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Search results (Displaying 31 grants)

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Earliest award date
24 Jan 2017
Latest award date
06 Nov 2019
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Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Amount: £283,711
Gender, health and the afterlife of colonialism. Engaging new problematisations to improve maternal and infant survival.
<p style="margin-left: 0cm; margin-right: 0cm">I will work at the intersection of public health, decolonisation theory and feminist ethnography to generate evidence and promote gender responsive strategies aimed at improving maternal and infant survival.</p> <p style="margin-left: 0cm; margin-right: 0cm">Historical gender and ethnic inequalities underlie low rates of skilled birth attendance and… more
Amount: £446,111
Our Planet, Our Health award: Complex Urban Systems for Sustainability and Health
<p style="margin-left: 0cm; margin-right: 0cm">Three work streams will address participatory local action (outcomes 1-3), national media (outcome 4), and global communication (outcome 5). After two years, we will have stimulated local discussion and co-designed and implemented public engagement interventions for urban environmental sustainability and health &ndash; centred on waste management - w… more
Amount: £248,615
Neuro-computational mechanisms of information acquisition and integration in social contexts
Understanding the social cognitive mechanisms that enable people to learn from and interact with others has been of considerable interest to psychologists and neuroscientists for decades. Yet, the mechanisms underlying our ability to gather information from other people and to learn from them by integrating this information into our beliefs remain to be elucidated. Here, I proposed to use a neuro… more
Amount: £300,000
Understanding and predicting individual differences in cannabis-induced psychosis-like experiences
Acute pharmacological challenge and observational studies in humans have shown that cannabis can induce psychosis-like experiences. However, not all individuals exhibit adverse experiences, implicating individual differences in cannabis-sensitivity. While a number of studies implicate a genetic contribution to cannabis-sensitivity, such evidence relies on genetic variables of limited interpretab… more
Amount: £300,000
Applying causal inference methods to investigate the impact of adverse childhood experiences on mental health
<p style="margin-left: 0cm; margin-right: 0cm">Children exposed to abuse, neglect, and dysfunctional home environments (e.g., parental substance abuse, mental illness, domestic violence) have an elevated risk of developing costly and impairing mental health problems. However, as highlighted in a recent report by the UK Science and Technology Select Committee, the extent to which these adverse chi… more
Amount: £300,000
Deep Learning of Cerebral Cortex Microstructure
<p style="margin-left: 0cm; margin-right: 0cm">My research aims to bridge the gap between <em>in vivo</em> neuroimaging and underlying brain microstructure. MRI can inform us of shape or signal intensity changes in neurological and psychiatric diseases but has limited interpretability with respect to underlying neurobiological disturbances. Currently such specific measurement of neurobiology is o… more
Amount: £300,000
The Role Of Small-molecule Dietary And Non-dietary Antioxidants In Predicting And Preventing Respiratory Disease
<p>Respiratory diseases caused by smoking and pollution are increasing in prevalence across all continents. At present, there are no simple blood tests for predicting those at highest risk and few molecular targets for primary prevention. This work programme will use pre-collected data to answer the following: do antioxidant molecules found in blood (bilirubin, uric acid, alpha-tocopherol, ascorb… more
Amount: £284,626
Harnessing pre-clinical lung cancer patient models for precision immuno-oncology
<p>Only 16% of non-small cell lung cancer (NSCLC) patients survive for 5 years. Improvement in survival has been slow as the histological and genomic features of the disease are heterogeneous. Tumour heterogeneity poses a challenge for therapy development and suggests the importance of a personalised medicine approach. One approach is to expand the subset of tumour-infiltrating lymphocytes (TILs)… more
Amount: £250,000
Using modern causal inference methods and general population data to investigate the role of inflammation in the aetiology of eating disorders
<p>Eating disorders are severe psychiatric conditions with typical onset in adolescence and a complex aetiology. Epidemiological studies have shown that inflammation is potentially implicated in the aetiology of several psychiatric conditions. However, although the hypothesis is plausible, robust epidemiological evidence that inflammation is involved in the pathogenesis of eating disorders is lar… more
Amount: £250,000
Arts, Society and Public Health: An Exploration of the Major UK Cohort Studies
<p>This fellowship will explore the impact of arts and cultural engagement on health and wellbeing at a population level, using the outstanding longitudinal cohort data that have been collected in the UK. Research will examine the effects of (i) cultural engagement (e.g. attending concerts/museums/galleries/cinemas/theatre); (ii) active arts participation (e.g. music/dance/crafts/drama); (iii) pa… more
Amount: £241,889
LncRNA scaffolds of nuclear RNP compartments, and their roles in embryogenesis.
