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Search results (Displaying 32 grants)

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Earliest award date
24 Jan 2017
Latest award date
31 Oct 2018
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A Hotbed for Liver Cancer: Biomedicine, Exposure and Uncertainty in West Africa
<p>Incidence rates of primary liver cancer vary strikingly across the globe. West Africans are more likely than most populations to develop and die from it. Focusing on Senegal and The Gambia, my project investigates how this association between place and <em>intensity of susceptibility</em> to liver cancer has been understood, and how it has been maintained by gaps in protection from risky expos… more
Amount: £301,612
Developing novel gene therapy technology for treatment of glycine encephalopathy
"Glycine encephalopathy, also known as non-ketotic hyperglycinaemia (NKH), is a life limiting inherited neuro-metabolic disease which presents soon after birth and leads to severe neurological outcomes including epilepsy and profound developmental delay. Current treatments for NKH are neither effective long-term, nor curative. Glycine encephalopathy is characterized by accumulation of glycine and… more
Amount: £365,837
Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Amount: £283,711
Wellcome Centre for Human Neuroimaging
<p>The Research Enrichment fund will enable us to embed public engagement (PE) into our Wellcome Centre research process.&nbsp;If funded, we will have achieved the following at the end of the proposed Research Enrichment programme:</p> <p>(1) &nbsp;Established a cultural change within our Centre where PE is integrated into all of our research programmes, with more researchers doing PE than not.&… more
Amount: £266,960
Auditory structured sequence learning on multiple timescales
<p>Regularities play an important role in analysing auditory scenes; for example, by exploiting the predictable sounds of the car engine, a driver can effortlessly ignore this irrelevant noise, freeing cognitive resources to focus on the road. Regularities also play an important role in language, dictating the relationship between syllables in word or the order words in a sentence, and have been … more
Amount: £300,000
Neurobiological foundations of flexible social behaviour
<p>A core aspect of healthy social function is the ability to map our private beliefs onto those that we express publicly according to the social context. It may be socially appropriate to express gratitude for a gift we do not want, or remorse for an action we do not regret. My goal is to understand the neurocognitive mechanisms supporting context-appropriate social behaviours and how they are a… more
Amount: £300,000
The Long and Winding Road: Connecting Cortex to Cortex Through the Thalamus.
<p>Our current model of the thalamus as a modulator and transmitter of sensory information is difficult to reconcile with the connectivity and physiology of the high-order thalamic nuclei (HOn). The dominance of cortical over peripheral input, variety of cortical areas providing modulation&nbsp;and cell-to-cell diversity in cortical projection targets have made the HOn difficult to understand. I … more
Amount: £300,000
Multi-spectral in vivo optical imaging system
<p>The use of bioluminescence reporting has revolutionized the imaging of small animals. Bioluminescence imaging (BLI) provides a robust technique, enabling researchers to gain essential insights into complex biological systems. BLI is used for the tracking of events in vivo, including the longitudinal monitoring of gene expression, tumour growth, enzyme activity, response to experimental drug th… more
Amount: £269,539
The Role Of Small-molecule Dietary And Non-dietary Antioxidants In Predicting And Preventing Respiratory Disease
<p>Respiratory diseases caused by smoking and pollution are increasing in prevalence across all continents. At present, there are no simple blood tests for predicting those at highest risk and few molecular targets for primary prevention. This work programme will use pre-collected data to answer the following: do antioxidant molecules found in blood (bilirubin, uric acid, alpha-tocopherol, ascorb… more
Amount: £284,626
Glutamate-gated chloride channel treatment of epilepsy
'Pharmacoresistant epilepsy affects approximately 0.3% of the population in developed countries (-200,000 in the UK alone) and represents a major unmet need. Although surgery to remove the seizure focus is effective, it is limited by risks to normal brain function. We have developed a targeted gene therapy strategy based on a modified glutamate-gated chloride channel (eGiuCI) expressed in excitat… more
