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Search results (Displaying 16 grants)

Total grants
16
Total funders
1
Total recipients
1
Earliest award date
24 Jan 2017
Latest award date
06 Dec 2017
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Skeletal muscle channelopathies: severe infantile phenotypes and sudden infant death syndrome
<p>Skeletal muscle channelopathies are mainly autosomal dominant disorders that typically cause muscle symptoms of myotonia, periodic paralysis or progressive myopathy. Until now the muscle channelopathy phenotypes described are disabling but not fatal. Pilot data implicates ion channel dysfunction in severe infantile phenotypes with respiratory compromise and some cases of sudden infant death sy… more
Amount: £283,711
The Role Of Small-molecule Dietary And Non-dietary Antioxidants In Predicting And Preventing Respiratory Disease
<p>Respiratory diseases caused by smoking and pollution are increasing in prevalence across all continents. At present, there are no simple blood tests for predicting those at highest risk and few molecular targets for primary prevention. This work programme will use pre-collected data to answer the following: do antioxidant molecules found in blood (bilirubin, uric acid, alpha-tocopherol, ascorb… more
Amount: £284,626
Harnessing pre-clinical lung cancer patient models for precision immuno-oncology
<p>Only 16% of non-small cell lung cancer (NSCLC) patients survive for 5 years. Improvement in survival has been slow as the histological and genomic features of the disease are heterogeneous. Tumour heterogeneity poses a challenge for therapy development and suggests the importance of a personalised medicine approach. One approach is to expand the subset of tumour-infiltrating lymphocytes (TILs)… more
Amount: £250,000
Using modern causal inference methods and general population data to investigate the role of inflammation in the aetiology of eating disorders
<p>Eating disorders are severe psychiatric conditions with typical onset in adolescence and a complex aetiology. Epidemiological studies have shown that inflammation is potentially implicated in the aetiology of several psychiatric conditions. However, although the hypothesis is plausible, robust epidemiological evidence that inflammation is involved in the pathogenesis of eating disorders is lar… more
Amount: £250,000
Arts, Society and Public Health: An Exploration of the Major UK Cohort Studies
<p>This fellowship will explore the impact of arts and cultural engagement on health and wellbeing at a population level, using the outstanding longitudinal cohort data that have been collected in the UK. Research will examine the effects of (i) cultural engagement (e.g. attending concerts/museums/galleries/cinemas/theatre); (ii) active arts participation (e.g. music/dance/crafts/drama); (iii) pa… more
Amount: £241,889
Enhancing emotion-regulation in adolescence: A developmental window of opportunity
<p>Adolescence is an emotionally challenging developmental stage. Adolescents frequently experience negative affect and rapid fluctuations in affective states. Difficulty in regulating these emotions is associated with a range of psychopathology. Successful emotion-regulation relies on executive control, the ability to attend and respond to goal-relevant information, while inhibiting responses to… more
Amount: £250,000
Amount: £123,300
Explicit representations of uncertainty drive attentional adjustments
<p>The aim of the proposed project is to understand how confidence serves cognitive control, more specifically how explicit representations of uncertainty guide attention.</p> <p>My own research findings and those of others suggest that humans possess an impressive ability to track and report uncertainty in the form of confidence judgements. Confidence has been found to co-vary with people&rsquo… more
Amount: £250,000
Development of metagenomics-based diagnostics of infectious diseases
<p>During this fellowship I will use high throughput sequencing (HTS) and novel analytical methods to develop a framework for the investigation and diagnosis of infectious diseases. The focus will be on complex and difficult to diagnose diseases, such as encephalitis and meningitis, where pathogen detection rates remain poor. I will first optimise my existing Bayesian mixture model approach<sup>1… more
Amount: £250,000
Pathological aversive learning as a mechanism in clinical anxiety
<p>Generalised anxiety disorder (GAD) is a common and debilitating condition. Its core symptoms are strongly related to subjective feelings evoked by uncertainty. This fellowship will build on advances in computational modelling to characterise the role of estimations of uncertainty about aversive events in GAD. The project has three key goals: 1) To develop behavioural tasks, and computational m… more
Amount: £250,000
Towards an individualised, mechanistic understanding of resilience to mental illness during development: the role of affective processing in adolescence
<p>This project examines how <strong><u>individual differences</u></strong> in <strong><u>affective processing</u></strong> contribute to the development of psychiatric traits in adolescence. My two-pronged approach tackles this question from complimentary angles: 1) applying sophisticated statistical methods to currently-available large-scale data to understand individual differences in affectiv… more
Amount: £250,000
How do middle ear stem cells and the immune system interact in the pathogenesis of chronic otitis media?
<p>Chronic middle ear inflammation (otitis media) poses a significant global burden of disease in adults and children leading to permanent deafness. The middle ear mucosa maintains a well-ventilated middle ear but undergoes abnormal remodelling in disease. Similar to the adult upper airway, basal cells are hypothesised to be stem cells actively maintaining middle ear mucosa. &nbsp;Pathological re… more
Amount: £309,724
Antibiotic resistance in urinary tract infections in a primary care cohort in East London
<p>Antimicrobial resistance (AMR) is an alarming global issue causing difficulties for individual patient management and health systems. Antimicrobial use and misuse is the main driver behind AMR, and prescribing interventions such as antimicrobial stewardship programmes are our our main defense against it. We currently have a limited understanding of who is at most risk and how specific prescrib… more
Amount: £290,622
Central nervous system compartmentalisation and drug resistance in HIV-1 sub-type C infection
<p>My research proposes to study HIV compartment shifts from the CNS to the peripheral blood, the evolution of drug resistance in the CNS and the relationship between CNS co-infection with other neurotropic organisms and CNS compartmentalisation in HIV-1 subtype C.</p> <p>&nbsp;</p> <p>Within a longitudinal cohort I will conduct a proof-of-principle study with the aim of testing the hypothesis th… more
Amount: £291,661
Utilising electronic health records and Mendelian randomisation to investigate the relationship between liver function biomarkers and gastrointestinal disease; an example of bilirubin
<p>Liver function tests (LFTs) are commonly performed in clinical practice and are often associated with malignant and inflammatory diseases. Bilirubin has an anti-oxidant, cytoprotective function, and reported inverse associations with conditions including cardiovascular disease, inflammatory bowel disease, colorectal cancer and overall mortality.</p> <p>&nbsp;</p> <p>We will use linked primary … more
Amount: £253,846