Several long non-coding RNAs (lncRNAs) are capable of scaffolding ribonucleoproteins (RNPs) that condense and phase-separate nuclear membraneless compartments. Both, lncRNAs and RNPs play many key regulatory roles in development and their function in cell fate choice is further enhanced by their cross-regulation. To demonstrate the importance of such cross-regulation for fine-tuning developmental… more
Amount: £300,000
Biomedical Vacation Scholarship Programme - University College London
<p>This award is for 6 students per year for 5 years. It includes ?a salary at the national living wage plus holiday pay and national insurance or equivalent,?as well as?funds to cover or significantly subsidise accommodation and travel (&pound;1500 outside of London and up to &pound;2000 in London).??? It includes &pound;500 to each studentship towards research expenses.??? Unspent funds can be … more
Amount: £197,340
One for All, All for One?
<p style="margin-left: 0cm; margin-right: 0cm">How people think about vaccines is a global concern<u><sup>1</sup></u>. <em>&lsquo;One for All?&rsquo;</em> asks: &ldquo;How does engagement with herd immunity influence attitudes to immunisation?&rdquo;. By working in close partnership with communities, researchers, artists, healthcare professionals, experts by experience, policy-makers and creative… more
Amount: £166,802
Enabling imaging of cells and tissues across scales
<p>We seek&nbsp;funding for an array tomography&nbsp;scanning electron microscope (SEM) with ATLAS 5 software together with components to upgrade an associated light microscope, to enable 3D correlative light and electron microscopy (CLEM)&nbsp;of cells and tissues with nm resolution.&nbsp;Array tomography&nbsp;SEM allows for the detection, mapping and automated imaging of serial sections of resi… more
Amount: £333,750
High throughput automated system for next generation sequencing (NGS) library preparation
<p style="margin-left: 0cm; margin-right: 0cm">The requested Hamilton NGS Star automated liquid handling workstation enables high-throughput automated preparation of sequencing libraries which enables basic and clinical UCL researchers to process increasing sample numbers in a consistent, reproducible and timely manner. The proposed instrument and associated auxiliary equipment includes all the n… more
Amount: £247,322
Subversive Practices: Traditions of Talismanic Healing in the Making of Modern China, c. 1850–1949
<p style="margin-left: 0cm; margin-right: 0cm">Throughout Chinese history, talismans have been central to healing for the vast majority of the population. From the Sui to the Qing dynasties (581-1644), talismans formed an imperially-sponsored medical discipline, after which they were permanently forsaken by the court. However, despite subsequent condemnation by the state, talismans remained perva… more
Amount: £141,717
Global Health 50/50
<p>Global Health 50/50 seeks to advance action and accountability for gender equality in global health. Co-led by Professor Sarah Hawkes and Dr Kent Buse and hosted by the UCL Centre for Gender and Global Health, GH5050 has three key assets: the groundbreaking 2018 GH5050 report, a review of the gender policies and practices of 140 organisations active in health, its high powered Advisory Council… more
Amount: £249,884
Prediction of Adolescent meNtal healTH from Electronic health Records (PANTHER)
Many people with depression or anxiety experience their first episode in adolescence. There is evidence that major episodes of these common mental disorders can be prevented or mitigated by early intervention. Yet this requires identification strategies that are effective and feasible, as well as acceptable to young people, their families and healthcare professionals. Primary care is often the fi… more
Amount: £488,900
Enhancing emotion-regulation in adolescence: A developmental window of opportunity
<p>Adolescence is an emotionally challenging developmental stage. Adolescents frequently experience negative affect and rapid fluctuations in affective states. Difficulty in regulating these emotions is associated with a range of psychopathology. Successful emotion-regulation relies on executive control, the ability to attend and respond to goal-relevant information, while inhibiting responses to… more
Amount: £250,000