Amount: £456,266
Harnessing pre-clinical lung cancer patient models for precision immuno-oncology
<p>Only 16% of non-small cell lung cancer (NSCLC) patients survive for 5 years. Improvement in survival has been slow as the histological and genomic features of the disease are heterogeneous. Tumour heterogeneity poses a challenge for therapy development and suggests the importance of a personalised medicine approach. One approach is to expand the subset of tumour-infiltrating lymphocytes (TILs)… more
Amount: £250,000
Using modern causal inference methods and general population data to investigate the role of inflammation in the aetiology of eating disorders
<p>Eating disorders are severe psychiatric conditions with typical onset in adolescence and a complex aetiology. Epidemiological studies have shown that inflammation is potentially implicated in the aetiology of several psychiatric conditions. However, although the hypothesis is plausible, robust epidemiological evidence that inflammation is involved in the pathogenesis of eating disorders is lar… more
Amount: £250,000
Arts, Society and Public Health: An Exploration of the Major UK Cohort Studies
<p>This fellowship will explore the impact of arts and cultural engagement on health and wellbeing at a population level, using the outstanding longitudinal cohort data that have been collected in the UK. Research will examine the effects of (i) cultural engagement (e.g. attending concerts/museums/galleries/cinemas/theatre); (ii) active arts participation (e.g. music/dance/crafts/drama); (iii) pa… more
Amount: £241,889
The Future of Maternity Care: challenges and opportunities to achieve person-centred care in the NHS
<p>I propose to review up-to-date research and evidence regarding new developments in technology and health education that aim to&nbsp;improve maternity care in the UK, particularly through improving&nbsp;women&rsquo;s access to information,&nbsp;services, and their own medical records.&nbsp;Parliamentarians will require a balanced and&nbsp;concise summary&nbsp;of the evidence behind these new te… more
Amount: £6,514
Efficient and transparent methods for linking and analysing longitudinal population studies and administrative data
<p>The Wellcome Trust LPS Strategy states that research is needed to i) underpin efficient linkage of multiple datasets, ii) quantify potential biases resulting from linkage, and iii) to handle linkage error in data analyses. We propose a programme of methodological research to develop efficient and transparent methods for linkage and analysis, to help maximise the joint potential of existing lon… more
Amount: £301,055
Residues and remains: Anthropology of practices around pregnancy endings
<p>My research explores the practices around pregnancy endings and their remains, including acts of forgetting and remembering, and asks what do these reveal about the status of foetuses, women and mothers in contemporary England?</p> <p>Pregnancy endings provide opportunities to interrogate anthropological assumptions about the contemporary family,&nbsp;motherhood, personhood and kinship. To an… more
Amount: £388,698
Personalising the pharmacological treatment of bipolar disorder
<p><strong><u>Background</u></strong></p> <p>Prescribing for bipolar disorder is a major clinical dilemma as long-term pharmacological treatment is often necessary. Lithium is&nbsp;the most effective mood stabiliser. However,&nbsp;only 30% of individuals have a good therapeutic response. Presently, there is no reliable way to predict response or adverse event risk, or if an alternative treatment… more
Amount: £460,704
Technologies of Health c. 1450-1750
<p>This project investigates the production, use and impact of everyday health technologies in Britain and the global world c. 1450-1750. It explores a wide range of objects from Issac Newton's drawing of an ear trumpet to birthing chairs to patient records. Using a series of detailed case studies,&nbsp;it seeks to understand how technologies crucially influenced past&nbsp;sickness experiences, m… more
Amount: £258,969
Enhancing emotion-regulation in adolescence: A developmental window of opportunity
<p>Adolescence is an emotionally challenging developmental stage. Adolescents frequently experience negative affect and rapid fluctuations in affective states. Difficulty in regulating these emotions is associated with a range of psychopathology. Successful emotion-regulation relies on executive control, the ability to attend and respond to goal-relevant information, while inhibiting responses to… more
Amount: £250,000