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- 06 Dec 2017
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Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Activity-dependent trafficking of mitochondria to synapses by Miro1.
This proposal will study the mechanisms that control the trafficking of the energy providing mitochondria within neurons, and how this relates to neuronal development and connectivity. Using imaging, molecular and cell biological techniques, combined with mouse transgenic approaches we will determine the molecular mechanisms underlying the activity-dependent subcellular positioning of mitochondri… more
Epigenomic Analysis of HPV positive and HPV negative Head and Neck Squamous Cell Cancer (HNSCC).
Head and Neck Squamous Cell Cancer (HNSCC) is the sixth most common cancer worldwide. A proportion of these cancers are caused by human papilloma virus and patients being diagnosed with this subtype have a significantly better outcome. The reasons and underlying mechanisms for this are not fully understood. The aim of this project is to carry out comprehensive methylome and microRNA analysis and … more
Differential leukocyte counts and the prognosis of specific coronary phenotypes.
Background: Leukocyte counts are routinely measured in coronary disease and are related to prognosis, but the shape, strength and significance of such relationships, particularly with regard to prognosis of specific coronary phenotypes, are unclear. In addition, there is a need for better risk prediction tools for stable angina. Aims: To investigate the association of counts of leukocyte subtypes… more
FTO and appetite regulation.
A single nucleotide polymorphism, rs9939609, in the first intron of the fat mass- and obesity associated gene (FTO) confers the greatest genetic risk for obesity. Subjects homozygous for the at-risk A allele exhibit reduced satiety, increased energy intake and energy-dense food preference. The mechanisms underlying these obesity-prone eating patterns remain unknown. Hypothesising a link between … more
The role of flavin-containing monooxygenase 5 (FMO5) in regulating age-related increases in plasma cholesterol and glucose and in body weight
Open Access award.
Tomography of type IV secretion system complexes
4.1 Visualisation of available T4SS subcomplexes by ET. Constructs encoding core- and mega-complexes of the pKM101 T4SS plasmid will be transformed into BL21 DE3 and B/r E. coli strains for inducible expression. Samples of induced BL21 DE3 cells will be high-pressure frozen, freezesubstituted into organic solvents and embedded in a plastic resin. Different freeze-substitution protocols will be te… more
VEGF signalling in the nervous system
This project aims to examine if VEGF-C patterns the nervous system during axon guidance or synapse formation, and to define the molecular pathway by which VEGF-A signals in neurons independently of its role in blood vessels. Define the role of VEGF-C and its receptor VEGFR3 in axon pathfinding Determine if VEGF-A and VEGF-C function co-operatively to control axon pathfinding Identify NRP1 co-rece… more
What is the difference between epithelial and mesenchymal cell junctions: understanding the molecular basis of contact inhibition of locomotion and epithelial-mesenchymal transition
When two epithelial cells make contact they form a stable cell adhesion complex that finally results in the formation of an epithelium. However when two mesenchymal cells make contact the outcome is completely different: they do not form a permanent adhesion complex and very frequently they move away from each other in a behavior called contact inhibition of locomotion . Intriguingly, cell adh… more
Value in People Award.
Automated high-dimensional outcome prediction in stroke
Stroke is a significant cause of death and disability around the world yet patient outcomes are not improving as fast as those for similar conditions such as heart disease.A major cause is the difficulty in providing targeted care in a patient group with hugely diverse treatment needs. Dr Parashkev Nachev of the UCL Institute of Neurology, London has been given a Translation Award to develop a s… more
Working memory and attention in the young-adult and ageing human brain: distractor suppression and cortical-striatal loops.
Working memory (WM) and selective attention (SA) are both vital in daily life, and may share common neural components, but the exact nature of their relation is unknown. Top-down control of distractor-filtering in WM, associated with a basal-ganglia/frontal/parietal mechanism, may contribute to an individual s WM capacity (McNab & Klingberg, 2008). Here we will address whether this mechanism is c… more
The Role Of Small-molecule Dietary And Non-dietary Antioxidants In Predicting And Preventing Respiratory Disease
<p>Respiratory diseases caused by smoking and pollution are increasing in prevalence across all continents. At present, there are no simple blood tests for predicting those at highest risk and few molecular targets for primary prevention. This work programme will use pre-collected data to answer the following: do antioxidant molecules found in blood (bilirubin, uric acid, alpha-tocopherol, ascorb… more
Harnessing pre-clinical lung cancer patient models for precision immuno-oncology
<p>Only 16% of non-small cell lung cancer (NSCLC) patients survive for 5 years. Improvement in survival has been slow as the histological and genomic features of the disease are heterogeneous. Tumour heterogeneity poses a challenge for therapy development and suggests the importance of a personalised medicine approach. One approach is to expand the subset of tumour-infiltrating lymphocytes (TILs)… more
Using modern causal inference methods and general population data to investigate the role of inflammation in the aetiology of eating disorders
<p>Eating disorders are severe psychiatric conditions with typical onset in adolescence and a complex aetiology. Epidemiological studies have shown that inflammation is potentially implicated in the aetiology of several psychiatric conditions. However, although the hypothesis is plausible, robust epidemiological evidence that inflammation is involved in the pathogenesis of eating disorders is lar… more
Arts, Society and Public Health: An Exploration of the Major UK Cohort Studies
<p>This fellowship will explore the impact of arts and cultural engagement on health and wellbeing at a population level, using the outstanding longitudinal cohort data that have been collected in the UK. Research will examine the effects of (i) cultural engagement (e.g. attending concerts/museums/galleries/cinemas/theatre); (ii) active arts participation (e.g. music/dance/crafts/drama); (iii) pa… more
Enhancing emotion-regulation in adolescence: A developmental window of opportunity
<p>Adolescence is an emotionally challenging developmental stage. Adolescents frequently experience negative affect and rapid fluctuations in affective states. Difficulty in regulating these emotions is associated with a range of psychopathology. Successful emotion-regulation relies on executive control, the ability to attend and respond to goal-relevant information, while inhibiting responses to… more
Lost&Found: engaging with narratives of ageing
<p>no abstract available.</p>
A cell culture model to find drugs that may be useful to treat dementia.
<p>I am an undergraduate Neuroscience Msci student studying at the University of Bristol. I am undergoing an industrial trainee year, with Alzheimer’s Research UK University College London drug discovery institute (AR-UK UCL DDI), as part of my course. <br>The AR-UK UCL DDI is a newly established unit in UCL, with core funding from Alzheimer’s Research UK. Its goal is to discover new … more