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Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
How well do web panel surveys measure behaviour in the general population and can they be improved? A comparison with a national probability sample.
<p>Despite the dramatic growth in the use of online/web surveys for market research and opinion polling, web methods are not widely used in the UK for collecting epidemiological or surveillance data (or for academic research)(1). Most web surveys rely on quota sampling from volunteer web panels (WPs) run by market research companies.* While volunteer WPs will increase in importance (5,6,12-15), t… more
Open access award.
The role of cervical innate immunity in preterm birth.
The ultimate aim of this research is to reduce the number women delivering prematurely. The study has two aspects that are of particular clinical relevance: (1) it seems likely that early identification of women who are at risk of bacteria triggered PTB will be essential to intervening in a timely fashion ? phenotyping maternal antimicrobial defences at an early gestation offers a logical way to … more
Student Elective prizes for University College London
Biomedical Vacation Scholarship.
The transition from unconscious to conscious visual perception in the intact and damaged human brain.
Clarifying the processes that determine the transition from unconscious to conscious perception is a central theme in visual awareness research. Emotionally-significant or familiar stimuli have modulatory influences on this perceptual transition, but such influences can be disrupted in perceptual and affective disorders. This research project will investigate the neural mechanisms underlying such… more
Trying and Trying and Trying extension.
Gethan Dick will work with six UCL scientists to write six song poems, each one based on the experience and research of a single scientist. She will then work with six bands, each with their own fans and community of interest, to record the pieces. The songs will be made available for free on CD at a number of venues around London and wider afield, as well as via popular download sites. The final CD will feature text and images from each scientist as a response to the song poem about their work.
Nanoparticles for topical administration of siRNA to the airways for cystic fibrosis therapy
We are assessing nanoparticle formulations for siRNA therapy of cystic fibrosis. Initial experiments on siRNA delivery to primary airway epithelial cells will characterise ICAM-1 cell receptor targeting and subsequent intracellular trafficking. ICAM-1 receptor is an interesting target, since it is also exploited by rhinovirus for epithelial cell binding and entry in the airways. ICAM-1 targeting … more
The Role Of Small-molecule Dietary And Non-dietary Antioxidants In Predicting And Preventing Respiratory Disease
<p>Respiratory diseases caused by smoking and pollution are increasing in prevalence across all continents. At present, there are no simple blood tests for predicting those at highest risk and few molecular targets for primary prevention. This work programme will use pre-collected data to answer the following: do antioxidant molecules found in blood (bilirubin, uric acid, alpha-tocopherol, ascorb… more
Harnessing pre-clinical lung cancer patient models for precision immuno-oncology
<p>Only 16% of non-small cell lung cancer (NSCLC) patients survive for 5 years. Improvement in survival has been slow as the histological and genomic features of the disease are heterogeneous. Tumour heterogeneity poses a challenge for therapy development and suggests the importance of a personalised medicine approach. One approach is to expand the subset of tumour-infiltrating lymphocytes (TILs)… more
Using modern causal inference methods and general population data to investigate the role of inflammation in the aetiology of eating disorders
<p>Eating disorders are severe psychiatric conditions with typical onset in adolescence and a complex aetiology. Epidemiological studies have shown that inflammation is potentially implicated in the aetiology of several psychiatric conditions. However, although the hypothesis is plausible, robust epidemiological evidence that inflammation is involved in the pathogenesis of eating disorders is lar… more
Arts, Society and Public Health: An Exploration of the Major UK Cohort Studies
<p>This fellowship will explore the impact of arts and cultural engagement on health and wellbeing at a population level, using the outstanding longitudinal cohort data that have been collected in the UK. Research will examine the effects of (i) cultural engagement (e.g. attending concerts/museums/galleries/cinemas/theatre); (ii) active arts participation (e.g. music/dance/crafts/drama); (iii) pa… more
Enhancing emotion-regulation in adolescence: A developmental window of opportunity
<p>Adolescence is an emotionally challenging developmental stage. Adolescents frequently experience negative affect and rapid fluctuations in affective states. Difficulty in regulating these emotions is associated with a range of psychopathology. Successful emotion-regulation relies on executive control, the ability to attend and respond to goal-relevant information, while inhibiting responses to… more
Lost&Found: engaging with narratives of ageing
<p>no abstract available.</p>
A cell culture model to find drugs that may be useful to treat dementia.
<p>I am an undergraduate Neuroscience Msci student studying at the University of Bristol. I am undergoing an industrial trainee year, with Alzheimer’s Research UK University College London drug discovery institute (AR-UK UCL DDI), as part of my course. <br>The AR-UK UCL DDI is a newly established unit in UCL, with core funding from Alzheimer’s Research UK. Its goal is to discover new … more
Explicit representations of uncertainty drive attentional adjustments
<p>The aim of the proposed project is to understand how confidence serves cognitive control, more specifically how explicit representations of uncertainty guide attention.</p> <p>My own research findings and those of others suggest that humans possess an impressive ability to track and report uncertainty in the form of confidence judgements. Confidence has been found to co-vary with people&rsquo… more
Development of metagenomics-based diagnostics of infectious diseases
<p>During this fellowship I will use high throughput sequencing (HTS) and novel analytical methods to develop a framework for the investigation and diagnosis of infectious diseases. The focus will be on complex and difficult to diagnose diseases, such as encephalitis and meningitis, where pathogen detection rates remain poor. I will first optimise my existing Bayesian mixture model approach<sup>1… more
Pathological aversive learning as a mechanism in clinical anxiety
<p>Generalised anxiety disorder (GAD) is a common and debilitating condition. Its core symptoms are strongly related to subjective feelings evoked by uncertainty. This fellowship will build on advances in computational modelling to characterise the role of estimations of uncertainty about aversive events in GAD. The project has three key goals: 1) To develop behavioural tasks, and computational m… more
Towards an individualised, mechanistic understanding of resilience to mental illness during development: the role of affective processing in adolescence
<p>This project examines how <strong><u>individual differences</u></strong> in <strong><u>affective processing</u></strong> contribute to the development of psychiatric traits in adolescence. My two-pronged approach tackles this question from complimentary angles: 1) applying sophisticated statistical methods to currently-available large-scale data to understand individual differences in affectiv… more