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- 27 Jan 2012
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- 06 Dec 2017
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Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Seminar series: 'Neuroscience in its Historical and Social Context .
The grant requested is intended to support a series of seminars to be hosted jointly by the Centre for the History of Medicine and the Department of Neuroscience, Physiology and Pharmacology at University College London. The aim of the series is to present a series of papers on themes relating to the history, sociology, and philosophy of the neurosciences from distinguished scholars in these fiel… more
Open access award 2012/13.
An investigation into the defective termination and resolution of acute inflammation in ulcerative colitis
Ulcerative colitis (UC) is a chronic inflammatory disorder, associated with protracted acute inflammation after bacterial challenge. I postulate that this results from failure of the mechanisms that normally terminate inflammation. The skin window technique permits examination of acute inflammatory responses in vivo following tissue damage or applied immunomodulators. I will use this to investig… more
The Secret Life of Proteins - Computational and Experimental Studies of Moonlighting Proteins.
The aim of the project is to further our understanding of protein moonlighting (multiple unrelatedfunctions of a single protein). During this project we will explore a number of questions that relate to the molecular mechanisms and properties that allow or enhance the moonlighting potential of a protein. the project will concentrate on computational approaches wit the aim of producing testable predictions, which we then hope to veryify with experimental studies.
A centralized platform for validation of genomic and epigenomic targets from clinical and non-clinical studies.
Over 1000 associations have recently been identified in over 100 traits and common human diseases using GWAS/EWAS. To further advance this research towards identification of the underlying causal variations for therapeutic targeting, requires follow-up on several levels. In the first instance, the identified associations need to be validated, ideally by an independent method and in additional sam… more
Establishing the Role of the FoxG1 transcription factor in normal and glioma-derived neural stem cells.
Glioblastoma (GBM) is the most common and lethal primary brain tumour. GBMs contain a population of cells that display characteristics of neural stem cells. Understanding the action of the lineage specific transcription factors responsible for orchestrating self-renewal in this population and in their normal stem counterparts offers promise in identifying therapeutic targets. Through pilot studie… more
Bridging microscopic and macroscopic measures of reward-guided decision making.
I propose a series of experiments targeted at understanding the role of prefrontal cortex in valueguided choice. All experiments will be conducted by recording single-unit activity from multiple regions of prefrontal cortex simultaneously in an animal model, and also bycollecting magnetoencephalography data in healthy human volunteers. This will facilitate comparison of neural responses across sp… more
Principles of neurotransmitter signal formation in the brain.
Memories are formed trough use-dependent modification of synaptic circuits of the brain. Establishing the cellular basis of such modification, in health and disease, remains a fundamental challenge in neurobiology. Our aim is to elucidate mechanisms through which presynaptic mechanisms and the synaptic environment control formation of fast neurotransmitter signals at central synapses. We are prop… more
Identifying mechanisms of mechanosensation in the Drosophila notum that contribute to the control of epithelial junction remodelling.
When two epithelial cells make contact they form a stable cell adhesion complex that finally results in the formation of an epithelium. However when two mesenchymal cells make contact the outcome is completely different: they do not form a permanent adhesion complex and very frequently they move away from each other in a behavior called contact inhibition of locomotion . Intriguingly, cell adh… more
The Role Of Small-molecule Dietary And Non-dietary Antioxidants In Predicting And Preventing Respiratory Disease
<p>Respiratory diseases caused by smoking and pollution are increasing in prevalence across all continents. At present, there are no simple blood tests for predicting those at highest risk and few molecular targets for primary prevention. This work programme will use pre-collected data to answer the following: do antioxidant molecules found in blood (bilirubin, uric acid, alpha-tocopherol, ascorb… more
Harnessing pre-clinical lung cancer patient models for precision immuno-oncology
<p>Only 16% of non-small cell lung cancer (NSCLC) patients survive for 5 years. Improvement in survival has been slow as the histological and genomic features of the disease are heterogeneous. Tumour heterogeneity poses a challenge for therapy development and suggests the importance of a personalised medicine approach. One approach is to expand the subset of tumour-infiltrating lymphocytes (TILs)… more
Using modern causal inference methods and general population data to investigate the role of inflammation in the aetiology of eating disorders
<p>Eating disorders are severe psychiatric conditions with typical onset in adolescence and a complex aetiology. Epidemiological studies have shown that inflammation is potentially implicated in the aetiology of several psychiatric conditions. However, although the hypothesis is plausible, robust epidemiological evidence that inflammation is involved in the pathogenesis of eating disorders is lar… more
Arts, Society and Public Health: An Exploration of the Major UK Cohort Studies
<p>This fellowship will explore the impact of arts and cultural engagement on health and wellbeing at a population level, using the outstanding longitudinal cohort data that have been collected in the UK. Research will examine the effects of (i) cultural engagement (e.g. attending concerts/museums/galleries/cinemas/theatre); (ii) active arts participation (e.g. music/dance/crafts/drama); (iii) pa… more
Enhancing emotion-regulation in adolescence: A developmental window of opportunity
<p>Adolescence is an emotionally challenging developmental stage. Adolescents frequently experience negative affect and rapid fluctuations in affective states. Difficulty in regulating these emotions is associated with a range of psychopathology. Successful emotion-regulation relies on executive control, the ability to attend and respond to goal-relevant information, while inhibiting responses to… more
Lost&Found: engaging with narratives of ageing
<p>no abstract available.</p>
A cell culture model to find drugs that may be useful to treat dementia.
<p>I am an undergraduate Neuroscience Msci student studying at the University of Bristol. I am undergoing an industrial trainee year, with Alzheimer’s Research UK University College London drug discovery institute (AR-UK UCL DDI), as part of my course. <br>The AR-UK UCL DDI is a newly established unit in UCL, with core funding from Alzheimer’s Research UK. Its goal is to discover new … more
Explicit representations of uncertainty drive attentional adjustments
<p>The aim of the proposed project is to understand how confidence serves cognitive control, more specifically how explicit representations of uncertainty guide attention.</p> <p>My own research findings and those of others suggest that humans possess an impressive ability to track and report uncertainty in the form of confidence judgements. Confidence has been found to co-vary with people&rsquo… more