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Search results (Displaying 84 grants)

Total grants
84
Total funders
1
Total recipients
1
Earliest award date
11 Jan 2016
Latest award date
06 Dec 2017
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Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Amount: £283,711
Overcoming constraints on T cells in the HBV-infected liver
<p>My request for enhancement funding arises from the component of my existing award focused on developing T cell immunotherapy of hepatitis B and hepatocellular carcinoma using patient samples. We recently made important contributions to the testing of genetically redirected T cells for a first-in-man treatment of HBV-related hepatocellular carcinoma1. We are also collaborating with academic and… more
Amount: £175,008
Advancing Psychiatric Mapping Translated into Innovations for Care: PsyMaptic-A
<p>My current and previous Wellcome Trust Fellowships (Henry Wellcome, 2009-13; Henry Dale 2014- present) focus on important aetiological questions about psychotic disorders, using epidemiological data. Psychotic disorders are a debilitating set of mental health disorders, characterised by hallucinations, delusions and cognitive deficits. My research demonstrates that these disorders have a robus… more
Amount: £204,479
University College London/Birkbeck Interdisciplinary Programme in Structural, Computational and Chemical Biology
<p>University College London/Birkbeck Interdisciplinary Programme in Structural, Computational and Chemical Biology</p>
Amount: £133,252
Neuroscience
Not available
Amount: £133,252
UCL - Neuroscience
Not available
Amount: £133,252
UCL - Neuroscience
Not available
Amount: £133,252
University College London/Birkbeck Interdisciplinary Programme in Structural, Computational and Chemical Biology
<p>University College London/Birkbeck Interdisciplinary Programme in Structural, Computational and Chemical Biology</p>
Amount: £133,252
UCL - Neuroscience
Not available
Amount: £133,252
Harnessing Diversity Generating Retroelements (DGRs) for in vivo evolution
<p>The goal of the project is to express the reverse transcriptase (RT), central to the Bordertella phage BPP-1 diversity generating retroelement (DGR), and test it for synthetic nucleic acid (XNA) synthesis as well as reverse transcription. In addition, I will focus on cloning the BPP-1 DGR elements into E. coli, creating a circuit where DGR function can activate a selectable marker (e.g. kanR).… more
Amount: £2,000
Patient and public involvement in priority setting: should we listen to the will of the people?
<p>Decision-makers tasked with allocating resources within health systems often face huge pressure about funding decisions from patients and the public, often described as lobbying. One question that we may want to settle is how far particular priority setting decisions <em>are</em> influenced by lobbying and lobbyists. However, we might also ask another, ethical question: namely, to what extent … more
Amount: £149,624
Amount: £100,133
Probing the synaptic mechanisms of human genetic neurological disorders
<p>We are interested in how mutations that lead to human neurological disorders (particularly epilepsy) impact neuronal function. Much of our previous work has focused on how mutations change intrinsic neuronal excitability, but epilepsy is increasingly being associated with genes which are also predicted to perturb synaptic activity, and the aim of this project is to probe whether a subset of mu… more
Amount: £5,805
The Role Of Small-molecule Dietary And Non-dietary Antioxidants In Predicting And Preventing Respiratory Disease
<p>Respiratory diseases caused by smoking and pollution are increasing in prevalence across all continents. At present, there are no simple blood tests for predicting those at highest risk and few molecular targets for primary prevention. This work programme will use pre-collected data to answer the following: do antioxidant molecules found in blood (bilirubin, uric acid, alpha-tocopherol, ascorb… more
Amount: £284,626
Harnessing pre-clinical lung cancer patient models for precision immuno-oncology
<p>Only 16% of non-small cell lung cancer (NSCLC) patients survive for 5 years. Improvement in survival has been slow as the histological and genomic features of the disease are heterogeneous. Tumour heterogeneity poses a challenge for therapy development and suggests the importance of a personalised medicine approach. One approach is to expand the subset of tumour-infiltrating lymphocytes (TILs)… more
Amount: £250,000
Using modern causal inference methods and general population data to investigate the role of inflammation in the aetiology of eating disorders
<p>Eating disorders are severe psychiatric conditions with typical onset in adolescence and a complex aetiology. Epidemiological studies have shown that inflammation is potentially implicated in the aetiology of several psychiatric conditions. However, although the hypothesis is plausible, robust epidemiological evidence that inflammation is involved in the pathogenesis of eating disorders is lar… more
Amount: £250,000
Arts, Society and Public Health: An Exploration of the Major UK Cohort Studies
<p>This fellowship will explore the impact of arts and cultural engagement on health and wellbeing at a population level, using the outstanding longitudinal cohort data that have been collected in the UK. Research will examine the effects of (i) cultural engagement (e.g. attending concerts/museums/galleries/cinemas/theatre); (ii) active arts participation (e.g. music/dance/crafts/drama); (iii) pa… more
Amount: £241,889
Complex Urban Systems for Sustainability and Health (CUSSH)
<p>The CUSSH programme will deliver strategically vital global research on the complex systemic connections between urban development and health. Based on transdisciplinary methods, it will develop critical evidence on how to achieve the far-reaching transformation of cities needed to address vital environmental imperatives for population and planetary health in the 21st century. <br />Its core c… more
Amount: £149,988
Planning Quechua Families: Indigenous Subjectivities, Inequalities & Kinship under the Peruvian Family Planning Programme
<p>This research will investigate how the Peruvian family planning (FP) programme is currently being implemented in an indigenous community, and the wider affects that this public health intervention may have on their family and community networks, as well as on a personal level. Anthropological literature describes how [bio] medical interventions can affect subjectivities and how people view the… more
Amount: £104,202
Loss of GABAergic cells and night-time hyperactivity in zebrafish mutants of autism risk genes
<p>Night-time hyperactivity makes up part of the unique behavioural profile of autism spectrum disorder (ASDs). Recent studies on zebrafish revealed that loss-of-function mutations in autism risk genes (e.g.&nbsp;<em>CNTNAP2</em>)&nbsp;lead to a reduction in GABAergic neurons in the hypothalamus. GABAergic cells are sleep promoting and play an important role in the regulation of sleep-wake cycle.… more
Amount: £2,000