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- 30 Jan 2015
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- 06 Dec 2017
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Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Salt, Diet & Hypertension: An integrative in vivo physiological investigation of WNK pathway controlled renal electrolyte and blood pressure homeostasis.
This project is designed to directly address a technique/technology gap that has prevented us from answering key biomedical questions in WNK controlled cardio-renal physiology. By modular combination of existing techniques/technologies the project puts forth a novel strategy to address the lack of direct, tubular segment-specific measurements of the renal physiology in vivo that may be integrated… more
Crowded growth: How volume and intracellular density relate to cell growth and proliferation.
Significant amount of research, mostly focusing on signalling processes, has been carried out to understand the regulation of cell growth and proliferation. While some biological evidence is starting to emerge that cell volume or cell mass might regulate cell growth, the role of intracellular density has been largely overlooked. This is surprising, considering that mathematical and biophysical ev… more
Multisensory Integration in Time and Space.
Although the majority of neuroscience research focuses on isolated sensory cues, in natural environments, the brain is invariably faced with a vast array of sensory stimuli. Animals must continually evaluate which of these multimodal cues should be associated with a single physical object, and which are separate. To this end, animals, including humans, take advantage of two types of correlation: … more
The hippocampus, sleep and memory consolidation
<table> <tbody> <tr> <td>My first goal is to provide a unified and mechanistic account of how the hippocampus supports episodic memory, imagining the future and spatial navigation. I will leverage this long-standing question by eschewing traditional notions regarding the architecture of memory and instead invoke the idea that scenes are central to hippocampal info… more
Regulatory control of T cell activation in the human liver microenvironment and its relationship to autoimmune hepatitis.
Understanding the function of 3’ UTR isoforms in the post-transcriptional mRNA regulatory network
Multimorbidity clusters and genetic pleiotropy in determining the effect of drug target modification in cardiometabolic diseases
UCL Wellcome Trust PhD Programme for Clinicians
UCL, Stem Cell and Developmental Biology.