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Search results (Displaying 83 grants)

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Earliest award date
24 Jan 2017
Latest award date
05 Dec 2019
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Principles of human development and germ cell program
<p>Specification of human primordial germ cells (hPGCs)&nbsp;occurs around gastrulation, a critical juncture when the specification of the primary somatic lineages&nbsp;also occurs. In combination with human preimplantation embryos, in<em> vitro</em> models and hPGCs from aborted fetuses, our objective is to elucidate the origin and properties of the early human germline.</p> <p>For&nbsp;the mec… more
Amount: £2,750,000
Darwin Tree of Life
<p>Life has evolved from a single origin to generate &gt;1.5 million eukaryotic species. Sequencing all species will provide an inventory of life, transform understanding of evolution, catalogue eukaryotic gene&nbsp;toolkits for biology and biotechnology, and enable monitoring of ecosystems under increasing stress. The Darwin Tree of Life (DToL) is a new initiative that will exploit long read tec… more
Amount: £264,009
Amount: £1,016,251
Amount: £2,000,000
Amount: £2,750,000
Amount: £2,610,000
Amount: £2,490,000
Understanding the role of ionocytes in a cystic fibrosis (CF) context using human induced pluripotent stem cell (hiPSC)-derived airway epithelial cells (AECs).
Cystic Fibrosis (CF) affects over 10000 people in the UK. It is a recessive monogenic disease caused by a double mutation in the gene encoding for CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) and it affects multiple tissues, especially the lung. There is still no cure for this disease and patients require life-long treatment and eventually lung transplantation. This projects aims t… more
Amount: £300,000
Biomolecular condensation of hairpin proteins coordinates cytoplasmic clients to spatially distinct microdomains of the ER membrane
The endoplasmic reticulum (ER), as a single continuous membrane network, coordinates a variety of biological processes across the entire cell, providing a platform for the spatiotemporal segregation of cytoplasmic biochemistry – a crucial feature for cell survival. Despite this, our understanding of how the ER corrals most cytoplasmic clients to specific sites on its membrane remains slim. ER st… more
Amount: £300,000
How do sugar-sweetened beverage taxes really work? A complexity-informed synthesis to guide best-practice development
Sugar-sweetened beverage (SSB) taxes are intended to reduce SSB consumption, and thereby reduce obesity and type 2 diabetes rates. However, SSB taxes vary greatly in terms of design and have been introduced in a variety of different contexts. It is unlikely that each of these taxes work in the same way. My goals are to 1) improve our understanding of how SSB taxes operate, and 2) produce evidence… more
Amount: £300,000
Wellcome Four Year PhD Programme in Stem Cell Biology and Medicine
<p>Specialist post-graduate training in Stem Cell Biology and Medicine is essential to produce a stream of highly skilled and innovative investigators equipped with a deep understanding of stem cell science and its significance for future medicine. In this context, the Wellcome PhD Programme in Stem Cell Biology and Medicine is unique in the UK in focus and scope. The enduring popularity of the p… more
Amount: £6,051,821
Living Assessment: measurement, thresholds and the health of disabled and at-risk children in England, 1989-present
<p><em>Living Assessment </em>will explore two assessments of children in England since 1989: attempts to measure the support requirements of disabled children; and attempts to measure threats of harm to children&rsquo;s health and development in statutory social work practice. How have measurements been made about how and when state provision is necessary? How have thresholds for provision opera… more
Amount: £290,128
Tethered exosomes and their role in MHC-II presentation
<p style="margin-left: 0cm; margin-right: 0cm">Peptide-loaded MHC-II (pMHC-II) is presented at the surface of antigen presenting cells and it has historically been assumed that pMHC-II is localised on the plasma membrane. However, immunofluorescence data reveals pMHC-II localised to patches rather than uniformly distributed. The loading of peptide onto MHC-II occurs within MVBs, specifically on I… more
Amount: £1,066,222
The role of FUS phase transition in axonal mRNA localisation and translation
<p>The neuropathological hallmark of the two closely related neurodegenerative diseases, ALS and FTD, is the presence of poorly soluble intracellular protein aggregates consisting of low-complexity domain-bearing RNA-binding proteins (RBPs). Intriguingly, these proteins are also key components of liquid-like ribonucleoproteins (RNPs) mediating diverse physiological processes, including transporti… more
Amount: £300,000
Generating a global view of cell lineage trees during early mouse embryo development
<p style="margin-left: 0cm; margin-right: 0cm">Understanding the routes through which a single cell populates the adult organism is one of the most fundamental yet elusive areas of biology. This project aims to use recent innovations in single-cell technology to generate a blueprint of cell fate decisions during early mouse development, and to examine the mechanisms behind the regulative nature o… more
Amount: £300,000
Bridging the gap between biological plausibility and function in models of prefrontal cortex
<p>Prefrontal cortex (PFC) plays a fundamental role when we make complex decisions. However, there are very few biologically plausible neural-network models that can explain PFC activity during decision making.&nbsp;Additionally, most studies focus on sensory information that does not change during&nbsp;trials and decisions must be made at specific&nbsp;times, unlike our more dynamic&nbsp;natural… more
Amount: £300,000
“Killing me softly”: role of forces in stiffness-dependent tumour-cell killing by T cells
<p style="margin-left: 0cm; margin-right: 0cm">My research proposal aims to study the influence of forces on immune cell activation and killing during tumour cell/target cell engagement.&nbsp;&nbsp;</p> <p style="margin-left: 0cm; margin-right: 0cm">T cells have been reported to be stiffness dependently activated, but while this phenomenon is well known, the underlying mechanism remains unclear.… more
Amount: £300,000