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Earliest award date
30 Jan 2007
Latest award date
30 Dec 2017
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Vacation Scholarships 2017 - University of Cambridge
<p>Vacation Scholarships 2017 - University of Cambridge</p>
Amount: £21,500
Mechanism of parasite mediated suppression of autoimmunity.
The development of autoimmune diseases such as Type 1 diabetes is influenced by both genetic and environmental factors. Data from both animal models of human autoimmune diseases and from human inflammatory and autoimmune conditions suggest that infections and in some cases products of infectious agents have the capacity to prevent or ameliorate autoimmune pathology. In this application the produc… more
Amount: £167,621
The structural basis for the interaction of carbohydrates with PfEMP1 proteins in malaria pathogenicity.
We have developed an expression system that allows us to produce large quantities of correctly folded, functional DBL domains from carbohydrate binding PfEMP1 proteins. We have also produced crystals of a chondroitin sulphate A (CSA) binding DBL domain. We will use these tools to investigate the structural basis for binding of CSA to this domain. (i) We will determine the structure of a CSA bindi… more
Amount: £140,347
Amount: £300,000
Functional characterisation of Kinesin using the Drosophila oocyte as a model system.
The goal of this project is to understand how the motor protein Kinesin recognises its cargoes, achieves specificity in its transport and is regulated during Drosophila melanogaster oogenesis. Kinesin is a molecular motor that uses energy utilised from the hydrolysis of ATP to move cargo towards the plus ends of microtubules [1]. Kinesin-mediated cargo transport is conserved in vertebrate and inv… more
Amount: £144,363
Amount: £144,363
Functional Genomics of the B-G multigene family.
The overall goal is to understand the functional genomics of the B-G multigene family. The three aims are to: 1. examine polygenism in the B-G region by analysing at least one haplotype in addition to the one already characterised 2. examine allelic polymorphism for several B-G genes by analysing sequences from seven standard haplotypes 3. examine potential functions by analysing interactions with candidate ligands, both extracellular and intracellular.
Amount: £144,363
The role of envelope proteins in the outcome of lentivirus infections in hominoids
The overall aim of the project is to better characterise the non-pathogenic HIV-1 and SIVcpz infection of chimpanzees, where a high viral load is maintained without progression to AIDS, and to determine the factors that result in this non-progressive outcome. Determining the differences between pathogenic infection of humans and non-pathogenic infection of our closest relative will provide unique… more
Amount: £144,363
In vivo regulation of Salmonella enterica serovar Typhi Vi polysaccharide and the consequences for the pathogenesis of the infection and induction of immune responses.
Vi is a surface polysaccharide capsule expressed by pathogenic isolates of S.enterica serovar Typhi, Dublin and Paratyphi. Vi enhances pathogenicity by inhibiting bacterial internalization and killing by phagocytes but can also be detrimental to the bacteria due to interference with key stages of the infection and to elicitation of anti-Vi antibodies. Thus, careful regulation of Vi biosynthesis i… more
Amount: £216,048
Expression and function coupling of P2Y1 and other P2Y nucleotide receptors in neurons.
P2Y receptors are G protein-coupled receptor targets for extracellular nucleotides. Some of these receptors are or appear to be present in the brain but their function therein is not well understood. By expressing different P2Y receptors in sympathetic neurons, we previously showed that their activation can variously modulate several neuronal ion channels. Recently we have localized one such rece… more
Amount: £230,244
The role of nucleophosmin in maintaining genomic ns inintegrity and implications in lymphomagenesis.
The role of Nucleophosmin in maintaining genomic integrity and implications in lymphomagenesis 1) To assess whether the NPM gene is mutated/deleted in lymphoma. 2) To examine the role of NPM in maintaining genomic integrity. 3) To examine the contribution of NPM haploinsufficiency to NPM-ALK-induced lymphomagenesis in a mouse model.
Amount: £10,062
From Cures to Courts of Justice: The Medical Encounter and Social Order in Early Modern Spain
<p>Early modern encounters have mainly been studied as transactions between individual sick people and their healers. This project shifts the focus by placing encounters within the communities that structured early modern lives and the practices and expectations of social order that shaped them. The variety of encounters that took place in the Catholic kingdom of Castile provides an ideal case st… more
Amount: £147,847
Applying causal interventions to brain networks underlying adaptive perceptual decision making.
<p>The contribution of individual brain regions to perception is not static, and is determined both by task experience and particular stimulus demands. To investigate these dynamic contributions, I propose to use non-invasive brain stimulation combined with electrophysiological measurements. This combination will provide a window into the dynamics of causal relationships between behaviour and spe… more
Amount: £250,000
Putting genomic surveillance at the heart of viral epidemic response.
<p>This proposal is to develop an end-to-end system for processing samples from viral outbreaks to generate real-time epidemiological information that is interpretable and actionable by public health bodies. Fast evolving RNA viruses (such as&nbsp;Ebola, MERS, SARS, influenza etc) continually accumulate changes in their genomes that can be used to reconstruct the epidemiological processes that dr… more
Amount: £482,639
Fractionating the human frontoparietal cortex: combining meta-analytic and real-time optimization approaches
<p>Disruptions in the same set of frontal and parietal brain regions are seen across a striking range of psychiatric and neurological conditions. This network of regions has been referred to as <em>multiple-demand</em> (MD) system and can be divided into at least two closely coupled subnetworks. However, despite extensive research efforts, the specific functional mechanism each subnetwork support… more
Amount: £250,000