathology.
Electrophysiological and imaging studies of mechanisms underlying brain white matter pathology This project will investigate in depth the mechanisms leading to oligodendrocyte damage in pathological conditions, and some properties of oligodendrocyte precursor cells relevant to normal myelination during development and to remyelination in pathological conditions.
Amount: £5,430
Amount: £300,000
Characterising the key role played by the sodium/ proton exchanger NHE8 in endosomal protein sorting.
Protein sorting at the multivesicular body (MVB) is essential for many processes including growth factor down regulation and antigen presentation. In addition, many viruses including the human immunodeficiency virus (HIV) exploit the MVB sorting machinery during assembly and release. MVBs are formed by the inward budding of the endosomal membrane to form internal vesicles, and proteins sorted i… more
Amount: £233,034
Expression and function coupling of P2Y1 and other P2Y nucleotide receptors in neurons.
P2Y receptors are G protein-coupled receptor targets for extracellular nucleotides. Some of these receptors are or appear to be present in the brain but their function therein is not well understood. By expressing different P2Y receptors in sympathetic neurons, we previously showed that their activation can variously modulate several neuronal ion channels. Recently we have localized one such rece… more
Amount: £159,979
The functional effects of alterations in the human voltage-gated P/Q-type calcium channel.
Mutations in the P/Q-type voltage-gated neuronal calcium channel are responsible for a diverse range of episodic and progressive neurological disorders. In humans, three allelic disorders, namely episodic ataxia type 2, familial hemiplegic migraine and spinocerebellar ataxia type 6 (SCA 6) have been identified. However, mutations in this gene are increasingly emerging as a cause or susceptibility… more
Amount: £111,824
Physiological regulation and pathological dysfunction of the nitric oxide receptor soluble guanylate cyclase: role in cardiovascular homeostasis and disease
Soluble guanylate cyclase (sGC) is a heterodimeric haemoprotein that represents the intracellular receptor for nitric oxide (NO). Activation of the enzyme facilitates formation of the second messenger cyclic GMP and it is this molecule that mediates the majority of biological actions attributed to NO. Due to its ubiquitous nature, inappropriate sGC activity may be fundamental to the aetiology of … more
Amount: £313,528
The Role Of Small-molecule Dietary And Non-dietary Antioxidants In Predicting And Preventing Respiratory Disease
<p>Respiratory diseases caused by smoking and pollution are increasing in prevalence across all continents. At present, there are no simple blood tests for predicting those at highest risk and few molecular targets for primary prevention. This work programme will use pre-collected data to answer the following: do antioxidant molecules found in blood (bilirubin, uric acid, alpha-tocopherol, ascorb… more
Amount: £284,626
Harnessing pre-clinical lung cancer patient models for precision immuno-oncology
<p>Only 16% of non-small cell lung cancer (NSCLC) patients survive for 5 years. Improvement in survival has been slow as the histological and genomic features of the disease are heterogeneous. Tumour heterogeneity poses a challenge for therapy development and suggests the importance of a personalised medicine approach. One approach is to expand the subset of tumour-infiltrating lymphocytes (TILs)… more
Amount: £250,000
Using modern causal inference methods and general population data to investigate the role of inflammation in the aetiology of eating disorders
<p>Eating disorders are severe psychiatric conditions with typical onset in adolescence and a complex aetiology. Epidemiological studies have shown that inflammation is potentially implicated in the aetiology of several psychiatric conditions. However, although the hypothesis is plausible, robust epidemiological evidence that inflammation is involved in the pathogenesis of eating disorders is lar… more
Amount: £250,000
Arts, Society and Public Health: An Exploration of the Major UK Cohort Studies
<p>This fellowship will explore the impact of arts and cultural engagement on health and wellbeing at a population level, using the outstanding longitudinal cohort data that have been collected in the UK. Research will examine the effects of (i) cultural engagement (e.g. attending concerts/museums/galleries/cinemas/theatre); (ii) active arts participation (e.g. music/dance/crafts/drama); (iii) pa… more
Amount: £241,889
Enhancing emotion-regulation in adolescence: A developmental window of opportunity
<p>Adolescence is an emotionally challenging developmental stage. Adolescents frequently experience negative affect and rapid fluctuations in affective states. Difficulty in regulating these emotions is associated with a range of psychopathology. Successful emotion-regulation relies on executive control, the ability to attend and respond to goal-relevant information, while inhibiting responses to… more
Amount: £250,000
Amount: £123,300
A cell culture model to find drugs that may be useful to treat dementia.
<p>I am an undergraduate Neuroscience Msci student studying at the University of Bristol. I am undergoing an industrial trainee year, with Alzheimer&rsquo;s Research UK University College London drug discovery institute (AR-UK UCL DDI), as part of my course. <br>The AR-UK UCL DDI is a newly established unit in UCL, with core funding from Alzheimer&rsquo;s Research UK. Its goal is to discover new … more
Amount: £7,000
Explicit representations of uncertainty drive attentional adjustments
<p>The aim of the proposed project is to understand how confidence serves cognitive control, more specifically how explicit representations of uncertainty guide attention.</p> <p>My own research findings and those of others suggest that humans possess an impressive ability to track and report uncertainty in the form of confidence judgements. Confidence has been found to co-vary with people&rsquo… more
Amount: £250,000
Development of metagenomics-based diagnostics of infectious diseases
<p>During this fellowship I will use high throughput sequencing (HTS) and novel analytical methods to develop a framework for the investigation and diagnosis of infectious diseases. The focus will be on complex and difficult to diagnose diseases, such as encephalitis and meningitis, where pathogen detection rates remain poor. I will first optimise my existing Bayesian mixture model approach<sup>1… more
Amount: £250,000
Pathological aversive learning as a mechanism in clinical anxiety
<p>Generalised anxiety disorder (GAD) is a common and debilitating condition. Its core symptoms are strongly related to subjective feelings evoked by uncertainty. This fellowship will build on advances in computational modelling to characterise the role of estimations of uncertainty about aversive events in GAD. The project has three key goals: 1) To develop behavioural tasks, and computational m… more
Amount: £250,000
Towards an individualised, mechanistic understanding of resilience to mental illness during development: the role of affective processing in adolescence
<p>This project examines how <strong><u>individual differences</u></strong> in <strong><u>affective processing</u></strong> contribute to the development of psychiatric traits in adolescence. My two-pronged approach tackles this question from complimentary angles: 1) applying sophisticated statistical methods to currently-available large-scale data to understand individual differences in affectiv… more
Amount: £250,000
How do middle ear stem cells and the immune system interact in the pathogenesis of chronic otitis media?
<p>Chronic middle ear inflammation (otitis media) poses a significant global burden of disease in adults and children leading to permanent deafness. The middle ear mucosa maintains a well-ventilated middle ear but undergoes abnormal remodelling in disease. Similar to the adult upper airway, basal cells are hypothesised to be stem cells actively maintaining middle ear mucosa. &nbsp;Pathological re… more
Amount: £309,724