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Search results (Displaying 845 grants)

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Earliest award date
17 Oct 2005
Latest award date
30 Sep 2020
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Amount: £1,494,699
Dissecting the neural circuits for visual perceptual learning
<p>Visual perceptual learning (VPL) is an improvement of performance of a visually guided task as a result of visual experience. However, it is not well understood whether improvements are due to changes in lower-level visual or in higher-level association brain areas, and whether improvements can transfer to untrained visual features and tasks.</p> <p>&nbsp;</p> <p>Here I propose to dissect th… more
Amount: £1,317,544
Cellular mechanisms of metabolic sensing by human hypothalamic neurons
<p>Obesity is a major public health problem, but its molecular mechanisms are poorly understood, frustrating efforts to develop broadly effective treatments. Obesity is characterised by abnormal energy homeostasis, which is regulated in large part by hypothalamic melanocortin neurons. The activity of melanocortin neurons is in turn regulated by circulating nutrients and hormones (e.g. leptin), bu… more
Amount: £1,212,840
Epigenetic inheritance: the influence of variable silencing of the repeat genome.
<p>Evidence from epidemiological studies and experiments in animal models suggests that effects of environment and lifestyle can be transmitted across generations via non-genetic mechanisms. Such mechanisms are challenging to unravel in mouse and man. In mammals, non-genetic inheritance is best exemplified by the<em> Agouti viable yellow</em> (<em>Avy</em>) mouse where phenotypic differences in g… more
Amount: £2,929,851
Disorders of Thyroid Hormone Action: Diagnosis, Pathophysiology and Therapy
<p>Having discovered that cystic degeneration of aortic media in human selenoprotein deficiency causes its aneurysmal dilatation, we will elucidate its pathogenesis using mice with conditional, aortic selenoprotein depletion and patients stem cell-derived vascular smooth muscle cells and determine whether antioxidants can inhibit this process. We will investigate structure-function relationships … more
Amount: £1,601,565
Youth, gender and teenage sexual counselling in Britain: The making of the Brook Advisory Centre, 1964-2000
<p>This research uses the history of Brook Advisory Centres (BAC) as a case study through which to reassess the history of teenage sexuality and of the anxieties it caused in postwar Britain. From the first Centre opened in 1964 in London to the present, BAC has been an important provider of contraceptive advice and sexual counselling for unmarried people and teenagers. Although the centres have … more
Amount: £155,453
Principles of human development and germ cell program
<p>Specification of human primordial germ cells (hPGCs)&nbsp;occurs around gastrulation, a critical juncture when the specification of the primary somatic lineages&nbsp;also occurs. In combination with human preimplantation embryos, in<em> vitro</em> models and hPGCs from aborted fetuses, our objective is to elucidate the origin and properties of the early human germline.</p> <p>For&nbsp;the mec… more
Amount: £2,750,000
Darwin Tree of Life
<p>Life has evolved from a single origin to generate &gt;1.5 million eukaryotic species. Sequencing all species will provide an inventory of life, transform understanding of evolution, catalogue eukaryotic gene&nbsp;toolkits for biology and biotechnology, and enable monitoring of ecosystems under increasing stress. The Darwin Tree of Life (DToL) is a new initiative that will exploit long read tec… more
Amount: £264,009
Amount: £1,016,251
Contribution of transposable elements in cell fate decision
<p>Transposable elements (TEs) are long known to be expressed in different cells during early mammalian development. However, the role of TEs in cellular differentiation has remained elusive. This proposal aims to develop new experimental and computational methods to understand the role of TEs in cellular differentiation. Single cell (sc) RNA sequencing (RNA-seq) has been developed extensively in… more
Amount: £300,000
Uncovering the roles of dynamic RNA interactions during assembly and assortment of multi-segmented viral genomes
<p>Rotaviruses (RV) comprise a diverse and rapidly evolving group of segmented double-stranded (ds)RNA viruses of the <em>Reoviridae</em> family that cause deadly gastroenteritis in children worldwide. A hallmark of rotavirus morphogenesis is the stoichiometric assembly of eleven distinct genome ssRNA segment precursors prior to packaging. Elucidating the mechanism of accurate &lsquo;molecular co… more
Amount: £1,177,077
Amount: £2,000,000
The Genetic Basis of Congenital Hypothyroidism
<p>I have already identified 2 novel genetic causal variants for congenital hypothyroidism (CH) by whole exome sequencing (WES); IGSF1 defects in central hypothyroidism and SLC26A7 in dyshormonogenetic CH. I will therefore continue this strategy to identify further genetic causes of CH. I will expand my CH cohort, enriched for probability of genetic mutations. After excluding candidate gene defec… more
Amount: £214,297
Amount: £2,750,000
Amount: £2,610,000
Socio-cultural factors in Zika virus outcomes in Lusophone African countries
<p>What is the research question?<br />1) What social barriers to, and enablers for, effective public health responses/adoption of<br />preventive measures can be identified in health beliefs and practices associated with<br />the Zika virus, with particular attention to variations between countries with different<br />incidence of the disease, socio-demographic groups, and over time? ( WT-DFID<b… more
Amount: £246,252